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1. 发明授权

US08309035B2 Multi-well system 有权
标题翻译：多井系统
公开(公告)号：US08309035B2
公开(公告)日：2012-11-13
申请号：US12418520
申请日：2009-04-03
申请人： Chun-Nan Chen , James O. Bowlby, Jr. , Richard Aleck Jorgensen
发明人： Chun-Nan Chen , James O. Bowlby, Jr. , Richard Aleck Jorgensen
IPC分类号： G01N21/75
CPC分类号： C12N15/1065 , C07K16/2896 , C07K16/40 , C07K2317/56 , G06F19/00 , Y02A90/26
摘要： A multi-well system is described which is comprised of a tray comprising a plurality of wells which may include thousands, tens of thousands or even hundreds of thousands of wells or more. Each of the wells has a unique address. The system includes a tray top comprised of a plurality of areas wherein each of the areas corresponds uniquely to each of the wells and includes a unique address. The system may include a second tray top also comprised of a plurality of areas with unique addresses which uniquely correspond to each of the wells. The areas on the tops have compounds bound to those areas which compounds bind to components present in the wells and are used to obtain specific material in each well for analysis.
摘要翻译：描述了一种多孔系统，其由包括多个井的托盘组成，所述多个井可以包括数千，甚至几十万个井或更多井。每个井都有一个独特的地址。该系统包括由多个区域组成的托盘顶板，其中每个区域对应于每个井的唯一地址并且包括唯一的地址。该系统可以包括第二托盘顶部，其也由具有唯一地址的多个区域组成，其唯一地对应于每个井。顶部上的区域具有与化合物结合存在于孔中的组分的那些区域结合的化合物，并且用于在每个孔中获得特定材料用于分析。

2. 发明授权

US5255023A Apparatus and method for improved paper marking 失效
标题翻译：改进纸标记的装置和方法
公开(公告)号：US5255023A
公开(公告)日：1993-10-19
申请号：US846481
申请日：1992-03-03
申请人： James O. Bowlby, Jr. , David R. Nygren
发明人： James O. Bowlby, Jr. , David R. Nygren
IPC分类号： G03G7/00 , G03G15/32 , G03G17/00 , G01D15/06 , G03G15/14 , G03G21/00
CPC分类号： G03G7/006 , G03G15/32 , G03G17/00 , G03G7/00
摘要： An apparatus for improved paper marking is provided which increases the percentage moisture content of the paper, thereby decreasing its electrical resistivity. The paper is then dried at selected pixels which results in high electrical resistivity of those pixels. Subsequently, the paper is charged with a high negative voltage. The areas with high moisture content rapidly discharge the applied charge, whereas the areas with low moisture content retain the charge. Finally, the areas with retained charge attract toner and are fused to the paper.
摘要翻译：提供了一种用于改进纸标记的装置，其增加了纸张的百分比含水量，从而降低了其电阻率。然后将纸张在所选择的像素处干燥，这导致那些像素的高电阻率。随后，纸张充有高负电压。含水量高的区域迅速释放施加的电荷，而含水量低的区域则保持充电。最后，具有保留电荷的区域吸引调色剂并与纸熔合。

3. 发明授权

US09328172B2 Method of obtaining antibodies of interest and nucleotides encoding same 有权
标题翻译：获得感兴趣的抗体的方法和编码相同的核苷酸
公开(公告)号：US09328172B2
公开(公告)日：2016-05-03
申请号：US12418519
申请日：2009-04-03
申请人： Chun-Nan Chen , James O. Bowlby , Richard Aleck Jorgensen , Mark Jay Shlomchik
发明人： Chun-Nan Chen , James O. Bowlby , Richard Aleck Jorgensen , Mark Jay Shlomchik
IPC分类号： C40B30/04 , C40B40/06 , G01N33/00 , C07K16/40 , C07K16/28
CPC分类号： C12N15/1065 , C07K16/2896 , C07K16/40 , C07K2317/56 , G06F19/00 , Y02A90/26
摘要： The invention is a methodology which makes it possible to select from a very large number of cells, a single cell or cells of interest and obtain specific information from those cells in a rapid and efficient manner. As an example of the methodology, a large number of antibody producing cells such as plasma cells are separated so that these individual antibody producing plasma cells are placed in individual wells. The cells are allowed to produce antibodies and the antibodies in the wells are then contacted with a protein bound to a solid surface such as a well top. The protein universally and specifically binds antibodies in the wells. The surface or well tray top includes addresses configured such that each address is specifically related to one of the individual wells containing a cell producing antibodies.
摘要翻译：本发明是一种方法，其可以从非常大量的细胞，单个细胞或感兴趣的细胞中进行选择，并以快速和有效的方式从这些细胞获得特定的信息。作为该方法的一个实例，分离大量抗体产生细胞如浆细胞，使得这些产生单个抗体的浆细胞放置在各个孔中。使细胞产生抗体，然后将孔中的抗体与结合到固体表面如蛋白质顶部的蛋白质接触。蛋白质通常和特异性结合孔中的抗体。表面或井托盘顶部包括配置为使得每个地址与包含产生抗体的细胞的单个井中的一个具体相关的地址。

