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1. 发明授权

US08691974B2 Three-dimensional bioprinting of biosynthetic cellulose (BC) implants and scaffolds for tissue engineering 有权
标题翻译：生物合成纤维素（BC）植入物和组织工程支架的三维生物印迹
公开(公告)号：US08691974B2
公开(公告)日：2014-04-08
申请号：US13498657
申请日：2010-09-28
申请人： Paul Gatenholm , Henrik Backdahl , Theodore Jon Tzavaras , Rafael V. Davalos , Michael B. Sano
发明人： Paul Gatenholm , Henrik Backdahl , Theodore Jon Tzavaras , Rafael V. Davalos , Michael B. Sano
IPC分类号： C08B1/00 , A61K31/717 , C12P1/04 , C12N11/12
CPC分类号： C08B1/00 , A61L27/20 , A61L27/38 , A61L27/56 , A61L2400/12 , C12N5/0062 , C12N11/12 , C12N2533/78 , C12P19/04 , C08L1/02
摘要： A novel BC fermentation technique for controlling 3D shape, thickness and architecture of the entangled cellulose nano-fibril network is presented. The resultant nano-cellulose based structures are useful as biomedical implants and devices, are useful for tissue engineering and regenerative medicine, and for health care products. More particularly, embodiments of the present invention relate to systems and methods for the production and control of 3-D architecture and morphology of nano-cellulose biomaterials produced by bacteria using any biofabrication process, including the novel 3-D Bioprinting processes disclosed. Representative processes according to the invention involve control of the rate of production of biomaterial by bacteria achieved by meticulous control of the addition of fermentation media using a microfluidic system. In exemplary embodiments, the bacteria gradually grew up along the printed alginate structure that had been placed into the culture, incorporating it. After culture, the printed alginate structure was successfully removed revealing porosity where the alginate had been placed. Porosity and interconnectivity of pores in the resultant 3-D architecture can be achieved by porogen introduction using, e.g., ink-jet printer technology.
摘要翻译：提出了一种用于控制缠结纤维素纳米纤维网络的3D形状，厚度和结构的新型BC发酵技术。所得的纳米纤维素基结构可用作生物医学植入物和装置，可用于组织工程和再生医学以及保健产品。更具体地说，本发明的实施方案涉及使用任何生物制造方法生产和控制由细菌生产的纳米纤维素生物材料的三维结构和形态的系统和方法，包括所公开的新型3-D生物印迹方法。根据本发明的代表性方法涉及通过细微控制使用微流体系统添加发酵培养基来控制细菌生物材料的生产速率。在示例性实施方案中，细菌沿已经放入培养物中的印刷的藻酸盐结构逐渐长大，并入其中。培养后，成功去除了印刷的藻酸盐结构，显示了藻酸盐放置的孔隙度。所得3-D结构中孔隙的孔隙率和互连性可以通过使用例如喷墨打印机技术的致孔剂引入来实现。

