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1. 发明授权

US08192982B2 Tissue culture microscope apparatus 有权
标题翻译：组织培养显微镜装置
公开(公告)号：US08192982B2
公开(公告)日：2012-06-05
申请号：US11522730
申请日：2006-09-18
申请人： Kazuhiro Hasegawa , Akitsugu Kagayama , Atsuhiro Tsuchiya , Ryuichi Hirano , Kenichi Koyama , Hideaki Endo
发明人： Kazuhiro Hasegawa , Akitsugu Kagayama , Atsuhiro Tsuchiya , Ryuichi Hirano , Kenichi Koyama , Hideaki Endo
IPC分类号： C12M1/00 , C12M3/00 , C12M1/34
CPC分类号： G02B21/30 , C12M23/48 , C12M41/14 , C12M41/36 , C12M41/46 , G01N2035/00425 , Y10S435/809
摘要： A tissue culture microscope apparatus includes a culture unit that includes a chamber in which a specimen is put, and maintains the chamber at a predetermined temperature to culture the specimen; an observation unit that forms an observation image of the specimen put in the chamber; and a liquid supply unit that stores a liquid in a protrusion portion penetrating into a wall of the chamber and protruding to an inside of the chamber, matches a temperature of the liquid with the temperature of the chamber, and injects the liquid from the protrusion portion to the specimen.
摘要翻译：组织培养显微镜装置包括培养单元，该培养单元包括其中放置样本的室，并将室维持在预定温度以培养样品; 观察单元，其形成放置在所述室中的样本的观察图像; 以及液体供应单元，其将液体存储在突出部分中，所述突出部分穿入所述室的壁并突出到所述室的内部，使所述液体的温度与所述室的温度相匹配，并且将所述液体从所述突出部分标本。

2. 发明授权

US07910355B2 Culture observation apparatus 有权
标题翻译：文化观察仪器
公开(公告)号：US07910355B2
公开(公告)日：2011-03-22
申请号：US11318416
申请日：2005-12-22
申请人： Atsuhiro Tsuchiya , Ryuichi Hirano , Hideaki Endo , Kenichi Koyama , Kazuhiro Hasegawa , Akitsugu Kagayama , Katsuyoshi Yamaguchi
发明人： Atsuhiro Tsuchiya , Ryuichi Hirano , Hideaki Endo , Kenichi Koyama , Kazuhiro Hasegawa , Akitsugu Kagayama , Katsuyoshi Yamaguchi
IPC分类号： C12M1/34 , C12M3/00 , G02B21/26 , G02B21/34 , G01N21/01
CPC分类号： C12M41/36 , C12M41/14 , G02B7/22 , G02B21/0088 , G02B21/02
摘要： A culture observation apparatus, which is used for observing a cultured cell while culturing the cell, includes a culture device that cultures the cultured cell, and a microscope used for observing the cultured cell. The culture device includes a first space that is controlled to an environment suitable for culture of the cell, and a second space that is controlled to a lower humidity condition in comparison with the first space. The microscope includes an objective optical unit including an objective lens; the objective optical unit having at least one portion located in the second space, and another portion extending into the first space through an opening formed in a partition wall that separates the first space and the second space, with a gap between the objective optical unit and the partition wall being sealed by a sealing member, and the objective lens includes a plurality of lens groups, with mutual spaces among the lens groups vented to the second space.
摘要翻译：用于在培养细胞时观察培养细胞的培养观察装置包括培养培养细胞的培养装置和用于观察培养细胞的显微镜。培养装置包括被控制到适于细胞培养的环境的第一空间和与第一空间相比被控制到较低湿度条件的第二空间。显微镜包括物镜光学单元，包括物镜; 所述物镜光学单元具有位于所述第二空间中的至少一个部分，以及另一部分，其通过形成在分隔所述第一空间和所述第二空间的分隔壁中的开口延伸到所述第一空间中，所述间隔物在所述物镜光学单元和所述分隔壁由密封构件密封，并且所述物镜包括多个透镜组，所述透镜组中的彼此间隔开放到所述第二空间。

