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1. 发明授权

US08486680B2 Xylanases, nucleic acids encoding them and methods for making and using them 有权
标题翻译：木聚糖酶，编码它们的核酸以及制备和使用它们的方法
公开(公告)号：US08486680B2
公开(公告)日：2013-07-16
申请号：US12681604
申请日：2008-08-01
申请人： Kevin A. Gray , Reinhard Dirmeier
发明人： Kevin A. Gray , Reinhard Dirmeier
IPC分类号： C12N9/24
CPC分类号： C12P19/14 , C12N9/248 , C12P19/02 , D21H17/22 , Y02E50/16 , Y02T50/678 , Y10T428/249921
摘要： The invention relates to enzymes having xylanase, mannanase and/or glucanase activity, e.g., catalyzing hydrolysis of internal β-1,4-xylosidic linkages or endo-β-1,4-glucanase linkages; and/or degrading a linear polysaccharide beta-1,4-xylan into xylose. Thus, the invention provides methods and processes for breaking down hemicellulose, which is a major component of the cell wall of plants, including methods and processes for hydrolyzing hemicelluloses in any plant or wood or wood product, wood waste, paper pulp, paper product or paper waste or byproduct. In addition, methods of designing new xylanases, mannanases and/or glucanases and methods of use thereof are also provided. The xylanases, mannanases and/or glucanases have increased activity and stability at increased pH and temperature.
摘要翻译：本发明涉及具有木聚糖酶，甘露聚糖酶和/或葡聚糖酶活性的酶，例如催化内部β-1,4-木糖苷键或内切-β-1,4-葡聚糖酶键的水解; 和/或将线性多糖β-1,4-木聚糖降解成木糖。因此，本发明提供了分解作为植物细胞壁的主要成分的半纤维素的方法和方法，包括在任何植物或木材或木制品，木材废料，纸浆，纸制品中水解半纤维素的方法和方法，废纸或副产品。另外，还提供了设计新的木聚糖酶，甘露聚糖酶和/或葡聚糖酶的方法及其使用方法。木聚糖酶，甘露聚糖酶和/或葡聚糖酶在增加的pH和温度下具有增加的活性和稳定性。

2. 发明申请

US20110171693A1 AMYLASES, NUCLEIC ACIDS ENCODING THEM AND METHODS FOR MAKING AND USING THEM 有权
标题翻译：氨基酸，编码它们的核酸及其制备和使用它们的方法
公开(公告)号：US20110171693A1
公开(公告)日：2011-07-14
申请号：US12822413
申请日：2010-06-24
申请人： WALTER CALLEN , TOBY RICHARDSON , GERHARD FREY , KEVIN A. GRAY , JANNE S. KEROVUO , MALGORZATA SLUPSKA , NELSON R. BARTON , EILEEN O'DONOGHUE , CARL MILLER
发明人： WALTER CALLEN , TOBY RICHARDSON , GERHARD FREY , KEVIN A. GRAY , JANNE S. KEROVUO , MALGORZATA SLUPSKA , NELSON R. BARTON , EILEEN O'DONOGHUE , CARL MILLER
IPC分类号： C12P19/20 , C07H21/00 , C12N15/63 , C12N5/10 , C12N1/21 , C12N1/15 , C12N1/19 , C12N9/34 , C12N9/26 , C12N11/00 , C12P19/14 , C12S9/00 , D06M16/00 , C12P7/06 , D21H17/22 , C12C11/00 , A21D8/04 , A23L1/09
CPC分类号： A21D8/042 , A61K38/00 , C12C5/004 , C12N9/2411 , C12N9/2414 , C12N9/2428 , C12P19/14 , C12P19/16 , C12P19/20 , Y02E50/17
摘要： In one aspect, the invention is directed to polypeptides having an amylase activity, polynucleotides encoding the polypeptides, and methods for making and using these polynucleotides and polypeptides. In one aspect, the polypeptides of the invention can be used as amylases, for example, alpha amylases, to catalyze the hydrolysis of starch into sugars. In one aspect, the invention provides delayed release compositions comprising an desired ingredient coated by a latex polymer coating.
摘要翻译：一方面，本发明涉及具有淀粉酶活性的多肽，编码多肽的多核苷酸，以及制备和使用这些多核苷酸和多肽的方法。在一个方面，本发明的多肽可用作淀粉酶，例如α-淀粉酶，以催化淀粉水解成糖。一方面，本发明提供包含通过胶乳聚合物涂层涂覆的所需成分的延迟释放组合物。