4. 发明申请

US20080140557A1 ON-LINE AUCTION SYSTEM AND METHOD 审中-公开
标题翻译：在线拍卖系统和方法
公开(公告)号：US20080140557A1
公开(公告)日：2008-06-12
申请号：US11749407
申请日：2007-05-16
申请人： James O. Bowlby , Chun-Nan Chen , Stephen P. Aranoff
发明人： James O. Bowlby , Chun-Nan Chen , Stephen P. Aranoff
IPC分类号： G06Q30/00
CPC分类号： G06Q40/02 , G06Q30/06 , G06Q40/04 , G06Q40/06 , G06Q50/18
摘要： A method and exchange for buying and selling rights in a legal contract or patent through an on-line exchange are disclosed. After obtaining a transfer of certain rights from the owner, and setting a transaction period during which the transferred rights can be bought and sold, the transferred rights are divided into fractions which can then be bought and sold, under buyer/seller exchange conditions. The bidding for fractions continues until a termination event occurs, which may be the expiration of the set transaction period or one of the participant buyer's acquiring a specified number of fractions of the transferred rights, in which case that participant can become the legal owner of the rights by acquiring all other ownership fractions in the rights at a predetermined price.
摘要翻译：披露了通过在线交换在法律合同或专利中购买和出售权利的方法和交换。在转让所有者的某些权利之后，设定转让权利可以买卖的交易期间，转让的权利分为几种，然后根据买卖双方交换条件进行买卖。分数的招标持续到终止事件发生，可能是设定的交易期间到期或参与者买方获得指定数量的转移权限的一部分，在这种情况下，该参与者可以成为合法所有者以预定价格获取权利中的所有其他所有权部分的权利。

5. 发明授权

US5283426A Methods and apparatus for obtaining nonlinear responses from photodetector arrays 失效
标题翻译：用于从光电检测器阵列获得非线性响应的方法和装置
公开(公告)号：US5283426A
公开(公告)日：1994-02-01
申请号：US63452
申请日：1993-05-17
申请人： James O. Bowlby, Jr. , Gregory E. Johnston
发明人： James O. Bowlby, Jr. , Gregory E. Johnston
IPC分类号： H04N3/15 , H01J40/14 , H04N3/14
CPC分类号： H04N3/155
摘要： A charge collection control circuit generates a time-varying voltage that is used to control the charge collection process in an MOS photodetector for the purpose of obtaining greater dynamic range. Control is exercised either by means of an integration control electrode that controls the flow of charge from a charge-collecting region to a sink or by means of a transfer electrode that controls the flow of charge from the charge-collecting region to a charge-transport region through which the collected charge flows to an output circuit.
摘要翻译：电荷收集控制电路产生用于控制MOS光电检测器中的电荷收集过程的时变电压，以获得更大的动态范围。通过控制电荷从电荷收集区到汇的流动的积分控制电极或通过控制从电荷收集区到电荷传输的电荷流的转移电极进行控制收集的电荷通过该区域流到输出电路。

