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1. 发明申请

US20140044752A1 INACTIVATED VIRUS COMPOSITIONS AND METHODS OF PREPARING SUCH COMPOSITIONS 有权
标题翻译：灭活的病毒组合物及其制备方法
公开(公告)号：US20140044752A1
公开(公告)日：2014-02-13
申请号：US14112263
申请日：2012-05-03
申请人： Wayne L. Ryan , James A Grunkemeyer
发明人： Wayne L. Ryan , James A Grunkemeyer
IPC分类号： A61K39/275
CPC分类号： A61K39/275 , A61K39/12 , A61K2039/5252 , C12N7/00 , C12N2760/16134 , C12N2760/16163
摘要： The present invention is directed at a composition comprising a live swine flu virus having an infectious component and a plurality of surface antigens in contact with a formaldehyde donor agent having a molecular weight that is less than about 400 g/mol. Preferably, the formaldehyde donor agent is selected from a non-crosslinking chemical fixative that contains urea.
摘要翻译：本发明涉及包含具有感染性成分的活猪流感病毒和与分子量小于约400g / mol的甲醛供体试剂接触的多种表面抗原的组合物。优选地，甲醛供体剂选自含有尿素的非交联化学固定剂。

2. 发明申请

US20110110975A1 INACTIVATED VIRUS COMPOSITIONS AND METHODS OF PREPARING SUCH COMPOSITIONS 审中-公开
标题翻译：灭活的病毒组合物及其制备方法
公开(公告)号：US20110110975A1
公开(公告)日：2011-05-12
申请号：US12940112
申请日：2010-11-05
申请人： James A. Grunkemeyer , Wayne L. Ryan
发明人： James A. Grunkemeyer , Wayne L. Ryan
IPC分类号： A61K39/12 , C12N7/06 , C12Q1/70 , A61P31/12 , A61P37/04
CPC分类号： C12N7/00 , A61K39/12 , A61K39/17 , A61K2039/5252 , A61K2039/552 , C12N2760/18134 , C12N2760/18163
摘要： The present invention is a composition comprising a live virus having an infectious component and a plurality of surface antigens in contact with a formaldehyde donor agent having a molecular weight that is less than about 400 g/mol. The present invention further provides a method for deactivating a live virus having an infectious component and a plurality of surface antigens, comprising the steps of: a) providing a live virus having an infectious component and a plurality of surface antigens; and b) contacting the virus with a formaldehyde donor agent having a molecular weight that is greater than about 50 g/mol and less than about 400 g/mol for a period of time (e.g., at least about 12 hours) sufficient for de-activating the infectious component with the formaldehyde donor agent and for preserving at least a portion of the surface antigens to form a deactivated virus. In another embodiment the invention is a method of preparing a composition useful as a vaccine comprising the abovementioned steps in combination with the step of c) mixing a non-toxic effective amount, for inducing an immune response in a subject to which the vaccine is administered, of the deactivated virus with a pharmaceutically acceptable carrier. Preferably the composition containing a pharmaceutically acceptable carrier is useful in, or as, a vaccine composition.
摘要翻译：本发明是一种组合物，其包含具有感染成分的活病毒和与分子量小于约400g / mol的甲醛供体试剂接触的多个表面抗原。本发明还提供了一种使具有感染成分和多种表面抗原的活病毒失活的方法，包括以下步骤：a）提供具有感染成分和多种表面抗原的活病毒; 和b）使病毒与分子量大于约50g / mol且小于约400g / mol的甲醛供体试剂接触足够的时间（例如至少约12小时）用甲醛供体试剂活化感染成分并保存至少一部分表面抗原以形成失活的病毒。在另一个实施方案中，本发明是一种制备可用作疫苗的组合物的方法，所述组合物包含上述步骤，与以下步骤组合：c）将无毒有效量混合，用于在施用疫苗的受试者中诱导免疫应答的失活病毒与药学上可接受的载体。优选地，含有药学上可接受的载体的组合物可用于或作为疫苗组合物。

3. 发明授权

US09956281B2 Inactivated virus compositions and methods of preparing such compositions 有权
公开(公告)号：US09956281B2
公开(公告)日：2018-05-01
申请号：US14112263
申请日：2012-05-03
申请人： Wayne L. Ryan , James A Grunkemeyer
发明人： Wayne L. Ryan , James A Grunkemeyer
IPC分类号： A61K39/00 , A61K39/145 , C07K14/005 , C07K14/11 , A61K39/12 , A61K39/275 , C12N7/00
CPC分类号： A61K39/275 , A61K39/12 , A61K2039/5252 , C12N7/00 , C12N2760/16134 , C12N2760/16163
摘要： The present invention is directed at a composition comprising a live swine flu virus having an infectious component and a plurality of surface antigens in contact with a formaldehyde donor agent having a molecular weight that is less than about 400 g/mol. Preferably, the formaldehyde donor agent is selected from a non-crosslinking chemical fixative that contains urea.

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