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1. 发明授权

US11246661B2 Devices systems and methods for coronary intervention assessment, planning, and treatment based on desired outcome 有权
公开(公告)号：US11246661B2
公开(公告)日：2022-02-15
申请号：US15764865
申请日：2016-09-28
申请人： Imperial Innovations Limited
发明人： Justin Davies
IPC分类号： A61B34/10 , A61B5/0215 , G16H50/50 , A61B5/00 , A61B5/02 , A61B17/22 , G16H40/20 , G16H20/30 , G16H10/60 , G16H30/20 , A61B6/00 , A61F2/82 , A61B90/00
摘要： The present disclosure relates generally to the assessment and treatment of vessels, including for percutaneous coronary intervention (PCI) and coronary artery bypass grafting (CABG). For example, some embodiments of the present disclosure are suited for identifying the available intervention technique(s) suitable to achieve a desired outcome selected or input by a user. For example, in some implementations a method comprises receiving pressure measurements obtained by one or more intravascular pressure-sensing instruments positioned within a vessel of a patient; receiving an input from a user regarding a desired pressure value for the vessel of the patient; identifying an available treatment option based on the received pressure measurements and the desired pressure value; and outputting, to a display device, a screen display including a visual representation of the available treatment option. Related devices and systems are also described.

2. 发明授权

US10928534B2 Method of, and apparatus for, full waveform inversion 有权
公开(公告)号：US10928534B2
公开(公告)日：2021-02-23
申请号：US15033045
申请日：2014-01-14
申请人： IMPERIAL INNOVATIONS LIMITED
发明人： Mike Warner , Lluis Guasch Batalla
IPC分类号： G01V1/36 , G01V1/28
摘要： A method of subsurface exploration includes generating a representation of a portional volume of the Earth from a seismic measurement of a physical parameter. The method includes providing observed seismic dataset having three distinct nonzero data values derived from three distinct nonzero seismic measured values of said portional volume of the Earth, generating a predicted seismic dataset having three distinct nonzero data values, generating a nontrivial convolutional filter including three nonzero filter coefficients, generating a convolved observed dataset by convolving the convolutional filter with said observed seismic dataset, generating primary objective functions to measure the similarity between said convolved observed dataset and said predicted dataset, maximizing and/or minimizing said primary objective functions by modifying at least one filter coefficient of the convolutional filter, generating predetermined reference filters having at least three reference coefficients generating secondary objective functions to measure the similarity between filter coefficients for the nontrivial filter and reference coefficients for the predetermined reference filters, and minimizing and/or maximizing said secondary objective functions by modifying a model coefficient of a subsurface model of a portion of the Earth to produce an updated subsurface model of a portion of the Earth.

3. 发明授权

US10928270B2 Monitoring fluid dynamics 有权
公开(公告)号：US10928270B2
公开(公告)日：2021-02-23
申请号：US15766898
申请日：2016-10-10
申请人： IMPERIAL INNOVATIONS LIMITED
发明人： Asher John Hoskins , Ivan Iordanov Stoianov
IPC分类号： G01M3/28 , G01F1/34 , G01F1/74
摘要： There is provided a method and an apparatus analysing the condition of a liquid conduit system. Data is received from at least one sensor indicative of pressure within the system and then processed to generate an inflexion coded data subset for each sensor. The inflexion coded data is then cycle counted across at least one time period to generate a second data subset for each time period comprising a count of pressure cycles, the amplitude of these pressure cycles and an average pressure. A cumulative pressure-induced stress can then be calculated for each of the at least one time periods using the second data subset.

4. 发明申请

US20200315477A1 Implantable Neural Interface 审中-公开
公开(公告)号：US20200315477A1
公开(公告)日：2020-10-08
申请号：US16301748
申请日：2017-05-19
申请人： Imperial Innovations Limited , University of Newcastle Upon Tyne
发明人： Timothy CONSTANDINOU , Andrew JACKSON
IPC分类号： A61B5/04 , A61B5/0478 , A61B5/00 , H04W4/80
摘要： A neural interface arrangement has multiple probes for subdural implantation into or onto a human brain. Each probe has at least one sensing electrode, a coil for receiving power via inductive coupling, signal processing circuitry coupled to the electrode(s), and a transmitter for wirelessly transmitting data signals arising from the electrode(s). An array of coils is implanted above the dura beneath the skull, for inductively coupling with the coil of each probe, and for transmitting power to the probes. A primary coil is connected to the coil array, for inductively coupling with an external transmitter device, and for receiving power from the external transmitter device. In use, the primary coil is operable to receive power from the external transmitter device by inductive coupling and to cause the coil array to transmit power to the probes by inductive coupling, and the probes wirelessly transmit data signals arising from the electrodes.

5. 发明授权

US10787542B2 Hybrid materials and process for production thereof 有权
公开(公告)号：US10787542B2
公开(公告)日：2020-09-29
申请号：US16089223
申请日：2017-03-31
申请人： IMPERIAL INNOVATIONS LIMITED , UNIVERSITÀ DEGLI STUDI DI MILANO-BICOCCA
发明人： Francesca Tallia , Julian Raymond Jones , Laura Francesca Cipolla , Laura Russo , Gloria Ruth Young
IPC分类号： C08G65/20 , C08G65/22 , C08G65/26 , C08L71/02 , C08K3/36 , C08G65/04 , C08K5/5435 , C08G65/336 , B33Y70/00
摘要： The invention relates to inorganic-organic hybrid materials comprising interpenetrated organic and inorganic components, wherein the organic component comprises polymer chains formed at least in part by ring-opening polymerization of a cyclic monomer, and processes for the production thereof.

