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    • 10. 发明申请
    • PROCESS FOR PRODUCING NITROGUANIDINE DERIVATIVES
    • 生产硝基胍衍生物的方法
    • US20090176990A1
    • 2009-07-09
    • US12278497
    • 2007-02-07
    • Hisato KamekawaTomotaka MiyashitaHiroyuki KatsutaToshio Kitashima
    • Hisato KamekawaTomotaka MiyashitaHiroyuki KatsutaToshio Kitashima
    • C07D213/04C07D307/06
    • C07D213/61C07D307/14
    • Disclosed is an improved process for producing nitroguanidine derivatives represented by the following general formula (3), which has an insecticidal activity, or a salt thereof. Specifically, disclosed is a process for producing nitroguanidine derivatives represented by the following general formula (3) or a salt thereof, in which nitroisourea derivatives represented by the following general formula (1) or a salt thereof and compounds represented by the following general formula (2) or a salt thereof are reacted in the presence of a base in an aqueous solution wherein an inorganic salt is dissolved at not less than 50% of its saturated solubility, wherein, in the formula, R1 represents an alkyl group having 1 to 4 carbon atoms or a benzyl group; R2 represents an alkyl group having 1 to 4 carbon atoms; and R3 represents a hydrogen atom or an alkyl group having 1 to 4 carbon atoms, wherein, in the formula, R4, R5 and R6 each independently represent a hydrogen atom or an alkyl group having 1 to 4 carbon atoms; and Q represents a 5- or 6-membered heterocyclic group which contains at least one each of a nitrogen atom, an oxygen atom and a sulfur atom and may be substituted with a halogen atom, wherein, in the formula, R2 represents an alkyl group having 1 to 4 carbon atoms; R3, R4, R5 and R6 each independently represent a hydrogen atom or an alkyl group having 1 to 4 carbon atoms; and Q represents a 5- or 6-membered heterocyclic group which contains at least one each of a nitrogen atom, an oxygen atom and a sulfur atom and may be substituted with a halogen atom.
    • 公开了一种改进的具有杀虫活性的由通式(3)表示的硝基胍衍生物的方法或其盐。 具体地说,公开了由以下通式(3)表示的硝基胍衍生物或其盐,其中由以下通式(1)表示的硝基异脲衍生物或其盐和由以下通式表示的化合物 2)或其盐在碱的存在下在不溶于其饱和溶解度的50%的无水盐溶液中的水溶液中反应,其中在式中,R1表示具有1-4个碳原子的烷基 碳原子或苄基; R2表示碳原子数1〜4的烷基, R3表示氢原子或碳原子数1〜4的烷基,式中,R4,R5,R6各自独立地表示氢原子或碳原子数1〜4的烷基。 Q表示含有氮原子,氧原子和硫原子中的至少一个的5元或6元杂环基,可以被卤素原子取代,式中,R 2表示烷基 具有1至4个碳原子; R 3,R 4,R 5和R 6各自独立地表示氢原子或碳原子数1〜4的烷基。 Q表示含有氮原子,氧原子和硫原子中的至少一个的5元或6元杂环基,可以被卤素原子取代。