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1. 发明授权

US09239325B2 Microchip-based apparatus for examining platelet composite functions 有权
标题翻译：用于检查血小板复合功能的基于Microchip的设备
公开(公告)号：US09239325B2
公开(公告)日：2016-01-19
申请号：US14237667
申请日：2012-08-09
申请人： Se Hyun Shin , Jeong Hun Nam , Chae Seung Lim
发明人： Se Hyun Shin , Jeong Hun Nam , Chae Seung Lim
IPC分类号： G01N33/50 , G01N33/49 , B01L3/00 , B01F13/08
CPC分类号： G01N33/5044 , B01F13/0818 , B01L3/5027 , B01L2200/16 , B01L2300/0816 , B01L2300/0864 , B01L2400/0475 , B01L2400/049 , G01N33/4905
摘要： There is provided a microchip-based platelet multi-function test apparatus. The apparatus includes a sample container configured to accommodate a blood sample therein, a stirrer that is installed inside the sample container and induces a shear flow in the blood sample, a parallel channel configured to divide and flow the blood stirred by the stirrer into a plurality of paths, a vacuum device that is connected to an end of each parallel channel, maintains constant pressure, allows the stirred blood to flow along the parallel channel, a light source that is installed in a rear side of the parallel channel and radiates light to the parallel channel, and an image sensor that receives light transmitted through the blood in the parallel channel, converts the light into an electrical signal, and measures a flowing distance of a blood flow.
摘要翻译：提供了一种基于微芯片的血小板多功能试验装置。所述装置包括被配置为容纳血液样本的样本容器，安装在所述样本容器内部并在所述血液样本中引起剪切流动的搅拌器，构造成将由所述搅拌器搅拌的血液分离并流动到多个连接到每个平行通道的端部的真空装置保持恒定的压力，允许搅动的血液沿着平行通道流动，安装在平行通道的后侧并将光照射到平行通道和接收通过并行通道中的血液透过的光的图像传感器将光转换成电信号，并测量血流的流动距离。

2. 发明授权

US08772040B2 Apparatus and method of platelet multi-function analysis, and micro stirring chip 有权
标题翻译：血小板多功能分析仪器及方法，微型搅拌片
公开(公告)号：US08772040B2
公开(公告)日：2014-07-08
申请号：US13600519
申请日：2012-08-31
申请人： Se Hyun Shin , Jeong Hun Nam , Hyun Jung Lim
发明人： Se Hyun Shin , Jeong Hun Nam , Hyun Jung Lim
IPC分类号： G01N33/86 , G01N33/48 , G01N27/00 , G01N21/07
CPC分类号： G01N33/86 , G01N21/5907 , G01N21/82
摘要： An apparatus and method for platelet multi-function analysis using measurement of electrical characteristics, and a stirring microchip are provided. The apparatus for platelet multi-function analysis includes a stirring microchip that has a sample storage chamber formed therein to hold a blood sample, and in which an inner part of the sample storage chamber is coated with reagents composed of collagen and epinephrine, or collagen and ADP. The apparatus for platelet multi-function analysis further includes a microstirrer installed inside the stirring microchip to stir the blood sample and the reagents in the stirring microchip and a stirring induction unit configured to facilitate stirring of the microstirrer. Therefore, the platelet aggregation and multi-function analysis can be performed using a trace of blood, and the platelet aggregation and multi-function analysis can also be performed using the whole blood taken from the veins through a vacuum tube containing an anticoagulant.
摘要翻译：提供使用电特性测量的血小板多功能分析的装置和方法以及搅拌微芯片。用于血小板多功能分析的装置包括：搅拌微芯片，其具有形成在其中的样品储存室，用于容纳血液样品，并且其中样品储存室的内部涂有由胶原蛋白和肾上腺素或胶原构成的试剂， ADP。用于血小板多功能分析的装置还包括安装在搅拌微芯片内部的微型搅拌器，以搅拌血液样品和搅拌微芯片中的试剂，以及配置成促进微型搅拌器搅拌的搅拌诱导单元。因此，可以使用血迹进行血小板聚集和多功能分析，还可以使用从静脉取出的全血通过含有抗凝血剂的真空管进行血小板聚集和多功能分析。

