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1. 发明申请

US20080255474A1 TEAR MENISCUS TEST DEVICE AND ITS MANUFACTURING METHOD 审中-公开
标题翻译： TEAR MENISCUS测试设备及其制造方法
公开(公告)号：US20080255474A1
公开(公告)日：2008-10-16
申请号：US12099215
申请日：2008-04-08
申请人： Katsushi Ishida , Kazuo Tsubota
发明人： Katsushi Ishida , Kazuo Tsubota
IPC分类号： A61B3/10 , B32B38/04
CPC分类号： A61B5/4514 , A61B3/101 , A61B10/0045 , A61B2010/0006 , A61B2010/0067 , A61B2090/3937 , G01N33/52 , Y10T156/1054
摘要： A tear meniscus test device 1 includes a body part 2 having a elongated shape, which comprises a synthetic resin material or a synthetic rubber material, wherein a groove 3 is formed along the length direction of the elongated shape, and a water absorbing member 4 arranged in the groove 3.
摘要翻译：撕裂弯液面测试装置1包括具有细长形状的主体部分2，其包括合成树脂材料或合成橡胶材料，其中沿着细长形状的长度方向形成有槽3，以及布置成在凹槽3中。

2. 发明申请

US20070254013A1 Medical Material and Process for Producing the Same 审中-公开
标题翻译：医疗材料及其生产工艺
公开(公告)号：US20070254013A1
公开(公告)日：2007-11-01
申请号：US10588309
申请日：2005-02-01
申请人： Tetsushi Taguchi , Hisatoshi Kobayashi , Junzo Tanaka , Kazuo Tsubota , Naoshi Shinozaki , Shigeto Shimmura , Hideyuki Miyashita
发明人： Tetsushi Taguchi , Hisatoshi Kobayashi , Junzo Tanaka , Kazuo Tsubota , Naoshi Shinozaki , Shigeto Shimmura , Hideyuki Miyashita
IPC分类号： A61F2/14
CPC分类号： A61L27/3804 , A61L27/3604 , A61L27/3641 , A61L27/3687 , A61L27/3839 , A61L2430/16
摘要： [Object] A medical material that improves therapeutic effects in epithelial cells such as keratoconjunctival epithelial cells with the use of an amnion, and a process for producing the same are provided. [Solving Means] A medical material includes an amnion, which is a placental tissue, a polymer film bonded to one surface of the amnion and crosslinked, and cells adhered to the other surface of the amnion. A process for producing the medical material includes the steps of preparing an amnion from which the spongy layer is removed, bonding a biocompatible polymer film to one surface of the amnion followed by crosslinking, adhering epithelial stem cells to the other surface of the amnion, and proliferating epithelial cells from the epithelial stem cells on the surface of the amnion.
摘要翻译：提供了一种使用羊膜改善上皮细胞如角膜结膜上皮细胞治疗效果的医疗材料及其制造方法。 [解决方案]药物材料包括羊膜，羊膜组织，与羊膜的一个表面结合并交联的聚合物膜，以及附着在羊膜的另一表面的细胞。制造医疗材料的方法包括以下步骤：制备从其中除去海绵层的羊膜，将生物相容性聚合物膜粘合到羊膜的一个表面，然后交联，将上皮干细胞粘附到羊膜的另一个表面，以及从羊膜表面的上皮干细胞增殖上皮细胞。

