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1. 发明申请

US20180043345A1 ION-EXCHANGE MEMBRANE WITH MULTI-LAYERED SUPPORT SUBSTRATE 审中-公开
公开(公告)号：US20180043345A1
公开(公告)日：2018-02-15
申请号：US15556735
申请日：2015-03-10
申请人： John H. BARBER , Russell James MACDONALD , Yongchang ZHENG , Kai ZHANG , Yonghong ZHAO , GENERAL ELECTRIC COMPANY
发明人： John H. BARBER , Russell James MACDONALD , Yongchang ZHENG , Kai ZHANG , Yonghong ZHAO
IPC分类号： B01J47/12 , B01J41/14 , C08J5/22 , B01D61/42 , B01D71/28 , B01D69/14 , B01D69/02 , B01D71/30 , B01D71/76 , B01J39/20 , B01D69/12
CPC分类号： B01J47/12 , B01D61/422 , B01D69/02 , B01D69/10 , B01D69/125 , B01D69/141 , B01D71/28 , B01D71/30 , B01D71/76 , B01D71/82 , B01D2321/28 , B01D2325/42 , B01J39/20 , B01J41/14 , B32B5/022 , B32B5/026 , B32B5/26 , B32B5/28 , B32B7/02 , B32B2260/023 , B32B2260/046 , B32B2262/0238 , B32B2262/0246 , B32B2262/0253 , B32B2262/0261 , B32B2262/0276 , B32B2307/20 , B32B2307/50 , B32B2307/54 , B32B2307/724 , B32B2307/732 , B32B2535/00 , C08J5/2231 , C08J2325/18 , C08J2333/14 , C25B13/08
摘要： An ion-exchange membrane is disclosed here including ion-permeable layers impregnated with an ion-exchange material and arranged in an order from one face of the membrane to the opposite face of the membrane such that opposing layers in the supporting membrane substrate provide sufficiently identical physical properties to substantially avoid irregular expansion when in a salt solution. The ion-permeable layers including at least one non-woven layer and at least one reinforcing layer.

2. 发明申请

US20170314526A1 WAVE POWER CONVERTER 审中-公开
公开(公告)号：US20170314526A1
公开(公告)日：2017-11-02
申请号：US15525395
申请日：2015-11-06
申请人： Francis James MacDonald FARLEY
发明人： Francis James MacDonald FARLEY
IPC分类号： F03B13/24 , F03B13/18
CPC分类号： F03B13/24 , F03B13/188 , F05B2220/706 , F05B2270/18 , Y02E10/38
摘要： A wave power converter is presented comprising an airtight compressible bag supporting a ballast and configured to be inflated with gas. The airtight compressible bag comprises flexible walls, wherein the shape and length of the bag is determined by the equilibrium between the weight of the ballast and the pressure inside the bag. A floating body is connected to the airtight compressible bag by a tube. The converter comprises one or more airtight vessels and a power conversion means for generating power from the reciprocating flow of gas between the bag and airtight vessel. The airtight compressible bag is submerged and surrounded by water on all sides wherein the heaving and/or pitching of said floating body excites the oscillation of said ballast which squeezes and expands said airtight compressible bag driving the contained gas via the tube and power conversion means into and out of the airtight vessel.

3. 发明申请

US20160340893A1 Ventilating Sill Plate 审中-公开
标题翻译：通风门板
公开(公告)号：US20160340893A1
公开(公告)日：2016-11-24
申请号：US15160933
申请日：2016-05-20
申请人： James MACDONALD
发明人： James MACDONALD
IPC分类号： E04B1/70 , E04B1/92 , E04B1/64 , E04C2/52
CPC分类号： E04B1/7076 , E04B1/644 , E04B2001/268 , E04C2/523
摘要： A ventilating sill for elevating a wall partition from a floor surface in order to isolate the wall partition from moisture and humidity that can emanate from the floor surface or be present thereon. The ventilating sill includes a block having a support surface, a base surface, two opposed side surfaces and a plurality of spaced channels extending between the side surfaces forming channeled surfaces. The ventilating sill further includes a pair of slats, each slat extending from each side surface upwardly towards the wall partition at a right angle to the support surface, the slats defining a support area, and being adapted to guide the wall partition onto the support surface and at least one aperture communicating between the support area and an ambient environment for ventilating the support area and draining moisture and humidity therefrom.
摘要翻译：一个用于将地板表面上的墙壁隔板升高的通风门，以便将墙壁隔离物与可能从地板表面发出或存在于其上的湿气和湿气隔离。通风门框包括具有支撑表面，基部表面，两个相对的侧表面和在形成通道表面的侧表面之间延伸的多个间隔通道的块。通风床还包括一对板条，每个板条从每个侧表面向上延伸到与支撑表面成直角的壁分隔件，板条限定支撑区域，并且适于将壁分隔件引导到支撑表面上以及在支撑区域和环境环境之间连通的至少一个孔，用于使支撑区域通风并从其排出湿气和湿气。

