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1. 发明授权

US08206580B2 Integrated blood treatment module 有权
标题翻译：综合血液处理模块
公开(公告)号：US08206580B2
公开(公告)日：2012-06-26
申请号：US10595546
申请日：2004-11-05
申请人： Jürgen Dannenmaier , Hermann Goehl , Thomas Ertl , Jacques Chevallet , Francesco Ribolzi , Björn Frederik Seidler , Lennart Jönsson , Eddie Nilsson
发明人： Jürgen Dannenmaier , Hermann Goehl , Thomas Ertl , Jacques Chevallet , Francesco Ribolzi , Björn Frederik Seidler , Lennart Jönsson , Eddie Nilsson
IPC分类号： B01D19/00 , B01D63/00 , A61M1/36 , C02F1/20 , C02F1/44
CPC分类号： A61M1/3627 , A61M1/1008 , A61M1/1039 , A61M1/1086 , A61M1/16 , A61M1/3639 , A61M1/3641 , A61M2205/12 , B01D61/30 , B01D63/02
摘要： An integrated blood treatment module comprises a blood treatment device (1) having a housing (2) and a first end-cap (4) and a second end-cap (5) closing both ends of the housing (2). A pump hose (17) for a peristaltic pump has a first end (18) that is secured to the housing (2) and a second end (16) that is connected to a blood inlet port (15) of the first end-cap (4) so as to form a loop. A degassing device (30) is connected to the second end-cap (5). The degassing device (30), which, in use, is full of liquid, comprises a hydrophobic membrane through which bubbles and micro-bubbles escape the degassing device.
摘要翻译：集成血液处理模块包括具有壳体（2）和第一端盖（4）的血液处理装置（1）和封闭壳体（2）的两端的第二端盖（5）。用于蠕动泵的泵管（17）具有固定到壳体（2）的第一端（18）和连接到第一端盖（16）的血液入口（15）的第二端（16）（4）以形成环路。脱气装置（30）连接到第二端帽（5）。在使用中充满液体的脱气装置（30）包括疏水膜，气泡和微气泡通过该疏水膜逸出脱气装置。

2. 发明授权

US07540958B2 Device for controlling blood circulation for a single needle circuit 失效
标题翻译：用于控制单针电路血液循环的装置
公开(公告)号：US07540958B2
公开(公告)日：2009-06-02
申请号：US11074067
申请日：2005-03-08
申请人： Jacques Chevallet , Jean-Louis Romarie , Alain Frugier
发明人： Jacques Chevallet , Jean-Louis Romarie , Alain Frugier
IPC分类号： B01D61/28 , B01D61/18
CPC分类号： A61M1/30 , A61M1/1006 , A61M1/1039 , A61M1/1081 , A61M1/302 , A61M1/303 , A61M1/308
摘要： Device for extracorporeal treatment of blood 1 intended to operate in a mode with a single needle 2, comprising: a treatment unit 3 having a first compartment 4 and a second compartment 5, which are separated by a semipermeable membrane 6, an extracorporeal blood circuit comprising a single needle 2, an intake line 7 in fluid communication with the first compartment 4 of the treatment unit 3, the first compartment 4, and a return line 8 in fluid communication with the first compartment 4 of the treatment unit 3, a purge line 9 at the outlet of the second compartment 5, a closure means (10, 11) acting on at least the intake line 7 and the return line 8 in order to generate the alternate sequence of blood intake and return, at least a first chamber 12 which is in fluid communication with the extracorporeal blood circuit and defines a first additional blood volume, the first chamber 12 having a variable total content; the first chamber 4 being rigid and including at least one wall capable of being moved, the device including a means 19 acting on the chamber 12 in order to modify the volume of the chamber 12, making it possible to store blood during the arterial phase and release blood during the venous phase.
摘要翻译：用于体外处理用于以单针2模式操作的血液1的装置，包括：具有由半透膜6分离的第一隔室4和第二隔室5的治疗单元3，体外血液回路包括单个针2，与处理单元3的第一隔室4流体连通的进入管线7，第一隔室4和与处理单元3的第一隔室4流体连通的返回管线8，净化管线 9，在第二隔室5的出口处，至少作用在进气管线7和返回管线8上的闭合装置（10,11），以产生血液进入和返回的交替序列，至少第一室12 其与体外血液回路流体连通并限定第一附加血液体积，第一腔室12具有可变的总含量; 第一腔室4是刚性的并且包括能够被移动的至少一个壁，该装置包括作用在腔室12上的装置19，以便改变腔室12的体积，使得可以在动脉期期间储存血液，在静脉期释放血液。

