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1. 发明申请

US20110065779A1 AAV VECTOR COMPOSITIONS AND METHODS FOR ENHANCED EXPRESSION OF IMMUNOGLOBULINS USING THE SAME 审中-公开
标题翻译： AAV载体组合物和使用其增强免疫球蛋白表达的方法
公开(公告)号：US20110065779A1
公开(公告)日：2011-03-17
申请号：US12718069
申请日：2010-03-05
申请人： Jianmin Fang , Karin Jooss , Jing Jing Qian
发明人： Jianmin Fang , Karin Jooss , Jing Jing Qian
IPC分类号： A61K31/7088 , C12N15/63 , C07K16/00 , C12N5/00 , C12P21/00 , A61P35/00
CPC分类号： C12N15/86 , A61K48/00 , C07K16/00 , C07K16/2863 , C07K2317/21 , C07K2317/74 , C12N2750/14132 , C12N2750/14143
摘要： Single AAV vector constructs for expression of an immunoglobulin molecule or fragment thereof and methods of making and using the same are described. The AAV vectors comprise a self-processing cleavage sequence between a first and second immunoglobulin coding sequence allowing for expression of a functional antibody molecule using a single promoter. The vector constructs may further include an additional proteolytic cleavage sequence which provides a means to remove the self processing peptide sequence from an expressed immunoglobulin molecule or fragment thereof. The vector constructs find utility in enhanced production of biologically active immunoglobulins or fragments thereof in vitro and in vivo.
摘要翻译：描述了用于表达免疫球蛋白分子或其片段的单一AAV载体构建体及其制备和使用方法。 AAV载体包含允许使用单一启动子表达功能性抗体分子的第一和第二免疫球蛋白编码序列之间的自加工切割序列。载体构建体可进一步包括另外的蛋白水解切割序列，其提供从表达的免疫球蛋白分子或其片段中除去自身加工肽序列的手段。载体构建体在体外和体内发现在生物活性免疫球蛋白或其片段的增强生产中起作用。

2. 发明申请

US20100317096A1 Compositions and methods for enhanced expression of recombinant polypeptides from a single vector using a peptide cleavage site 审中-公开
公开(公告)号：US20100317096A1
公开(公告)日：2010-12-16
申请号：US11977788
申请日：2007-10-26
申请人： Jianmin Fang , Karin Jooss , Andrew Simmons , Jing-Jing Qian
发明人： Jianmin Fang , Karin Jooss , Andrew Simmons , Jing-Jing Qian
IPC分类号： C12N15/63 , C07H21/04
CPC分类号： C12N15/86 , C07K16/00 , C07K16/2863 , C07K2317/21 , C07K2317/76 , C07K2319/30 , C07K2319/50 , C12N15/8273 , C12N2750/14143 , C12N2800/60 , C12N2830/00 , C12N2830/15 , C12N2830/42 , C12N2830/48 , C12N2830/85 , C12N2830/90 , C12N2840/203
摘要： Vector constructs for expression of two or more functional proteins or polypeptides under operative control of a single promoter and methods of making and using the same are described. The vectors comprise a self-processing cleavage site between each respective protein or polypeptide coding sequence. The vector constructs include the coding sequence for a self-processing cleavage site and may further include an additional proteolytic cleavage sequence which provides a means to remove the self processing peptide sequence from expressed protein(s) or polypeptide(s). The vector constructs find utility in methods for enhanced production of biologically active proteins and polypeptides in vitro and in vivo.

