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1. 发明申请

US20140227762A1 NOVEL MANNANASE PRODUCED FROM CELLULOSIMICROBIUM SP. STRAIN HY-13 有权
标题翻译：从细胞膜生成的新型甘露聚糖菌株HY-13
公开(公告)号：US20140227762A1
公开(公告)日：2014-08-14
申请号：US14232483
申请日：2011-12-28
申请人： Ho-Yong Park , Kwang-Hee Son , Do Young Kim , Dong-Ha Shin , Han-Young Cho
发明人： Ho-Yong Park , Kwang-Hee Son , Do Young Kim , Dong-Ha Shin , Han-Young Cho
IPC分类号： A23L1/305 , C12N9/24
CPC分类号： A23L1/3058 , A23K10/14 , A23K20/168 , A23K20/189 , A23K50/30 , A23K50/75 , A23L33/195 , C12N9/2491 , C12Y302/01025
摘要： The present invention relates to a mannanase produced from Celluosimicrobium sp. strain HY-13 and more particularly to a highly active novel mannanase produced from Cellulosimicrobium sp. strain HY-13 as separated from an invertebrate. The mannanase produced from the said Cellulosimicrobium ap. strain HY-13 can be used in the decomposition of a mannan found in hemicellulose contained in grains and plants and in enhancing the utility value of a hydrolysate, which uses the decomposed mannan, for the transformation of biomass or as an animal feed material.
摘要翻译：本发明涉及由Celluosimicrobes sp。生产的甘露聚糖酶。菌株HY-13，更具体地涉及由Cellulosimicrobes sp。生产的高活性新型甘露聚糖酶。菌株HY-13与无脊椎动物分离。由所述纤维素微球形成的甘露聚糖酶。菌株HY-13可用于在谷物和植物中含有的半纤维素中发现的甘露聚糖的分解，并且用于分解甘露聚糖的水解产物的效用值用于转化生物质或作为动物饲料。

2. 发明申请

US20130127263A1 WASHER WASHING BALL INDUCTIVE DEVICE AND A DRAIN COVER FOR THE WASHING BALLS 审中-公开
标题翻译：洗衣机洗衣机感应装置和洗衣机的排水盖
公开(公告)号：US20130127263A1
公开(公告)日：2013-05-23
申请号：US13509024
申请日：2010-11-05
申请人： Ho Yong Park
发明人： Ho Yong Park
IPC分类号： H02K57/00 , B08B3/04
CPC分类号： B08B3/04 , B08B9/0808 , B08B9/0817 , D06F33/02 , D06F35/00 , D06F35/008 , D06F39/024 , D06F39/083 , H02K99/20
摘要： Disclosed are a washing unit for washing contaminants within a washing machine, a permanent magnet inducing unit for effectively washing an inner wall of a water tank by using induction of an electric field or providing a motion to an artificial floating body of the water tank, and a drain cover for a washing machine for assisting a washing operation of a washing ball of the washing machine. The washing unit has a body for maintaining a certain shape such as a ball and a plurality of washing projections, and is introduced into spaces between the water container and the washing tub and between the water tank and the pulsator to frictionally remove various filths attached to the washing tank, the washing tub and the pulsator with the washing projections that floats at a predetermined depth of washing water.
摘要翻译：公开了一种用于洗涤洗衣机内的污染物的洗涤单元，用于通过使用感应电场或向水箱的人造浮体提供运动来有效地清洗水箱的内壁的永磁体诱导单元，以及用于洗衣机的排水盖，用于帮助洗衣机的洗涤球的洗涤操作。洗涤单元具有用于保持一定形状的主体，例如球和多个洗涤突起，并且被引入到水容器和洗涤桶之间以及在水箱和波轮之间的空间中，以摩擦地去除附接到洗涤槽，洗涤桶和波轮，其中洗涤突起浮在洗涤水的预定深度。