3. 发明申请

US20080060988A1 EXTRACORPOREAL BLOOD TREATMENT MACHINE 有权
标题翻译：超声波血液治疗机
公开(公告)号：US20080060988A1
公开(公告)日：2008-03-13
申请号：US11938940
申请日：2007-11-13
申请人： Annalisa Delnevo , Francesco Ribolzi , Claudio Tonelli , Vincenzo Baraldi , Massimo Zaccarelli , Jacques Chevallet , Jacques Duchamp , Aziz Aberkane , Gabriel Meyssonnier , Dominique Pouchoulin
发明人： Annalisa Delnevo , Francesco Ribolzi , Claudio Tonelli , Vincenzo Baraldi , Massimo Zaccarelli , Jacques Chevallet , Jacques Duchamp , Aziz Aberkane , Gabriel Meyssonnier , Dominique Pouchoulin
IPC分类号： B01D29/50 , B01D29/00 , B01D29/52
CPC分类号： A61M1/16 , A61M1/1605 , A61M1/342 , A61M1/3434 , A61M1/3437 , A61M1/3451 , A61M2205/12 , A61M2205/128 , A61M2205/3393 , A61M2205/50 , A61M2230/30
摘要： The invention relates to an extracorporeal blood treatment machine in which a blood circuit (3) is equipped with an inlet line leading to a filtration unit (2) and with an outlet line (3b) from the filtration unit; a fluid circuit comprises an inlet line (4a) leading to the filtration unit and an outlet line (4b) from the filtration unit so as to allow a fluid taken from a primary container (5) to circulate within the filtration unit, thus enabling the treatment of the patient's blood. There is further an infusion line (6) acting on the outlet line of the blood circuit, which is supplied by an auxiliary fluid container (7). The inlet line of the fluid circuit is equipped with at least an infusion branch (8) acting on the outlet line of the blood circuit so as to enable the intensive therapy machine to manage therapies with large exchange of fluids.
摘要翻译：本发明涉及一种体外血液处理机，其中血液回路（3）配备有通向过滤单元（2）的入口管线和来自过滤单元的出口管线（3b）; 流体回路包括通向过滤单元的入口管线（4a）和来自过滤单元的出口管线（4b），以便允许从主容器（5）中取出的流体在过滤单元内循环，从而能够治疗患者的血液。还有一个输入管线（6）作用在血液回路的出口管线上，该输液管线由辅助流体容器（7）供应。流体回路的入口管线配备有至少一个作用在血液回路出口管路上的输液支路（8），以使得强化治疗机器能够以大量的流体交换来管理治疗。

4. 发明申请

US20070269340A1 Fluid Distribution Module and Extracorporeal Blood Circuit Including Such a Module 有权
标题翻译：流体分布模块和体外血液循环包括这样一个模块
公开(公告)号：US20070269340A1
公开(公告)日：2007-11-22
申请号：US10595705
申请日：2004-10-29
申请人： Jurgen Dannenmaier , Hermann Goehl , Thomas Ertl , Jacques Chevallet
发明人： Jurgen Dannenmaier , Hermann Goehl , Thomas Ertl , Jacques Chevallet
IPC分类号： B01D61/00
CPC分类号： A61M1/3627 , A61M1/1008 , A61M1/1039 , A61M1/1086 , A61M1/16 , A61M1/3639 , A61M1/3641 , A61M2205/12 , B01D61/30 , B01D63/02
摘要： A fluid distribution module (1) for causing and monitoring the circulation of fluids from and to a patient through an extracorporeal blood treatment device, comprises a degassing device (11) connected to a connecting structure (10). The degassing device (11) comprises a first chamber (12) having a lower inlet (13) for a liquid and a second chamber (14) having an upper opening (79) closed by a hydrophobic membrane (78) and an outlet (15) for discharging the liquid. The connecting structure (10) has at least a first and a second conduits (20, 21) defined therein, wherein the first conduit (20) comprises a first end for connection to a discharge tube (7) from the treatment device and a second end connected to the inlet (13) of the first chamber (12) of the degassing device (11), and the second conduit (21) comprises a first end connected to the outlet (15) of the second chamber (14) of the degassing device (11) and a second end for connection to a blood return tube (6) to a patient.
摘要翻译：一种用于通过体外血液处理装置引导和监测来自和来自患者的流体循环的流体分配模块（1），包括连接到连接结构（10）的脱气装置（11）。脱气装置（11）包括具有用于液体的下入口（13）的第一室（12）和具有由疏水膜（78）和出口（15）封闭的上开口（79）的第二室（14））用于排出液体。连接结构（10）具有至少限定在其中的第一和第二导管（20,21），其中第一导管（20）包括用于从治疗装置连接到放电管（7）的第一端和第二导管端部连接到脱气装置（11）的第一室（12）的入口（13），并且第二导管（21）包括连接到第二室（14）的出口（15）的第一端脱气装置（11）和用于连接到患者的血液回流管（6）的第二端。

