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1. 发明授权

US10144736B2 Substituted pteridines useful for the treatment and prevention of viral infections 有权
公开(公告)号：US10144736B2
公开(公告)日：2018-12-04
申请号：US12374457
申请日：2007-07-20
申请人： Piet AndréMaurits Maria Herdewijn , Steven Cesar Alfons De Jonghe , William John Watkins , Lee Shun Chong
发明人： Piet AndréMaurits Maria Herdewijn , Steven Cesar Alfons De Jonghe , William John Watkins , Lee Shun Chong
IPC分类号： C07D487/00 , C07D475/02 , C07D475/00 , C07D475/04 , C07D475/06 , C07D475/08
摘要： The invention provides 4,6-di- and 2,4,6-tri-substituted pteridine derivatives with a specific substitution pattern which exhibit a significant and selective activity against certain types of viral infections, in particular selectively inhibit replication of Flaviridae such as the hepatitis C virus, and are useful for the prevention and treatment of such viral infections.

2. 发明授权

US08557232B2 Stabilization of Fc-interferon-beta fusion proteins 失效
标题翻译： Fc-干扰素-β融合蛋白的稳定化
公开(公告)号：US08557232B2
公开(公告)日：2013-10-15
申请号：US12395165
申请日：2009-02-27
申请人： Stephen D. Gillies , Nigel John Watkins , Matthew Paul Baker , Kin-Ming Lo , Steven C. Degon
发明人： Stephen D. Gillies , Nigel John Watkins , Matthew Paul Baker , Kin-Ming Lo , Steven C. Degon
IPC分类号： A61K38/21 , A61K38/00 , A61K39/00 , C07K14/565
CPC分类号： C07K16/46 , A61K38/00 , A61K47/48423 , A61K47/6813 , C07K14/565 , C07K2319/30
摘要： Disclosed are Fc-interferon-beta (Fc-IFN-β) fusion proteins and nucleic acid molecules encoding them. The Fc-IFN-β fusion proteins include variants of the interferon-beta (IFN-β) protein that are altered to achieve enhanced biological activity, prolonged circulating half-life and greater solubility. Also disclosed are methods of producing the fusion proteins and methods of using the fusion proteins and/or nucleic acid molecules for treating diseases and conditions alleviated by the administration of interferon-beta.
摘要翻译：公开了Fc-干扰素-β（Fc-IFN-β）融合蛋白和编码它们的核酸分子。 Fc-IFN-β融合蛋白包括干扰素-β（IFN-β）蛋白的变体，其被改变以实现增强的生物活性，延长的循环半衰期和更大的溶解度。还公开了产生融合蛋白的方法和使用融合蛋白和/或核酸分子治疗通过施用干扰素-β缓解的疾病和病症的方法。

3. 发明授权

US08452335B2 Methods and systems for increasing wireless traffic capacity in the vicinity of an event site 有权
标题翻译：增加事件现场附近无线通信容量的方法和系统
公开(公告)号：US08452335B2
公开(公告)日：2013-05-28
申请号：US13620411
申请日：2012-09-14
申请人： Alan Graves , Jeffrey Fitchett , Brian Vezza , John Watkins
发明人： Alan Graves , Jeffrey Fitchett , Brian Vezza , John Watkins
IPC分类号： H04W40/00
CPC分类号： H04W24/02 , H04W16/04 , H04W24/04
摘要： Network entity, method and computer-readable storage medium for use in a network that includes an arrangement of cell sites, each cell site configured to provide wireless services within a respective coverage region. The network entity may include an input configured to receive position information regarding occurrence of an event at an event site, and a processing entity configured to determine, based on the position information regarding occurrence of the event and policy information regarding the network, whether the event warrants coverage region reconfiguration and, if so, to generate a message commanding an adjustment to the coverage region of at least one cell site. An output is configured to release the message towards the at least one cell site, whereby application of the adjustment to the coverage region of the at least one cell site enables an increase in traffic to be accommodated in a vicinity of the event site.
摘要翻译：网络实体，方法和计算机可读存储介质，用于包括小区站点的布置的网络中，每个小区站点被配置为在相应覆盖区域内提供无线服务。网络实体可以包括被配置为接收关于在事件站点处的事件的发生的位置信息的输入，以及被配置为基于关于事件的发生的位置信息和关于网络的策略信息来确定事件的事件保证覆盖区重新配置，并且如果是，则生成指示对至少一个小区站点的覆盖区域的调整的消息。输出被配置为向所述至少一个小区站点释放消息，由此将所述调整应用于所述至少一个小区站点的覆盖区域能够增加要容纳在所述事件站点附近的业务量。

