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1. 发明申请

US20050112549A1 Method and apparatus for measuring nitric oxide production and oxygen consumption in cultures of adherent cells 失效
标题翻译：用于测量粘附细胞培养物中一氧化氮产生和氧消耗的方法和装置
公开(公告)号：US20050112549A1
公开(公告)日：2005-05-26
申请号：US10996395
申请日：2004-11-26
申请人： James Baumgardner , Cynthia Otto
发明人： James Baumgardner , Cynthia Otto
IPC分类号： B01L5/00 , C12M1/00 , C12M1/04 , C12M1/36 , C12M3/00 , C12Q1/00 , C12Q1/02 , C12Q1/26 , G01N33/00 , G01N33/50
CPC分类号： C12M41/34 , G01N33/0037 , Y02A50/245 , Y10S435/807
摘要： An apparatus and method for measuring nitric oxide production and oxygen consumption in cultures of adherent cells continuously and without destroying the cells. The method involves flowing growth media through a tube having adherent cells are adhered to the inner surface thereof and then contacting the growth media with an NO or O2 sensor to detect the concentration of NO or O2 in the growth media.
摘要翻译：一种用于连续测量粘附细胞培养物中一氧化氮产生和耗氧并且不破坏细胞的装置和方法。该方法包括使生长培养基流过具有粘附细胞的管粘附到其内表面，然后使生长培养基与NO或O 2传感器接触以检测NO或O 2的浓度， 2 。

2. 发明授权

US07714386B2 Carbon nanotube field effect transistor 有权
标题翻译：碳纳米管场效应晶体管
公开(公告)号：US07714386B2
公开(公告)日：2010-05-11
申请号：US11449758
申请日：2006-06-09
申请人： Aaron Anthony Pesetski , Hong Zhang , John Douglas Adam , John Przybysz , Jim Murduck , Norman Goldstein , James Baumgardner
发明人： Aaron Anthony Pesetski , Hong Zhang , John Douglas Adam , John Przybysz , Jim Murduck , Norman Goldstein , James Baumgardner
IPC分类号： H01L27/01
CPC分类号： H01L51/0048 , B82Y10/00 , H01L51/0554 , H01L51/0558
摘要： A carbon nanotube field effect transistor includes a substrate, a source electrode, a drain electrode and a carbon nanotube. The carbon nanotube forms a channel between the source electrode and the drain electrode. The carbon nanotube field effect transistor also includes a gate dielectric and a gate electrode. The gate electrode is separated from the carbon nanotube by the gate dielectric, and an input radio frequency voltage is applied to the gate electrode.
摘要翻译：碳纳米管场效应晶体管包括基板，源电极，漏电极和碳纳米管。碳纳米管在源电极和漏电极之间形成通道。碳纳米管场效应晶体管还包括栅极电介质和栅电极。栅电极通过栅极电介质与碳纳米管分离，并且将输入射频电压施加到栅电极。

3. 发明申请

US20080006099A1 Temperature Controller for Small Fluid Samples With Different Heat Capacities 有权
标题翻译：具有不同热容的小流体样品的温度控制器
公开(公告)号：US20080006099A1
公开(公告)日：2008-01-10
申请号：US11814620
申请日：2006-01-20
申请人： James Baumgardner
发明人： James Baumgardner
IPC分类号： G01N1/00 , B01J19/00
CPC分类号： B01L3/502715 , B01L3/5027 , B01L5/00 , B01L7/54 , B01L2200/147 , B01L2300/1822 , B01L2300/1827 , B01L2300/1844 , B01L2300/185
摘要： A system for controlling the temperature of fluidic samples includes a device having a first outer surface and a second outer surface which are parallel to one another. The interior of the device contains two or more channels suitable for accommodating samples. The channels lay on a common plane that is also parallel to the first and second outer surfaces. A temperature sensor is positioned between the channels along the common plane. A heater is thermally coupled to one of the two outer surfaces while a heat sink is coupled to the other of the two outer surfaces, thereby establishing a temperature gradient between the first and second outer surfaces. A temperature controller receives sensed temperature input from the temperature sensor and adjusts the heater in response thereto.
摘要翻译：用于控制流体样品的温度的系统包括具有彼此平行的第一外表面和第二外表面的装置。设备的内部包含两个或更多个适用于容纳样品的通道。通道位于平行于第一和第二外表面的公共平面上。温度传感器位于沿共同平面的通道之间。加热器热耦合到两个外表面中的一个，同时散热器耦合到两个外表面中的另一个，从而在第一和第二外表面之间建立温度梯度。温度控制器接收来自温度传感器的感测温度输入并响应于此调节加热器。

4. 发明授权

US07072706B2 Equilibration method for high resolution imaging of lung compliance and distribution of functional residual capacity 有权
标题翻译：平衡方法用于高分辨率成像肺顺应性和功能残留能力分布
公开(公告)号：US07072706B2
公开(公告)日：2006-07-04
申请号：US10071435
申请日：2002-02-08
申请人： James Baumgardner , David Lipson , Rahim Rizi , David Roberts , Mitchell Schnall
发明人： James Baumgardner , David Lipson , Rahim Rizi , David Roberts , Mitchell Schnall
IPC分类号： A61B5/55
CPC分类号： G01R33/5601
摘要： The present invention offers novel equilibration methods for very high resolution, three-dimensional imaging of imaging of lung compliance and distribution of functional residual capacity (FRC) in the lung using hyperpolarized helium-3 (3He) gas (H3He), and collecting local magnetic resonance image data therefrom. Using the present methods permits many functions that have been performed on a regional level for the whole lung using non-polarized helium, to be calculated for the first time from the local MRI measurements of local H3He, such as measuring volume or compliance.
摘要翻译：本发明提供新颖的平衡方法，用于使用超极化氦-3（3+ He）气体在肺中非常高分辨率，三维成像肺顺应性成像和功能残留容量（FRC）分布（H 3 He），并从中收集局部磁共振图像数据。使用本方法允许使用非极化氦在全球范围内对全肺进行的许多功能首次从局部H 3 He的局部MRI测量计算，例如测量体积或符合性。