5. 发明授权

US07291269B2 Apparatus and process for extracorporeal treatment of blood with selective extraction of solutes 有权
标题翻译：选择性提取溶质的血液体外处理的装置和方法
公开(公告)号：US07291269B2
公开(公告)日：2007-11-06
申请号：US10801830
申请日：2004-03-17
申请人： Jacques Chevallet , Guy Mercier , Hiram Rada , Mehran Monchi
发明人： Jacques Chevallet , Guy Mercier , Hiram Rada , Mehran Monchi
IPC分类号： B01D61/00 , B01D61/18 , B01D61/22 , B01D61/24 , B01D61/28 , B01D61/32 , A61M1/34 , A61M1/16
CPC分类号： A61M1/3496 , A61L2/0011 , A61L2/0017 , A61M1/1696 , A61M1/342 , A61M1/3434 , A61M1/3437 , A61M1/3441 , A61M1/3451 , A61M1/3468 , A61M1/3479 , A61M1/3482 , A61M1/3486 , A61M1/3681 , G06F19/00
摘要： A device and method for an extracorporeal blood treatment is described. The device comprising at least one exchanger equipped with at least one first inlet for the blood to be treated, a first fluid outlet and a second fluid outlet, an input line for blood to be treated connected to the first inlet of the exchanger, a blood output line (or venous line) connected to the first outlet of the exchanger, at least one treatment unit comprising at least one first fluid inlet and at least one first fluid outlet, the second outlet of the exchanger being in fluid communication with the first inlet of the treatment unit, where the first outlet from the treatment unit is in fluid communication with the input line and the second outlet of the treatment unit is in fluid communication with a first waste liquid discharge line.
摘要翻译：描述了用于体外血液处理的装置和方法。所述装置包括至少一个交换器，其配备有用于待处理血液的至少一个第一入口，第一流体出口和第二流体出口，用于待处理血液的输入管线，连接到所述交换器的第一入口，血液连接到交换器的第一出口的输出管线（或静脉管），至少一个处理单元，其包括至少一个第一流体入口和至少一个第一流体出口，所述交换器的第二出口与第一入口流体连通处理单元的第一出口与输入管线流体连通并且处理单元的第二出口与第一废液排放管线流体连通。

6. 发明申请

US20060283801A1 Method and device for in-line preparation of liquid for an extracorporeal blood treatment apparatus 失效
标题翻译：用于体外血液处理装置的液体的在线制备方法和装置
公开(公告)号：US20060283801A1
公开(公告)日：2006-12-21
申请号：US11507614
申请日：2006-08-22
申请人： Jacques Chevallet , Guy Mercier , Laurent Simard
发明人： Jacques Chevallet , Guy Mercier , Laurent Simard
IPC分类号： B01D61/00
CPC分类号： C02F1/444 , A61M1/1656 , A61M1/1668 , A61M2205/14 , A61M2205/60 , A61M2205/7518 , A61M2205/7581 , B01D61/142 , B01D61/20 , B01D61/22
摘要： A method for in-line preparation of liquid for an extracorporeal blood treatment apparatus that makes provision for placing a filter in correspondence with each of two successive filtration stations, for carrying out a liquid preparation cycle, for removing the filter, which operates in correspondence with a first filtration station, for placing in correspondence with the first filtration station the filter that operated in correspondence with the second filtration station, for placing a new filter in correspondence with a second filtration station and for launching a new sterile liquid preparation cycle. The invention also provides a device for implementing the described method and an apparatus for extracorporeal blood treatment, which incorporates this device.
摘要翻译：一种用于体外血液处理装置的液体的在线制备方法，其用于设置与两个连续的过滤站中的每一个相对应的过滤器，用于进行液体制备循环，用于除去与第一过滤站，用于与第一过滤站相对应地放置与第二过滤站相对应地操作的过滤器，用于与第二过滤站相对放置新的过滤器，以及发射新的无菌液体制备循环。本发明还提供了一种用于实现所述方法的装置和用于体外血液处理的装置，其包括该装置。