3. 发明申请

US20120003204A1 COMPOSITION CONTAINING ARAZYME FOR THE PREVENTION AND TREATMENT OF CANDER 有权
标题翻译：含有ARAZYME的组合物用于预防和治疗CANDER
公开(公告)号：US20120003204A1
公开(公告)日：2012-01-05
申请号：US13225317
申请日：2011-09-02
申请人： Ho-Yong PARK , Kwang-Hee SON , Dong-Ha SHIN , Kyu-Shik JEONG
发明人： Ho-Yong PARK , Kwang-Hee SON , Dong-Ha SHIN , Kyu-Shik JEONG
IPC分类号： A61K38/48 , A61P35/00
CPC分类号： A61K38/4886 , A23C15/065 , A23G1/423 , A23G3/366 , A23G4/123 , A23G9/363 , A23L2/02 , A23L2/66 , A23L13/424 , A23L13/48 , A23L23/00 , A23L33/19
摘要： The present invention relates to a pharmaceutical composition for the prevention and treatment of cancer comprising arazyme as an active ingredient. More precisely, when arazyme produced by Aranicola proteolycius was administered to the nude mice transplanted with human lung carcinoma cell line, weight gaining, inhibition of tumor cell growth and infiltration, and down-regulations of MMP-9, NF-κB and PCNA, were observed. In addition, when arazyme was treated to human breast cancer cells (MDA-MB-231), down regulations of p21, PCNA (Proliferating Cell Nuclear Antigen), VEGF (Vascular Endothelial Growth Factor), BCl2 (B-cell CLL/lymphoma 2), p-p38, PKC (Protein Kinase C) and MMP-1 (Matrix MetalloProteinase-1) which are involved in tumor cell growth, differentiation, proliferation and metastasis, were observed along with the up-regulation of catalase which inhibits tumor development. Therefore, the arazyme can be effectively used as a pharmaceutical composition for the prevention and treatment of cancer.
摘要翻译：本发明涉及一种用于预防和治疗癌症的药物组合物，其包含作为活性成分的阿拉木霉。更准确地说，当将Aranicola proteolycius产生的arazyme给予移植有人肺癌细胞系的裸鼠，体重增加，抑制肿瘤细胞生长和浸润，以及MMP-9，NF-和Kgr B和PCNA的下调，观察。另外，当将arazyme处理到人乳腺癌细胞（MDA-MB-231）时，下调p21，PCNA（增殖细胞核抗原），VEGF（血管内皮生长因子），BCl2（B细胞CLL /淋巴瘤2 ），参与肿瘤细胞生长，分化，增殖和转移的p-p38，PKC（蛋白激酶C）和MMP-1（基质金属蛋白酶-1）以及抑制肿瘤发生的过氧化氢酶的上调。因此，可以有效地使用胂酸盐作为预防和治疗癌症的药物组合物。

4. 发明申请

US20100322917A1 PHARMACEUTICAL COMPOSITION CONTAINING ARAZYME FOR THE PREVENTION OF LIVER DYSFUNCTION 审中-公开
标题翻译：含有ARAZYME用于预防肝功能障碍的药物组合物
公开(公告)号：US20100322917A1
公开(公告)日：2010-12-23
申请号：US12521618
申请日：2006-12-28
申请人： Ho-Yong Park , Kwang-Hee Son , Dong-Ha Shin , Kyu-Shik Jeong
发明人： Ho-Yong Park , Kwang-Hee Son , Dong-Ha Shin , Kyu-Shik Jeong
IPC分类号： A61K38/48 , A61P1/16 , A61P35/00 , C12N9/52
CPC分类号： A61K38/4886 , A23L33/10 , A23L33/135
摘要： The present invention relates to a pharmaceutical composition for the prevention of liver dysfunction which contains arazyme as an active ingredient, more precisely a pharmaceutical composition for the prevention of liver dysfunction which contains arazyme produced by Aranicola proteolyticus. The arazyme of the present invention inhibits apoptosis in injured liver cells, increases SMP30 expression, inhibits P-smad3 expression and protects liver by inhibiting liver injury around central vein region. Therefore, the arazyme of the invention can be effectively used as a pharmaceutical composition for the prevention of liver dysfunction.
摘要翻译：本发明涉及一种用于预防肝功能障碍的药物组合物，其含有作为活性成分的阿拉木霉，更准确地说，涉及含有由Aranicola proteolyticus产生的arazyme的用于预防肝功能障碍的药物组合物。本发明的arazyme抑制受损肝细胞凋亡，增加SMP30表达，抑制P-smad3表达，通过抑制中心静脉区域周围的肝损伤来保护肝脏。因此，本发明的芳脒可以有效地用作预防肝功能障碍的药物组合物。

