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1. 发明申请

US20070037834A1 Bicyclic pyrimidine derivatives 失效
标题翻译：双环嘧啶衍生物
公开(公告)号：US20070037834A1
公开(公告)日：2007-02-15
申请号：US10516750
申请日：2003-06-06
申请人： Hitoshi Arai , Tsutomu Matsumura , Hiroshi Ishida , Yosuke Yamaura , Seiji Aratake , Etsuo Ohshima , Koji Yanagawa , Motoki Miyama , Koji Suzuki , Ari Kawabe , Satoshi Nakanishi , Katsuya Kobayashi , Takashi Sato , Ichiro Miki , Kimihisa Ueno , Shinya Fujii , Miho Iwase
发明人： Hitoshi Arai , Tsutomu Matsumura , Hiroshi Ishida , Yosuke Yamaura , Seiji Aratake , Etsuo Ohshima , Koji Yanagawa , Motoki Miyama , Koji Suzuki , Ari Kawabe , Satoshi Nakanishi , Katsuya Kobayashi , Takashi Sato , Ichiro Miki , Kimihisa Ueno , Shinya Fujii , Miho Iwase
IPC分类号： A61K31/519 , C07D487/02
CPC分类号： C07D263/58 , C07D471/04 , C07D487/04
摘要： [wherein m and n may be the same or different and each represents an integer of 1 to 3 wherein m+n is 4 or less; R1 represents —NR4R5 (wherein R4 and R5 may be the same or different and each represents a hydrogen atom, substituted or unsubstituted lower alkyl, substituted or unsubstituted aralkyl or the like); R2 represents the above Formula (II), Formula (IV) or the like; A represents a single bond, —C(═O)—, —SO2—, —OC(═O)— or the like; and R3 represents substituted or unsubstituted lower alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted aralkyl or the like]Bicyclic pyrimidine derivatives represented by the above Formula (I), or quaternary ammonium salts thereof, or pharmaceutically acceptable salts thereof, or the like, are provided. These have anti-inflammatory activities or modulation activities on the functions of TARC and/or MDC and are useful for treating and/or preventing a disease which is related to T cells, such as an allergic disease, an autoimmune disease or transplant rejection.
摘要翻译： [其中m和n可以相同或不同，并且各自表示1〜3的整数，其中m + n为4以下; R 1表示-NR 4 R 5（其中R 4，R 5和R 5）可以相同或不同，各自表示氢原子，取代或未取代的低级烷基，取代或未取代的芳烷基等）; R 2表示上述式（II），式（IV）等; A表示单键，-C（-O） - ， - SO 2 - ， - OC（-O） - 等; 和R 3表示取代或未取代的低级烷基，取代或未取代的环烷基，取代或未取代的芳烷基等〕由上式（I）表示的双环嘧啶衍生物或其季铵盐或药学上可接受的盐可接受的盐等。它们具有对TARC和/或MDC的功能的抗炎活性或调节活性，并且可用于治疗和/或预防与T细胞相关的疾病，例如过敏性疾病，自身免疫疾病或移植排斥反应。

2. 发明申请

US20060286040A1 Medicament compositions comprising a heterocyclic compound and an anticholinergic 审中-公开
标题翻译：包含杂环化合物和抗胆碱能药物的药物组合物
公开(公告)号：US20060286040A1
公开(公告)日：2006-12-21
申请号：US10567127
申请日：2004-08-05
申请人： Christopher Meade , Michel Pairet , Michael Pieper , Yuzuru Abe , Ichiro Miki
发明人： Christopher Meade , Michel Pairet , Michael Pieper , Yuzuru Abe , Ichiro Miki
IPC分类号： A61K9/14 , A61K31/4747 , A61K31/4745 , A61L9/04
CPC分类号： A61K9/0075 , A61K9/008 , A61K31/357 , A61K31/46
摘要： The present invention relates to novel pharmaceutical compositions based on anticholinergics of the formula 1; wherein X−, R1 ? and Ar are defined as in claim 1, and a heterocyclic compound of the formula 2. Furthermore, the invention relates to processes for preparing them and their use in the treatment of respiratory complaints.
摘要翻译：本发明涉及基于式1的抗胆碱能药物的新型药物组合物; 其中X 1，R 2，和Ar如权利要求1所定义，和式2的杂环化合物。此外，本发明涉及其制备方法及其在治疗呼吸道疾病中的用途。

