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1. 发明授权

US07771947B2 Methods and compositions for rapid light-activated isolation and detection of analytes 有权
标题翻译：用于快速光激活分离和检测分析物的方法和组合物
公开(公告)号：US07771947B2
公开(公告)日：2010-08-10
申请号：US12034236
申请日：2008-02-20
申请人： Rachel Anne Holmes-Davis , Heather Koshinsky , Miaomiao Wang , Brian David Warner
发明人： Rachel Anne Holmes-Davis , Heather Koshinsky , Miaomiao Wang , Brian David Warner
IPC分类号： C12Q1/68 , C07H21/02 , C07H21/04
CPC分类号： C12Q1/6816 , C12Q2563/173 , C12Q2525/107
摘要： The present invention relates to novel methods for isolating a target molecule from a sample suspected of containing the target molecule. The methods of the present invention utilize solid substrates as a means for capturing, separating, and releasing target molecules, such as chemical or biological compounds. The present invention is specifically directed to novel approaches for capturing, separating and releasing such target molecules.
摘要翻译：本发明涉及从怀疑含有靶分子的样品中分离靶分子的新方法。本发明的方法利用固体底物作为捕获，分离和释放靶分子如化学或生物化合物的手段。本发明特别涉及用于捕获，分离和释放这些靶分子的新方法。

2. 发明授权

US07745119B2 System for detecting polynucleotides 有权
标题翻译：多核苷酸检测系统
公开(公告)号：US07745119B2
公开(公告)日：2010-06-29
申请号：US11285025
申请日：2005-11-21
申请人： Heather Koshinsky , Michael S. Zwick , K. Yeon Choi
发明人： Heather Koshinsky , Michael S. Zwick , K. Yeon Choi
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6816 , Y02A50/52 , Y10T436/143333 , C12Q2565/107 , C12Q2525/113 , C12Q2525/107 , C12Q2545/113 , C12Q2527/125
摘要： The present invention relates to methods for detecting the presence or amount of a target polynucleotide. A polynucleotide, target nucleic acid analog, and dye are combined to form a mixture. The optical property of the dye is observed after the mixture is exposed to a stimulating means. Optionally, after the stimulating means is employed, the mixture is compared to a reference value characteristic of the rate of change in the optical property of the dye in a similar mixture containing a known amount of a target polynucleotide/nucleic acid analog hybrid to determine a relative rate of change in the optical property. The change in a property of the mixture after exposure thereof to a stimulating means or the relative rate of change in the optical property of dye in the mixture is correlated with the presence or amount of the specified target polynucleotide in the sample.
摘要翻译：本发明涉及用于检测靶多核苷酸的存在或量的方法。将多核苷酸，靶核酸类似物和染料合并形成混合物。在将混合物暴露于刺激装置之后，观察染料的光学性质。任选地，在使用刺激装置之后，将混合物与包含已知量的靶多核苷酸/核酸模拟杂交体的类似混合物中的染料的光学性能变化率的特性参考值进行比较，以确定相对光学性质的变化率。将混合物暴露于刺激装置后的混合物的性质的变化或混合物中染料的光学性质的相对变化率与样品中指定的靶多核苷酸的存在或量相关。

3. 发明申请

US20100209909A1 ASSAYS BASED ON DETECTION OF PHOTOBLEACHING REACTION PRODUCTS FROM DYE CATALYTIC COMPLEX 有权
标题翻译：基于从染料复合物中检测光催化反应产物的测定
公开(公告)号：US20100209909A1
公开(公告)日：2010-08-19
申请号：US12372439
申请日：2009-02-17
申请人： Miaomiao Wang , Rachel Anne Holmes-Davis , Rick Blidner , Zbigniew Rafinski , Beata Anna Jedrzejewska , Jerzy Paczkowski , Brian David Warner , Heather Koshinsky
发明人： Miaomiao Wang , Rachel Anne Holmes-Davis , Rick Blidner , Zbigniew Rafinski , Beata Anna Jedrzejewska , Jerzy Paczkowski , Brian David Warner , Heather Koshinsky
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6825 , C12Q2563/107 , C12Q2525/107
摘要： The present invention relates to the methods for assaying an analyte comprising a nucleic acid analog binding substrate in a sample, comprising reacting a catalytic complex comprising a nucleic acid analog, a nucleic acid analog specific binding substrate and a light reactive dye with a light stimulus, and detecting the presence or absence or amount of a reaction product of the catalytic complex and light stimulus. The present invention also relates to a method of assaying a nucleic acid analyte in a sample using an analyte-specific reporter complex. The present invention also relates to a method of assaying an analyte in a sample using a reporter molecule.
摘要翻译：本发明涉及用于测定样品中核酸类似物结合底物的分析物的方法，包括使包含核酸类似物，核酸类似特异性结合底物和轻活性染料的催化复合物与光刺激反应，并检测催化复合物和光刺激的反应产物的存在或不存在或量。本发明还涉及使用分析物特异性报道复合物测定样品中的核酸分析物的方法。本发明还涉及使用报告分子测定样品中分析物的方法。