3. 发明授权

US07816108B2 Methods for using polypeptides having amylase activity and nucleic acids encoding them 有权
标题翻译：使用具有淀粉酶活性的多肽和编码它们的核酸的方法
公开(公告)号：US07816108B2
公开(公告)日：2010-10-19
申请号：US11621543
申请日：2007-01-09
申请人： Walter Callen , Toby Richardson , Gerhard Frey , Jay M. Short , Eric J. Mathur , Kevin A. Gray , Janne S. Kerovuo , Malgorzata Slupska
发明人： Walter Callen , Toby Richardson , Gerhard Frey , Jay M. Short , Eric J. Mathur , Kevin A. Gray , Janne S. Kerovuo , Malgorzata Slupska
IPC分类号： C12P7/14 , C12N9/26 , C12N9/28
CPC分类号： C12N9/2417 , A21D8/042 , C12N9/2414 , C12P19/04 , C12P19/14 , C12Y302/01001 , Y02E50/16 , Y02E50/17
摘要： The invention relates to uses of polypeptides having amylase activity, nucleic acids encoding them, and methods for making and using them. For example, in one aspect, the invention provides methods for making alcohol using polypeptides of the invention. In one aspect, the polypeptides having amylase activity have increased activity and stability at acidic, neutral and alkaline pH and increased temperature. In one aspect, the invention provides methods for producing an alcohol, for producing a high-maltose or a high-glucose syrup or a mixed syrup, for liquifying a starch-comprising composition, for hydrolyzing a starch, comprising use of polypeptides of the invention, or polypeptides encoded by the nucleic acids of this invention.
摘要翻译：本发明涉及具有淀粉酶活性的多肽的用途，编码它们的核酸以及制备和使用它们的方法。例如，一方面，本发明提供了使用本发明多肽制备醇的方法。一方面，具有淀粉酶活性的多肽在酸性，中性和碱性pH和升高的温度下具有增加的活性和稳定性。一方面，本发明提供用于生产高麦芽糖或高葡萄糖浆或混合糖浆的醇的方法，用于液化包含淀粉的组合物，用于水解淀粉，包括使用本发明的多肽，或由本发明的核酸编码的多肽。

4. 发明授权

US07078035B2 Phytases, nucleic acids encoding them and methods for making and using them 失效
公开(公告)号：US07078035B2
公开(公告)日：2006-07-18
申请号：US10156660
申请日：2002-05-24
申请人： Jay M. Short , Kevin A. Gray , Nelson R. Barton , James B. Garrett , Eileen O'Donoghue
发明人： Jay M. Short , Kevin A. Gray , Nelson R. Barton , James B. Garrett , Eileen O'Donoghue
IPC分类号： C12N9/06 , C07K1/00 , C07H21/04 , A23J1/00 , A61K38/46
CPC分类号： A21D8/042 , A01K2217/05 , A23J3/14 , A23K10/30 , A23K20/189 , A23L5/25 , A23L7/107 , A23L11/33 , A23L29/06 , A23V2002/00 , A61K38/00 , C12N9/16 , C12Y301/03008 , C12Y301/03026 , A23V2300/21
摘要： The invention provides isolated and recombinant phytase enzymes. In one aspect, the phytases are produced by modification of the wild type appA of E. coli. The enzyme can be produced from recombinant host cells. The phytases of the invention can be used to aid in the digestion of phytate where desired. In particular, the phytases of the invention can be used in foodstuffs to improve the feeding value of phytate rich ingredients. The phytases of the invention can be thermotolerant and/or thermostable. Also provided are methods for obtaining a variant polynucleotide encoding a phytase and for obtaining a phytase with thermostability or thermotolerant at high or low temperatures.