3. 发明授权

US07822257B2 Observation apparatus and observation method 有权
标题翻译：观察仪器和观察方法
公开(公告)号：US07822257B2
公开(公告)日：2010-10-26
申请号：US11517874
申请日：2006-09-08
申请人： Hideaki Endo , Akitsugu Kagayama , Atsuhiro Tsuchiya , Kazuhiro Hasegawa
发明人： Hideaki Endo , Akitsugu Kagayama , Atsuhiro Tsuchiya , Kazuhiro Hasegawa
IPC分类号： G06K9/00
CPC分类号： G02B21/367
摘要： An observation apparatus includes an incident-light illumination optical system, a transmitting illumination optical system, an imaging unit, an input device, a storage unit, an imaging controller, a microscope controller, an imaging information management unit. The imaging information management unit compares an area position, of an imaging area of the imaging unit, indicated by position information input from the input device with an area position stored in the storage unit to determine whether the area position indicated by the position information is stored in the storage unit. When the area position is not stored in the storage unit, the imaging controller controls the imaging unit to image the specimen and to generate an observation image, and stores the observation image in the storage unit. The microscope controller controls one of the optical systems to illuminate the specimen only during an imaging period, when the imaging unit images the specimen.
摘要翻译：观察装置包括入射光照明光学系统，发射照明光学系统，成像单元，输入装置，存储单元，成像控制器，显微镜控制器，成像信息管理单元。成像信息管理单元将从输入设备输入的由位置信息指示的摄像单元的成像区域的区域位置与存储在存储单元中的区域位置进行比较，以确定是否存储由位置信息指示的区域位置在存储单元中。当区域位置不存储在存储单元中时，成像控制器控制成像单元对样本进行成像并生成观察图像，并将观察图像存储在存储单元中。显微镜控制器控制其中一个光学系统仅在成像周期期间，当成像单元对样本进行成像时照亮样本。

4. 发明申请

US20090316257A1 MICROSCOPE SYSTEM AND CONTROL METHOD FOR SAME 有权
标题翻译：微阵列系统及其控制方法
公开(公告)号：US20090316257A1
公开(公告)日：2009-12-24
申请号：US12485163
申请日：2009-06-16
申请人： Toshiya KOMURO , Hideaki Endo
发明人： Toshiya KOMURO , Hideaki Endo
IPC分类号： G02B21/00
CPC分类号： G02B21/365 , Y10T307/76
摘要： The microscope system comprises: an imaging apparatus used for picking up an image of a specimen; an electric unit; a control apparatus for controlling turning On and Off of the power supply to the electric unit; a storage apparatus storing the initialization requirement time of the electric unit; and a drive management arithmetic operation apparatus for calculating, on the basis of an image pickup interval and initialization requirement time, a clock time for controlling turning On/Off of the power supply to the electric unit.
摘要翻译：显微镜系统包括：用于拾取样本图像的成像装置; 电单元控制装置，用于控制向电气单元供电的开启和关闭; 存储所述电气单元的初始化要求时间的存储装置; 以及驱动管理算术运算装置，用于根据摄像间隔和初始化要求时间计算用于控制向电气单元供电的开/关的时钟时间。

5. 发明申请

US20070064101A1 Observation apparatus 审中-公开
标题翻译：观察装置
公开(公告)号：US20070064101A1
公开(公告)日：2007-03-22
申请号：US11522729
申请日：2006-09-18
申请人： Kazuhiro Hasegawa , Atsuhiro Tsuchiya , Hideaki Endo , Akitsugu Kagayama
发明人： Kazuhiro Hasegawa , Atsuhiro Tsuchiya , Hideaki Endo , Akitsugu Kagayama
IPC分类号： H04N7/18
CPC分类号： G02B21/367 , G06T7/0012 , G06T2207/30024
摘要： An observation apparatus includes an illuminating unit that illuminates a sample; an imaging unit that captures an image of the sample to generate an observation image; a storage unit that stores the observation image in association with an illumination condition of the illuminating unit at generation of the observation image by the imaging unit; an imaging controller that controls the imaging unit to capture the image of the sample to generate the observation image and stores the observation image in the storage unit; and an illumination controller that controls the illuminating unit to illuminate the sample, and stores the illumination condition in the storage unit every time the imaging unit captures the image of the sample.
摘要翻译：观察装置包括：照射样品的照明单元; 成像单元，其捕获所述样本的图像以生成观察图像; 存储单元，其通过所述摄像单元在所述观察图像的产生时，与所述照明单元的照明条件相关联地存储所述观察图像; 成像控制器，其控制所述成像单元捕获所述样本的图像以生成所述观察图像，并将所述观察图像存储在所述存储单元中; 以及照明控制器，其控制所述照明单元照亮所述样本，并且每当所述成像单元捕获所述样本的图像时，将所述照明条件存储在所述存储单元中。