5. 发明申请

US20090317374A1 COMPOSITION CONTAINING ARAZYME FOR THE PREVENTION AND TREATMENT OF CANCER 审中-公开
标题翻译：含有ARAZYME用于预防和治疗癌症的组合物
公开(公告)号：US20090317374A1
公开(公告)日：2009-12-24
申请号：US12521676
申请日：2007-12-28
申请人： Ho-Yong Park , Kwang-Hee Son , Dong-Ha Shin , Kyu-Shik Jeong
发明人： Ho-Yong Park , Kwang-Hee Son , Dong-Ha Shin , Kyu-Shik Jeong
IPC分类号： A61K38/48 , A61P35/00
CPC分类号： A61K38/4886 , A23C15/065 , A23G1/423 , A23G3/366 , A23G4/123 , A23G9/363 , A23L2/02 , A23L2/66 , A23L13/424 , A23L13/48 , A23L23/00 , A23L33/19
摘要： The present invention relates to a pharmaceutical composition for the prevention and treatment of cancer comprising arazyme as an active ingredient. More precisely, when arazyme produced by Aranicola proteolycius was administered to the nude mice transplanted with human lung carcinoma cell line, weight gaining, inhibition of tumor cell growth and infiltration, and down-regulations of MMP-9, NF-κB and PCNA, were observed. In addition, when arazyme was treated to human breast cancer cells (MDA-MB-231), down regulations of p21, PCNA (Proliferating Cell Nuclear Antigen), VEGF (Vascular Endothelial Growth Factor), BCl2 (B-cell CLL/lymphoma 2), p-p38, PKC (Protein Kinase C) and MMP-1 (Matrix MetalloProteinase-1) which are involved in tumor cell growth, differentiation, proliferation and metastasis, were observed along with the up-regulation of catalase which inhibits tumor development. Therefore, the arazyme can be effectively used as a pharmaceutical composition for the prevention and treatment of cancer.
摘要翻译：本发明涉及一种用于预防和治疗癌症的药物组合物，其包含作为活性成分的胂酸盐。更准确地说，当将Aranicola proteolycius产生的arazyme给予移植有人肺癌细胞系的裸鼠时，体重增加，抑制肿瘤细胞生长和浸润以及MMP-9，NF-κB和PCNA的下调均为观察到的。另外，当将arazyme处理到人乳腺癌细胞（MDA-MB-231）时，下调p21，PCNA（增殖细胞核抗原），VEGF（血管内皮生长因子），BCl2（B细胞CLL /淋巴瘤2 ），参与肿瘤细胞生长，分化，增殖和转移的p-p38，PKC（蛋白激酶C）和MMP-1（基质金属蛋白酶-1）以及抑制肿瘤发生的过氧化氢酶的上调。因此，可以有效地使用胂酸盐作为预防和治疗癌症的药物组合物。

6. 发明授权

US07416880B2 Metarhizium genus microorganism and the method for controlling the soil pests using the same 有权
标题翻译： Metarhizium属微生物和使用该微生物控制土壤害虫的方法
公开(公告)号：US07416880B2
公开(公告)日：2008-08-26
申请号：US10494111
申请日：2002-11-02
申请人： Ho Yong Park , Kwang Hee Son , Eun Young Suh , Ki-Duk Kim , Dong Ha Shin
发明人： Ho Yong Park , Kwang Hee Son , Eun Young Suh , Ki-Duk Kim , Dong Ha Shin
IPC分类号： C12N1/14 , A61L101/52 , A01N25/12 , A01N25/14
CPC分类号： A01N63/04 , C12N1/14 , C12R1/645 , A01N25/30 , A01N25/14 , A01N2300/00
摘要： The present invention relates to a novel fungus of Metarhizium genus and a method for controlling soil pests using the same, more particularly to a novel Metarhizium anisopliae HY-2 and a microbial insecticide comprising the same and a method for controlling soil pests using the same. The Metarhizium anisopliae HY-2 can effectively be used to control the soil pests such as Scarabaeidae.
摘要翻译：本发明涉及一种新型的Metarhizium属真菌及其控制土壤害虫的方法，更具体地涉及一种新型Metarhizium anisopliae HY-2和一种含有该菌的微生物杀虫剂及使用其的土壤害虫防治方法。 Metarhizium anisopliae HY-2可以有效地用于控制诸如Scarabaeidae的土壤害虫。