4. 发明申请

US20120109340A1 System and Method for Providing Power Management in a Sensor Network 审中-公开
标题翻译：在传感器网络中提供电源管理的系统和方法
公开(公告)号：US20120109340A1
公开(公告)日：2012-05-03
申请号：US13281533
申请日：2011-10-26
申请人： Brian Vezza , Kent Felske , Alan Graves , John Watkins , Guy Duxbury , Tom Chihara , Jeff Fitchett
发明人： Brian Vezza , Kent Felske , Alan Graves , John Watkins , Guy Duxbury , Tom Chihara , Jeff Fitchett
IPC分类号： G05B11/01
CPC分类号： H02J1/00 , G01D21/00 , H04L67/125 , Y04S40/18 , Y10T307/406
摘要： Providing power management to sensing nodes in a sensor network may include a plurality of sensing nodes, each sensing node connected through a power management device to an external power source, such as a powered node of another network, for managing power from the external power source to the sensing node. Multiple power management devices allow for a sensor network of fixed or mobile wireless sensing nodes or sensor gateways to make use of power from an external source such as an another network. An intelligent power management device connected to at least one of the sensing nodes may provide for power policy management.
摘要翻译：向传感器网络中的感测节点提供电力管理可以包括多个感测节点，每个感测节点通过电力管理设备连接到外部电源，例如另一网络的供电节点，用于管理来自外部电源的电力到感测节点。多个电力管理设备允许固定或移动无线传感节点或传感器网关的传感器网络利用来自诸如另一网络的外部源的电力。连接到至少一个感测节点的智能电力管理装置可以提供功率策略管理。

5. 发明授权

US08143394B2 Pyrido(3,2-d)pyrimidines useful for treating viral infections 有权
标题翻译：吡啶（3,2-d）嘧啶可用于治疗病毒感染
公开(公告)号：US08143394B2
公开(公告)日：2012-03-27
申请号：US12519496
申请日：2007-12-24
申请人： William John Watkins , Lee Shun Chong , Jennifer R. Zhang
发明人： William John Watkins , Lee Shun Chong , Jennifer R. Zhang
IPC分类号： C07D471/00 , C07D487/00
CPC分类号： C07D471/04
摘要： 2-amino-pyrido(3,2-d)pyrimidine derivatives with a specific substitution pattern on positions 4 and 6 of the core structure are useful in the treatment or prevention of an infection due to a virus from the Flaviviridae family, especially HCV, when administered to a patient in a therapeutically effective amount.
摘要翻译：具有核心结构位置4和6上特定取代模式的2-氨基 - 吡啶并（3,2-d）嘧啶衍生物可用于治疗或预防由于来自黄病毒科的病毒感染，特别是HCV，当以治疗有效量施用于患者时。

6. 发明授权

US07610431B1 Configuration space compaction 有权
标题翻译：配置空间压缩
公开(公告)号：US07610431B1
公开(公告)日：2009-10-27
申请号：US11250731
申请日：2005-10-14
申请人： John Watkins , Ola Tørudbakken , John Petry , Michelle L Wong , Ravinandan R Buchamwandla
发明人： John Watkins , Ola Tørudbakken , John Petry , Michelle L Wong , Ravinandan R Buchamwandla
IPC分类号： G06F13/36
CPC分类号： G06F13/4022
摘要： In an interconnect apparatus for interconnecting at least one host to at least a plurality of presentation registers provide a presentation interface for the device to the host. The interconnect apparatus includes memory for holding the presentation registers and a governor operable to manage the presentation registers in the memory.
摘要翻译：在用于将至少一个主机与至少多个呈现寄存器互连的互连装置中，为主机提供该设备的呈现接口。互连装置包括用于保持呈现寄存器的存储器和可操作以管理存储器中的呈现寄存器的调节器。