6. 发明申请

US20110190148A1 METHOD OF OBTAINING ANTIBODIES OF INTEREST AND NUCLEOTIDES ENCODING SAME 有权
标题翻译：获得感兴趣的抗体的方法和编码其的核苷酸
公开(公告)号：US20110190148A1
公开(公告)日：2011-08-04
申请号：US12418519
申请日：2009-04-03
申请人： Chun-Nan Chen , James O. Bowlby , Richard Aleck Jorgensen , Mark Jay Shlomchik
发明人： Chun-Nan Chen , James O. Bowlby , Richard Aleck Jorgensen , Mark Jay Shlomchik
IPC分类号： C40B30/04 , C40B40/06
CPC分类号： C12N15/1065 , C07K16/2896 , C07K16/40 , C07K2317/56 , G06F19/00 , Y02A90/26
摘要： The invention is a methodology which makes it possible to select from a very large number of cells, a single cell or cells of interest and obtain specific information from those cells in a rapid and efficient manner. As an example of the methodology, a large number of antibody producing cells such as plasma cells are separated so that these individual antibody producing plasma cells are placed in individual wells. The cells are allowed to produce antibodies and the antibodies in the wells are then contacted with a protein bound to a solid surface such as a well top. The protein universally and specifically binds antibodies in the wells. The surface or well tray top includes addresses configured such that each address is specifically related to one of the individual wells containing a cell producing antibodies.
摘要翻译：本发明是一种方法，其可以从非常大量的细胞，单个细胞或感兴趣的细胞中进行选择，并以快速和有效的方式从这些细胞获得特定的信息。作为该方法的一个实例，分离大量抗体产生细胞如浆细胞，使得这些产生单个抗体的浆细胞放置在各个孔中。使细胞产生抗体，然后将孔中的抗体与结合到固体表面如蛋白质顶部的蛋白质接触。蛋白质通常和特异性结合孔中的抗体。表面或井托盘顶部包括配置为使得每个地址与包含产生抗体的细胞的单个井中的一个具体相关的地址。

7. 发明授权

US5748491A Deconvolution method for the analysis of data resulting from analytical separation processes 失效
标题翻译：解卷积方法用于分析分析过程中产生的数据
公开(公告)号：US5748491A
公开(公告)日：1998-05-05
申请号：US579204
申请日：1995-12-20
申请人： Daniel B. Allison , James O. Bowlby, Jr.
发明人： Daniel B. Allison , James O. Bowlby, Jr.
IPC分类号： G01N33/50 , G01N27/447 , G01N30/86 , G06F17/00 , G06F17/14 , G06F17/15 , H03H17/02 , G06F17/11
CPC分类号： G06K9/00503 , G01N30/8617
摘要： An improved signal processing method in a signal processor for performing the deconvolution of a signal resulting from an analytical separation process is disclosed. In a first aspect, a signal representing a plurality of partially separated sample zones is measured, a point-spread-function of the signal is determined, and the Fourier transform of the signal and the point-spread-function is taken. Next, a noise component n of the signal is determined and the value of a result signal A(f) is calculated using the following filter ##EQU1## where D(f) is the Fourier transform of the signal, P(f) is the Fourier transform of the point-spread-function, and P*(f) is the complex conjugate of P(i). Finally, the inverse Fourier transform of the result A(f) is taken and reported as A(t). Preferably, the point-spread function is a Gaussian function having a standard deviation .sigma., where .sigma. is determined using either an .alpha..beta. tracker or the function .sigma.=(a+bt.sup.2).sup.1/2, where a and b are constants. In a second aspect of the invention, a plurality of possible point-spread-functions of the signal are determined and the above-described method is applied using each PSF. The value of the largest point-spread-function which provides a nonnegative result is determined, and the associated value of A(t) is reported. In a third aspect of the invention, a program storage device readable by a machine, tangibly embodying a program of instructions executable by a machine to perform the method steps of the first or the second aspects of the invention is provided.
摘要翻译：公开了一种用于执行由分析分离过程产生的信号的去卷积的信号处理器中的改进的信号处理方法。在第一方面，测量表示多个部分分离的采样区域的信号，确定信号的点扩展函数，并且采用信号的傅立叶变换和点扩展函数。接下来，确定信号的噪声分量n，并且使用以下滤波器计算结果信号A（f）的值，其中D（f）是信号的傅立叶变换，P（f）是点扩展函数的傅里叶变换，P *（f）是P（i）的复共轭。最后，得到结果A（f）的傅里叶逆变换并报告为A（t）。优选地，点扩散函数是具有标准偏差σ的高斯函数，其中使用αβ跟踪器或函数sigma =（a + bt2）+ E，fra 1/2 + EE确定sigma，其中a和 b是常数。在本发明的第二方面中，确定信号的多个可能的点扩展函数，并且使用每个PSF应用上述方法。确定提供非负结果的最大点扩展函数的值，并报告相关值A（t）。在本发明的第三方面中，提供了一种由机器可读的程序存储装置，其有形地体现了可由机器执行的指令程序，以执行本发明的第一或第二方面的方法步骤。