7. 发明授权

US09068010B2 Cloning and base sequence determination of novel iturin biosynthesis gene from antagonistic microorganism Bacillus subtilis and characteristics of the gene 有权
标题翻译：克隆和碱基序列测定拮抗微生物枯草芽孢杆菌的新型神经细胞生物合成基因及其基因特征
公开(公告)号：US09068010B2
公开(公告)日：2015-06-30
申请号：US13699104
申请日：2011-10-26
申请人： Sung Uk Kim , Ingyu Hwang , Byoung-Keun Park , Seungeun Kim , Jae Sun Moon , Ho Yong Park , Kwang Hee Son , Tae Sook Jeong
发明人： Sung Uk Kim , Ingyu Hwang , Byoung-Keun Park , Seungeun Kim , Jae Sun Moon , Ho Yong Park , Kwang Hee Son , Tae Sook Jeong
IPC分类号： C07K14/32 , C12N9/00 , C12P21/02 , C12N15/52
CPC分类号： C07K14/32 , C12N9/00 , C12N15/52 , C12P21/02
摘要： The present invention relates to novel iturin biosynthesis genes, and uses thereof. More specifically, the present invention provides novel iturin biosynthesis genes, wherein the iturin biosynthesis genes were cloned from Bacillus subtilis subsp. krictiensis ATCC 55079, the base sequence was determined after checking whether the cloned genes are iturin biosynthesis genes or not, and it was ascertained that the identified genes are novel genes different from the reported gene by comparing the base sequences with that of the reported gene, and uses thereof.
摘要翻译：本发明涉及新颖的神经细胞生物合成基因及其用途。更具体地，本发明提供了新颖的神经细胞生物合成基因，其中从枯草芽孢杆菌亚种克隆了神经元生物合成基因。克氏杆菌ATCC 55079，检查克隆基因是否是神经元生物合成基因，确定基因序列，通过比较基因序列与报道基因的基因序列，确定鉴定的基因是与报道基因不同的新基因，及其用途。

8. 发明授权

US08367060B2 Pharmaceutical composition containing arazyme for the prevention of liver dysfunction 有权
标题翻译：含有arazyme用于预防肝功能障碍的药物组合物
公开(公告)号：US08367060B2
公开(公告)日：2013-02-05
申请号：US13234847
申请日：2011-09-16
申请人： Ho-Yong Park , Kwang-Hee Son , Dong-Ha Shin , Kyu-Shik Jeong
发明人： Ho-Yong Park , Kwang-Hee Son , Dong-Ha Shin , Kyu-Shik Jeong
IPC分类号： A61K38/48
CPC分类号： A61K38/4886 , A23L33/10 , A23L33/135
摘要： The present invention relates to a composition and a method for the treatment of liver dysfunction which contains administration of a composition containing arazyme as an active ingredient, more precisely arazyme produced by Aranicola proteolyticus. The arazyme of the present invention inhibits apoptosis in injured liver cells, increases SMP30 expression, inhibits P-smad3 expression and protects the liver by inhibiting liver injury around the central vein region. Therefore, the arazyme of the invention can be effectively used as a composition for the treatment of liver dysfunction.
摘要翻译：本发明涉及一种治疗肝功能障碍的组合物和方法，其包含施用含有阿拉木霉作为活性成分的组合物，更准确地说是由Aranicola proteolyticus产生的arazyme。本发明的arazyme抑制受损肝细胞凋亡，增加SMP30表达，抑制P-smad3表达，并通过抑制中心静脉区周围的肝损伤来保护肝脏。因此，本发明的胂酸盐可以有效地用作治疗肝功能障碍的组合物。