6. 发明申请

US20060141613A1 Culture observation apparatus 有权
标题翻译：文化观察仪器
公开(公告)号：US20060141613A1
公开(公告)日：2006-06-29
申请号：US11318416
申请日：2005-12-22
申请人： Atsuhiro Tsuchiya , Ryuichi Hirano , Hideaki Endo , Kenichi Koyama , Kazuhiro Hasegawa , Akitsugu Kagayama , Katsuyoshi Yamaguchi
发明人： Atsuhiro Tsuchiya , Ryuichi Hirano , Hideaki Endo , Kenichi Koyama , Kazuhiro Hasegawa , Akitsugu Kagayama , Katsuyoshi Yamaguchi
IPC分类号： C12M1/34 , G02B21/26 , G02B21/34
CPC分类号： C12M41/36 , C12M41/14 , G02B7/22 , G02B21/0088 , G02B21/02
摘要： A culture observation apparatus, which is used for observing a cultured cell while culturing the cell, includes a culture device that cultures the cultured cell, and a microscope used for observing the cultured cell. The culture device includes a first space that is controlled to an environment suitable for culture of the cell, and a second space that is controlled to a lower humidity condition in comparison with the first space. The microscope includes an objective optical unit including an objective lens; the objective optical unit having at least one portion located in the second space, and another portion extending into the first space through an opening formed in a partition wall that separates the first space and the second space, with a gap between the objective optical unit and the partition wall being sealed by a sealing member, and the objective lens includes a plurality of lens groups, with mutual spaces among the lens groups vented to the second space.
摘要翻译：用于在培养细胞时观察培养细胞的培养观察装置包括培养培养细胞的培养装置和用于观察培养细胞的显微镜。培养装置包括被控制到适于细胞培养的环境的第一空间和与第一空间相比被控制到较低湿度条件的第二空间。显微镜包括物镜光学单元，包括物镜; 所述物镜光学单元具有位于所述第二空间中的至少一个部分，以及另一部分，其通过形成在分隔所述第一空间和所述第二空间的分隔壁中的开口延伸到所述第一空间中，所述间隔物在所述物镜光学单元和所述分隔壁由密封构件密封，并且所述物镜包括多个透镜组，所述透镜组中的彼此间隔开放到所述第二空间。

7. 发明申请

US20060128005A1 Observation apparatus 有权
公开(公告)号：US20060128005A1
公开(公告)日：2006-06-15
申请号：US11302591
申请日：2005-12-12
申请人： Kazuhiro Hasegawa , Akitsugu Kagayama , Hideaki Endo , Ryuichi Hirano , Atsuhiro Tsuchiya , Kenichi Koyama , Katsuyoshi Yamaguchi
发明人： Kazuhiro Hasegawa , Akitsugu Kagayama , Hideaki Endo , Ryuichi Hirano , Atsuhiro Tsuchiya , Kenichi Koyama , Katsuyoshi Yamaguchi
IPC分类号： C12M1/36 , C12M1/34
CPC分类号： C12M23/50 , C12M23/10 , C12M23/48 , C12M41/36
摘要： An observation apparatus includes a sample tray that holds a container housing a cultured cell and a culture medium and covered with a lid; an observation unit that serves for observation of the cultured cell; and a shifting unit that relatively shifts the sample tray and a light axis of the observation unit along a plane that is orthogonal to the light axis of the observation unit, wherein the sample tray includes a container holding unit that holds the container by utilizing an elastic force, and at least one of the lid and one portion of the lid is made detachable, with the container being held in the sample tray by the container holding unit.