3. 发明申请

US20060205756A1 Antitussives 审中-公开
标题翻译：镇咳药
公开(公告)号：US20060205756A1
公开(公告)日：2006-09-14
申请号：US10549932
申请日：2004-03-31
申请人： Ichiro Miki , Hidee Ishii
发明人： Ichiro Miki , Hidee Ishii
IPC分类号： A61K31/4743 , A61K31/407 , A61K31/38 , C07D498/02
CPC分类号： A61K31/381 , C07D337/12
摘要： An antitussive which comprises, as an active ingredient, a tricyclic compound represented by Formula (I) [wherein R1 represents a hydrogen atom, substituted or unsubstituted lower alkyl or the like, X1—X2—X3 represents CR5═CR6—CR7═CR8 (wherein R5, R6, R7 and R8 may be the same or different and each represents a hydrogen atom, substituted or unsubstituted lower alkyl or the like, Y represents —CH2S— or the like, and R2 represents a hydrogen atom, substituted or unsubstituted lower alkyl or the like] or a pharmaceutically acceptable salt thereof.
摘要翻译：一种镇咳剂，其包含作为活性成分的由式（I）表示的三环化合物[其中R 1表示氢原子，取代或未取代的低级烷基等，X 1， / SUP→-X 2 -X 3表示CR 5 -CR 6 -CR 7， /其中R 5，R 6，R 7和R 8，可以相同或不同，各自表示氢原子，取代或未取代的低级烷基等，Y表示-CH 2 -S-等等，R 2 代表氢原子，取代或未取代的低级烷基等]或其药学上可接受的盐。

4. 发明申请

US20060205749A1 Remedy and/or preventive for lung diseases 审中-公开
标题翻译：补救和/或预防肺部疾病
公开(公告)号：US20060205749A1
公开(公告)日：2006-09-14
申请号：US10550030
申请日：2004-03-31
申请人： Yuzuru Abe , Ichiro Miki
发明人： Yuzuru Abe , Ichiro Miki
IPC分类号： A61K31/4747
CPC分类号： C07D405/06 , A61K31/443
摘要： The present invention provides a therapeutic and/or preventive agent for pulmonary disease that exhibits neutrophilic inflammation, such as, chronic obstructive pulmonary disease (COPD), pulmonary emphysema, chronic bronchitis, acute respiratory distress syndrome (ARDS), acute lung injury (ALI) and the like, which comprises 7-[2-(3,5-dichloro-4-pyridyl)-1-oxoethyl]-4-methoxy-spiro[1,3-benzodioxol-2,1′-cyclopentane] or a pharmaceutically acceptable salt thereof as an active ingredient.
摘要翻译：本发明提供了呈现中性粒细胞炎症的慢性肺部疾病的治疗和/或预防剂，例如慢性阻塞性肺病（COPD），肺气肿，慢性支气管炎，急性呼吸窘迫综合征（ARDS），急性肺损伤（ALI）其包含7- [2-（3,5-二氯-4-吡啶基）-1-氧代乙基] -4-甲氧基 - 螺[1,3-苯并间二氧杂环戊烯-2,1'-环戊烷]或其药学上可接受的盐可接受的盐作为活性成分。

5. 发明申请

US20060194811A1 Pyrimidine derivatives 审中-公开
标题翻译：嘧啶衍生物
公开(公告)号：US20060194811A1
公开(公告)日：2006-08-31
申请号：US10546215
申请日：2004-02-20
申请人： Etsuo Ohshima , Motoki Miyama , Koji Yanagawa , Seiji Aratake , Ichiro Miki , Katsuya Kobayashi
发明人： Etsuo Ohshima , Motoki Miyama , Koji Yanagawa , Seiji Aratake , Ichiro Miki , Katsuya Kobayashi
IPC分类号： A61K31/506 , C07D403/02
CPC分类号： C07D401/04
摘要： A pyrimidine derivative represented by Formula (I) wherein Ar represents substituted or unsubstituted aryl, R1 represents —NR2R3 and wherein R2 represents a hydrogen atom or substituted or unsubstituted lower alkyl and R3 represents substituted or unsubstituted lower alkyl, substituted or unsubstituted aralkyl, A represents a single bond, Formula (III) wherein m1 is 0 to 2, n1 is 0 to 4, a1 is from 0 to a substitutable number, R5 represents substituted or unsubstituted lower alkyl, and each R5 may be the same or different when a1 is 2 or more), and Q represents —NR6R7 (wherein R6 and R7 may be the same or different and each represents a hydrogen atom, a substituted or unsubstituted heteroalicyclic group, a substituted or unsubstituted heteroalicyclic group, substituted or unsubstituted piperidin-4-ylamino, or quaternary ammonium salts thereof, or pharmaceutically acceptable salts thereof.
摘要翻译：由式（I）表示的嘧啶衍生物，其中Ar表示取代或未取代的芳基，R 1表示-NR 2 R 3，并且其中R 1， O 2表示氢原子或取代或未取代的低级烷基，R 3表示取代或未取代的低级烷基，取代或未取代的芳烷基，A表示单键，式（III）其中 m 1是0至2，n 1是0至4，a 1是0至可取代数，R 5 代表取代或未取代的低级烷基，并且每个R 5可以相同或不同，当O 1为2或更多时），并且Q表示-NR 其中R 6和R 7可以相同或不同，并且各自表示氢原子，取代或未取代的杂脂环基，取代或未取代的杂脂环基，取代或未取代的哌啶-4-基氨基或季铵其盐或其药学上可接受的盐。