9. 发明授权

US08362034B2 Quinoline compound, and composition containing centipede extract or compounds isolated therefrom for prevention and treatment of cardiovascular disease 有权
标题翻译：喹啉化合物和含有蜈蚣提取物或其分离的化合物的组合物用于预防和治疗心血管疾病
公开(公告)号：US08362034B2
公开(公告)日：2013-01-29
申请号：US13462727
申请日：2012-05-02
申请人： Ho Yong Park , Tae-Sook Jeong , Hyun-Woo Oh , Woo-Song Lee , Doo-Sang Park , Jong-Min Han
发明人： Ho Yong Park , Tae-Sook Jeong , Hyun-Woo Oh , Woo-Song Lee , Doo-Sang Park , Jong-Min Han
IPC分类号： C07D215/26 , A61P3/06 , A61P9/10 , A61P9/00 , A61K31/47
CPC分类号： C07D215/26
摘要： The present invention relates to a composition for the prevention and treatment of cardiovascular diseases containing the novel quinoline compound, the centipede extracts or compounds isolated from the extracts. The novel quinoline compound, the centipede extracts or a quinoline compound and a phenol compound isolated from the extracts of the invention exhibit excellent LDL-antioxidant activity, ACAT inhibiting activity, and anti-inflammatory activities, so that they can be included as an effective ingredient in a composition for the prevention and treatment of cardiovascular disease including hyperlipidemia, atherosclerosis, coronary heart disease, and myocardial infarction mediated by LDL-oxidation, cholesteryl ester synthesis and accumulation, and inflammation.
摘要翻译：本发明涉及用于预防和治疗含有新喹啉化合物，蜈蚣提取物或从提取物分离的化合物的心血管疾病的组合物。从本发明提取物中分离的新颖喹啉化合物，蜈蚣提取物或喹啉化合物和酚化合物表现出优异的LDL-抗氧化活性，ACAT抑制活性和抗炎活性，因此它们可以作为有效成分用于预防和治疗心血管疾病的组合物，包括高脂血症，动脉粥样硬化，冠心病和LDL氧化，胆固醇酯合成和积累介导的心肌梗死以及炎症。

10. 发明申请

US20080069846A1 Protease, a Gene Therefor and the Use Thereof 有权
标题翻译：蛋白酶，其基因及其用途
公开(公告)号：US20080069846A1
公开(公告)日：2008-03-20
申请号：US11853899
申请日：2007-09-12
申请人： Ho-Yong Park , Kwang-Hee Son , Doo-Sang Park , Sang-Woon Shin , Hyun-Woo Oh , Mi-Gwang Kim , Dong-Ha Shin
发明人： Ho-Yong Park , Kwang-Hee Son , Doo-Sang Park , Sang-Woon Shin , Hyun-Woo Oh , Mi-Gwang Kim , Dong-Ha Shin
IPC分类号： A61K8/02 , A61K38/48 , C07H21/04 , C11D3/386 , C12N15/00 , C12N5/02
CPC分类号： A61Q19/00 , A61K8/66 , A61K38/00 , A61K2800/86 , C11D3/386 , C12N9/52
摘要： The present invention relates to a protease, and more specifically to a protease derived from Aranicola proteolyticus, a gene coding for said enzyme, a gene expression system for said protease, a process for purifying the protease, and the uses of said protease in industrial applications, such as for example, detergents, cosmetics, leather processing agents, chemicals for laboratory research, solubilizing or softening agents for food, meat modifier, feed or food additives, or oil and fat separating agents, as well as pharmaceutical compositions.
摘要翻译：本发明涉及一种蛋白酶，更具体地说涉及来源于蛋白水解伞菌的蛋白酶，编码所述酶的基因，所述蛋白酶的基因表达系统，蛋白酶的纯化方法以及所述蛋白酶在工业应用中的用途，例如洗涤剂，化妆品，皮革加工剂，用于实验室研究的化学品，用于食品的增溶或软化剂，肉改性剂，饲料或食品添加剂或油脂分离剂，以及药物组合物。

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