8. 发明授权

US06219181B1 Monitor-aided microscope 失效
标题翻译：显示器辅助显微镜
公开(公告)号：US06219181B1
公开(公告)日：2001-04-17
申请号：US09090631
申请日：1998-06-04
申请人： Takashi Yoneyama , Takashi Nagano , Hideaki Endo , Atsuhiro Tsuchiya
发明人： Takashi Yoneyama , Takashi Nagano , Hideaki Endo , Atsuhiro Tsuchiya
IPC分类号： G02B2106
CPC分类号： G02B21/248 , G02B21/18 , G02B21/362
摘要： A microscope includes a stage on which a specimen is placed, a light source for illuminating the specimen, an objective lens for passing an illumination light from the specimen, an image formation system for forming an optical image of the specimen, a monitor for displaying as a visible picture the optical image of the specimen obtained from the image formation system, and an observation condition switch for switching the observation condition for the specimen from one to another. In particular, the optical axis extending from the light source to the image formation system is horizontal over the floor and various controls constituting the observation condition switch are mounted intensively on one side of a main body of the microscope.
摘要翻译：显微镜包括放置样本的阶段，用于照射样本的光源，用于使来自标本的照明光通过的物镜，用于形成样本的光学图像的图像形成系统，显示为从图像形成系统获得的样本的光学图像的可视图像和用于将样本的观察条件从一个切换到另一个的观察条件开关。特别地，从光源延伸到图像形成系统的光轴在地板上是水平的，并且构成观察条件开关的各种控制器集中地安装在显微镜的主体的一侧上。

9. 发明申请

US20110058253A1 MICROSCOPE AND METHOD FOR CONTROLLING MICROSCOPE 有权
标题翻译：显微镜和控制微阵列的方法
公开(公告)号：US20110058253A1
公开(公告)日：2011-03-10
申请号：US12946067
申请日：2010-11-15
申请人： Masayoshi KARASAWA , Keisuke Tamura , Hideaki Endo , Tetsuya Shirota , Tsuyoshi Mochizuki
发明人： Masayoshi KARASAWA , Keisuke Tamura , Hideaki Endo , Tetsuya Shirota , Tsuyoshi Mochizuki
IPC分类号： G02B21/06
CPC分类号： G02B21/06
摘要： A microscope includes a microscope main unit including a stage on which a specimen is to be placed; and a light source provided on the microscope main unit and emitting illumination light for illuminating the specimen. The microscope also includes a main power supply operable to be turned on and off; a sensor that senses the presence or absence of a subject in a front or side area of the microscope main unit; a determining unit that determines based on a result of the sensing whether the subject moves; and a control unit that turns on the light source when the main power supply is turned on, maintains the light source in an ON state when the determining unit determines that the subject moves, and turns off the light source when the determining unit determines that the subject does not move and a predetermined period of time passes.
摘要翻译：显微镜包括显微镜主单元，其包括待放置样本的载物台; 以及设置在显微镜主单元上并发射用于照射样本的照明光的光源。显微镜还包括可操作以打开和关闭的主电源; 检测显微镜主单元的正面或侧面的被检体的存在或不存在的传感器; 确定单元，其基于所述感测的结果来确定所述被摄体是否移动; 以及控制单元，当所述主电源接通时接通所述光源，当所述确定单元确定所述被摄体移动时，将所述光源保持在ON状态，并且当所述确定单元确定所述光源被摄体不移动并且经过预定的时间段。

10. 发明授权

US07486886B2 Photo-micrographing device and its control method 有权
标题翻译：照相显影装置及其控制方法
公开(公告)号：US07486886B2
公开(公告)日：2009-02-03
申请号：US11330874
申请日：2006-01-11
申请人： Hideaki Endo , Akitsugu Kagayama , Katsuyoshi Yamaguchi
发明人： Hideaki Endo , Akitsugu Kagayama , Katsuyoshi Yamaguchi
IPC分类号： G02B21/36
CPC分类号： G02B21/367 , G02B21/26
摘要： A photo-micrographing device includes a microscope, a unit for obtaining an image of an inspection object, a unit for setting a plurality of view fields of the microscope and storing position information of a stage corresponding to each view field, a unit for storing setting information of the microscope and a camera unit in each view field, a unit for storing shooting conditions corresponding to each view field where time-lapse shooting is applied, a unit for obtaining a time-lapse shooting image for each view field where the time-lapse shooting is applied, based on the stored position information, the stored setting information and the stored shooting conditions, and a unit for collectively displaying latest taken time-lapse shooting images for each view field where the time-lapse shooting is applied.
摘要翻译：照相显影装置包括显微镜，用于获得检查对象的图像的单元，用于设置显微镜的多个视场的单元，并存储与每个视野相对应的台的位置信息，用于存储设置的单元每个视野中的显微镜和相机单元的信息，用于存储与应用了延时拍摄的每个视野相对应的拍摄条件的单元，用于获得每个视场的延时拍摄图像的单元，基于所存储的位置信息，存储的设置信息和存储的拍摄条件来应用经过拍摄，以及用于对应用延时拍摄的每个视野进行集体显示最新拍摄的延时拍摄图像的单元。

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