7. 发明申请

US20050247203A1 Gas separation devices 有权
标题翻译：气体分离装置
公开(公告)号：US20050247203A1
公开(公告)日：2005-11-10
申请号：US10518787
申请日：2003-05-26
申请人： Jacques Chevallet , Nicolas Semenzato , Alain Frugier
发明人： Jacques Chevallet , Nicolas Semenzato , Alain Frugier
IPC分类号： A61M1/34 , A61M1/36 , B01D19/00 , B01F5/00 , B04C5/103
CPC分类号： B01D19/0057 , A61M1/3437 , A61M1/3627 , A61M1/3639 , A61M1/3641 , A61M1/3676 , A61M2205/3382 , A61M2206/16 , B01F5/0057 , B04C5/103
摘要： A description is given of a gas separation device for a physiological fluid, comprising a containing body (6) having at least a first inlet aperture (7) for a physiological fluid, positioned with a tangential direction of access, at least one outlet aperture (9) for the said fluid, spaced apart from the said inlet aperture, and a guide element (17) housed within the said body. The guide element (17) has a continuous active surface (15) designed to contact and guide the said fluid and delimits, together with the containing body (6), a first annular chamber (20) into which the first inlet aperture (7) opens directly.
摘要翻译：给出了用于生理流体的气体分离装置的描述，其包括容纳体（6），该容纳体具有至少一个用于生理流体的第一入口孔（7），定位在切向方向上，至少一个出口孔所述流体与所述入口孔间隔开，以及容纳在所述主体内的引导元件（17）。引导元件（17）具有设计成接触和引导所述流体并与容纳体（6）一起界定的连续有效表面（15），第一环形室（20），第一入口孔（7）直接打开

8. 发明申请

US20070249983A1 Machine for extracorporeal blood treatment coupled to a support element 有权
标题翻译：用于体外血液处理的机器耦合到支撑元件
公开(公告)号：US20070249983A1
公开(公告)日：2007-10-25
申请号：US11808068
申请日：2007-06-06
申请人： Claudio Tonelli , Vincenzo Baraldi , Massimo Zaccarelli , Annalisa Delnevo , Francesco Ribolzi , Jacques Chevallet , Jacques Duchamp , Aziz Aberkane , Gabriel Meyssonnier , Dominique Pouchoulin
发明人： Claudio Tonelli , Vincenzo Baraldi , Massimo Zaccarelli , Annalisa Delnevo , Francesco Ribolzi , Jacques Chevallet , Jacques Duchamp , Aziz Aberkane , Gabriel Meyssonnier , Dominique Pouchoulin
IPC分类号： A61M1/14
CPC分类号： A61M1/16 , A61M1/1643 , A61M1/34 , A61M1/3413 , A61M1/3434 , A61M1/3437 , A61M1/3451 , A61M1/3465 , A61M2205/126 , A61M2205/3331 , A61M2205/3334 , A61M2205/3393 , Y10T137/877
摘要： The invention relates to support element (4) comprising a main body (6) having a front wall (25) and a peripheral wall (32) projecting away from the front wall. The front wall and the peripheral wall define a housing compartment (33) designed to receive a fluid distribution circuitry cooperating with a treatment unit for defining an integrated blood treatment module.
摘要翻译：本发明涉及包括主体（6）的支撑元件（4），所述主体（6）具有前壁（25）和远离前壁突出的周壁（32）。前壁和周边壁限定了一个外壳隔室（33），设计成容纳与治疗单元配合的流体分配电路，用于定义一个集成的血液处理模块。

