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1. 发明申请

US20120220664A1 USE OF METFORMIN IN CANCER TREATMENT AND PREVENTION 审中-公开
标题翻译：在治疗和预防中使用金属蛋白酶
公开(公告)号：US20120220664A1
公开(公告)日：2012-08-30
申请号：US13391890
申请日：2010-08-25
申请人： Kevin Struhl , Heather Hirsch , Dimitrios Iliopoulos
发明人： Kevin Struhl , Heather Hirsch , Dimitrios Iliopoulos
IPC分类号： A61K31/155 , A61P35/00
CPC分类号： A61K31/155 , A61K31/704 , A61K45/06 , A61K2300/00
摘要： Disclosed herein is a method for treating a tumor in a subject in need thereof comprising administering an enhancing amount of metformin and a reduced amount of one or more chemotherapeutic agents. One example of an enhancing amount of metformin is about 250 mg/day. Also disclosed is a Untreated method for preventing cancer or delaying the recurrence of cancer in a subject comprising administering an effective amount of metformin to the subject. In one example of such a method, the amount of metformin is about 75 mg/day. Also disclosed is a composition comprising an enhancing amount of metformin, and a reduced amount of one or more chemotherapeutic agents and a pharmaceutically acceptable carrier. Kits comprising metformin and one or more chemotherapeutic agents are also disclosed.
摘要翻译：本文公开了一种用于治疗有需要的受试者的肿瘤的方法，包括给予增加量的二甲双胍和减少量的一种或多种化学治疗剂。二甲双胍的增加量的一个例子是约250mg /天。还公开了一种用于预防癌症或延缓受试者中癌症复发的未治疗方法，其包括向受试者施用有效量的二甲双胍。在这种方法的一个实例中，二甲双胍的量为约75mg /天。还公开了包含增加量的二甲双胍和减少量的一种或多种化学治疗剂和药学上可接受的载体的组合物。还公开了包含二甲双胍和一种或多种化学治疗剂的试剂盒。

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