4. 发明申请

US20080220436A1 METHODS AND COMPOSITIONS FOR RAPID LIGHT-ACTIVATED ISOLATION AND DETECTION OF ANALYTES 有权
标题翻译：快速激活分离的方法和组合物和分析物的检测
公开(公告)号：US20080220436A1
公开(公告)日：2008-09-11
申请号：US12034236
申请日：2008-02-20
申请人： Rachel Anne Holmes-Davis , Heather Koshinsky , Miaomiao Wang , Brian David Warner
发明人： Rachel Anne Holmes-Davis , Heather Koshinsky , Miaomiao Wang , Brian David Warner
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6816 , C12Q2563/173 , C12Q2525/107
摘要： The present invention relates to novel methods for isolating a target molecule from a sample suspected of containing the target molecule. The methods of the present invention utilize solid substrates as a means for capturing, separating, and releasing target molecules, such as chemical or biological compounds. The present invention is specifically directed to novel approaches for capturing, separating and releasing such target molecules.
摘要翻译：本发明涉及从怀疑含有靶分子的样品中分离靶分子的新方法。本发明的方法利用固体底物作为捕获，分离和释放靶分子如化学或生物化合物的手段。本发明特别涉及用于捕获，分离和释放这些靶分子的新方法。

5. 发明授权

US07152492B2 Lid for sample holder 有权
公开(公告)号：US07152492B2
公开(公告)日：2006-12-26
申请号：US10486802
申请日：2002-08-13
申请人： Michael Zwick , Heather Koshinsky
发明人： Michael Zwick , Heather Koshinsky
IPC分类号： G01N1/18 , G01N1/38 , B01L11/00
CPC分类号： B01L3/50853 , B01L2200/021 , B01L2200/026 , B01L2200/0642 , B01L2300/04 , B01L2300/046 , B01L2300/0829 , B01L2300/0864 , G01N1/18 , Y10T436/25 , Y10T436/2575
摘要： A lid for a sample holder that includes a load port, a first flow channel, and a second flow channel. The first flow channel includes a first end connected to the load port and a second end that opens into a first reservoir of the sample holder. The second flow channel also includes a first end connected to the load port and a second end that opens into a second reservoir of the sample holder.

6. 发明申请

US20110008905A1 SYSTEM FOR DETECTING POLYNUCLEOTIDES 审中-公开
标题翻译：检测多核苷酸的系统
公开(公告)号：US20110008905A1
公开(公告)日：2011-01-13
申请号：US12797157
申请日：2010-06-09
申请人： HEATHER KOSHINSKY , MICHAEL S. ZWICK , K. YEON CHOI
发明人： HEATHER KOSHINSKY , MICHAEL S. ZWICK , K. YEON CHOI
IPC分类号： G01N33/53
CPC分类号： C12Q1/6816 , Y02A50/52 , Y10T436/143333 , C12Q2565/107 , C12Q2525/113 , C12Q2525/107 , C12Q2545/113 , C12Q2527/125
摘要： The present invention relates to methods for detecting the presence or amount of a target polynucleotide. A polynucleotide, target nucleic acid analog, and dye are combined to form a mixture. The optical property of the dye is observed after the mixture is exposed to a stimulating means. Optionally, after the stimulating means is employed, the mixture is compared to a reference value characteristic of the rate of change in the optical property of the dye in a similar mixture containing a known amount of a target polynucleotide/nucleic acid analog hybrid to determine a relative rate of change in the optical property. The change in a property of the mixture after exposure thereof to a stimulating means or the relative rate of change in the optical property of dye in the mixture is correlated with the presence or amount of the specified target polynucleotide in the sample.
摘要翻译：本发明涉及用于检测靶多核苷酸的存在或量的方法。将多核苷酸，靶核酸类似物和染料合并形成混合物。在将混合物暴露于刺激装置之后，观察染料的光学性质。任选地，在使用刺激装置之后，将混合物与包含已知量的靶多核苷酸/核酸模拟杂交体的类似混合物中的染料的光学性能变化率的特性参考值进行比较，以确定相对光学性质的变化率。将混合物暴露于刺激装置后的混合物的性质的变化或混合物中染料的光学性质的相对变化率与样品中指定的靶多核苷酸的存在或量相关。