9. 发明申请

US20070181483A1 Integrated blood treatment module and extracorporeal blood treatment apparatus 有权
标题翻译：综合血液处理模块和体外血液处理仪
公开(公告)号：US20070181483A1
公开(公告)日：2007-08-09
申请号：US11783165
申请日：2007-04-06
申请人： Claudio Tonelli , Vincenzo Baraldi , Massimo Zaccarelli , Annalisa Delnevo , Francesco Ribolzi , Jacques Chevallet , Jacques Duchamp , Aziz Aberkane , Gabriel Meyssonnier , Dominique Pouchoulin
发明人： Claudio Tonelli , Vincenzo Baraldi , Massimo Zaccarelli , Annalisa Delnevo , Francesco Ribolzi , Jacques Chevallet , Jacques Duchamp , Aziz Aberkane , Gabriel Meyssonnier , Dominique Pouchoulin
IPC分类号： B01D63/00
CPC分类号： A61M1/3621 , A61M2205/126 , A61M2205/128
摘要： The invention relates to an integrated blood treatment module (1) comprising a support element (4) and a fluid distribution circuitry associated thereto; the distribution circuitry comprises at least a blood line (44), a portion of which is secured to the support element and defines with the latter at least a U-shaped tube length (44a) designed to cooperate, when in use, with a respective pump (3a). There are then further fluid lines (45, 48, 50, 51) fastened to the support element and defining each at least a U-shaped tube length (45a, 48a, 50a, 51a) with respect to said element and each designed to cooperate, when in use, with a respective pump (3b, 3c, 3d, 3e). The support element has a first zone (274) in which the portion of the blood line is secured, and at least a second zone (275) opposite said first zone, to which all the corresponding further tube lengths are fastened.
摘要翻译：本发明涉及一种集成血液处理模块（1），其包括支撑元件（4）和与其相关联的流体分配电路; 分配电路包括至少一条血液线（44），其一部分固定在支撑元件上，并且与血管线固定在至少一个U形管长度（44a）上，U形管长度（44a）在使用时与相应的泵（3a）。然后将另外的流体管线（45,48,50,51）固定到支撑元件并且限定每个至少U形管长度（45a，48a，50a，51a）相对于所述元件和每个设计用于在使用时与相应的泵（3b，3c，3d，3e）配合。所述支撑元件具有第一区域（274），其中所述血液线的所述部分被固定，以及至少第二区域（275），所述第二区域与所述第一区域相对，所有相应的另外的管段被紧固到所述第二区域。

10. 发明授权

US06976964B2 Pressure measurement device comprising a motorized load sensor and a process for controlling the device 失效
标题翻译：压力测量装置包括电动负载传感器和用于控制装置的过程
公开(公告)号：US06976964B2
公开(公告)日：2005-12-20
申请号：US10004862
申请日：2001-12-07
申请人： Jacques Chevallet , Thierry Court
发明人： Jacques Chevallet , Thierry Court
IPC分类号： G01L7/08 , A61B5/0215 , A61M1/36 , G01L7/00 , G01L19/00 , G01L19/02 , A61B5/02
CPC分类号： A61M1/3639 , A61M1/3641 , A61M2205/12 , G01L19/0023 , G01L19/02
摘要： A device for measuring the pressure of blood, intended to engage with a section (16) for measuring the pressure of blood, which section includes a membrane (38) which is axially deformable under the effect of the blood pressure and which is designed to be mounted on a support structure (20, 22) bearing especially a load sensor (26) arranged substantially facing the membrane (38), characterized in that it includes controlled elements (58) for the relative axial displacement of the sensitive member (52) of the load sensor (26), with respect to the support structure (20, 22), so that the axial position of the sensitive member (52) can be adjusted with respect to the external face (42) of the membrane (38), especially for the purpose of carrying out an initial calibration operation. The invention also proposes a process for controlling the device.
摘要翻译：一种用于测量血液压力的装置，其用于与用于测量血压的部分（16）接合，该部分包括在血压作用下可轴向变形的膜（38），其被设计为安装在支撑结构（20,22）上，该支撑结构（20,22）特别地承载基本上面向所述膜（38）的负载传感器（26），其特征在于，其包括用于所述敏感部件（52）的相对轴向位移的受控元件相对于支撑结构（20,22）的负载传感器（26），使得可以相对于膜（38）的外表面（42）调节敏感部件（52）的轴向位置，特别是为了进行初始校准操作。本发明还提出了一种用于控制装置的方法。

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