3. 发明申请

US20080280356A1 Compositions and methods for enhanced expression of recombinant polypeptides from a single vector using a peptide cleavage site 失效
标题翻译：使用肽切割位点从单个载体增强表达重组多肽的组合物和方法
公开(公告)号：US20080280356A1
公开(公告)日：2008-11-13
申请号：US11977787
申请日：2007-10-26
申请人： Jianmin Fang , Karin Jooss , Andrew Simmons , Jing-Jing Qian
发明人： Jianmin Fang , Karin Jooss , Andrew Simmons , Jing-Jing Qian
IPC分类号： C12N15/00
CPC分类号： C12N15/86 , C07K16/00 , C07K16/2863 , C07K2317/21 , C07K2317/76 , C07K2319/30 , C07K2319/50 , C12N15/8273 , C12N2750/14143 , C12N2800/60 , C12N2830/00 , C12N2830/15 , C12N2830/42 , C12N2830/48 , C12N2830/85 , C12N2830/90 , C12N2840/203
摘要： Vector constructs for expression of two or more functional proteins or polypeptides under operative control of a single promoter and methods of making and using the same are described. The vectors comprise a self-processing cleavage site between each respective protein or polypeptide coding sequence. The vector constructs include the coding sequence for a self-processing cleavage site and may further include an additional proteolytic cleavage sequence which provides a means to remove the self processing peptide sequence from expressed protein(s) or polypeptide(s). The vector constructs find utility in methods for enhanced production of biologically active proteins and polypeptides in vitro and in vivo.
摘要翻译：描述了在单个启动子的操作控制下表达两种或更多种功能性蛋白质或多肽的载体构建体及其制备和使用方法。载体在每个相应的蛋白质或多肽编码序列之间包含自加工切割位点。载体构建体包括自加工切割位点的编码序列，并且还可以包括另外的蛋白水解切割序列，其提供从表达的蛋白质或多肽中除去自身加工肽序列的手段。载体构建体在体外和体内增强生物活性蛋白质和多肽生产的方法中有用。

4. 发明申请

US20060146997A1 Communications system and method for providing customized messages based on presence and preference information 有权
标题翻译：基于存在和偏好信息提供定制消息的通信系统和方法
公开(公告)号：US20060146997A1
公开(公告)日：2006-07-06
申请号：US11016254
申请日：2004-12-17
申请人： Jing Qian , Aziz Mohammed , Fuming Wu
发明人： Jing Qian , Aziz Mohammed , Fuming Wu
IPC分类号： H04M11/00
CPC分类号： H04M3/42059 , H04M3/42068 , H04M3/42374 , H04M3/4872 , H04M3/533 , H04M3/53391 , H04M3/54
摘要： A communications system provides customized messages based on presence and preference information by collecting presence information and preference information on a plurality of subscribers. The presence information includes information on the availability of a subscriber, while the preference information includes policies for different priority levels of callers. In response to unavailability of a called subscriber for a communication session, the communications manager transmits a customized response to the caller that is generated based on the presence information and the preference information of the called subscriber.
摘要翻译：通信系统通过在多个订户上收集存在信息和偏好信息，基于存在和偏好信息来提供定制消息。存在信息包括关于订户的可用性的信息，而优选信息包括针对不同优先级的呼叫者的策略。响应于用于通信会话的被叫用户的不可用性，通信管理器基于被叫用户的存在信息和偏好信息来生成针对呼叫者的定制响应。