3. 发明申请

US20060188410A1 Sample fluid collecting device 审中-公开
标题翻译：样品流体收集装置
公开(公告)号：US20060188410A1
公开(公告)日：2006-08-24
申请号：US11350700
申请日：2006-02-09
申请人： Katsushi Ishida , Kazuo Tsubota
发明人： Katsushi Ishida , Kazuo Tsubota
IPC分类号： B01L3/00
CPC分类号： B01L3/5027 , A61B5/14532 , A61B5/150022 , A61B5/150213 , A61B5/150358 , A61B10/0051 , A61B10/0064 , A61B2010/0067 , B01L3/021 , B01L2300/028 , B01L2300/0663 , B01L2300/0825 , B01L2300/0838 , B01L2400/0481
摘要： A sample fluid collecting device includes a capillary tube for collecting a sample fluid; and an air reservoir portion 5 having an air hole 10 capable of being closed, which is located at one end of the capillary tube, the capillary tube being formed by two or more supporting members 2, 3 arranged with one or more gap portions 1 being provided in the lengthwise direction; and at least two transparent films 6, 9 lapped on the supporting members 2, 3 so as to cover the gap portion 1.
摘要翻译：样品流体收集装置包括用于收集样品流体的毛细管; 以及位于毛细管的一端的具有能够封闭的通气孔10的储气部5，毛细管由两个以上配置有一个以上间隙部1的支撑部件2,3形成，沿长度方向设置; 并且至少两个透明膜6,9重叠在支撑构件2,3上，以覆盖间隙部分1。

4. 发明授权

US5795912A Therapeutic composition for corneal impairment 失效
标题翻译：角膜损伤的治疗组合物
公开(公告)号：US5795912A
公开(公告)日：1998-08-18
申请号：US815511
申请日：1997-03-12
申请人： Kazuo Tsubota
发明人： Kazuo Tsubota
IPC分类号： A61K31/665 , A61K31/355
CPC分类号： A61K31/683 , A61K31/665 , Y10S514/912
摘要： This invention provides a therapeutic composition for corneal impairment which comprises a phosphoric acid diester compound of the following formula or a pharmacologically acceptable salt thereof, ##STR1## wherein R.sub.1 and R.sub.2 are the same or different and each represents a hydrogen atom or a methyl group. The therapeutic composition of this invention is useful for the treatment of electricity-related ophthalmia, snow-related ophthalmia, corneal lesions caused by contact lens wearing, and corneal impairment associated with hypolacrimia.
摘要翻译：本发明提供了一种角膜损伤治疗组合物，其包含下式的磷酸二酯化合物或其药理学上可接受的盐，其中R 1和R 2相同或不同，各自表示氢原子或甲基。本发明的治疗组合物可用于治疗电相关性眼炎，雪相关性眼炎，由隐形眼镜佩戴引起的角膜损伤和与hypolacrimia相关的角膜损伤。

5. 发明授权

US08770743B2 Eyewear 有权
标题翻译：眼镜
公开(公告)号：US08770743B2
公开(公告)日：2014-07-08
申请号：US13299357
申请日：2011-11-18
申请人： Kazuo Tsubota , Hitoshi Tanaka
发明人： Kazuo Tsubota , Hitoshi Tanaka
IPC分类号： G02C11/00 , G02C5/00
CPC分类号： G02C5/001 , A61F9/0008 , G02C11/00
摘要： Eyewear comprising a frame and a liquid storage portion that is disposed within the frame and that includes a cavity for storing liquid. The liquid storage portion includes a gas passing section that allows gas to pass therethrough from the cavity to an inside surface of the frame, which is a surface facing a head of a wearer when the frame is worn on the head, but does not allow liquid to pass therethrough from the cavity to the inside surface of the frame. The liquid storage portion may be disposed such that an outer surface of the liquid storage portion is further inside the frame than an outer surface of the frame.
摘要翻译：眼镜包括框架和液体储存部分，其设置在框架内并且包括用于储存液体的空腔。液体储存部分包括气体通过部分，其允许气体从腔体通过到框架的内表面，该框架是当框架佩戴在头部上时面向佩戴者头部的表面，但不允许液体从腔中通过到框架的内表面。液体储存部可以布置成使得液体存储部分的外表面在框架内部比框架的外表面更进一步。