6. 发明授权

US5118701A Tricyclic compounds as TXA.sub.2 antagonists 失效
标题翻译： TRICYCLIC化合物作为TXA2拮抗剂
公开(公告)号：US5118701A
公开(公告)日：1992-06-02
申请号：US612446
申请日：1990-11-14
申请人： Etsuo Oshima , Hiroyuki Obase , Akira Karasawa , Kazuhiro Kubo , Ichiro Miki , Akio Ishii
发明人： Etsuo Oshima , Hiroyuki Obase , Akira Karasawa , Kazuhiro Kubo , Ichiro Miki , Akio Ishii
IPC分类号： A61K31/19 , A61K31/00 , A61K31/41 , A61K31/415 , A61K31/44 , A61K31/443 , A61K31/4433 , A61K31/47 , A61K31/505 , A61P7/02 , A61P9/00 , A61P29/00 , A61P37/08 , A61P43/00 , C07C57/46 , C07C59/13 , C07C63/49 , C07C65/26 , C07C67/00 , C07C229/50 , C07C233/52 , C07C233/81 , C07C235/14 , C07C235/40 , C07C235/54 , C07C235/62 , C07C235/78 , C07C235/82 , C07C235/84 , C07C237/04 , C07C237/24 , C07C237/38 , C07C241/00 , C07C251/20 , C07C317/44 , C07C323/61 , C07D235/06 , C07D313/12 , C07D405/12 , C07D409/12 , C07D417/12 , C07D471/04 , C07D491/056 , C07D521/00
CPC分类号： C07D235/06 , C07D231/12 , C07D233/56 , C07D249/08 , C07D313/12 , C07D405/12 , C07D417/12 , C07D471/04 , Y10S514/824 , Y10S514/826
摘要： Novel tricyclic compound represented by formula (I): ##STR1## possess a TXA.sub.2 biosynthesis inhibiting activity and/or a TXA.sub.2 receptor antagonizing activity, and are expected to have preventive and therapeutic effects on ischemic diseases, cerebro-vascular diseases, etc.

7. 发明申请

US20070172447A1 Agent for preventing and/or treating tissue disruption-accompanied diseases 审中-公开
标题翻译：用于预防和/或治疗组织破裂伴随疾病的药剂
公开(公告)号：US20070172447A1
公开(公告)日：2007-07-26
申请号：US10556768
申请日：2004-05-14
申请人： Kazuhiro Sakurada , Yoji Yamada , Hiroshi Ando , Hidetaka Sato , Hiromi Yokoyama , Masahiko Ishihara , Ichiro Miki , Akiko Watanabe
发明人： Kazuhiro Sakurada , Yoji Yamada , Hiroshi Ando , Hidetaka Sato , Hiromi Yokoyama , Masahiko Ishihara , Ichiro Miki , Akiko Watanabe
IPC分类号： A61K38/19
CPC分类号： A61K38/193 , A61K31/203 , A61K2300/00
摘要： The present invention relates to an agent for preventing and/or treating diseases accompanied by tissue disruption, which comprises a polypeptide having granulocyte colony-stimulating factor activity as an active ingredient, and a medicament for mobilizing a multipotent stem cell from a tissue into peripheral blood, which comprises a polypeptide having granulocyte colony-stimulating factor activity as an active ingredient.
摘要翻译：本发明涉及一种用于预防和/或治疗伴随组织破坏的疾病的药剂，其包含具有粒细胞集落刺激因子活性作为活性成分的多肽，以及用于将多能干细胞从组织移动到外周血中的药物，其包含具有粒细胞集落刺激因子活性作为活性成分的多肽。