5. 发明授权

US5780436A Peptide compositions with growth factor-like activity 失效
标题翻译：具有生长因子样活性的肽组合物
公开(公告)号：US5780436A
公开(公告)日：1998-07-14
申请号：US742256
申请日：1996-10-31
申请人： Rajendra S. Bhatnagar , Jing Jing Qian
发明人： Rajendra S. Bhatnagar , Jing Jing Qian
IPC分类号： A61K47/30 , A61K38/00 , A61K38/22 , A61K47/48 , A61L27/22 , A61P17/02 , A61P25/00 , A61P43/00 , C07K7/06 , C07K14/495 , A61K38/04 , A61K38/08 , C07K5/10
CPC分类号： C07K7/06 , A61L27/227 , C07K14/495 , A61K38/00
摘要： Small peptide mimics of TGF-.beta., having the general sequence AA.sub.i -AA.sub.i+1 -AA.sub.i+2 followed by AA.sub.i+n shortly thereafter, have been prepared. In this sequence, AA.sub.i is alanine, asparagine, or leucine, AA.sub.i+1 is valine or isoleucine, AA.sub.i+2 is alanine, n is 3, 4, or 5 such that there are n-3 amino acid residues in between AA.sub.i+2 and AA.sub.i+n, and AA.sub.i+n is glutamic acid, aspartic acid, glutamine or asparagine. Because the essential requirement for TGF-.beta. activity is the peptide's ability to form a stable .beta.-bend structure under physiologic conditions, the inventive peptides are collectively referred to as .beta.-bend peptides. Compositions for applications such as tissue repair are also provided that comprise a biocompatible matrix having cytomodulin or a cytomodulin analog admixed with or carried by the matrix.
摘要翻译：已经制备了具有通用序列AAi-AAi + 1-AAi + 2，随后是AAi + n的TGF-β的小肽模拟物。在该序列中，AAi是丙氨酸，天冬酰胺或亮氨酸，AAi + 1是缬氨酸或异亮氨酸，AAi + 2是丙氨酸，n是3,4或5，使得在AAi + 2之间存在n-3个氨基酸残基 AAi + n，AAi + n为谷氨酸，天冬氨酸，谷氨酰胺或天冬酰胺。因为TGF-β活性的基本要求是肽在生理条件下形成稳定的β-末端结构的能力，所以本发明的肽统称为β-末端肽。还提供了诸如组织修复的组合物，其包含具有与基质混合或携带的细胞调节蛋白或细胞模型蛋白类似物的生物相容性基质。

6. 发明授权

US09304226B2 Scintillator-based neutron detector for oilfield applications 有权
标题翻译：用于油田应用的基于闪烁体的中子探测器
公开(公告)号：US09304226B2
公开(公告)日：2016-04-05
申请号：US14127898
申请日：2012-06-26
申请人： Markus Berheide , Bradley A. Roscoe , Jing Qian , Timothy Spillane
发明人： Markus Berheide , Bradley A. Roscoe , Jing Qian , Timothy Spillane
IPC分类号： G01V5/10 , G01T3/06
CPC分类号： G01V5/10 , G01T3/06 , G01V5/107
摘要： Borehole logging tools and systems that include a scintillator positioned to interact with scattered source neutrons that are received from a target formation. The scintillator emits luminescence in response to interaction with the scattered neutrons. The scintillator includes an aluminofluoride host material (e.g., LiCAF). In a specific embodiment, the aluminofluoride host material is doped with europium. In a further specific embodiment, a processor distinguishes scattered neutrons from gamma rays based upon identifying a peak within an output signal from the scintillator. In yet another specific embodiment, a system includes a first scintillator and a second scintillator. The processor subtracts luminescence generated by the second scintillator from luminescence generated by the first scintillator to identify a neutron response of the first scintillator.
摘要翻译：钻孔测井工具和系统，其包括定位成与从靶层接收的散射源中子相互作用的闪烁体。闪烁体响应于与分散中子的相互作用发射发光。闪烁体包括氟化铝主体材料（例如LiCAF）。在一个具体实施方案中，所述氟化铝主体材料掺杂有铕。在另一特定实施例中，处理器基于识别来自闪烁体的输出信号内的峰值，将散射的中子与伽马射线区分开。在又一具体实施例中，系统包括第一闪烁体和第二闪烁体。处理器从由第一闪烁体产生的发光中减去由第二闪烁体产生的发光，以识别第一闪烁体的中子响应。