6. 发明申请

US20130245119A1 THERAPEUTIC OR PROPHYLACTIC AGENT FOR CORNEAL EPITHELIUM DISORDERS AND/OR CONJUNCTIVAL EPITHELIUM DISORDERS 审中-公开
标题翻译：角膜上皮病和/或连续上皮疾病的治疗剂或预防剂
公开(公告)号：US20130245119A1
公开(公告)日：2013-09-19
申请号：US13885826
申请日：2011-11-18
申请人： Akiko Harauma , Fuminori Kawabata , Toru Moriguchi , Tetsuya Kawakita , Kazuo Tsubota
发明人： Akiko Harauma , Fuminori Kawabata , Toru Moriguchi , Tetsuya Kawakita , Kazuo Tsubota
IPC分类号： A61K31/202
CPC分类号： A61K31/202 , A61K9/0053 , A61K31/20 , A61K31/232 , A61K31/661 , A61K35/60 , A61K35/612
摘要： The present invention provides an effective and safe prophylactic and therapeutic pharmaceutical agent and supplement for corneal epithelium disorders and/or conjunctival epithelial disorders. This is a therapeutic and/or prophylactic agent for corneal epithelium disorders and/or conjunctival epithelial disorders comprising eicosapentaenoic acid and/or docosahexaenoic acid, a glycerin ester or phospholipid comprising these fatty acids as constituent fatty acids, or a lower alcohol ester of these fatty acids as active ingredients. These preferably comprise EPA and/or DHA in the form of a refined fish oil or refined krill oil. A total of at least approximately 50 to 5,000 mg of EPA and/or DHA or the esters thereof are taken daily, thereby easing corneal epithelium disorders and/or conjunctival epithelial disorders. In addition, the amount of tears may be recovered.
摘要翻译：本发明提供了一种有效和安全的预防和治疗药剂以及角膜上皮病和/或结膜上皮疾病的补充剂。这是包含二十碳五烯酸和/或二十二碳六烯酸的角膜上皮细胞病和/或结膜上皮病症的治疗和/或预防剂，包含这些脂肪酸作为构成脂肪酸的甘油酯或磷脂，或这些脂肪酸的低级醇酯酸作为活性成分。这些优选包含精制鱼油或精制磷虾油形式的EPA和/或DHA。每天服用至少约50至5,000mg的EPA和/或DHA或其酯，从而缓解角膜上皮病和/或结膜上皮病。此外，眼泪量可以恢复。

7. 发明申请

US20120162598A1 EYEWEAR 有权
标题翻译：眼镜
公开(公告)号：US20120162598A1
公开(公告)日：2012-06-28
申请号：US13299357
申请日：2011-11-18
申请人： Kazuo TSUBOTA , Hitoshi TANAKA
发明人： Kazuo TSUBOTA , Hitoshi TANAKA
IPC分类号： G02C11/00
CPC分类号： G02C5/001 , A61F9/0008 , G02C11/00
摘要： Eyewear comprising a frame and a liquid storage portion that is disposed within the frame and that includes a cavity for storing liquid. The liquid storage portion includes a gas passing section that allows gas to pass therethrough from the cavity to an inside surface of the frame, which is a surface facing a head of a wearer when the frame is worn on the head, but does not allow liquid to pass therethrough from the cavity to the inside surface of the frame. The liquid storage portion may be disposed such that an outer surface of the liquid storage portion is further inside the frame than an outer surface of the frame.
摘要翻译：眼镜包括框架和液体储存部分，其设置在框架内并且包括用于储存液体的空腔。液体储存部分包括气体通过部分，其允许气体从腔体通过到框架的内表面，该框架是当框架佩戴在头部上时面向佩戴者头部的表面，但不允许液体从腔中通过到框架的内表面。液体储存部可以布置成使得液体存储部分的外表面在框架内部比框架的外表面更进一步。

