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1. 发明申请

US20100144818A1 1-BENZYLPYRAZOLE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF 审中-公开
标题翻译： 1-苄氧基吡唑衍生物，其制备方法及其治疗方法
公开(公告)号：US20100144818A1
公开(公告)日：2010-06-10
申请号：US12630470
申请日：2009-12-03
申请人： Francis BARTH , Laurent BOULU , Joseph MILLAN , Murielle RINALDI-CARMONA
发明人： Francis BARTH , Laurent BOULU , Joseph MILLAN , Murielle RINALDI-CARMONA
IPC分类号： A61K31/415 , C07D231/12 , A61P41/00
CPC分类号： C07D231/12 , C07D405/12 , C07D409/12
摘要： The present invention relates to compounds corresponding to formula (I): in which Y, R1, R2, R3, R4, R5 and R6 are as defined herein. The present invention also relates to the methods of preparation and the therapeutic applications of the compounds of formula (I).
摘要翻译：本发明涉及对应于式（I）的化合物：其中Y，R 1，R 2，R 3，R 4，R 5和R 6如本文所定义。本发明还涉及式（I）化合物的制备方法和治疗应用。

2. 发明授权

US06916838B1 1-benzylpyrazole-3-carboxylic acid tricyclic derivatives as cannabinoid receptor antagonists 有权
标题翻译： 1-苄基吡唑-3-羧酸三环衍生物作为大麻素受体拮抗剂
公开(公告)号：US06916838B1
公开(公告)日：2005-07-12
申请号：US10111916
申请日：2000-11-02
申请人： Francis Barth , Joseph Millan , Didier Oustric , Murielle Rinaldi , Martine Vernhet
发明人： Francis Barth , Joseph Millan , Didier Oustric , Murielle Rinaldi , Martine Vernhet
IPC分类号： A61K31/416 , A61P1/00 , A61P1/04 , A61P1/06 , A61P1/08 , A61P3/10 , A61P7/00 , A61P7/06 , A61P9/00 , A61P11/06 , A61P17/06 , A61P19/02 , A61P19/08 , A61P25/00 , A61P25/08 , A61P25/14 , A61P25/16 , A61P25/18 , A61P25/28 , A61P27/02 , A61P27/06 , A61P29/00 , A61P31/00 , A61P31/04 , A61P31/12 , A61P31/18 , A61P33/00 , A61P35/00 , A61P37/00 , A61P37/02 , A61P37/08 , A61P43/00 , C07D231/54
CPC分类号： C07D231/54
摘要： Tricyclic derivatives of 1-benzylpyrazole-3-carboxylic acid which are antagonists of the cannabinoid CB2 receptors; their method of preparation and pharmaceutical compositions containing them.
摘要翻译： 1-苄基吡唑-3-羧酸的三环衍生物<？img id =“CUSTOM-CHARACTER-00001”he =“279.40mm”wi =“215.90mm”file =“US06916838-20050712-P00900.TIF”alt =“custom 作为大麻素CB 2受体的拮抗剂的字符“img-content =”character“img-format =”tif“？其制备方法和含有它们的药物组合物。

