专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20050191302A1 Treatment for liver disease 审中-公开
标题翻译：治疗肝病
公开(公告)号：US20050191302A1
公开(公告)日：2005-09-01
申请号：US10650074
申请日：2003-08-28
申请人： Michael Arthur , Derek Mann , John Iredale , Christopher Benyon , Frank Murphy , Fiona Oakley , Richard Ruddell , Matthew Wright
发明人： Michael Arthur , Derek Mann , John Iredale , Christopher Benyon , Frank Murphy , Fiona Oakley , Richard Ruddell , Matthew Wright
IPC分类号： A61K31/00 , A61K31/437 , A61K31/4402 , A61K31/454 , A61K31/496 , A61K31/4995 , A61K31/548 , A61K38/48 , A61K39/395 , A61P1/16 , C07K14/47
CPC分类号： A61K31/454 , A61K31/00 , A61K31/437 , A61K31/4402 , A61K31/496 , A61K31/4995 , A61K31/548 , A61K38/4886 , C07K14/4747 , Y02A50/423
摘要： The present invention is based on the finding that the artificial induction of hepatic stellate cell (HSC) apoptosis in vivo can promote the resolution of liver fibrosis. Thus, the present invention provides methods for treating liver disease in a subject involving administration of an inducer of apoptosis which is capable of selectively inducing hepatic stellate cell apoptosis in the liver of the subject or of an agent which is capable of giving rise to such an inducer in the subject. In addition, the invention provides methods for treating liver fibrosis in a subject comprising the selective delivery of an inducer of apoptosis specifically to the hepatic stellate cells of the subject or of an agent which is capable of giving rise to an inducer of hepatic stellate cell apoptosis.
摘要翻译：本发明是基于人体诱导肝星状细胞（HSC）体内细胞凋亡的发现，可促进肝纤维化的分解。因此，本发明提供了治疗涉及施用细胞凋亡诱导剂的受试者的肝脏疾病的方法，所述方法能够选择性地诱导受试者的肝脏中的肝星状细胞凋亡或能够产生这种诱导器在主题。此外，本发明提供了治疗受试者肝纤维化的方法，包括选择性递送细胞凋亡诱导物，特异性地向受试者的肝星状细胞或能产生肝星状细胞凋亡诱导剂的试剂。

2. 发明授权

US4670709A Portable audio system and audio cable continuity tester 失效
标题翻译：便携式音频系统和音频电缆连续性测试仪
公开(公告)号：US4670709A
公开(公告)日：1987-06-02
申请号：US595341
申请日：1984-03-30
申请人： John Iredale
发明人： John Iredale
IPC分类号： G01R31/02 , G01R31/04
CPC分类号： G01R31/045 , G01R31/026
摘要： A portable battery powered tone source with a built-in audio cable tester. Plural outputs consist of -40 dB, mic level; -10 dB line level and 1W speaker level. Continuity in the system under test from input to speakers causes an audio frequency signal to be present at speakers. This systems own speakers can be used as monitors in the testing process. Moving the device (source) enables the user to audibly locate the point at which the continuity starts/stops. At such time the user can test the audio castle at that point. The various plugs of the device are compatible with all common audio jacks enabling the user to test all types of audio equipment as well as all types of audio cables with only one device. The device can also be used to test any direct point-to-point connection such as common ground or a PC board run with a simple test lead adaptor.
摘要翻译：带有内置音频电缆测试仪的便携式电池供电音源。多个输出包括-40 dB，麦克风电平; -10 dB线电平和1W扬声器电平。从输入到扬声器的待测系统的连续性会导致音频信号出现在扬声器上。该系统自带的扬声器可用作测试过程中的显示器。移动设备（源）使用户可以可视地定位连续性开始/停止的点。在这样的时间，用户可以在那时测试音频城堡。设备的各种插头与所有常见的音频插孔兼容，使用户能够使用只有一个设备来测试所有类型的音频设备以及所有类型的音频电缆。该设备还可用于测试任何直接点对点连接，如公共地面或使用简单的测试导线适配器运行的PC板。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式