5. 发明授权

US06855365B2 Recombinant bacterial phytases and uses thereof 有权
标题翻译：重组细菌植酸酶及其用途
公开(公告)号：US06855365B2
公开(公告)日：2005-02-15
申请号：US09866379
申请日：2001-05-24
申请人： Jay M. Short , Keith A. Kretz , Kevin A. Gray , Nelson Robert Barton , James B. Garrett , Eileen O'Donoghue , Eric J. Mathur
发明人： Jay M. Short , Keith A. Kretz , Kevin A. Gray , Nelson Robert Barton , James B. Garrett , Eileen O'Donoghue , Eric J. Mathur
IPC分类号： A01H5/00 , A01K67/027 , A21D8/04 , A23J3/14 , A23K1/14 , A23K1/16 , A23K1/165 , A23L1/015 , A23L1/03 , A23L1/105 , A23L1/20 , A23L1/211 , A23L1/30 , A61K38/00 , C07K16/40 , C12M1/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/16 , C12N15/09 , C12P21/08 , C12Q1/42 , G01N33/53 , G01N33/566 , C07H21/04 , C12N1/20 , C12N15/00 , C12Q1/34
CPC分类号： A21D8/042 , A01K2217/05 , A23J3/14 , A23K10/30 , A23K20/189 , A23L5/25 , A23L7/107 , A23L11/33 , A23L29/06 , A23V2002/00 , A61K38/00 , C12N9/16 , C12Y301/03008 , C12Y301/03026 , A23V2300/21
摘要： A purified and modified phytase enzyme from Escherichia coli K12 appA phytase is provided. The enzyme has phytase activity and improved thermal tolerance as compared with the wild-type enzyme. In addition, the enzyme has improved protease stability at low pH. Glycosylation of the modified phytase provided a further improved enzyme having improved thermal tolerance and protease stability. The enzyme can be produced from native or recombinant host cells and can be used to aid in the digestion of phytate where desired. In particular, the phytase of the present invention can be used in foodstuffs to improve the feeding value of phytate rich ingredients.
摘要翻译：提供了来自大肠杆菌K12 appA植酸酶的纯化和修饰的植酸酶。与野生型酶相比，该酶具有植酸酶活性和改善的耐热性。此外，该酶在低pH下具有改善的蛋白酶稳定性。修饰的植酸酶的糖基化提供了具有改善的热耐受性和蛋白酶稳定性的进一步改进的酶。该酶可以由天然或重组宿主细胞产生，并且可以用于有助于在需要时消化植酸盐。特别地，本发明的植酸酶可用于食品中以改善富含植酸盐的成分的摄食量。

6. 发明授权

US5811285A DSZD utilization in desulfurization of DBT by rhodococcus sp. IGTS8 失效
标题翻译： DBZ通过罗红球菌脱硫后的DSZD利用率 IGTS8
公开(公告)号：US5811285A
公开(公告)日：1998-09-22
申请号：US715554
申请日：1996-09-19
申请人： Kevin A. Gray , Charles H. Squires , Daniel J. Monticello
发明人： Kevin A. Gray , Charles H. Squires , Daniel J. Monticello
IPC分类号： C12N15/09 , C10G31/00 , C10G32/00 , C12N1/20 , C12N1/21 , C12N9/02 , C12N9/04 , C12N15/52 , C12N15/53 , C12P1/00 , C12R1/01 , C12S1/02 , C12N15/00 , C07H21/04
CPC分类号： C12N1/20 , C10G31/00 , C10G32/00 , C12N15/52 , C12N9/0004 , C12N9/0006 , C12P1/00 , C12R1/01
摘要： The invention relates to the discovery that the rate of reaction of the desulfurization of fossil fuels is enhanced by the addition of an oxidoreductase to the biocatalyst. The invention is drawn to a method for enhancing the rate of desulfurizing a fossil fuel containing organic sulfur compounds, comprising the steps of: a) contacting the fossil fuel with an aqueous phase containing a biocatalyst capable of cleaving carbon-sulfur bonds and a rate-enhancing amount of an oxidoreductase, thereby forming a fossil fuel and aqueous phase mixture; b) maintaining the mixture of step (a) under conditions sufficient for cleavage of the carbon-sulfur bonds of the organic sulfur molecules by the biocatalyst, thereby resulting in a fossil fuel having a reduced organic sulfur content; and c) separating the fossil fuel having a reduced organic sulfur content from the resulting aqueous phase. The invention also relates to a recombinant microorganism containing one or more recombinant DNA molecules which encode a biocatalyst capable of desulfurizing a fossil fuel containing organic sulfur molecules and which encode an oxidoreductase. The invention also relates to a composition comprising (a) a biocatalyst capable of desulfurizing a fossil fuel containing organic sulfur molecules and (b) an oxidoreductase.
摘要翻译：本发明涉及通过向生物催化剂中加入氧化还原酶来提高化石燃料脱硫反应速率的发现。本发明涉及提高含有机硫化合物的化石燃料脱硫速率的方法，包括以下步骤：a）使化石燃料与含有能够裂解碳 - 硫键的生物催化剂的水相接触，增加氧化还原酶的量，从而形成化石燃料和水相混合物; b）将步骤（a）的混合物保持在足以通过生物催化剂裂解有机硫分子的碳 - 硫键的条件下，从而导致具有降低的有机硫含量的化石燃料; 和c）从所得水相中分离具有降低的有机硫含量的化石燃料。本发明还涉及含有一种或多种重组DNA分子的重组微生物，所述重组DNA分子编码能够脱硫含有有机硫分子的化石燃料并编码氧化还原酶的生物催化剂。本发明还涉及一种组合物，其包含（a）能够使含有机硫分子的化石燃料脱硫的生物催化剂和（b）氧化还原酶。

