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1. 发明授权

US09132101B2 Administration form based on cross-linked hydrophilic polymers 有权
标题翻译：基于交联亲水聚合物的管理形式
公开(公告)号：US09132101B2
公开(公告)日：2015-09-15
申请号：US10596194
申请日：2004-12-13
申请人： Johannes Bartholomaus , Maria Cristina Vázquez Lantes
发明人： Johannes Bartholomaus , Maria Cristina Vázquez Lantes
IPC分类号： A61K9/70 , A61K9/00
CPC分类号： A61K9/7053 , A61K9/006 , A61K9/7007 , A61K9/7084
摘要： The invention relates to a film-shaped administration form for surface administration of at least one active ingredient and/or foodstuff to a living thing. Said administration form comprises at least one layer containing an active ingredient and/or foodstuff, said layer being based on cross-linked hydrophilic polymers and containing 20 wt.-% glycerine as a softener, in relation to the total amount of cross-linked hydrophilic polymers.
摘要翻译：本发明涉及一种用于将至少一种活性成分和/或食品表面施用于生物的薄膜状施用形式。所述施用形式包含含有活性成分和/或食品的至少一层，所述层基于交联的亲水性聚合物，并且含有作为软化剂的20重量％的甘油，相对于交联的亲水性的总量聚合物。

2. 发明申请

US20090104266A1 3-(2-DIMETHYLAMINOMETHYLCY CLOHEXYL)PHENOL RETARD FORMULATION 审中-公开
标题翻译： 3-（2-二甲基氨基甲酰基）苯酚残留制剂
公开(公告)号：US20090104266A1
公开(公告)日：2009-04-23
申请号：US12066927
申请日：2005-09-15
申请人： Tobias Jung , Johannes Bartholomaus
发明人： Tobias Jung , Johannes Bartholomaus
IPC分类号： A61K9/10 , C07C215/64 , A61P25/00 , A61K31/138
CPC分类号： A61K9/286 , A61K9/2018 , A61K9/2054 , A61K31/133 , A61K47/38 , A61K2300/00
摘要： The invention relates to a dosage form for controlled release of the active ingredient 3-(2-dimethylaminomethylcyclohexyl)phenol, preferably (1R,2R)-3-(2-dimethylamino-methylcyclohexyl)phenol, or one of the pharmaceutically acceptable salts thereof, which (i) in vivo achieves the peak plasma level of the active ingredient after 2 to 10 h, and/or (ii) in vitro, measured in accordance with the European Pharmacopoeia with a paddle stirrer apparatus in buffer at a pH value of 6.8 (preferably 900 ml), a temperature of 37° C. and 75 rpm releases after 0.5 hours 3.0 to 37 wt. %, after 1 hour 5.0 to 56 wt. %, after 2 hours 10 to 77 wt. %, after 3 hours 15 to 88 wt. %, after 6 hours at least 30 wt. %, after 12 hours at least 50 wt. %, after 18 hours at least 70 wt. % and after 24 hours at least 80 wt. % of the active ingredient originally contained in the dosage form.
摘要翻译：本发明涉及活性成分3-（2-二甲基氨基甲基环己基）苯酚，优选（1R，2R）-3-（2-二甲基氨基 - 甲基环己基）苯酚或其药学上可接受的盐之一的受控释放剂型，其中（i）体内实现活性成分在2至10小时后的峰值血浆水平，和/或（ii）在体外，使用桨式搅拌器装置在pH值为6.8的缓冲液中测量，根据欧洲药典（优选900ml），在0.5小时后释放37℃和75rpm的温度，3.0至37wt。％，1小时5.0〜56重量％％，2小时后10〜77wt。％，3小时后15〜88wt。％，6小时后至少30wt。％，12小时后至少50wt。％，18小时后至少70wt。％和24小时后至少80wt。原始包含在剂型中的活性成分的％。

3. 发明申请

US20080247959A1 FORM OF ADMINISTRATION SECURED AGAINST MISUSE 审中-公开
标题翻译：禁止管理的管理形式
公开(公告)号：US20080247959A1
公开(公告)日：2008-10-09
申请号：US12140444
申请日：2008-06-17
申请人： Johannes Bartholomaus , Heinrich Kugelmann , Elisabeth Arkenau-Maric
发明人： Johannes Bartholomaus , Heinrich Kugelmann , Elisabeth Arkenau-Maric
IPC分类号： A61K9/20
CPC分类号： A61K31/135 , A61K9/0053 , A61K9/20 , A61K9/2013 , A61K9/2027 , A61K9/2031 , A61K9/205 , A61K9/2054 , A61K9/2068 , A61K9/2095 , A61K31/485 , A61K31/515 , A61K31/5513 , A61K47/10
摘要： The invention relates to a form of administration which is thermoformed without extrusion, comprising at least one synthetic or natural polymer having a resistance to breaking of at least 500 N in addition to one or several active ingredients with a misuse potential and, optionally physiologically compatible auxiliary substances. The invention also relates to a method for the production thereof.
摘要翻译：本发明涉及一种在不挤出的情况下热成型的给药形式，包括至少一种合成或天然聚合物，除了具有滥用潜力的一种或多种活性成分以及任选的生理上相容的辅助剂之外，还具有至少500N的断裂耐受性物质本发明还涉及其制备方法。

