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1. 发明授权

US09198680B2 Combination imaging and therapy transducer with therapy transducer amplifier 有权
标题翻译：组合成像和治疗传感器与治疗传感器放大器
公开(公告)号：US09198680B2
公开(公告)日：2015-12-01
申请号：US12064309
申请日：2006-08-25
申请人： John Fraser , Jeffry E. Powers , Michalakis Averkiou
发明人： John Fraser , Jeffry E. Powers , Michalakis Averkiou
IPC分类号： A61B8/00 , A61B8/12 , A61B17/22 , A61B8/08 , A61B8/14 , A61B17/225 , G01S15/89 , A61B19/00
CPC分类号： A61B17/22004 , A61B8/0833 , A61B8/14 , A61B8/4405 , A61B8/481 , A61B17/2256 , A61B2017/22028 , A61B2090/378 , G01S15/8918 , G01S15/8977
摘要： A combined ultrasound imaging and therapy transducer (10) includes a linear array of imaging transducer elements (14). First and second linear arrays of therapy transducer elements (18, 20) extend longitudinally along respective first and second sides of the imaging transducer elements and are canted inwardly toward each other. The imaging and therapy transducer is used with an ultrasound imaging system to locate clots in a region of interest. After the region of interest has been perfused with a microbubble contrast agent, the therapy transducer elements are driven by an amplifier located in the transducer to dissolve the clot. The use of the imaging transducer elements and the therapy transducer elements can be interleaved so that the therapy can be conditioned on an ultrasound image showing substantial destruction of the contrast agent microbubbles, re-perfusion of microbubbles in the region of interest, or the continued presence of the clot.
摘要翻译：组合的超声成像和治疗换能器（10）包括成像换能器元件（14）的线性阵列。治疗换能器元件（18,20）的第一和第二线性阵列沿着成像换能器元件的相应的第一和第二侧纵向延伸并且向内朝向彼此倾斜。成像和治疗传感器与超声成像系统一起使用以定位感兴趣区域中的凝块。在用微泡造影剂灌注感兴趣区域之后，治疗换能器元件由位于换能器中的放大器驱动以溶解凝块。可以使用成像换能器元件和治疗换能器元件进行交织，使得治疗可以对超声图像进行调节，该超声图像显示造影剂微泡的显着破坏，感兴趣区域中微泡的再次灌注，或持续存在的凝块。

2. 发明申请

US20110263985A1 Dual Path Color Doppler Imaging System and Method for Simultaneous Invasive Device Visualization and Vasculature Imaging 审中-公开
标题翻译：双路彩色多普勒成像系统和同时侵入性装置可视化和脉管系统成像方法
公开(公告)号：US20110263985A1
公开(公告)日：2011-10-27
申请号：US12674500
申请日：2008-08-14
申请人： Thomas Gauthier , Aline Criton , Matthew Bruce , Robert Entrekin , Jeffry E. Powers
发明人： Thomas Gauthier , Aline Criton , Matthew Bruce , Robert Entrekin , Jeffry E. Powers
IPC分类号： A61B8/06
CPC分类号： G01S15/8979 , A61B8/06 , A61B8/0833 , A61B8/0841 , A61B8/13 , A61B8/488 , A61B2017/3413 , G01S7/52026 , G01S7/52084
摘要： An ultrasound imaging system (10) is disclosed for creating simultaneous needle and vascular blood flow color Doppler imaging. A B mode image of an anatomical area of interest is created. A first set of Doppler image data optimized for the visualization of vascular blood flow is created along one Doppler image processing path. A second set of Doppler image data optimized for the visualization of a needle or other invasive device is created along another, parallel Doppler image processing path. A color Doppler image is created, and then displayed, by combining some or all of the B mode image, the first Doppler image data and the second Doppler image data based on a plurality of user selectable modes.
摘要翻译：公开了一种用于创建同时针和血管血流彩色多普勒成像的超声成像系统（10）。创建感兴趣的解剖区域的B模式图像。沿着一个多普勒图像处理路径创建针对血管血流可视化优化的第一组多普勒图像数据。沿着另一个并行的多普勒图像处理路径创建针对针或其他侵入性设备的可视化优化的第二组多普勒图像数据。通过基于多个用户可选择模式组合B模式图像，第一多普勒图像数据和第二多普勒图像数据中的一些或全部来创建彩色多普勒图像，然后显示。