8. 发明申请

US20060281173A1 Composition for coating support for preparation of cell sheet support for preparation of cell sheet and process for producing cell sheet 审中-公开
标题翻译：用于制备细胞片载体用于制备细胞片的涂层支持物的组合物和用于生产细胞片的方法
公开(公告)号：US20060281173A1
公开(公告)日：2006-12-14
申请号：US10572453
申请日：2004-03-25
申请人： Keiichi Fukuda , Yuji Itabashi , Kazuo Tsubota
发明人： Keiichi Fukuda , Yuji Itabashi , Kazuo Tsubota
IPC分类号： C12N5/06 , C12N5/00 , A61K35/12
CPC分类号： C12N5/0068 , C12N2533/56
摘要： Disclosed are a method for manufacturing a cell sheet, comprising culturing cells on a fibrin-coated surface of a substrate until the cells reach confluency, continuing the cultivation of the cells for a sufficient time period to cause the degradation of fibrin at the bottom of the cells, and detaching the cultured cells from the substrate surface in a sheet-like form to give a cell sheet; a substrate for cell sheet preparation, a surface of which is coated with fibrin; and a composition for use in coating with fibrin a surface of a substrate for cell sheet preparation, the composition comprising fibrinogen and thrombin. The invention enables to cell sheets to be manufactured by a simple manipulation using a substrate coated with a commercial, commonly available material of which safety has been confirmed.
摘要翻译：公开了一种制造细胞片的方法，包括在基质的纤维蛋白包被的表面上培养细胞直到细胞达到融合，继续培养细胞足够的时间以引起纤维蛋白降解在细胞，并以片状形式将培养的细胞从基底表面分离，得到细胞片; 用于细胞片制备的基底，其表面涂有纤维蛋白; 以及用于细胞片制备用底物的表面纤维蛋白的涂布用组合物，所述组合物含有纤维蛋白原和凝血酶。本发明使得能够通过简单的操作使用涂覆有已经确认了安全性的商业的通常可获得的材料的基材来制造细胞片。

9. 发明授权

US4990150A Bandage for maintaining anterior chamber of eye 失效
标题翻译：用于维持眼前房的绷带
公开(公告)号：US4990150A
公开(公告)日：1991-02-05
申请号：US376580
申请日：1989-07-07
申请人： Kazuo Tsubota , Hiroshi Sakai
发明人： Kazuo Tsubota , Hiroshi Sakai
IPC分类号： A61F9/007 , A61F13/00 , A61F13/12
CPC分类号： A61F9/007 , A61F13/124 , A61F2013/00182 , A61F2013/00497
摘要： The bandage for maintaining the anterior chamber of an eye according to the present invention is formed so as to cover an incision during operation and to tightly contact with the incision and its circumference, has a small hole for insertion of instruments for operation and is transparent. This bandage can prevent the outflow of aqueous humor through an incision during ocular operation without conducting the temporary suture of incision and thereby enables ocular operation in a state where the anterior chamber is maintained. Therefore, the bandage has solved various problems (e.g. complicated operation procedure, long operation time, high invasion associated with operation) encountered in the conventional ocular operation wherein the incision is temporarily sutured to prevent the outflow of aqueous humor therethrough and thereby to maintain the anterior chamber.

10. 发明申请

US20070008492A1 Method and apparatus for measuring operating visual acuity 有权
标题翻译：用于测量手术视力的方法和装置
公开(公告)号：US20070008492A1
公开(公告)日：2007-01-11
申请号：US11482845
申请日：2006-07-07
申请人： Minako Kaido , Kazuo Tsubota
发明人： Minako Kaido , Kazuo Tsubota
IPC分类号： A61B3/02
CPC分类号： A61B3/028 , A61B3/032
摘要： The present invention provides a method and apparatus for measuring operating vision. An optotype mark is displayed (step 103). A subject's response to the optotype mark is accepted via an input device (step 104). A determination is made as to whether or not the response is correct (step 105). When the current response of the subject is correct and the previous response or one of the previous response and the last-but-one response is incorrect, an optotype mark corresponding to the same visual acuity is presented (step 112). When the previous response is correct or both the previous response and the last-but-one response are correct, an optotype mark corresponding to a visual acuity one level higher is presented (step 110). When the current response is incorrect, an optotype mark corresponding to a visual acuity one level lower is presented (step 111).
摘要翻译：本发明提供了一种用于测量操作视觉的方法和装置。显示视标标记（步骤103）。受试者对视标标记的响应通过输入装置被接受（步骤104）。确定响应是否正确（步骤105）。当对象的当前响应是正确的，并且先前的响应或先前的响应和最后一个响应中的一个不正确时，呈现对应于相同视力的视标（步骤112）。当先前的响应是正确的或者先前的响应和最后一个响应都是正确的时，呈现对应于一个级别更高的视敏度的视标标记（步骤110）。当电流响应不正确时，呈现对应于一级视觉敏锐度的视标标记（步骤111）。

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