7. 发明授权

US08071350B2 Amylases, nucleic acids encoding them and methods for making and using them 有权
标题翻译：淀粉酶，编码它们的核酸和制备和使用它们的方法
公开(公告)号：US08071350B2
公开(公告)日：2011-12-06
申请号：US12756079
申请日：2010-04-07
申请人： Kevin A. Gray , Nahla Aboushadi , James B. Garrett
发明人： Kevin A. Gray , Nahla Aboushadi , James B. Garrett
IPC分类号： C12N9/34 , C12P21/06 , C12P19/20 , C12P7/06 , C02F3/34 , D06M16/00 , D21C1/00 , D21C3/00 , C12C1/00 , C12C11/00 , A61K38/43 , C07H21/04
CPC分类号： C12N9/2411 , A21D8/042 , A23K10/14 , A23K20/189 , A23L29/06 , A23L29/35 , A23V2002/00 , C11D3/386 , C12C5/004 , C12N9/2417 , C12N9/2428 , C12N9/2451 , C12Y302/01 , C12Y302/01001 , C12Y302/01002 , Y02E50/17
摘要： In one aspect, the invention is directed to polypeptides having an amylase activity, polynucleotides encoding the polypeptides, and methods for making and using these polynucleotides and polypeptides. The polypeptides of the invention can be used as amylases to catalyze the hydrolysis of starch into sugars.
摘要翻译：一方面，本发明涉及具有淀粉酶活性的多肽，编码多肽的多核苷酸，以及制备和使用这些多核苷酸和多肽的方法。本发明的多肽可用作淀粉酶以催化淀粉水解成糖。

8. 发明授权

US07824895B2 Phytases, nucleic acids encoding them and methods for making and using them 有权
标题翻译：植酸酶，编码它们的核酸和制备和使用它们的方法
公开(公告)号：US07824895B2
公开(公告)日：2010-11-02
申请号：US11933174
申请日：2007-10-31
申请人： Jay M. Short , Kevin A. Gray , Nelson R. Barton , James B. Garrett , Eileen O'Donoghue , Dan E. Robertson
发明人： Jay M. Short , Kevin A. Gray , Nelson R. Barton , James B. Garrett , Eileen O'Donoghue , Dan E. Robertson
IPC分类号： C07H21/00 , C12N15/00 , C12N5/10 , C12N1/21 , C12P21/00 , C12N9/16 , C07K14/00 , C12Q1/68 , C12Q1/44
CPC分类号： A21D8/042 , A01K2217/05 , A23J3/14 , A23K10/30 , A23K20/189 , A23L5/25 , A23L7/107 , A23L11/33 , A23L29/06 , A23V2002/00 , A61K38/00 , C12N9/16 , C12Y301/03008 , C12Y301/03026 , A23V2300/21
摘要： The invention provides isolated and recombinant phytase enzymes. In one aspect, the phytases are produced by modification of the wild type appA of E. coli. The enzyme can be produced from recombinant host cells. The phytases of the invention can be used to aid in the digestion of phytate where desired. In particular, the phytases of the invention can be used in foodstuffs to improve the feeding value of phytate rich ingredients. The phytases of the invention can be thermotolerant and/or thermostable. Also provided are methods for obtaining a variant polynucleotide encoding a phytase and for obtaining a phytase with thermostability or thermotolerant at high or low temperatures.
摘要翻译：本发明提供了分离和重组的植酸酶。一方面，通过修饰大肠杆菌的野生型appA产生植酸酶。该酶可以从重组宿主细胞产生。本发明的植酸酶可以用于有助于在需要时消化植酸盐。特别地，本发明的植酸酶可用于食品中以改善富含植酸盐的成分的摄食量。本发明的植酸酶可以是耐热和/或耐热的。还提供了获得编码植酸酶的变体多核苷酸和在高温或低温下获得具有热稳定性或耐热性的植酸酶的方法。