3. 发明授权

US06676606B2 Ultrasonic diagnostic micro-vascular imaging 有权
标题翻译：超声诊断微血管成像
公开(公告)号：US06676606B2
公开(公告)日：2004-01-13
申请号：US10170178
申请日：2002-06-11
申请人： David Hope Simpson , Jeffry E. Powers , Michael Schauf , Cyrille Villet
发明人： David Hope Simpson , Jeffry E. Powers , Michael Schauf , Cyrille Villet
IPC分类号： A61B814
CPC分类号： A61B8/481 , A61B8/06 , G01S7/52026 , G01S7/52038 , G01S7/52039 , G01S7/52085 , G01S15/8918 , G01S15/8963 , G01S15/8981
摘要： A method and apparatus are described for ultrasonically imaging tiny blood vessels with the aid of a contrast agent. The locations of microbubbles of the contrast agent are detected in a series of images as the microbubbles move through the blood vessels. These images are temporally processed to identify the moving microbubbles, and persistence processed to depict images which show the tracks followed by the microbubbles through the blood vessels. A maximum intensity persistence can be used to show the steady buildup of microbubble tracks through the vasculature, or a slow decay employed so that the tracks will fade to black over time.
摘要翻译：描述了借助于造影剂超声成像微小血管的方法和装置。当微泡移动通过血管时，在一系列图像中检测造影剂微泡的位置。这些图像在时间上被处理以识别移动的微泡，并且持续处理以描绘图像，其显示通过血管的微泡之后的轨道。可以使用最大强度持续性来显示通过脉管系统的微泡轨迹的稳定积累，或者采用慢衰减，使得轨迹将随着时间而逐渐变黑。

4. 发明授权

US06575910B2 Ultrasonic image persistence using contrast agents 有权
公开(公告)号：US06575910B2
公开(公告)日：2003-06-10
申请号：US10008003
申请日：2001-11-08
申请人： Michalakis Averkiou , Matthew Bruce , Jeffry E. Powers
发明人： Michalakis Averkiou , Matthew Bruce , Jeffry E. Powers
IPC分类号： A61B800
CPC分类号： A61B8/481 , A61B5/0456 , A61B5/7239 , A61B8/06 , A61B8/08 , A61B8/13 , A61B8/463 , A61B8/483 , A61B8/488 , A61B8/543 , A61K49/223 , G01S7/52026 , G01S7/52038 , G01S7/52039 , G01S7/52041 , G01S15/8959 , G01S15/8963 , G01S15/8993
摘要： Apparatus and methods are disclosed for the detection and imaging of ultrasonic contrast agents. Ultrasonic apparatus is provided for coherent imaging of ultrasonic contrast agents, and for detecting harmonic contrast agents. The inventive apparatus includes a dual display for simultaneously viewing a real time image which displays the location of the contrast agent and a triggered contrast image. Methods of contrast agent detection and imaging include the measurement of perfusion rate characteristics, multizone contrast imaging, multifrequency contrast imaging, tissue perfusion display, and high PRF contrast image artifact elimination.

5. 发明授权

US06468216B1 Ultrasonic diagnostic imaging of the coronary arteries 有权
标题翻译：冠状动脉超声诊断成像
公开(公告)号：US06468216B1
公开(公告)日：2002-10-22
申请号：US09645872
申请日：2000-08-24
申请人： Jeffry E. Powers , Michalakis Averkiou , Matthew Bruce , Danny M. Skyba , Robert R. Entrekin , John D. Fraser , Clifford R. Cooley , Brent Stephen Robinson , David N. Roundhill , Gary Allen Schwartz , Patrick René Pesque
发明人： Jeffry E. Powers , Michalakis Averkiou , Matthew Bruce , Danny M. Skyba , Robert R. Entrekin , John D. Fraser , Clifford R. Cooley , Brent Stephen Robinson , David N. Roundhill , Gary Allen Schwartz , Patrick René Pesque
IPC分类号： A61B800
CPC分类号： A61B8/483 , A61B8/06 , A61B8/0883 , A61B8/0891 , A61B8/4472 , A61B8/481 , A61B8/543 , G01S7/52025 , G01S7/52074 , G01S7/5208 , G01S7/52095 , G01S15/8918 , G01S15/8925 , G01S15/894 , G01S15/8963 , G01S15/8979 , G01S15/8993 , G10K11/341 , Y10S128/916
摘要： An ultrasonic imaging method and apparatus are described for imaging the coronary arteries of the heart. The vascular system is infused with an ultrasonic contrast agent. A volumetric region of the heart wall including a coronary artery is three dimensionally scanned. A projection image of the volumetric region is produced from the scanning, providing a two dimensional contrast image of the coronary artery with the appearance of an angiogram. Preferably the coronary artery signals are segmented from contrast signals emanating from the myocardium and the heart blood pool so that the coronary arteries are clearly highlighted and distinct in the ultrasonic angiogram.
摘要翻译：描述了用于对心脏的冠状动脉成像的超声成像方法和装置。血管系统注入超声造影剂。包括冠状动脉的心壁的体积区域被三维扫描。从扫描产生体积区域的投影图像，提供冠状动脉的二维造影图像和血管造影图像的外观。优选地，冠状动脉信号从从心肌和心脏血池发出的对比信号分段，使得冠状动脉在超声波血管造影中被清楚地突出显示和不同。