3. 发明申请

US20140065715A1 APPARATUS AND METHOD OF PLATELET MULTI-FUNCTION ANALYSIS, AND MICRO STIRRING CHIP 有权
标题翻译：电极多功能分析的装置和方法以及微电极切片
公开(公告)号：US20140065715A1
公开(公告)日：2014-03-06
申请号：US13600519
申请日：2012-08-31
申请人： Se Hyun SHIN , Jeong Hun NAM , Hyun Jung LIM
发明人： Se Hyun SHIN , Jeong Hun NAM , Hyun Jung LIM
IPC分类号： G01N27/00
CPC分类号： G01N33/86 , G01N21/5907 , G01N21/82
摘要： An apparatus and method for platelet multi-function analysis using measurement of electrical characteristics, and a stirring microchip are provided. The apparatus for platelet multi-function analysis includes a stirring microchip that has a sample storage chamber formed therein to hold a blood sample, and in which an inner part of the sample storage chamber is coated with reagents composed of collagen and epinephrine, or collagen and ADP. The apparatus for platelet multi-function analysis further includes a microstirrer installed inside the stirring microchip to stir the blood sample and the reagents in the stirring microchip and a stirring induction unit configured to facilitate stirring of the microstirrer. Therefore, the platelet aggregation and multi-function analysis can be performed using a trace of blood, and the platelet aggregation and multi-function analysis can also be performed using the whole blood taken from the veins through a vacuum tube containing an anticoagulant.
摘要翻译：提供使用电特性测量的血小板多功能分析的装置和方法以及搅拌微芯片。用于血小板多功能分析的装置包括：搅拌微芯片，其具有形成在其中的样品储存室，用于容纳血液样品，并且其中样品储存室的内部涂有由胶原蛋白和肾上腺素或胶原构成的试剂， ADP。用于血小板多功能分析的装置还包括安装在搅拌微芯片内部的微型搅拌器，以搅拌血液样品和搅拌微芯片中的试剂，以及配置成促进微型搅拌器搅拌的搅拌诱导单元。因此，可以使用血迹进行血小板聚集和多功能分析，还可以使用从静脉取出的全血通过含有抗凝血剂的真空管进行血小板聚集和多功能分析。

4. 发明申请

US20150010995A1 MICROCHIP-BASED APPARATUS FOR EXAMINING PLATELET COMPOSITE FUNCTIONS 有权
标题翻译：用于检查板组合功能的基于微孔器的设备
公开(公告)号：US20150010995A1
公开(公告)日：2015-01-08
申请号：US14237667
申请日：2012-08-09
申请人： Se Hyun Shin , Jeong Hun Nam , Chae Seung Lim
发明人： Se Hyun Shin , Jeong Hun Nam , Chae Seung Lim
IPC分类号： G01N33/50
CPC分类号： G01N33/5044 , B01F13/0818 , B01L3/5027 , B01L2200/16 , B01L2300/0816 , B01L2300/0864 , B01L2400/0475 , B01L2400/049 , G01N33/4905
摘要： There is provided a microchip-based platelet multi-function test apparatus. The apparatus includes a sample container configured to accommodate a blood sample therein, a stirrer that is installed inside the sample container and induces a shear flow in the blood sample, a parallel channel configured to divide and flow the blood stirred by the stirrer into a plurality of paths, a vacuum device that is connected to an end of each parallel channel, maintains constant pressure, allows the stirred blood to flow along the parallel channel, a light source that is installed in a rear side of the parallel channel and radiates light to the parallel channel, and an image sensor that receives light transmitted through the blood in the parallel channel, converts the light into an electrical signal, and measures a flowing distance of a blood flow.
摘要翻译：提供了一种基于微芯片的血小板多功能试验装置。所述装置包括被配置为容纳血液样本的样本容器，安装在所述样本容器内部并在所述血液样本中引起剪切流动的搅拌器，构造成将由所述搅拌器搅拌的血液分离并流动到多个连接到每个平行通道的端部的真空装置保持恒定的压力，允许搅动的血液沿着平行通道流动，安装在平行通道的后侧并将光照射到平行通道和接收通过并行通道中的血液透过的光的图像传感器将光转换成电信号，并测量血流的流动距离。

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