4. 发明申请

US20160179460A1 INTELLIGENT SAFER MUSIC SYSTEM FOR AN OPERATING ROOM 有权
标题翻译：用于操作室的智能保护音乐系统
公开(公告)号：US20160179460A1
公开(公告)日：2016-06-23
申请号：US14958724
申请日：2015-12-03
申请人： Alistair James MacDonald
发明人： Alistair James MacDonald
IPC分类号： G06F3/16 , H04R3/00 , A61B5/0205
CPC分类号： G06F3/165 , A61B5/0002 , A61B5/0205 , A61B5/021 , A61B5/024 , A61B5/0816 , A61B5/14551 , A61B5/6889 , A61B5/7275 , A61B5/7405 , A61B2503/12 , A61B2505/05 , G06F19/00 , G16H40/20 , G16H40/63 , G16H50/20 , H04R3/00 , H04R2430/01
摘要： An integrated and reactive music control system designed for silencing music in an operating room during critical events. The preferred system contains a music input, a hardware interface to integrate real-time patient physiologic data, a software application to process the data, a user interface, and a music output, any portion or all of which may be hardwired or wireless. Through the user interface, medical personnel may adjust pre-set limits on physiologic parameters that indicate abnormality or risk to a particular patient. To reduce ambient noise pollution and permit communication and concentration of the surgical team, volume is reduced as a patient's condition deteriorates. Resulting in additional safety to patients in the operating room, the cessation of music may capture the attention of health care professionals who suffer from alarm desensitization. The system's integration includes an anesthesia monitor, but may extend to include a hospital data server and EMR systems.
摘要翻译：一个集成和反应性的音乐控制系统，旨在在关键事件期间在手术室中消除音乐。优选的系统包括音乐输入，用于集成实时患者生理数据的硬件接口，用于处理数据的软件应用程序，用户界面和音乐输出，其任何部分或全部可以是硬连线或无线的。通过用户界面，医务人员可以调整对特定患者的异常或风险的生理参数的预设限制。为了减少环境噪声污染，并允许手术组的沟通和集中，随着病人的状况恶化，体积减少。导致手术室患者的额外安全性，停止音乐可能会吸引那些遭受报警脱敏的医护人员的关注。该系统的整合包括麻醉监视器，但可扩展到包括医院数据服务器和EMR系统。

5. 发明授权

US09067891B2 1,4-disubstituted 3-cyano-pyridone derivatives and their use as positive allosteric modulators of mGluR2-receptors 有权
标题翻译： 1,4-二取代的3-氰基 - 吡啶酮衍生物及其作为mGluR2受体的正变构调节剂的用途
公开(公告)号：US09067891B2
公开(公告)日：2015-06-30
申请号：US13610000
申请日：2012-09-11
申请人： Jose Maria Cid-Nunez , Andres Avelino Trabanco-Suarez , Gregor James Macdonald , Guillaume Albert Jacques Duvey , Robert Johannes Lutjens
发明人： Jose Maria Cid-Nunez , Andres Avelino Trabanco-Suarez , Gregor James Macdonald , Guillaume Albert Jacques Duvey , Robert Johannes Lutjens
IPC分类号： A61K31/443 , C07D401/04 , C07D213/85 , A61K31/198 , A61K31/444
CPC分类号： C07D213/85 , A61K31/198 , A61K31/444
摘要： The present invention relates to novel compounds, in particular novel pyridinone derivatives according to Formula (I) including any stereochemically isomeric form thereof, or a pharmaceutically acceptable salt thereof or a solvate thereof, wherein all radicals are defined in the application and claims. The compounds according to the invention are positive allosteric modulators of metabotropic glutamate receptors subtype 2 (“mGluR2”) which are useful for the treatment or prevention of neurological and psychiatric disorders associated with glutamate dysfunction and diseases in which the mGluR2 subtype of metabotropic receptors is involved. In particular, such diseases are central nervous system disorders selected from the group of anxiety, schizophrenia, migraine, depression, and epilepsy. The invention is also directed to pharmaceutical compositions and processes to prepare such compounds and such compositions, as well as to the use of such compounds for the prevention and treatment of such diseases in which mGluR2 is involved.
摘要翻译：本发明涉及新化合物，特别是包括其任何立体化学异构形式的式（I）的新型吡啶酮衍生物或其药学上可接受的盐或其溶剂合物，其中所有基团在本申请和权利要求书中定义。根据本发明的化合物是代谢型谷氨酸受体亚型2（“mGluR2”）的正变构调节剂，其可用于治疗或预防与谷氨酸功能障碍相关的神经和精神病学障碍以及涉及代谢型受体的mGluR2亚型的疾病。特别地，这些疾病是选自焦虑，精神分裂症，偏头痛，抑郁症和癫痫组的中枢神经系统疾病。本发明还涉及药物组合物和制备这些化合物和这些组合物的方法，以及这些化合物用于预防和治疗其中涉及mGluR2的疾病的用途。

