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1. 发明申请

US20100035804A1 POLYPEPTIDE ANTAGONIST 审中-公开
标题翻译：多肽拮抗剂
公开(公告)号：US20100035804A1
公开(公告)日：2010-02-11
申请号：US12296180
申请日：2007-04-05
申请人： Sarbendra Pradhananga , John Sayers , Richard Ross , Peter Artymiuk
发明人： Sarbendra Pradhananga , John Sayers , Richard Ross , Peter Artymiuk
IPC分类号： A61K38/17 , C12P21/06 , C12N1/21 , C12N15/63 , A61K31/7088 , C07K14/435 , C07H21/04
CPC分类号： C07K14/61
摘要： We describe a circularly permuted growth hormone polypeptide antagonist; compositions comprising said antagonist and methods to treat conditions that would benefit from administration of said antagonist.
摘要翻译：我们描述一种循环置换的生长激素多肽拮抗剂; 包含所述拮抗剂的组合物和治疗将受益于所述拮抗剂施用的病症的方法。

2. 发明申请

US20080262689A1 Method of Operating A Vehicle 审中-公开
标题翻译：运行车辆的方法
公开(公告)号：US20080262689A1
公开(公告)日：2008-10-23
申请号：US12103489
申请日：2008-04-15
申请人： Ian John Sayers , Charles David Nicklin
发明人： Ian John Sayers , Charles David Nicklin
IPC分类号： G06F19/00
CPC分类号： B60T8/246 , B60T2210/16 , B62D11/003 , B62D11/24
摘要： A method of operating a vehicle is described, in which the vehicle includes a frame structure carrying a ground engaging structure whereby the vehicle may travel over the ground, the ground engaging structure including a pair of steerable wheels which with the vehicle travelling in a travelling direction, are front wheels, and a pair of rear wheels which may each independently be braked by the operation of respective brake devices, the vehicle further including a controller which is capable of providing signals independently to the brake devices of the rear wheels to effect application and release of a selected brake, and the method including sensing the vehicle travelling speed and providing a first input to the controller, sensing steering of the vehicle by the operator and providing a second input to the controller, and where the travelling speed is below a threshold speed, and depending on the direction of steering of the vehicle, the controller applying one of the brakes.
摘要翻译：描述了一种操作车辆的方法，其中车辆包括承载地面接合结构的框架结构，由此车辆可以在地面上行进，地面接合结构包括一对可转向车轮，车辆沿行驶方向行驶是前轮，并且一对后轮可以各自独立地通过各个制动装置的操作来制动，所述车辆还包括控制器，其能够独立地向后轮的制动装置提供信号以实现应用，释放所选择的制动器，并且所述方法包括感测车辆行驶速度并向控制器提供第一输入，感测操作者感测车辆的转向并向控制器提供第二输入，并且其中行驶速度低于阈值速度，并且取决于车辆的转向方向，控制器应用其中一个制动器。

3. 发明申请

US20050123558A1 Modifeid polypeptide 失效
标题翻译： Modiferid多肽
公开(公告)号：US20050123558A1
公开(公告)日：2005-06-09
申请号：US10498497
申请日：2002-12-06
申请人： Richard Ross , John Sayers , Peter Artymiuk
发明人： Richard Ross , John Sayers , Peter Artymiuk
IPC分类号： C12N15/09 , A61K38/00 , A61K38/17 , A61K38/27 , A61P3/10 , A61P5/06 , A61P5/08 , A61P9/10 , A61P13/12 , A61P27/02 , A61P35/00 , A61P43/00 , C07K14/61 , C07K14/72 , C07K19/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/12 , C12N15/18 , C12N15/62 , C12P21/02 , C07H21/04 , A61K39/00
CPC分类号： C07K14/72 , A61K38/00 , C07K14/61 , C07K2319/00 , C07K2319/20 , C07K2319/32 , C07K2319/75 , C12N15/62
摘要： The invention relates to chimeric polypeptides wherein said polypeptides comprise a modified binding domain of growth hormone linked to a receptor binding domain of growth hormone receptor; and tandems/oligomers of said modified growth hormone binding domains.
摘要翻译：本发明涉及嵌合多肽，其中所述多肽包含与生长激素受体的受体结合结构域连接的生长激素的修饰结合结构域; 和所述修饰的生长激素结合结构域的串联/低聚物。

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