7. 发明申请

US20080096193A1 Methods and compositions for detecting polynucleotides 审中-公开
标题翻译：用于检测多核苷酸的方法和组合物
公开(公告)号：US20080096193A1
公开(公告)日：2008-04-24
申请号：US11362359
申请日：2006-10-24
申请人： Charles Robert Bupp , K. Yeon Choi , Heather Koshinsky , Christopher Nulf , Mickey Urdea , Miaomiao Wang , Michael Zwick
发明人： Charles Robert Bupp , K. Yeon Choi , Heather Koshinsky , Christopher Nulf , Mickey Urdea , Miaomiao Wang , Michael Zwick
IPC分类号： C12Q1/68 , C07H21/04 , C07D417/02
CPC分类号： C12Q1/6816 , C12Q2565/107
摘要： Methods of determining the presence or amount of a target polynucleotide in a sample are provided. A sample that contains a target polynucleotide, a nucleic acid analog that is complementary to a target nucleic acid sequence of the target polynucleotide, and a dye for which the rate of change in an optical property is different in the presence and absence of a target polynucleotide/nucleic acid analog hybrid are combined to produce a reaction mixture. The rate of change in an optical property of the dye in the reaction mixture is compared to a reference value characteristic of the rate of change in the optical property of the dye in a similar reaction mixture containing a known amount of a polynucleotide/nucleic acid analog hybrid to determine a relative rate of change in the optical property. The relative rate of change in the optical property of dye in the reaction mixture is correlated with the presence or amount of the specified target polynucleotide in the sample.
摘要翻译：提供了确定样品中靶多核苷酸的存在或量的方法。含有目标多聚核苷酸，与靶多核苷酸的靶核酸序列互补的核酸类似物的样品和在存在和不存在靶多核苷酸时光学性质的变化率不同的染料 /核酸类似物混合物组合以产生反应混合物。将反应混合物中染料的光学性质的变化率与含有已知量的多核苷酸/核酸类似物的类似反应混合物中的染料的光学性质变化率的参考值进行比较混合以确定光学性质的相对变化率。反应混合物中染料的光学性质的相对变化率与样品中特定靶多核苷酸的存在或数量相关。

8. 发明申请

US20070231821A1 Methods and compositions for detecting polynucleotides 有权
标题翻译：用于检测多核苷酸的方法和组合物
公开(公告)号：US20070231821A1
公开(公告)日：2007-10-04
申请号：US11710667
申请日：2007-02-23
申请人： Charles Bupp , K. Choi , Rachel Holmes-Davis , Alexander Izmailov , Heather Koshinsky , Christopher Nulf , Mickey Urdea , Miaomiao Wang , Brian Warner , Michael Zwick
发明人： Charles Bupp , K. Choi , Rachel Holmes-Davis , Alexander Izmailov , Heather Koshinsky , Christopher Nulf , Mickey Urdea , Miaomiao Wang , Brian Warner , Michael Zwick
IPC分类号： C12Q1/68 , C07D417/02 , C07D413/02 , C07D401/02
CPC分类号： C12Q1/6876 , C12Q1/6813 , C12Q2600/156
摘要： Methods of determining the presence or amount of a target polynucleotide in a sample are provided. A sample that contains a target polynucleotide, a polynucleotide that may include nucleic acid analogs and that is complementary to a target nucleic acid sequence of the target polynucleotide, and a dye for which the rate of change in an optical property is different in the presence and absence of a target polynucleotide/polynucleotide hybrid are combined to produce a reaction mixture. The rate of change in an optical property of the dye in the reaction mixture is compared to a reference value characteristic of the rate of change in the optical property of the dye in a similar reaction mixture containing a known amount of a polynucleotide/polynucleotide hybrid to determine a relative rate of change in the optical property. The relative rate of change in the optical property of dye in the reaction mixture is correlated with the presence or amount of the specified target polynucleotide in the sample.
摘要翻译：提供了确定样品中靶多核苷酸的存在或量的方法。含有靶多核苷酸，可包括核酸类似物并与靶多核苷酸的靶核酸序列互补的多核苷酸的样品和在存在和/或存在的情况下光学性质的变化率不同的染料组合不存在靶多核苷酸/多核苷酸杂交体以产生反应混合物。将反应混合物中染料的光学性质的变化率与含有已知量的多核苷酸/多核苷酸杂化物的类似反应混合物中的染料的光学性质变化率的变化率的参考值进行比较确定光学性质的相对变化率。反应混合物中染料的光学性质的相对变化率与样品中特定靶多核苷酸的存在或数量相关。