2. 发明申请

US20120190078A1 THREE-DIMENSIONAL BIOPRINTING OF BIOSYNTHETIC CELLULOSE (BC) IMPLANTS AND SCAFFOLDS FOR TISSUE ENGINEERING 有权
标题翻译：生物塑料纤维素（BC）植物和组织的组织工程三维生物学
公开(公告)号：US20120190078A1
公开(公告)日：2012-07-26
申请号：US13498657
申请日：2010-09-28
申请人： Paul Gatenholm , Henrik Backdahl , Theodore Jon Tzavaras , Rafael V. Davalos , Michael B. Sano
发明人： Paul Gatenholm , Henrik Backdahl , Theodore Jon Tzavaras , Rafael V. Davalos , Michael B. Sano
IPC分类号： C12P19/04 , C12N5/02 , C12N11/12
CPC分类号： C08B1/00 , A61L27/20 , A61L27/38 , A61L27/56 , A61L2400/12 , C12N5/0062 , C12N11/12 , C12N2533/78 , C12P19/04 , C08L1/02
摘要： A novel BC fermentation technique for controlling 3D shape, thickness and architecture of the entangled cellulose nano-fibril network is presented. The resultant nano-cellulose based structures are useful as biomedical implants and devices, are useful for tissue engineering and regenerative medicine, and for health care products. More particularly, embodiments of the present invention relate to systems and methods for the production and control of 3-D architecture and morphology of nano-cellulose biomaterials produced by bacteria using any biofabrication process, including the novel 3-D Bioprinting processes disclosed. Representative processes according to the invention involve control of the rate of production of biomaterial by bacteria achieved by meticulous control of the addition of fermentation media using a microfluidic system. In exemplary embodiments, the bacteria gradually grew up along the printed alginate structure that had been placed into the culture, incorporating it. After culture, the printed alginate structure was successfully removed revealing porosity where the alginate had been placed. Porosity and interconnectivity of pores in the resultant 3-D architecture can be achieved by porogen introduction using, e.g., ink-jet printer technology.
摘要翻译：提出了一种用于控制缠结纤维素纳米纤维网络的3D形状，厚度和结构的新型BC发酵技术。所得的纳米纤维素基结构可用作生物医学植入物和装置，可用于组织工程和再生医学以及保健产品。更具体地说，本发明的实施方案涉及使用任何生物制造方法生产和控制由细菌生产的纳米纤维素生物材料的三维结构和形态的系统和方法，包括所公开的新型3-D生物印迹方法。根据本发明的代表性方法涉及通过细微控制使用微流体系统添加发酵培养基来控制细菌生物材料的生产速率。在示例性实施方案中，细菌沿已经放入培养物中的印刷的藻酸盐结构逐渐长大，并入其中。培养后，成功去除了印刷的藻酸盐结构，显示了藻酸盐放置的孔隙度。所得3-D结构中孔隙的孔隙率和互连性可以通过使用例如喷墨打印机技术的致孔剂引入来实现。

3. 发明申请

US20100042197A1 PREPARATION OF HOLLOW CELLULOSE VESSELS 审中-公开
标题翻译：中空纤维素容器的制备
公开(公告)号：US20100042197A1
公开(公告)日：2010-02-18
申请号：US12444141
申请日：2007-10-02
申请人： Aase Bodin , Henrik Backdahl , Paul Gatenholm , Lena Gustafsson , Bo Risberg
发明人： Aase Bodin , Henrik Backdahl , Paul Gatenholm , Lena Gustafsson , Bo Risberg
IPC分类号： A61F2/06 , C12P19/04 , C08B15/06 , B32B1/08 , A61F2/02
CPC分类号： C12P19/04 , A61L27/20 , A61L27/3808 , A61L27/507 , C08L1/02 , Y02P20/582 , Y10T428/13
摘要： The present invention relates to an improved method for the preparation of hollow cellulose vessels produced by a microorganism, and hollow cellulose vessels prepared by this method. The method is characterized by the culturing of the cellulose-producing microorganisms being performed on the outer surface of a hollow carrier, and providing an oxygen containing gas on the inner side of the hollow carrier, the oxygen containing gas having an oxygen level higher than atmospheric oxygen. The hollow microbial cellulose vessels of the present invention are characterized by improved mechanical properties and can be used in surgical procedures to replace or repair an internal hollow organ such as the urethra, ureter, the trachea, a digestive tract, a lymphatic vessel or a blood vessel
摘要翻译：本发明涉及一种制备由微生物生产的中空纤维素容器的改进方法和通过该方法制备的中空纤维素容器。该方法的特征在于在中空载体的外表面上培养产生纤维素的微生物，并在中空载体的内侧提供含氧气体，氧含量高于大气压的含氧气体氧。本发明的中空微生物纤维素容器的特征在于改进的机械性能，并且可用于外科手术以替代或修复诸如尿道，输尿管，气管，消化道，淋巴管或血液的内部中空器官船只

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