6. 发明授权

US06458083B1 Ultrasonic harmonic imaging with adaptive image formation 失效
标题翻译：超声波谐波成像与自适应图像形成
公开(公告)号：US06458083B1
公开(公告)日：2002-10-01
申请号：US09518348
申请日：2000-03-03
申请人： James R. Jago , David N. Roundhill , Jeffry E. Powers , Michalakis Averkiou
发明人： James R. Jago , David N. Roundhill , Jeffry E. Powers , Michalakis Averkiou
IPC分类号： A61B800
CPC分类号： G01S7/52046 , A61B8/08 , A61B8/14 , A61B8/488 , G01S7/52026 , G01S7/52033 , G01S7/52036 , G01S7/52038 , G01S7/5206 , G01S7/52074 , G01S15/8979 , G01S15/8993
摘要： An ultrasonic diagnostic imaging system receives fundamental frequency, harmonic contrast, and tissue harmonic echo information for image processing. The fundamental and harmonic signal content of the echo information is analyzed and the relative content of an output signal is adjusted as necessary to take advantage of the different characteristics of the different types of echo information present in the echo signal. The ultrasound system can produce images which are an adaptive blend of fundamental, tissue harmonic and harmonic contrast echo information.
摘要翻译：超声波诊断成像系统接收基频，谐波对比度和图像处理的组织谐波回波信息。分析回波信息的基波和谐波信号内容，并根据需要调整输出信号的相对内容，以利用回波信号中存在的不同类型的回波信息的不同特性。超声系统可以产生基本，组织谐波和谐波对比回波信息的自适应混合图像。

7. 发明授权

US06251074B1 Ultrasonic tissue harmonic imaging 有权
标题翻译：超声组织谐波成像
公开(公告)号：US06251074B1
公开(公告)日：2001-06-26
申请号：US09440779
申请日：1999-11-16
申请人： Michalakis Averkiou , Jeffry E. Powers , Peter N. Burns , David N. Roundhill , Juin-Jet Hwang , Jeremy D. Wiggins
发明人： Michalakis Averkiou , Jeffry E. Powers , Peter N. Burns , David N. Roundhill , Juin-Jet Hwang , Jeremy D. Wiggins
IPC分类号： A61B800
CPC分类号： G01S15/895 , A61B8/08 , A61B8/14 , A61B8/463 , A61B8/488 , G01S7/52026 , G01S7/52033 , G01S7/52036 , G01S7/52038 , G01S7/52046 , G01S7/5206 , G01S7/52074 , G01S7/52077 , G01S15/8979 , G01S15/8993
摘要： An ultrasonic diagnostic imaging system and methods are described which produce tissue harmonic ultrasonic images from harmonic echo components of a transmitted fundamental frequency. Fundamental frequency waves are transmitted by an array transducer to focus at a focal depth. As the transmitted waves penetrate the body, the harmonic effect develops as the wave components begin to focus. The harmonic response from the tissue is detected and displayed, while clutter from the fundamental response is reduced by excluding fundamental frequencies. The technique is especially useful for imaging the endocardial tissue of the heart.
摘要翻译：描述了从发射的基频的谐波回波分量产生组织谐波超声图像的超声诊断成像系统和方法。基波频率由阵列传感器传输，以聚焦于焦深。随着透射波穿透身体，谐波效应随波分量开始集中发展。检测并显示来自组织的谐波响应，同时通过排除基本频率来减小基波响应的杂波。该技术对于心脏心内膜的成像特别有用。