7. 发明授权

US07536743B2 Multi-surfaces cleaning implement 有权
标题翻译：多面清洁工具
公开(公告)号：US07536743B2
公开(公告)日：2009-05-26
申请号：US10934875
申请日：2004-09-03
申请人： Jerome Joo Ge Goh , Christine Marie Kurjan , Jennifer Ellen Davis-Wilson , Leo Kopelow , Jan Hendik Maria Verbiest , Arthur Bryon Stackpole, Jr. , Thomas George Crowe , Elizabeth Ann Rohrbaugh , Tracey Ann Wurzelbacher , Matthew Lloyd Newman , Erin Meredith Lang , Ramona Zenkich , Jeffrey Thomas Halter , Anthony John Watkins
发明人： Jerome Joo Ge Goh , Christine Marie Kurjan , Jennifer Ellen Davis-Wilson , Leo Kopelow , Jan Hendik Maria Verbiest , Arthur Bryon Stackpole, Jr. , Thomas George Crowe , Elizabeth Ann Rohrbaugh , Tracey Ann Wurzelbacher , Matthew Lloyd Newman , Erin Meredith Lang , Ramona Zenkich , Jeffrey Thomas Halter , Anthony John Watkins
IPC分类号： A47L11/29 , A47L13/256
CPC分类号： A47L13/256 , A47L11/12 , A47L11/4036 , A47L11/4069 , A47L11/4075 , A47L13/20 , A47L13/24 , B25G3/38
摘要： A cleaning implement is provided for cleaning surfaces with a cleaning substrate. The cleaning implement includes a handle connected via a universal joint to a mop head. The mop head includes a bumper pad, which is made of a deformable and nonabsorbent material. The bumper pad can be deformed in the Z direction and within the X-Y plane. The cleaning implement can also include a motor for causing a portion of the mop head to move relative to the handle.
摘要翻译：提供了用清洁表面清洁基板的清洁工具。清洁器具包括通过万向接头连接到拖把头上的手柄。拖把头包括保险杠垫，其由可变形和非吸收性材料制成。保险杠垫可以在Z方向和X-Y平面内变形。清洁器具还可以包括用于使拖把头部分相对于把手移动的马达。

8. 发明授权

US07425533B2 Modified hirudin proteins and T-cell epitopes in hirudin 失效
标题翻译：水蛭素修饰水蛭素蛋白和T细胞表位
公开(公告)号：US07425533B2
公开(公告)日：2008-09-16
申请号：US10560918
申请日：2004-06-25
申请人： Matthew Baker , John Watkins
发明人： Matthew Baker , John Watkins
IPC分类号： C07K14/00
CPC分类号： C07K14/815
摘要： Modified forms of hirudin having improved properties are disclosed. The modified hirudin compounds are hirudin variants comprising amino acid substitutions in the sequence of hirudin. Peptide molecules consisting of the amino acid residue sequence CILGSDGEKNQCVTGEGTPKPESHNDGDFE (SEQ ID NO: 1) or a sequence consisting of at least 9 consecutive amino acid residues of SEQ ID NO: 1 having a potential MHC class II binding activity are disclosed. The peptide has a stimulation index of >1.8 in a biological assay of cellular proliferation, in which the index is defined as the value of cellular proliferation scored following stimulation by the peptide and divided by the value of cellular proliferation scored in control cells that have not been exposed to the peptide.
摘要翻译：公开了具有改进性能的水蛭素的修饰形式。修饰水蛭素化合物是水蛭素变体，其包含水蛭素序列中的氨基酸取代。公开了由氨基酸残基序列CILGSDGEKNQCVTGEGTPKPESHNDGDFE（SEQ ID NO：1）组成的肽分子或由具有潜在MHC II类结合活性的SEQ ID NO：1的至少9个连续氨基酸残基组成的序列。该肽在细胞增殖的生物测定中具有> 1.8的刺激指数，其中该指数被定义为在肽刺激后评分的细胞增殖值除以未分配的对照细胞中得到的细胞增殖的值暴露于肽。