6. 发明授权

US08940743B2 Piperidin-4-yl-pyridazin-3-ylamine derivatives as fast dissociating dopamine 2 receptor antagonists 有权
标题翻译：哌啶-4-基 - 哒嗪-3-基胺衍生物作为快速解离的多巴胺2受体拮抗剂
公开(公告)号：US08940743B2
公开(公告)日：2015-01-27
申请号：US12091219
申请日：2006-10-24
申请人： Marcel Frans Leopold De Bruyn , Gregor James MacDonald , Ludo Edmond Josephine Kennis , Xavier Jean Michel Langlois , Frans Alfons Maria Van Den Keybus , Yves Emiel Maria Van Roosbroeck
发明人： Marcel Frans Leopold De Bruyn , Gregor James MacDonald , Ludo Edmond Josephine Kennis , Xavier Jean Michel Langlois , Frans Alfons Maria Van Den Keybus , Yves Emiel Maria Van Roosbroeck
IPC分类号： C07D401/12 , C07D401/14 , A61K31/501 , C07D409/14 , C07D491/113 , C07D211/44 , C07D211/58 , C07D237/20 , A61P25/18
CPC分类号： C07D401/12 , A61K31/501 , C07D409/14
摘要： The present invention relates to compounds that are fast dissociating dopamine 2 receptor antagonists, processes for preparing these compounds, pharmaceutical compositions comprising these compounds as an active ingredient. The compounds find utility as medicines for treating or preventing central nervous system disorders, for example schizophrenia, by exerting an antipsychotic effect without motor side effects.
摘要翻译：本发明涉及快速解离多巴胺2受体拮抗剂，制备这些化合物的方法，包含这些化合物作为活性成分的药物组合物。该化合物可用作治疗或预防中枢神经系统疾病（例如精神分裂症）的药物，通过发挥抗精神病作用而没有运动副作用。

7. 发明授权

US08933101B2 Thia(dia)zoles as fast dissociating dopamine 2 receptor antagonists 有权
标题翻译： Thia（dia）zoles作为快速解离的多巴胺2受体拮抗剂
公开(公告)号：US08933101B2
公开(公告)日：2015-01-13
申请号：US12597164
申请日：2008-04-18
申请人： Gregor James MacDonald , José Manuel Bartolomé-Nebreda , Michiel Luc Maria Van Gool
发明人： Gregor James MacDonald , José Manuel Bartolomé-Nebreda , Michiel Luc Maria Van Gool
IPC分类号： A61K31/454 , C07D417/12 , C07D401/12
CPC分类号： C07D401/12 , C07D417/12
摘要： The present invention relates to [1-(benzyl)-piperidin-4-yl]-([1,3,4]thiadiazol-2-yl)-amine and [1-(benzyl)-piperidin-4-yl]-(thiazol-2-yl)-amine derivatives of formula (I) that are fast dissociating dopamine 2 receptor antagonists, processes for preparing these compounds, pharmaceutical compositions comprising these compounds as an active ingredient. The compounds find utility as medicines for treating or preventing central nervous system disorders, for example schizophrenia, by exerting an antipsychotic effect without motor side effects.
摘要翻译：本发明涉及[1-（苄基） - 哌啶-4-基] - （[1,3,4]噻二唑-2-基） - 胺和[1-（苄基） - 哌啶-4-基] - （I）的（噻唑-2-基） - 胺衍生物，其是快速解离的多巴胺2受体拮抗剂，制备这些化合物的方法，包含这些化合物作为活性成分的药物组合物。该化合物可用作治疗或预防中枢神经系统疾病（例如精神分裂症）的药物，通过发挥抗精神病作用而没有运动副作用。

