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1. 发明申请

US20100004339A1 Somatostatin Receptor 1 and/or 4 Selective Agonists and Antagonists 审中-公开
标题翻译：生长抑素受体1和/或4种选择性激动剂和拮抗剂
公开(公告)号：US20100004339A1
公开(公告)日：2010-01-07
申请号：US12559324
申请日：2009-09-14
申请人： Jussi Tomperi , Päivi Hautamäki , Harri Salo , Mia Engström , Andrei Tauber , Anna-Marja Hoffrén , Siegfried Wurster
发明人： Jussi Tomperi , Päivi Hautamäki , Harri Salo , Mia Engström , Andrei Tauber , Anna-Marja Hoffrén , Siegfried Wurster
IPC分类号： A61K31/18 , A61P25/00 , A61P35/00 , A61P27/00 , A61P7/00
CPC分类号： C07D333/62 , A61K31/18 , A61K31/445 , C07C311/19 , C07C2601/02 , C07C2601/14 , C07C2602/08 , C07C2602/10 , C07D209/16
摘要： The invention relates to (hetero)arylsulfonylamino based peptidomimetics of formula (I), wherein R1, R2, R3, A, B, D, Q, k and n are defined as disclosed, or a pharmaceutically acceptable salt or ester thereof. Compounds of formula (I) possess high affinity and selectivity for the somatostatin receptor subtypes SSTR1 and/or SSTR4 and can be used for the treatment or diagnosis of diseases or conditions wherein an interaction with SSTR1 and/or SSTR4 is indicated to be useful.
摘要翻译：本发明涉及式（I）的（杂）芳基磺酰氨基基肽模拟物，其中R1，R2，R3，A，B，D，Q，k和n如所公开的定义，或其药学上可接受的盐或酯。式（I）化合物对生长抑素受体亚型SSTR1和/或SSTR4具有高亲和力和选择性，并且可用于治疗或诊断与SSTR1和/或SSTR4的相互作用被认为有用的疾病或病症。

2. 发明授权

US06767909B2 Compounds useful for treatment or prevention of disease mediated by alpha-2B-adrenoceptor 失效
标题翻译：可用于治疗或预防由α-2B肾上腺素受体介导的疾病的化合物
公开(公告)号：US06767909B2
公开(公告)日：2004-07-27
申请号：US10196123
申请日：2002-07-17
申请人： Topi Joutsamo , Andrei Yurievitch Tauber , Harri Salo , Anna-Maria Hoffrén , Siegfreid Wurster
发明人： Topi Joutsamo , Andrei Yurievitch Tauber , Harri Salo , Anna-Maria Hoffrén , Siegfreid Wurster
IPC分类号： C07D23942
CPC分类号： C07D239/42 , C07D401/12 , C07D403/12
摘要： A compound, suitable as an alpha-2B-adrenoceptor antagoist, having a structure of formula (I) or a pharmaceutically acceptable salt thereof wherein R1, R2, R3, R4 and R5 are independently of each other H, a straight or branched alkyl or alkoxy group with 1 to 4 carbon atoms, or a halogen; X is H, a straight or branched alkyl chain with 1 to 4 carbon atoms, phenyl, —OH or ═O; Z is H, acetyl, —CH2—Ph—O—CF3 or —CH2—Ph—CF3, Y is a ring structure optionally linked to formula (I) with an alkyl chain having one or two carbon atoms. The compound is suitable for use in a method for treatment or prevention of a disease mediated by the alpha-2B-adrenoceptor in a mammal.
摘要翻译：适合作为α-2B肾上腺素受体拮抗剂的化合物，其具有式（I）结构或其药学上可接受的盐，其中R 1，R 2，R 3，R 4和R 5彼此独立地为H，直链或支链烷基或具有1至4个碳原子的烷氧基，或卤素; X是H，具有1至4个碳原子的直链或支链烷基链，苯基，-OH或= O; Z是H，乙酰基，-CH2-Ph-O-CF3或-CH2-Ph-CF3，Y是任选与式（I）连接的具有一个或两个碳原子的烷基链的环结构。该化合物适合用于治疗或预防哺乳动物中由α-2B-肾上腺素受体介导的疾病的方法。