9. 发明申请

US20070269435A1 Artificial proteins with reduced immunogenicity 有权
标题翻译：具有降低免疫原性的人造蛋白
公开(公告)号：US20070269435A1
公开(公告)日：2007-11-22
申请号：US11716878
申请日：2007-03-12
申请人： Stephen Gillies , Francis Carr , Jones Tim , Graham Carter , Anila Hamilton , Stephen Williams , Marian Hanlon , John Watkins , Matthew Baker , Jeffrey Way
发明人： Stephen Gillies , Francis Carr , Jones Tim , Graham Carter , Anila Hamilton , Stephen Williams , Marian Hanlon , John Watkins , Matthew Baker , Jeffrey Way
IPC分类号： A61K39/395 , A61P35/00 , C07H21/00 , C12P21/08
CPC分类号： C07K16/30 , C07K16/28 , C07K16/2863 , C07K2317/24 , C07K2317/34 , C07K2319/00 , C07K2319/30
摘要： The invention relates to artificial modified proteins, preferably fusion proteins, having a reduced immunogenicity compared to the parent non-modified molecule when exposed to a species in vivo. The invention relates, above all, to novel immunoglobulin fusion proteins which essentially consist of an immunoglobulin molecule or a fragment thereof covalently fused via its C-terminus to the N-terminus of a biologically active non-immunoglobulin molecule, preferably a polypeptide or protein or a biologically active fragment thereof. In a specific embodiment, the invention relates to fusion proteins consisting of an Fc portion of an antibody which is fused as mentioned to the non-immunological target molecule which elicits biological or pharmacological efficacy. The molecules of the invention have amino acid sequences which are altered in one or more amino acid residue positions but have in principal the same biological activity as compared with the non-altered molecules. The changes are made in regions of the molecules which are identified as T-cell epitopes, which contribute to an immune reaction in a living host. Thus, the invention also relates to a novel method of making such fusion proteins by identifying said epitopes comprising calculation of T-cell epitope values for MHC Class II molecule binding sites in a peptide by computer-aided methods.
摘要翻译：本发明涉及人体修饰蛋白，优选融合蛋白，当与体内物种暴露时，与亲本非修饰分子相比具有降低的免疫原性。本发明首先涉及新的免疫球蛋白融合蛋白，其基本上由通过其C-末端与生物活性非免疫球蛋白分子（优选多肽或蛋白质）的N末端共价融合的免疫球蛋白分子或其片段组成，或其生物活性片段。在一个具体的实施方案中，本发明涉及由抗体的Fc部分组成的融合蛋白，所述Fc部分如提及的非免疫靶标分子融合而引起生物学或药理学功效。本发明的分子具有氨基酸序列，其在一个或多个氨基酸残基位置被改变，但与未改变的分子相比具有相同的生物学活性。在被鉴定为T细胞表位的分子的区域中进行改变，其有助于在宿主中的免疫反应。因此，本发明还涉及通过鉴定所述表位来制备此类融合蛋白的新方法，包括通过计算机辅助方法计算肽中MHC II类分子结合位点的T细胞表位值。

10. 发明申请

US20050066061A1 Systems and methods for preventing an attack on healthcare data processing resources in a hospital information system 失效
标题翻译：防止在医院信息系统中对医疗数据处理资源的攻击的系统和方法
公开(公告)号：US20050066061A1
公开(公告)日：2005-03-24
申请号：US10819349
申请日：2004-04-07
申请人： Alan Graves , Jeffrey Fitchett , Stephen Elliott , John Watkins , Dany Sylvain
发明人： Alan Graves , Jeffrey Fitchett , Stephen Elliott , John Watkins , Dany Sylvain
IPC分类号： G06F15/16 , G06Q99/00 , H04B7/00 , H04L12/28 , H04M11/06 , G06F17/60
CPC分类号： H04M11/066 , G06F19/00 , G06Q50/22 , G06Q90/00 , G06Q99/00 , G16H40/20 , H04L29/06 , H04L63/08 , H04L63/10 , H04L63/1441
摘要： A system comprising a switching entity disposed between healthcare data processing resources and non-healthcare data processing resources. The switching entity is capable of operation in a first state in which an end user device is communicatively coupled to the healthcare data processing resources to support a healthcare session and a second state in which the end user device is communicatively coupled to the non-healthcare data processing resources to support a non-healthcare session. If the authentication request message is received while the switching entity is operating in the second state and a particular non-healthcare session is in progress, and the selected authentication entity is the healthcare authentication entity, initiating a memory purge at the end user device. Attacks on the healthcare data processing resources, both from the non-healthcare resources directly and via the end user device, are thus prevented.
摘要翻译：一种包括设置在保健数据处理资源和非保健数据处理资源之间的交换实体的系统。切换实体能够在第一状态下操作，其中最终用户设备通信地耦合到保健数据处理资源以支持医疗保健会话和第二状态，其中终端用户设备通信地耦合到非保健数据处理资源以支持非医疗保健会议。如果在切换实体处于第二状态并且特定非医疗保健会话正在进行时接收到认证请求消息，并且所选择的认证实体是健康认证实体，则在终端用户设备处启动存储器清除。因此可以防止来自非医疗保健资源的医疗保健数据处理资源的直接和终端用户设备的攻击。

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