5. 发明申请

US20090224230A1 Carbon nanotube field effect transistor 有权
标题翻译：碳纳米管场效应晶体管
公开(公告)号：US20090224230A1
公开(公告)日：2009-09-10
申请号：US11449758
申请日：2006-06-09
申请人： Aaron Anthony Pesetski , Hong Zhang , John Douglas Adam , John Przybysz , Jim Murduck , Norman Goldstein , James Baumgardner
发明人： Aaron Anthony Pesetski , Hong Zhang , John Douglas Adam , John Przybysz , Jim Murduck , Norman Goldstein , James Baumgardner
IPC分类号： H01L29/66 , H01L29/786
CPC分类号： H01L51/0048 , B82Y10/00 , H01L51/0554 , H01L51/0558
摘要： A carbon nanotube field effect transistor includes a substrate, a source electrode, a drain electrode and a carbon nanotube. The carbon nanotube forms a channel between the source electrode and the drain electrode. The carbon nanotube field effect transistor also includes a gate dielectric and a gate electrode. The gate electrode is separated from the carbon nanotube by the gate dielectric, and an input radio frequency voltage is applied to the gate electrode.
摘要翻译：碳纳米管场效应晶体管包括基板，源电极，漏电极和碳纳米管。碳纳米管在源电极和漏电极之间形成通道。碳纳米管场效应晶体管还包括栅极电介质和栅电极。栅电极通过栅极电介质与碳纳米管分离，并且将输入射频电压施加到栅电极。

6. 发明授权

US07087436B2 Membrane countercurrent exchanger and membrane inlet mass spectrometer for the analysis of gas partial pressure in liquid samples 失效
公开(公告)号：US07087436B2
公开(公告)日：2006-08-08
申请号：US10465637
申请日：2003-06-20
申请人： James Baumgardner , Gordon Neufeld
发明人： James Baumgardner , Gordon Neufeld
IPC分类号： G01N33/00 , H01J49/04
CPC分类号： H01J49/0436 , G01N1/22 , G01N1/24 , G01N2001/4066 , Y10T436/117497 , Y10T436/204998 , Y10T436/207497 , Y10T436/209163 , Y10T436/21 , Y10T436/24 , Y10T436/25 , Y10T436/255 , Y10T436/25875
摘要： A method and apparatus for the analysis of blood or other liquids by mass spectrometry to determine the partial pressures of gases and other volatile substances dissolved in the blood or other liquid in a manner independent of the solubility of the gases in the blood or other liquid. A countercurrent membrane exchanger (CCME) is provided for equilibrating a carrier fluid with the sample of blood or other liquid, the output of which is coupled to a tubular direct insertion membrane probe (t-DIMP) type of membrane inlet mass spectrometer. The CCME preferably has complementary spiral grooves on opposing metal plates for the water carrier and sample liquids so as to induce secondary flows which greatly reduce the resistance to equilibration between the liquid sample and water carrier phases. The t-DIMP is characterized by the use of Teflon™ sleeves specifically to reduce noise introduced at the connection between the silicone membrane in the t-DIMP and the steel tubing for the water carrier, by the use of radiation shields to prevent heating of the silicone membrane and water carrier to allow lower carrier flow rates, and by the heating of the section between the ion source and the vacuum pumps specifically to improve linearity of the t-DIMP.

7. 发明授权

US06915151B2 Quantitative pulmonary imaging 有权
标题翻译：定量肺成像
公开(公告)号：US06915151B2
公开(公告)日：2005-07-05
申请号：US10071434
申请日：2002-02-08
申请人： James Baumgardner , David Lipson , Rahim Rizi , David Roberts , Mitchell Schnall
发明人： James Baumgardner , David Lipson , Rahim Rizi , David Roberts , Mitchell Schnall
IPC分类号： G01R33/54 , A61B5/055
CPC分类号： G01R33/5601
摘要： The present invention comprises imaging and quantitative measurement of lung ventilation, particularly in a human lung. Methods for quantitative imaging of lung ventilation, and the further provided systems and algorithmic tools therefore, comprise three primary components: the combined MRI ventilation/perfusion (V/Q) imaging techniques using hyperpolarized helium-3 (3He) gas (H3He); the three-dimensional quantitative imaging of absolute lung perfusion (Q) and collection of local magnetic resonance image data therefrom to produce an absolute lung perfusion image data; and the algorithmic co-registration of the two image data sets, (HP-3He MRI image of V/Q and MR imaging of quantitative perfusion (Q) in the lung). From the data acquired in the combined data sets and their spatial co-registration, absolute ventilation (V) is computed.
摘要翻译：本发明包括肺通气的成像和定量测量，特别是在人肺中。肺通气定量成像的方法，以及进一步提供的系统和算法工具包括三个主要组成部分：使用超极化氦-3（^{3）的组合MRI通气/灌注（V / Q）成像技术 He）气（H 3 H 3）; 绝对肺灌注（Q）的三维定量成像和从其中收集局部磁共振图像数据产生绝对肺灌注图像数据; 以及两个图像数据集的算法共同配准（在HP中的V-Q的HP-3 He MRI图像和定量灌注（Q）的MR成像）。根据组合数据集中获取的数据及其空间共同登记，计算绝对通气量（V）。}

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