8. 发明授权

US06234967B1 Ultrasonic diagnostic imaging systems with power modulation for contrast and harmonic imaging 失效
标题翻译：超声波诊断成像系统具有对比度和谐波成像的功率调制
公开(公告)号：US06234967B1
公开(公告)日：2001-05-22
申请号：US09216693
申请日：1998-12-18
申请人： Jeffry E. Powers
发明人： Jeffry E. Powers
IPC分类号： A61B800
CPC分类号： G01S7/52038 , A61B8/481 , G01S7/52039 , G01S7/52041 , G01S15/8927 , G10K11/341
摘要： A method and ultrasonic diagnostic imaging system for contrast agent imaging or tissue harmonic imaging is described which modulates the transmit power as a function of the angle of an electronically steered beam or the location of the beam in the scan plane to compensate for the reduction in delivered energy to points in the image field resulting from off-angle steering or a reduction in the number of elements of the transmit aperture.
摘要翻译：描述了用于造影剂成像或组织谐波成像的方法和超声诊断成像系统，其将发射功率作为电子转向束的角度或光束在扫描平面中的位置的函数进行调节，以补偿递送的减少由偏角转向导致的图像场中的能量的能量或发射孔径的元素数量的减少。

9. 发明授权

US06186950B1 Ultrasonic pulse inversion harmonic separation with reduced motional effects 失效
标题翻译：超声脉冲反演谐波分离具有减少的运动效应
公开(公告)号：US06186950B1
公开(公告)日：2001-02-13
申请号：US09434328
申请日：1999-11-04
申请人： Michalakis Averkiou , Jeffry E. Powers
发明人： Michalakis Averkiou , Jeffry E. Powers
IPC分类号： A61B0800
CPC分类号： G01S15/8981 , A61B8/06 , A61B8/08 , A61B8/13 , A61B8/488 , G01S7/52026 , G01S7/52034 , G01S7/52038 , G01S7/52085 , G01S7/52095 , G01S15/8959 , G01S15/8963 , G01S15/8993
摘要： Pulse inversion harmonic separation is performed utilizing echoes from three or more pulses of alternating phase or polarity. Temporally different echoes of opposite phase or polarity are combined in pairs, which are in turn combined to form partial sums and a final sum in which fundamental frequency signal components are substantially eliminated. Preferably the signals are normalized to a common reference level. The inventive technique can be performed by a filter structure using weighting coefficients exhibiting a Gaussian variation.
摘要翻译：使用来自三个或更多个交替相位或极性脉冲的回波来执行脉冲反相谐波分离。成对地组合相反相位或极性的时间不同的回波，这些回波又被组合以形成基本消除基频信号分量的部分和和最终和。优选地，将信号归一化为公共参考电平。本发明的技术可以通过使用表现出高斯变化的加权系数的滤波器结构来执行。

10. 发明授权

US5197477A Ultrasonic Doppler flow measurement system with tissue motion discrimination 失效
标题翻译：超声波多普勒流量测量系统与组织运动辨别
公开(公告)号：US5197477A
公开(公告)日：1993-03-30
申请号：US596838
申请日：1990-10-12
申请人： Roy B. Peterson , Jeffry E. Powers
发明人： Roy B. Peterson , Jeffry E. Powers
IPC分类号： A61B8/06 , G01F1/66 , G01P5/00 , G01P5/24 , G01S15/52 , G01S15/58 , G01S15/89
CPC分类号： A61B8/06 , G01F1/663 , G01P5/241 , G01S15/52 , G01S15/582 , G01S15/8981
摘要： An ultrasonic diagnostic system for measuring fluid flow velocities through Doppler techniques is provided which eliminates the effects of tissue motion from fluid flow velocity information. In a preferred embodiment Doppler information signal are discriminated to determine the presence of signal components resulting from moving tissue, which signal components are located at frequencies of a Doppler spectrum other than the predetermined frequency location of stationary tissue signals. The tissue motion signal components present are shifted to the predetermined frequency location and removed by high pass filtering the Doppler signals. The remaining signals are then shifted back to their original frequency location and transmitted to a Doppler velocity estimator for further processing of the fluid flow velocity information and ultimate display of the information. To overcome problems of Doppler frequency inaccuracies at discrete spatial positions, the Doppler signals from a plurality of neighboring spatial locations are examined in the aggregate to determine the frequency location of tissue motion signal components.
摘要翻译：提供了一种用于通过多普勒技术测量流体流速的超声波诊断系统，其消除了来自流体流速信息的组织运动的影响。在优选实施例中，多普勒信息信号被识别以确定由移动组织产生的信号分量的存在，该信号分量位于除了静止组织信号的预定频率位置之外的多普勒频谱的频率处。存在的组织运动信号分量移动到预定频率位置，并通过高通滤波多普勒信号去除。然后将剩余的信号移回到它们的原始频率位置，并传输到多普勒速度估计器，以进一步处理流体流速信息和信息的最终显示。为了克服离散空间位置处的多普勒频率不准确的问题，从集合中检查来自多个相邻空间位置的多普勒信号，以确定组织运动信号分量的频率位置。

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