3. 发明授权

US5925768A 3-pyrazolecarboxamide derivatives having cannabinoid receptor affinity 失效
标题翻译：具有大麻素受体亲和力的3-吡唑酰胺衍生物
公开(公告)号：US5925768A
公开(公告)日：1999-07-20
申请号：US77767
申请日：1998-06-03
申请人： Francis Barth , Pierre Casellas , Joseph Millan , Didier Oustric , Murielle Rinaldi , Martine Sarran
发明人： Francis Barth , Pierre Casellas , Joseph Millan , Didier Oustric , Murielle Rinaldi , Martine Sarran
IPC分类号： A61K31/00 , A61K31/415 , A61P37/00 , A61P37/02 , A61P43/00 , C07D231/14
CPC分类号： C07D231/14
摘要： The present invention relates to compounds of the formula ##STR1## in which: X.sub.1 is a group --NR.sub.1 R.sub.2 or a group --OR.sub.2 ;g.sub.2, g.sub.3, g.sub.4, g.sub.5, g.sub.6 and w.sub.2, w.sub.3, w.sub.4, w.sub.5, w.sub.6 are identical or different and are each independently hydrogen, a halogen atom, a (C.sub.1 -C.sub.4)alkyl, a (C.sub.1 -C.sub.4)alkoxy, a trifluoromethyl, a nitro or a (C.sub.1 -C.sub.4)alkylthio, with the proviso that at least one of the substituents g.sub.2, g.sub.3, g.sub.4, g.sub.5, g.sub.6 and at least one of the substituents w.sub.2, w.sub.3, w.sub.4, w.sub.5, w.sub.6 are other than hydrogen;R.sub.1 is hydrogen or a (C.sub.1 -C.sub.4)alkyl;R.sub.2 is a non-aromatic (C.sub.3 -C.sub.15)carbocyclic radical which is unsubstituted or monosubstituted or polysubstituted by a substituent selected from a halogen atom, a (C.sub.1 -C.sub.4)alkyl and a (C.sub.1 -C.sub.4)alkoxy;R.sub.3 is hydrogen or a group --CH.sub.2 R.sub.6 ; andR.sub.4 and R.sub.5 are each independently a hydrogen, a (C.sub.1 -C.sub.4)alkyl or a trifluoromethyl;or else R.sub.4 is hydrogen and R.sub.5 and w.sub.6 together constitute an ethylene or trimethylene radical; andR.sub.6 is hydrogen, a (C.sub.1 -C.sub.4)alkyl, a fluorine, a hydroxyl, a (C.sub.1 -C.sub.5)alkoxy, a (C.sub.1 -C.sub.5)alkylthio, a hydroxy(C.sub.1 -C.sub.5)alkoxy, a cyano, a (C.sub.1 -C.sub.5)alkylsulfinyl or a (C.sub.1 -C.sub.5)alkylsulfonyl with the proviso that when the substituents g.sub.2, g.sub.3, g.sub.4, g.sub.5 and/or g.sub.6 are a (C.sub.1 -C.sub.4)alkyl R.sub.6 is only hydrogen;to a process for their preparation and to the pharmaceutical compositions in which they are present.These compounds have a good affinity for the peripheral cannabinoid receptors.
摘要翻译： PCT No.PCT / FR96 / 01953 Sec。 371日期1998年6月3日第 102（e）1998年6月3日PCT PCT 1996年12月6日PCT公布。公开号WO97 / 21682 日期：1997年6月19日本发明涉及下式的化合物，其中：X 1为基团-NR 1 R 2或基团-OR 2; g2，g3，g4，g5，g6和w2，w3，w4，w5，w6相同或不同，各自独立地为氢，卤素原子，（C1-C4）烷基，（C1-C4）烷氧基，三氟甲基，硝基或（C 1 -C 4）烷硫基，条件是至少一个取代基g2，g3，g4，g5，g6和至少一个取代基w2，w3，w4，w5，w6是其他比氢; R1是氢或（C1-C4）烷基; R 2是未被取代或被选自卤素原子，（C 1 -C 4）烷基和（C 1 -C 4）烷氧基的取代基单取代或多取代的非芳族（C 3 -C 15）碳环基团; R3是氢或基团-CH2R6; 和R 4和R 5各自独立地为氢，（C 1 -C 4）烷基或三氟甲基; 或者R4是氢，R5和w6一起构成乙烯或三亚甲基; （C 1 -C 5）烷氧基，（C 1 -C 5）烷硫基，羟基（C 1 -C 5）烷氧基，氰基，（C 1 -C 5）烷氧基， -C 5）烷基亚磺酰基或（C 1 -C 5）烷基磺酰基，条件是当取代基g2，g3，g4，g5和/或g6为（C1-C4）烷基时，R6仅为氢; 涉及其制备方法及其存在的药物组合物。这些化合物对外周大麻素受体具有良好的亲和力。

4. 发明授权

US5204099A Cosmetic composition containing amino acid copolymers which is useful as a moisturizer 失效
标题翻译：含有氨基酸共聚物的化妆品组合物有助于作为滋润剂
公开(公告)号：US5204099A
公开(公告)日：1993-04-20
申请号：US654187
申请日：1991-02-12
申请人： Alain Barbier , Joseph Millan , Michel Sabadie
发明人： Alain Barbier , Joseph Millan , Michel Sabadie
IPC分类号： A61K8/72 , A61K8/06 , A61K8/39 , A61K8/64 , A61K8/88 , A61Q1/00 , A61Q1/02 , A61Q1/12 , A61Q17/04 , A61Q19/00 , C08G69/10 , C09K3/00
CPC分类号： C08G69/10 , A61K8/068 , A61K8/39 , A61K8/64 , A61K8/88 , A61Q19/00 , A61Q1/02 , A61Q17/00 , A61Q19/007 , A61Q19/08 , Y10S514/801 , Y10S514/873
摘要： The invention relates to the cosmetic use of an amino acid copolymer of the statistical formula ##STR1## in which: a and b are each independently 1 or 2;A and B are similar or different and are an amino acid selected from: arginine, serine, proline, glycine, histidine, alanine, lysine, ornithine, citrulline, urocanic acid, asparagine or tyrosine;m, n, p and q are integers such that the ratio (n+q)/(m+p) is between 0.5 and 4; andz is an integer such that the average molecular weight is between 1000 and 100,000; and/or one of its salts.Application: cosmetic products.
摘要翻译：本发明涉及统计学式（IMAGE）（I）的氨基酸共聚物的化妆品用途，其中：a和b各自独立地为1或2; A和B类似或不同，是选自精氨酸，丝氨酸，脯氨酸，甘氨酸，组氨酸，丙氨酸，赖氨酸，鸟氨酸，瓜氨酸，尿刊，天冬酰胺或酪氨酸的氨基酸; m，n，p和q是整数，使得比率（n + q）/（m + p）在0.5和4之间; 并且z是使得平均分子量在1000和100,000之间的整数; 和/或其盐之一。应用：化妆品。

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