7. 发明授权

US07714119B2 AAV vector compositions and methods for enhanced expression of immunoglobulins using the same 失效
标题翻译： AAV载体组合物和使用其的增强免疫球蛋白表达的方法
公开(公告)号：US07714119B2
公开(公告)日：2010-05-11
申请号：US11179639
申请日：2005-07-13
申请人： Jianmin Fang , Karin Jooss , Jing Jing Qian
发明人： Jianmin Fang , Karin Jooss , Jing Jing Qian
IPC分类号： C07H21/04 , C12N15/00 , C12N5/00 , C12N5/02 , C12N15/64
CPC分类号： C12N15/86 , A61K48/00 , C07K16/00 , C07K16/2863 , C07K2317/21 , C07K2317/74 , C12N2750/14132 , C12N2750/14143
摘要： Single AAV vector constructs for expression of an immunoglobulin molecule or fragment thereof and methods of making and using the same are described. The AAV vectors comprise a self-processing cleavage sequence between a first and second immunoglobulin coding sequence allowing for expression of a functional antibody molecule using a single promoter. The vector constructs may further include an additional proteolytic cleavage sequence which provides a means to remove the self processing peptide sequence from an expressed immunoglobulin molecule or fragment thereof. The vector constructs find utility in enhanced production of biologically active immunoglobulins or fragments thereof in vitro and in vivo.
摘要翻译：描述了用于表达免疫球蛋白分子或其片段的单一AAV载体构建体及其制备和使用方法。 AAV载体包含允许使用单一启动子表达功能性抗体分子的第一和第二免疫球蛋白编码序列之间的自加工切割序列。载体构建体可进一步包括另外的蛋白水解切割序列，其提供从表达的免疫球蛋白分子或其片段中除去自身加工肽序列的手段。载体构建体在体外和体内发现在生物活性免疫球蛋白或其片段的增强生产中起作用。

8. 发明授权

US07662623B2 Compositions and methods for enhanced expression of recombinant polypeptides from a single vector using a peptide cleavage site 失效
标题翻译：使用肽切割位点从单个载体增强表达重组多肽的组合物和方法
公开(公告)号：US07662623B2
公开(公告)日：2010-02-16
申请号：US11977787
申请日：2007-10-26
申请人： Jianmin Fang , Karin Jooss , Andrew Simmons , Jing-Jing Qian
发明人： Jianmin Fang , Karin Jooss , Andrew Simmons , Jing-Jing Qian
IPC分类号： C12N15/00 , C12N15/11 , C12N15/13 , C12P21/08
CPC分类号： C12N15/86 , C07K16/00 , C07K16/2863 , C07K2317/21 , C07K2317/76 , C07K2319/30 , C07K2319/50 , C12N15/8273 , C12N2750/14143 , C12N2800/60 , C12N2830/00 , C12N2830/15 , C12N2830/42 , C12N2830/48 , C12N2830/85 , C12N2830/90 , C12N2840/203
摘要： Vector constructs for expression of two or more functional proteins or polypeptides under operative control of a single promoter and methods of making and using the same are described. The vectors comprise a self-processing cleavage site between each respective protein or polypeptide coding sequence. The vector constructs include the coding sequence for a self-processing cleavage site and may further include an additional proteolytic cleavage sequence which provides a means to remove the self processing peptide sequence from expressed protein(s) or polypeptide(s). The vector constructs find utility in methods for enhanced production of biologically active proteins and polypeptides in vitro and in vivo.
摘要翻译：描述了在单个启动子的操作控制下表达两种或更多种功能性蛋白质或多肽的载体构建体及其制备和使用方法。载体在每个相应的蛋白质或多肽编码序列之间包含自加工切割位点。载体构建体包括自加工切割位点的编码序列，并且还可以包括另外的蛋白水解切割序列，其提供从表达的蛋白质或多肽中除去自身加工肽序列的手段。载体构建体在体外和体内增强生物活性蛋白质和多肽生产的方法中有用。

