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1. 发明授权

US06291424B1 Nitrosated and nitrosylated heme proteins 失效
标题翻译：亚硝化和亚硝基化血红素蛋白
公开(公告)号：US06291424B1
公开(公告)日：2001-09-18
申请号：US09092622
申请日：1998-06-05
申请人： Johnathan Stamler , Joseph Loscalzo , David J. Singel
发明人： Johnathan Stamler , Joseph Loscalzo , David J. Singel
IPC分类号： A61K3814
CPC分类号： A61K38/42 , C07K1/1077 , C07K14/3153 , C07K14/4702 , C07K14/76 , C07K14/765 , C07K14/775 , C07K14/805 , C07K16/00 , C12N9/6459 , C12N9/6472 , C12Y304/21069 , Y10S514/832 , Y10S530/829 , A61K2300/00
摘要： Nitrosylation of proteins and amino acid groups enables selective regulation of protein function, and also endows the proteins and amino acids with additional smooth muscle relaxant and platelet inhibitory capabilities. Thus, the invention relates to novel compounds achieved by nitrosylation of protein thiols. Such compounds include: S-nitroso-t-PA, S-nitroso-cathepsin; S-nitroso-lipoprotein; and S-nitroso-immunoglobulin. The invention also relates to therapeutic use if S-nitroso-protein compounds for regulating protein function, cellular metabolism and effecting vasodilation, platelet inhibition, relaxation of non-vascular smooth muscle, and increasing blood oxygen transport by hemoglobin and myoglobin. The compounds are also used to deliver nitric oxide in its most bioactive form in order to achieve the effects described above, or for in vitro nitrosylation of molecules present in the body. The invention also relates to the nitrosylation of oxygen, carbon and nitrogen moieties present on proteins and amino acids, and the use thereof to achieve the above physiological effects.
摘要翻译：蛋白质和氨基酸基团的亚硝化可以选择性调节蛋白质功能，并赋予蛋白质和氨基酸更多的平滑肌松弛剂和血小板抑制能力。因此，本发明涉及通过蛋白质硫醇的亚硝基化实现的新化合物。这些化合物包括：S-亚硝基-t-PA，S-亚硝基组织蛋白酶; S-亚硝基脂蛋白; 和S-亚硝基 - 免疫球蛋白。本发明还涉及用于调节蛋白质功能，细胞代谢和影响血管舒张，血小板抑制，非血管平滑肌松弛以及通过血红蛋白和肌红蛋白增加血氧转运的S-亚硝基蛋白化合物的治疗用途。这些化合物也用于以最具生物活性的形式递送一氧化氮，以达到上述效果，或用于身体中存在的分子的体外亚硝基化。本发明还涉及存在于蛋白质和氨基酸上的氧，碳和氮部分的亚硝基化，以及其用于实现上述生理作用的用途。

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