4. 发明申请

US20070071796A1 Administration form based on cross-linked hydrophilic polymers 有权
标题翻译：基于交联亲水聚合物的管理形式
公开(公告)号：US20070071796A1
公开(公告)日：2007-03-29
申请号：US10596194
申请日：2004-12-13
申请人： Johannes Bartholomaus
发明人： Johannes Bartholomaus
IPC分类号： A61K9/70 , A01N25/00
CPC分类号： A61K9/7053 , A61K9/006 , A61K9/7007 , A61K9/7084
摘要： The invention relates to a film-shaped administration form for surface administration of at least one active ingredient and/or foodstuff to a living thing. Said administration form comprises at least one layer containing an active ingredient and/or foodstuff, said layer being based on cross-linked hydrophilic polymers and containing 20 wt.-% glycerine as a softener, in relation to the total amount of cross-linked hydrophilic polymers.
摘要翻译：本发明涉及一种用于将至少一种活性成分和/或食品表面施用于生物的薄膜状施用形式。所述施用形式包含含有活性成分和/或食品的至少一层，所述层基于交联的亲水性聚合物，并且含有作为软化剂的20重量％的甘油，相对于交联的亲水性的总量聚合物。

5. 发明申请

US20060147497A1 Administration form and kit for the oral administration of active substances, vitamins and/or nutrients and use thereof 审中-公开
标题翻译：用于口服施用活性物质，维生素和/或营养物质的用途形式和试剂盒及其用途
公开(公告)号：US20060147497A1
公开(公告)日：2006-07-06
申请号：US11373148
申请日：2006-03-13
申请人： Elke Sternberger , Rasoul Sedaghat Kerdar , Johannes Bartholomaus
发明人： Elke Sternberger , Rasoul Sedaghat Kerdar , Johannes Bartholomaus
IPC分类号： A61K47/00 , E03B9/20
CPC分类号： A61J7/0038 , A47G21/183
摘要： An administration form for oral administration of active substances, vitamins and/or nutrients including a drinking straw (1) provided with a barrier device (3) which is impermeable to the active substance formulation, vitamin formulation and/or nutrient formulation (2) and which is permeable to air and to a transport liquid. The closing device has a uniform density/thickness and a hydrophobic finish.
摘要翻译：用于口服施用活性物质，维生素和/或营养物质的管理形式，包括具有不可渗透活性物质制剂，维生素制剂和/或营养制剂（2）的阻隔装置（3）的饮用吸管（1）和其对空气和运输液体是可渗透的。闭合装置具有均匀的密度/厚度和疏水性表面。

6. 发明申请

US20050267084A1 Hormonal contraceptive containing a combination of ethinyloestradiol and chlormadinone acetate 有权
标题翻译：含有乙炔雌二醇和醋酸氯地孕酮的组合的激素避孕药
公开(公告)号：US20050267084A1
公开(公告)日：2005-12-01
申请号：US11009938
申请日：2004-12-10
申请人： Janine Klose , Johannes Bartholomaus , Klaus-Michael Wilsmann , Georg Schramm
发明人： Janine Klose , Johannes Bartholomaus , Klaus-Michael Wilsmann , Georg Schramm
IPC分类号： A61K9/28 , A61K31/565 , A61K31/57 , A61K31/56
CPC分类号： A61K9/2866 , A61K31/565 , A61K31/567 , A61K31/57 , A61K2300/00
摘要： The present invention relates to a hormonal contraceptive including 21 to 25 hormone-containing daily units, which contain a combination of ethinyloestradiol in an amount of ≧25 μg and chlormadinone acetate in an amount of ≧5 mg, and optionally 7 to 3 hormone-free daily units for oral administration to women.
摘要翻译：本发明涉及包含21-25激素含量的每日单位的激素避孕药，其含有量大于25ug的乙炔雌二醇和≥5mg量的醋酸氯地孕酮和任选的7至3个激素 - 每天为妇女口服的单位。