9. 发明申请

US20100221779A1 PHYTASES, NUCLEIC ACIDS ENCODING THEM AND METHODS FOR MAKING AND USING THEM 审中-公开
标题翻译： PHYTASES，NUCLEIC ACID ENCODING THEM AND METHODS FOR MAKING AND USING THEM
公开(公告)号：US20100221779A1
公开(公告)日：2010-09-02
申请号：US12778854
申请日：2010-05-12
申请人： JAY M. SHORT , KEVIN A. GRAY , NELSON R. BARTON , JAMES B. GARRETT , EILEEN O'DONOGHUE , DAN E. ROBERTSON
发明人： JAY M. SHORT , KEVIN A. GRAY , NELSON R. BARTON , JAMES B. GARRETT , EILEEN O'DONOGHUE , DAN E. ROBERTSON
IPC分类号： C12P21/02 , C07H21/04 , C12N15/74 , C12N5/10 , C12N1/21 , C12N1/19 , C12N9/14 , C07K14/00
CPC分类号： A21D8/042 , A01K2217/05 , A23J3/14 , A23K10/30 , A23K20/189 , A23L5/25 , A23L7/107 , A23L11/33 , A23L29/06 , A23V2002/00 , A61K38/00 , C12N9/16 , C12Y301/03008 , C12Y301/03026 , A23V2300/21
摘要： The invention provides isolated and recombinant phytase enzymes. In one aspect, the phytases are produced by modification of the wild type appA of E. coli. The enzyme can be produced from recombinant host cells. The phytases of the invention can be used to aid in the digestion of phytate where desired. In particular, the phytases of the invention can be used in foodstuffs to improve the feeding value of phytate rich ingredients. The phytases of the invention can be thermotolerant and/or thermostable. Also provided are methods for obtaining a variant polynucleotide encoding a phytase and for obtaining a phytase with thermostability or thermotolerant at high or low temperatures.
摘要翻译：本发明提供了分离和重组的植酸酶。一方面，通过修饰大肠杆菌的野生型appA产生植酸酶。该酶可以从重组宿主细胞产生。本发明的植酸酶可以用于有助于在需要时消化植酸盐。特别地，本发明的植酸酶可用于食品中以改善富含植酸盐的成分的摄食量。本发明的植酸酶可以是耐热和/或耐热的。还提供了获得编码植酸酶的变体多核苷酸和在高温或低温下获得具有热稳定性或耐热性的植酸酶的方法。

10. 发明申请

US20100047392A1 Enzymes Having Alpha Amylase Activity and Methods of Making and Using Them 有权
标题翻译：具有α-淀粉酶活性的酶和制备和使用它们的方法
公开(公告)号：US20100047392A1
公开(公告)日：2010-02-25
申请号：US12567550
申请日：2009-09-25
申请人： Walter Callen , Toby Richardson , Gerhard Frey , Jay M. Short , Eric J. Mathur , Kevin A. Gray , Janne S. Kerovuo , Malgorzata Slupska
发明人： Walter Callen , Toby Richardson , Gerhard Frey , Jay M. Short , Eric J. Mathur , Kevin A. Gray , Janne S. Kerovuo , Malgorzata Slupska
IPC分类号： C12N9/26 , C12P19/14 , C11D3/386 , D06M16/00 , C13K1/06 , C09K8/20 , D21C5/02
CPC分类号： C12N9/2417 , A21D8/042 , C12N9/2414 , C12P19/04 , C12P19/14 , C12Y302/01001 , Y02E50/16 , Y02E50/17
摘要： The invention relates to alpha amylases and to polynucleotides and polypeptides encoding the alpha amylases. In addition, methods of using the alpha amylases are also provided. The alpha amylases have increased activity and stability at acidic, neutral and alkaline pH and at increased temperatures.
摘要翻译：本发明涉及α-淀粉酶和编码α-淀粉酶的多核苷酸和多肽。此外，还提供了使用α-淀粉酶的方法。在酸性，中性和碱性pH和升高的温度下，α-淀粉酶具有增加的活性和稳定性。

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