9. 发明授权

US07498024B2 Compositions and methods for enhanced expression of immunoglobulins from a single vector using a peptide cleavage site 失效
标题翻译：使用肽切割位点从单个载体增强免疫球蛋白表达的组合物和方法
公开(公告)号：US07498024B2
公开(公告)日：2009-03-03
申请号：US10831302
申请日：2004-04-26
申请人： Jianmin Fang , Karin Jooss , Jing-Jing Qian
发明人： Jianmin Fang , Karin Jooss , Jing-Jing Qian
IPC分类号： C12N7/01 , C12N15/00 , C12N15/11 , C12N15/13 , C12N5/10 , C12P21/00 , C12P21/08
CPC分类号： C12N15/86 , C07K16/00 , C07K16/2863 , C07K2317/21 , C07K2317/76 , C07K2319/30 , C07K2319/50 , C12N15/8273 , C12N2750/14143 , C12N2800/60 , C12N2830/00 , C12N2830/15 , C12N2830/42 , C12N2830/48 , C12N2830/85 , C12N2830/90 , C12N2840/203
摘要： Single vector constructs for expression of an immunoglobulin molecule or fragment thereof and methods of making and using the same are described. The vectors comprise a self-processing cleavage sequence between a first and second immunoglobulin coding sequence allowing for expression of a functional antibody molecule using a single promoter. The vector constructs include the coding sequence for a self-processing cleavage site and may further include an additional proteolytic cleavage sequence which provides a means to remove the self processing peptide sequence from an expressed immunoglobulin molecule or fragment thereof. The vector constructs find utility in methods for enhanced production of biologically active immunoglobulins or fragments thereof in vitro or in vivo.
摘要翻译：描述了用于表达免疫球蛋白分子或其片段的单载体构建体及其制备和使用其的方法。载体包含使用单一启动子表达功能性抗体分子的第一和第二免疫球蛋白编码序列之间的自处理切割序列。载体构建体包括自加工切割位点的编码序列，并且还可以包括额外的蛋白水解切割序列，其提供从表达的免疫球蛋白分子或其片段中除去自身加工肽序列的手段。载体构建体可用于在体外或体内增强生物活性免疫球蛋白或其片段生产的方法中。

10. 发明申请

US20050042721A1 Compositions and methods for enhanced expression of recombinant polypeptides from a single vector using a peptide cleavage site 失效
标题翻译：使用肽切割位点从单个载体增强表达重组多肽的组合物和方法
公开(公告)号：US20050042721A1
公开(公告)日：2005-02-24
申请号：US10831304
申请日：2004-04-26
申请人： Jianmin Fang , Karin Jooss , Andrew Simmons , Jing-Jing Qian
发明人： Jianmin Fang , Karin Jooss , Andrew Simmons , Jing-Jing Qian
IPC分类号： C07H21/00 , C07H21/04 , C07K1/00 , C07K16/00 , C07K16/18 , C07K16/28 , C12N20060101 , C12N5/06 , C12N15/00 , C12N15/63 , C12N15/64 , C12N15/85 , C12N15/86 , C12N15/864 , C12P21/02 , C12P21/06
CPC分类号： C12N15/86 , C07K16/00 , C07K16/2863 , C07K2317/21 , C07K2317/76 , C07K2319/30 , C07K2319/50 , C12N15/8273 , C12N2750/14143 , C12N2800/60 , C12N2830/00 , C12N2830/15 , C12N2830/42 , C12N2830/48 , C12N2830/85 , C12N2830/90 , C12N2840/203
摘要： Vector constructs for expression of two or more functional proteins or polypeptides under operative control of a single promoter and methods of making and using the same are described. The vectors comprise a self-processing cleavage site between each respective protein or polypeptide coding sequence. The vector constructs include the coding sequence for a self-processing cleavage site and may further include an additional proteolytic cleavage sequence which provides a means to remove the self processing peptide sequence from expressed protein(s) or polypeptide(s). The vector constructs find utility in methods for enhanced production of biologically active proteins and polypeptides in vitro and in vivo.
摘要翻译：描述了在单个启动子的操作控制下表达两种或更多种功能性蛋白质或多肽的载体构建体及其制备和使用方法。载体在每个相应的蛋白质或多肽编码序列之间包含自加工切割位点。载体构建体包括自加工切割位点的编码序列，并且还可以包括另外的蛋白水解切割序列，其提供从表达的蛋白质或多肽中除去自身加工肽序列的手段。载体构建体在体外和体内增强生物活性蛋白质和多肽生产的方法中有用。

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