7. 发明申请

US20050191244A1 Abuse-resistant pharmaceutical dosage form 审中-公开
标题翻译：滥用药物剂型
公开(公告)号：US20050191244A1
公开(公告)日：2005-09-01
申请号：US11113020
申请日：2005-04-25
申请人： Johannes Bartholomaus , Klaus-Dieter Langner
发明人： Johannes Bartholomaus , Klaus-Dieter Langner
IPC分类号： A61K9/00 , A61K9/16 , A61K9/24 , A61K9/44 , A61K9/50 , A61K31/4725 , A61K31/485 , A61K45/06
CPC分类号： A61K45/06 , A61K9/0004 , A61K9/1635 , A61K9/1652 , A61K9/209 , A61K9/5042 , A61K9/5047 , A61K9/5084 , A61K31/4725 , A61K31/485 , A61K2300/00
摘要： A solid pharmaceutical dosage form that is safeguarded against abuse containing at least one active substance that could be subject to abuse and at least one antagonist for the active substance, which antagonist is spatially separate from the active substance. The active substance or substances is/are present in at least one subunit (a), and the at least one antagonist is present in at least one subunit (b), and the at least one antagonist in subunit (b) is to all intents and purposes not released in the body if the dosage form is correctly administered as prescribed.
摘要翻译：防止滥用的固体药物剂型，其含有至少一种可能被滥用的活性物质和至少一种活性物质的拮抗剂，该拮抗剂与活性物质在空间上分离。活性物质存在于至少一个亚基（a）中，至少一个拮抗剂存在于至少一个亚基（b）中，并且亚单位（b）中的至少一个拮抗剂是全部意图如果剂型按照规定正确施用，不会在体内释放的目的。

8. 发明授权

US08192722B2 Abuse-proof dosage form 有权
标题翻译：滥用药剂
公开(公告)号：US08192722B2
公开(公告)日：2012-06-05
申请号：US12140665
申请日：2008-06-17
申请人： Elisabeth Arkenau-Maric , Johannes Bartholomaus , Heinrich Kugelmann
发明人： Elisabeth Arkenau-Maric , Johannes Bartholomaus , Heinrich Kugelmann
IPC分类号： A61K31/485 , A61K9/20 , A61K49/00 , A61K9/14 , A01N43/42
CPC分类号： A61K9/2031 , A61J3/07 , A61K9/0092 , A61K9/2004 , A61K9/2009 , A61K9/2013 , A61K9/2027 , A61K9/2054 , A61K9/2068 , A61K9/2072 , A61K9/2086 , A61K9/2095 , A61K31/135 , A61K31/485
摘要： The invention relates to a dosage form that is thermoformed without discoloration and is safeguarded from abuse, comprising at least one synthetic or natural polymer having a breaking strength of at least 500 N in addition to one or more active substances that could be subject to abuse. The invention also relates to a corresponding method for producing said dosage form.
摘要翻译：本发明涉及一种热成型而不变色并且防止滥用的剂型，除了一种或多种可能遭受滥用的活性物质之外，还包含至少一种具有至少500N的断裂强度的合成或天然聚合物。本发明还涉及用于生产所述剂型的相应方法。

9. 发明申请

US20080312264A1 Process for the production of an abuse-proofed solid dosage form 有权
标题翻译：生产滥用防腐固体剂型的方法
公开(公告)号：US20080312264A1
公开(公告)日：2008-12-18
申请号：US12140496
申请日：2008-06-17
申请人： Elisabeth Arkenau-Maric , Johannes Bartholomaus
发明人： Elisabeth Arkenau-Maric , Johannes Bartholomaus
IPC分类号： A61K31/485
CPC分类号： A61K9/2095 , A61K9/1635
摘要： The present invention relates to a process for the production of an abuse-proofed solid dosage form containing at least one active ingredient with potential for abuse and a synthetic or natural polymer with a breaking strength of =500 N, characterised in that a corresponding mixture is processed by melt extrusion with the assistance of a planetary-gear extruder.
摘要翻译：本发明涉及生产含有至少一种具有滥用潜力的活性成分和具有= 500N的断裂强度的合成或天然聚合物的抗滥用固体剂型的方法，其特征在于相应的混合物为在行星齿轮挤出机的帮助下通过熔融挤出加工。

10. 发明申请

US20080286342A1 Form of Administration Based on Crosslinked Hydrophilic Polymers 有权
标题翻译：基于交联亲水聚合物的管理形式
公开(公告)号：US20080286342A1
公开(公告)日：2008-11-20
申请号：US10596202
申请日：2004-12-13
申请人： Johannes Bartholomaus , Maria Cristina Vazquez Lantes
发明人： Johannes Bartholomaus , Maria Cristina Vazquez Lantes
IPC分类号： A61K9/70 , A23L1/03
CPC分类号： C08J5/18 , A61K9/006 , A61K9/7007 , A61K9/7053 , C08B15/005 , C08J2333/02
摘要： The invention relates to a film-shaped form of administration for topically administering at least one agent and/or nutrient to a living being. Said form of administration comprises at least one agent-containing and/or nutrient-containing layer that is based on crosslinked hydrophilic polymers which are crosslinked with at least one polyacrylic acid derivative.
摘要翻译：本发明涉及一种用于向活体局部施用至少一种药剂和/或营养物的膜状给药形式。所述施用形式包含至少一种含有代谢物和/或营养物的层，其基于交联的亲水性聚合物，其与至少一种聚丙烯酸衍生物交联。

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