6. 发明授权

US10689704B2 Method for predicting cervical shortening and preterm birth 有权
公开(公告)号：US10689704B2
公开(公告)日：2020-06-23
申请号：US15555900
申请日：2016-03-07
申请人： IMPERIAL INNOVATIONS LIMITED
发明人： Joanna Cook , Philip Bennett , Vasiliki Terzidou , David MacIntyre
IPC分类号： C12Q1/6883 , C12Q1/6869
摘要： The present invention provides method for predicting risk of cervical shortening, methods for predicting risk of preterm labour (PTL), and methods for characterising a pregnant subject having a history of previous PTL, mid-trimester loss or cervical cone biopsy as being in need of surveillance and/or intervention to prevent preterm labour, comprising determining the expression level of one or more of the miRNA molecules identified in Table 1 or Table 2 extracted from a biological sample obtained from said subject and comparing to a control value. Biochips and kits for use in carrying out the methods of the invention are also provided.

7. 发明申请

US20200063252A1 METHOD OF FORMING PARTS FROM SHEET METAL ALLOY 审中-公开
公开(公告)号：US20200063252A1
公开(公告)日：2020-02-27
申请号：US16672943
申请日：2019-11-04
申请人： IMPERIAL INNOVATIONS LIMITED , IMPRESSION TECHNOLOGIES LIMITED
发明人： George Adam , Daniel Balint , Trevor Dean , John Dear , Omer El Fakir , Alistair Foster , Jianguo Lin , Liliang Wang
IPC分类号： C22F1/047 , C22F1/05 , C22F1/04
摘要： A method of forming a part from sheet metal alloy is provided, for example, forming a part from aluminium alloy. The method comprises heating (A) the sheet metal alloy to a temperature at which solution heat treatment of the alloy occurs and so as to achieve solution heat treatment. The sheet is cooled (B) at at least the critical cooling rate for the alloy and then placed between dies to form (C) it into or towards the part.

8. 发明申请

US20200038029A1 SURGICAL FASTENER AND APPARATUS 审中-公开
公开(公告)号：US20200038029A1
公开(公告)日：2020-02-06
申请号：US16341400
申请日：2017-10-10
申请人： IMPERIAL INNOVATIONS LIMITED
发明人： Mikael Sodergren , Christopher Payne
IPC分类号： A61B17/122 , A61B17/128
摘要： A surgical fastener having a first part and a second part, each of the first and second parts comprising a clamping bar and a centrally-positioned perpendicular bracing bar extending therefrom, the clamping bar and bracing bar together defining a “T”-shape, wherein the surgical fastener further comprises at least one bracing element connecting the bracing bar of each of the first and second parts. A surgical apparatus for the application of a fastener to tissue comprising a handle assembly, a shaft extending distally from the handle assembly, a drive assembly, an articulation assembly and a jaw assembly mounted adjacent a distal end of the shaft comprising fixed support jaw and a clamping jaw, at least one of the jaws comprises a rotatable fastener support defining a T-shaped recess therein for receiving a surgical fastener, wherein the articulation assembly is operable to rotate the fastener support and the drive assembly is operable by the handle assembly to move the clamping jaw in and out of a closed configuration with respect to the support jaw.

9. 发明申请

US20200008890A1 COUPLING FOR A ROBOTIC SURGICAL INSTRUMENT 审中-公开
公开(公告)号：US20200008890A1
公开(公告)日：2020-01-09
申请号：US16338099
申请日：2017-10-04
申请人： IMPERIAL INNOVATIONS LIMITED
发明人： CARLO ALBERTO SENECI , JIANZHONG SHANG , GUANG-ZHONG YANG
IPC分类号： A61B34/30 , A61B34/00 , A61B90/00
摘要： The present invention provides a load sensing device for a surgical robot comprising a load sensing means and a hook mounted to the load sensing means, wherein the coupling is slideable longitudinally and engageable with a tendon for actuating a surgical instrument such that longitudinal movement of the hook imparts a load on the tendon and the load sensing means measures such load.

10. 发明申请

US20190240282A1 Nanocage 审中-公开
公开(公告)号：US20190240282A1
公开(公告)日：2019-08-08
申请号：US16342714
申请日：2017-10-19
申请人： IMPERIAL INNOVATIONS LIMITED
发明人： Geoffrey Baldwin , James Field
IPC分类号： A61K38/08 , C07K7/06 , A61K47/42 , G01N33/84 , A61K49/00 , A61P35/00 , A61K9/00
CPC分类号： A61K38/08 , A61K9/0019 , A61K9/5169 , A61K33/00 , A61K41/0028 , A61K47/42 , A61K47/62 , A61K47/6923 , A61K47/6925 , A61K47/6929 , A61K49/00 , A61K49/0047 , A61K49/0093 , A61P35/00 , B82Y5/00 , B82Y30/00 , C07K7/06 , C07K14/245 , C07K14/47 , C07K2319/21 , G01N33/84 , G01N2333/47 , G01N2500/00
摘要： The invention provides nanocages, and in particular to protein nanocages, and especially ferritin nanocages. The invention extends to variant ferritin polypeptides and their encoding nucleic acids, mutant ferritin nanocages, and their uses in diagnostics and drug delivery, as well as in phenotypic screens in drug development.

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