8. 发明授权

US08309317B2 Method of screening single cells for the production of biologically active agents 有权
标题翻译：筛选单细胞用于生产生物活性剂的方法
公开(公告)号：US08309317B2
公开(公告)日：2012-11-13
申请号：US12418521
申请日：2009-04-03
申请人： Chun-Nan Chen , James O. Bowlby, Jr. , Richard Aleck Jorgensen
发明人： Chun-Nan Chen , James O. Bowlby, Jr. , Richard Aleck Jorgensen
IPC分类号： G01N33/00
CPC分类号： C12N15/1065 , C07K16/2896 , C07K16/40 , C07K2317/56 , G06F19/00 , Y02A90/26
摘要： This invention generally relates to a methods, devices and kits for screening single cells for the production of one or more biologically active agents of interest, such as a protein, nucleic acid, or a protein and the nucleic acid encoding same.
摘要翻译：本发明一般涉及用于筛选用于生产一种或多种感兴趣的生物活性剂如蛋白质，核酸或蛋白质以及编码其的核酸的单个细胞的方法，装置和试剂盒。

9. 发明申请

US20100035763A1 METHOD OF SCREENING SINGLE CELLS FOR THE PRODUCTION OF BIOLOGICALLY ACTIVE AGENTS 有权
标题翻译：筛选单细胞生产生物活性剂的方法
公开(公告)号：US20100035763A1
公开(公告)日：2010-02-11
申请号：US12418521
申请日：2009-04-03
申请人： CHUN-NAN CHEN , JAMES O. BOWLBY, JR. , RICHARD ALECK JORGENSEN
发明人： CHUN-NAN CHEN , JAMES O. BOWLBY, JR. , RICHARD ALECK JORGENSEN
IPC分类号： C40B30/04 , G01N33/53 , C12Q1/68 , C40B30/00
CPC分类号： C12N15/1065 , C07K16/2896 , C07K16/40 , C07K2317/56 , G06F19/00 , Y02A90/26
摘要： This invention generally relates to a methods, devices and kits for screening single cells for the production of one or more biologically active agents of interest, such as a protein, nucleic acid, or a protein and the nucleic acid encoding same.
摘要翻译：本发明一般涉及用于筛选用于生产一种或多种感兴趣的生物活性剂如蛋白质，核酸或蛋白质以及编码其的核酸的单个细胞的方法，装置和试剂盒。

10. 发明申请

US20090280992A1 MULTI-WELL SYSTEM 有权
标题翻译：多层系统
公开(公告)号：US20090280992A1
公开(公告)日：2009-11-12
申请号：US12418520
申请日：2009-04-03
申请人： CHUN-NAN CHEN , JAMES O. BOWLBY, JR. , RICHARD ALECK JORGENSEN
发明人： CHUN-NAN CHEN , JAMES O. BOWLBY, JR. , RICHARD ALECK JORGENSEN
IPC分类号： C40B20/00 , C40B60/10
CPC分类号： C12N15/1065 , C07K16/2896 , C07K16/40 , C07K2317/56 , G06F19/00 , Y02A90/26
摘要： A multi-well system is described which is comprised of a tray comprising a plurality of wells which may include thousands, tens of thousands or even hundreds of thousands of wells or more. Each of the wells has a unique address. The system includes a tray top comprised of a plurality of areas wherein each of the areas corresponds uniquely to each of the wells and includes a unique address. The system may include a second tray top also comprised of a plurality of areas with unique addresses which uniquely correspond to each of the wells. The areas on the tops have compounds bound to those areas which compounds bind to components present in the wells and are used to obtain specific material in each well for analysis.
摘要翻译：描述了一种多孔系统，其由包括多个井的托盘组成，所述多个井可以包括数千，甚至几十万个井或更多井。每个井都有一个独特的地址。该系统包括由多个区域组成的托盘顶板，其中每个区域对应于每个井的唯一地址并且包括唯一的地址。该系统可以包括第二托盘顶部，其也由具有唯一地址的多个区域组成，其唯一地对应于每个井。顶部上的区域具有与化合物结合存在于孔中的组分的那些区域结合的化合物，并且用于在每个孔中获得特定材料用于分析。

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