8. 发明申请

US20140339087A1 SUPERCAPACITOR DESALINATION CELLS, DEVICES AND METHODS 有权
标题翻译：超级脱盐细胞，装置和方法
公开(公告)号：US20140339087A1
公开(公告)日：2014-11-20
申请号：US14117388
申请日：2012-05-22
申请人： Rihua Xiong , Wei Cai , John Harold Barber , Chengqian Zhang , Russell James MacDonald , Keith James Sims
发明人： Rihua Xiong , Wei Cai , John Harold Barber , Chengqian Zhang , Russell James MacDonald , Keith James Sims
IPC分类号： C02F1/469
CPC分类号： C02F1/4691 , C02F2101/10 , C02F2103/08 , C02F2201/002 , C02F2201/46 , C02F2303/22
摘要： A supercapacitor desalination cell comprises a first electrode, a second electrode, a spacer disposed between the first and second electrodes, and a monovalent ion selective layer disposed on at least one of the first and second electrodes. A supercapacitor desalination device and a method for desalination of a liquid are further presented.
摘要翻译：超级电容器海水淡化单元包括第一电极，第二电极，设置在第一和第二电极之间的间隔物和设置在第一和第二电极中的至少一个上的单价离子选择层。进一步介绍超级电容器脱盐装置和液体脱盐方法。

9. 发明授权

US08859543B2 Imidazo[1,2-a]pyrazine derivatives and their use for the prevention or treatment of neurological, psychiatric and metabolic disorders and diseases 有权
标题翻译：咪唑并[1,2-a]吡嗪衍生物及其用于预防或治疗神经，精神和代谢疾病和疾病的用途
公开(公告)号：US08859543B2
公开(公告)日：2014-10-14
申请号：US13583514
申请日：2011-03-08
申请人： José Manuel Bartolomé-Nebreda , Susana Conde-Ceide , Gregor James MacDonald , Joaquin Pastor-Fernández , Michiel Luc Maria Van Gool , María Luz Martín-Martín , Greta Constantia Peter Vanhoof
发明人： José Manuel Bartolomé-Nebreda , Susana Conde-Ceide , Gregor James MacDonald , Joaquin Pastor-Fernández , Michiel Luc Maria Van Gool , María Luz Martín-Martín , Greta Constantia Peter Vanhoof
IPC分类号： C07D487/04 , A61K31/5377
CPC分类号： C07D487/04 , A61K31/5377
摘要： The present invention relates to novel imidazo[1,2-a]pyrazine derivatives which are inhibitors of the phosphodiesterase 10 enzyme (PDE10) and which are useful for the treatment or prevention of neurological, psychiatric and metabolic disorders in which the PDE10 enzyme is involved. The invention is also directed to pharmaceutical compositions comprising such compounds, to processes to prepare such compounds and compositions, to the use of such compounds or pharmaceutical compositions for the prevention or treatment of neurological, psychiatric and metabolic disorders and diseases.
摘要翻译：本发明涉及作为磷酸二酯酶10酶（PDE10）的抑制剂的新的咪唑并[1,2-a]吡嗪衍生物，其可用于治疗或预防涉及PDE10酶的神经，精神和代谢紊乱。本发明还涉及包含这些化合物的药物组合物，以制备这些化合物和组合物以使用这些化合物或药物组合物来预防或治疗神经，精神和代谢疾病和疾病。

10. 发明授权

US08779158B2 Trisubstituted pyrazoles as acetylcholine receptor modulators 有权
标题翻译：三取代吡唑作为乙酰胆碱受体调节剂
公开(公告)号：US08779158B2
公开(公告)日：2014-07-15
申请号：US12991119
申请日：2009-05-08
申请人： Johannes Wilhelmus John F. Thuring , Gregor James MacDonald , Wei Zhuang
发明人： Johannes Wilhelmus John F. Thuring , Gregor James MacDonald , Wei Zhuang
IPC分类号： A61K31/4155 , A01N43/36 , C07D231/02 , C07D401/04
CPC分类号： C07D401/04 , C07D231/38 , C07D405/04 , C07D405/14
摘要： The present invention relates to 1-alkyl-3-aniline-5-aryl-pyrazole derivatives and pharmaceutically acceptable salts thereof, processes for preparing them, pharmaceutical compositions containing them and their use in therapy, according to Formula (I).The invention particularly relates to positive allosteric modulators of nicotinic acetylcholine receptors, such positive allosteric modulator having the capability to increase the efficacy of nicotinic receptor agonists.
摘要翻译：本发明涉及1-烷基-3-苯胺-5-芳基吡唑衍生物及其药学上可接受的盐，其制备方法，含有它们的药物组合物及其在治疗中的用途，根据式（I）。本发明特别涉及烟碱乙酰胆碱受体的正变构调节剂，这种正变构调节剂具有增加烟碱受体激动剂功效的能力。

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