8. 发明授权

US5302602A Tricyclic thromboxane A.sub.2 antagonists 失效
标题翻译：三环血栓素A2拮抗剂
公开(公告)号：US5302602A
公开(公告)日：1994-04-12
申请号：US884208
申请日：1992-05-18
申请人： Etsuo Oshima , Hiroyuki Obase , Akira Karasawa , Kazuhiro Kubo , Ichiro Miki , Akio Ishii , Hidee Ishii , Kenji Ohmori
发明人： Etsuo Oshima , Hiroyuki Obase , Akira Karasawa , Kazuhiro Kubo , Ichiro Miki , Akio Ishii , Hidee Ishii , Kenji Ohmori
IPC分类号： C07D211/14 , C07D313/12 , C07D333/34 , C07D405/06 , C07D405/12 , C07D405/14 , C07D407/12 , C07D409/12 , C07D471/10 , A61K31/445 , C07D211/22
CPC分类号： C07D405/06 , C07D211/14 , C07D313/12 , C07D333/34 , C07D405/12 , C07D405/14 , C07D407/12 , C07D409/12 , C07D471/10
摘要： Novel tricyclic compounds having a TXA.sub.2 antagonizing activity represented by formula (I): ##STR1## possess a potent antagonizing against thromboxane A.sub.2 and also an antiallergic and/or antihistaminic activity, and are expected to have preventive and therapeutic effects on ischemic diseases, cerebro-vascular diseases, etc.
摘要翻译：具有由式（I）表示的TXA2拮抗活性的新型三环化合物：具有对血栓素A2的有效拮抗作用，还具有抗过敏和/或抗组胺活性，并且预期对缺血性疾病具有预防和治疗作用脑血管疾病等

9. 发明授权

US5248684A Certain 2-oxo-quinoline carboxylates or corresponding carboxamides useful as anti-emetics and suppressants of migraine 失效
标题翻译：某些2-氧杂喹啉羧酸酯或相应的碳酰胺作为抗微生物剂和抑制剂有用
公开(公告)号：US5248684A
公开(公告)日：1993-09-28
申请号：US703849
申请日：1991-05-21
申请人： Fumio Suzuki , Hiroaki Hayashi , Yoshikazu Miwa , Akio Ishii , Shunji Ichikawa , Ichiro Miki
发明人： Fumio Suzuki , Hiroaki Hayashi , Yoshikazu Miwa , Akio Ishii , Shunji Ichikawa , Ichiro Miki
IPC分类号： A61K31/435 , A61K31/4375 , A61K31/46 , A61K31/47 , A61K31/4704 , A61P1/08 , A61P25/04 , A61P25/06 , A61P25/18 , A61P25/20 , A61P25/22 , A61P43/00 , C07D451/04 , C07D451/12 , C07D451/14 , C07D519/00
CPC分类号： C07D451/04 , C07D451/12 , C07D451/14
摘要： There is disclosed a heterocyclic compound represented by general formula: ##STR1## wherein R.sup.1 represents hydrogen, lower alkyl or aryl; R.sup.2 represents hydrogen, hydroxyl or lower alkyl; A represents CH or N; X represents --O-- or --NH--; R.sup.3 represents hydrogen, hydroxyl or lower alkyl; R.sup.4 represents lower alkyl; represents 0 or 1, or a pharmaceutically acceptable salt thereof.

10. 发明授权

US5143922A Tricyclic thromboxane A.sub.2 antagonists 失效
标题翻译：三环血栓素A2拮抗剂
公开(公告)号：US5143922A
公开(公告)日：1992-09-01
申请号：US616095
申请日：1990-11-20
申请人： Etsuo Oshima , Hiroyuki Obase , Akira Karasawa , Kazuhiro Kubo , Ichiro Miki , Akio Ishii , Hidee Ishii , Kenji Ohmori
发明人： Etsuo Oshima , Hiroyuki Obase , Akira Karasawa , Kazuhiro Kubo , Ichiro Miki , Akio Ishii , Hidee Ishii , Kenji Ohmori
IPC分类号： C07D211/14 , C07D313/12 , C07D333/34 , C07D405/06 , C07D405/12 , C07D405/14 , C07D407/12 , C07D409/12 , C07D471/10
CPC分类号： C07D405/06 , C07D211/14 , C07D313/12 , C07D333/34 , C07D405/12 , C07D405/14 , C07D407/12 , C07D409/12 , C07D471/10
摘要： Novel tricyclic compounds having a TXA.sub.2 antagonizing activity represented by formula (I): ##STR1## possess a potent antagonizing action against thromboxane A.sub.2 and also an antiallergic and/or antihistaminic acitvity, and are expected to have preventive and therapeutic effects on ischemic diseases, cerebro-vascular diseases, etc.
摘要翻译：具有由式（I）表示的TXA2拮抗活性的新型三环化合物：对抗凝血恶烷A2具有有效的拮抗作用，并且还具有抗过敏和/或抗组胺活性，并且预期对缺血性具有预防和治疗作用疾病，脑血管疾病等

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