9. 发明申请

US20060147958A1 System for detecting polynucleotides 有权
标题翻译：多核苷酸检测系统
公开(公告)号：US20060147958A1
公开(公告)日：2006-07-06
申请号：US11285025
申请日：2005-11-21
申请人： Heather Koshinsky , Michael Zwick , K. Choi
发明人： Heather Koshinsky , Michael Zwick , K. Choi
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6816 , Y02A50/52 , Y10T436/143333 , C12Q2565/107 , C12Q2525/113 , C12Q2525/107 , C12Q2545/113 , C12Q2527/125
摘要： The present invention relates to methods for detecting the presence or amount of a target polynucleotide. A polynucleotide, target nucleic acid analog, and dye are combined to form a mixture. The optical property of the dye is observed after the mixture is exposed to a stimulating means. Optionally, after the stimulating means is employed, the mixture is compared to a reference value characteristic of the rate of change in the optical property of the dye in a similar mixture containing a known amount of a target polynucleotide/nucleic acid analog hybrid to determine a relative rate of change in the optical property. The change in a property of the mixture after exposure thereof to a stimulating means or the relative rate of change in the optical property of dye in the mixture is correlated with the presence or amount of the specified target polynucleotide in the sample.
摘要翻译：本发明涉及用于检测靶多核苷酸的存在或量的方法。将多核苷酸，靶核酸类似物和染料合并形成混合物。在将混合物暴露于刺激装置之后，观察染料的光学性质。任选地，在使用刺激装置之后，将混合物与包含已知量的靶多核苷酸/核酸模拟杂交体的类似混合物中的染料的光学性能的变化率的特性参考值进行比较，以确定相对光学性质的变化率。将混合物暴露于刺激装置后的混合物的性质的变化或混合物中染料的光学性质的相对变化率与样品中指定的靶多核苷酸的存在或量相关。

10. 发明授权

US06626051B2 Lid for sample holder 有权
标题翻译：盖样品架
公开(公告)号：US06626051B2
公开(公告)日：2003-09-30
申请号：US09930099
申请日：2001-08-14
申请人： Michael Zwick , Heather Koshinsky
发明人： Michael Zwick , Heather Koshinsky
IPC分类号： B01L300
CPC分类号： B01L3/50853 , B01L2200/021 , B01L2200/026 , B01L2200/0642 , B01L2300/04 , B01L2300/046 , B01L2300/0829 , B01L2300/0864 , G01N1/18 , Y10T436/25 , Y10T436/2575
摘要： A lid for a sample holder that includes a load port, a first flow channel, and a second flow channel. The first flow channel includes a first end connected to the load port and a second end that opens into a first reservoir of the sample holder. The second flow channel also includes a first end connected to the load port and a second end that opens into a second reservoir of the sample holder.
摘要翻译：一种用于样本保持器的盖子，其包括负载端口，第一流动通道和第二流动通道。第一流动通道包括连接到负载端口的第一端和通向样品保持器的第一储存器的第二端。第二流动通道还包括连接到负载端口的第一端和通向样品保持器的第二储存器的第二端。

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