3. 发明授权

US08921378B2 Androgen receptor modulating carboxamides 有权
标题翻译：雄激素受体调节甲酰胺
公开(公告)号：US08921378B2
公开(公告)日：2014-12-30
申请号：US14112727
申请日：2012-04-20
申请人： Olli Törmäkangas , Gerd Wohlfahrt , Harri Salo , Rathna Durga Ramasubramanian , Pranab Kumar Patra , Arputharaj Ebenezer Martin , Terhi Heikkinen , Anniina Vesalainen , Anu Moilanen , Arja Karjalainen
发明人： Olli Törmäkangas , Gerd Wohlfahrt , Harri Salo , Rathna Durga Ramasubramanian , Pranab Kumar Patra , Arputharaj Ebenezer Martin , Terhi Heikkinen , Anniina Vesalainen , Anu Moilanen , Arja Karjalainen
IPC分类号： A61K31/519 , C07D231/14 , C07D487/04 , C07D403/04 , C07D471/04 , C07D403/14 , C07D401/14 , C07D403/12 , C07D401/04 , C07D413/14 , C07D413/12 , C07D513/04
CPC分类号： C07D487/04 , C07D231/14 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D413/12 , C07D413/14 , C07D471/04 , C07D513/04
摘要： Compounds of formula (I) or (II) wherein Rx, Rz, R9, R10, R14, R14′, R15, R15′, A and B are as defined in the claims and pharmaceutically acceptable salts and esters thereof, are disclosed. The compounds possess utility as tissue-selective androgen receptor modulators (SARM) and are useful as medicaments in the treatment of prostate cancer and other AR dependent conditions and diseases where AR antagonism is desired.
摘要翻译：其中Rx，Rz，R9，R10，R14，R14'，R15，R15'，A和B如权利要求中所定义并且其药学上可接受的盐和酯的式（I）或（II）化合物。该化合物具有作为组织选择性雄激素受体调节剂（SARM）的作用，并且可用作治疗前列腺癌和其它AR依赖性疾病和AR拮抗作用的疾病的药物。

4. 发明授权

US08456627B2 Structure of measurement window 有权
标题翻译：测量窗结构
公开(公告)号：US08456627B2
公开(公告)日：2013-06-04
申请号：US12892415
申请日：2010-09-28
申请人： Harri Salo
发明人： Harri Salo
IPC分类号： G01N21/01
CPC分类号： G01N21/01 , G01N21/0317
摘要： A measurement window structure is disclosed for an optical process measurement device. The measurement window structure can include a measurement window made of an optical material and having a measurement surface that is arranged to be placed into a process solution, a sealing surface formed to a frame structure of the optical process measurement device and facing the process solution, the measurement window made of an optical material being arranged to press against the sealing surface, and an attaching device or mechanism for pressing the measurement window made of an optical material against the sealing surface and for attaching it to the frame structure. The sealing surface formed to the frame structure can be a rotationally symmetrical surface and the surface pressing against the sealing surface formed to the frame structure of the measurement window made of an optical material can be a rotationally symmetrical surface.
摘要翻译：公开了一种用于光学过程测量装置的测量窗结构。测量窗口结构可以包括由光学材料制成的测量窗口，并且具有布置成放置在处理溶液中的测量表面，形成于光学测量装置的框架结构并面向工艺溶液的密封表面，由光学材料制成的测量窗被设置成压靠密封表面，以及用于将由光学材料制成的测量窗口压靠在密封表面上并用于将其附接到框架结构的附接装置或机构。形成到框架结构的密封面可以是旋转对称的表面，并且压靠形成于由光学材料制成的测量窗的框架结构的密封表面的表面可以是旋转对称的表面。

5. 发明授权

US07741362B2 Somatostatin receptor 1 and/or 4 selective agonists and antagonists 失效
标题翻译：生长抑素受体1和/或4种选择性激动剂和拮抗剂
公开(公告)号：US07741362B2
公开(公告)日：2010-06-22
申请号：US10574584
申请日：2004-10-05
申请人： Jussi Tomperi , Paivi Hautamaki , Harri Salo , Mia Engstrom , Andrei Tauber , Anna-Marja Hoffren , Siegfried Wurster
发明人： Jussi Tomperi , Paivi Hautamaki , Harri Salo , Mia Engstrom , Andrei Tauber , Anna-Marja Hoffren , Siegfried Wurster
IPC分类号： A61K31/40 , A61K31/38 , A01N41/06 , A61K31/18 , C07D209/36 , C07D333/00
CPC分类号： A61K31/18 , A61K31/381 , A61K31/404 , A61K31/445 , C07C311/19 , C07C2601/02 , C07C2601/14 , C07C2602/08 , C07C2602/10 , C07D209/14 , C07D209/16 , C07D333/62
摘要： The invention relates to (hetero)arylsulfonylamino based peptidomimetics of formula (I), wherein R1, R2, R3, A, B, D, Q, k and n are defined as disclosed, or a pharmaceutically acceptable salt or ester thereof. Compounds of formula (I) possess high affinity and selectivity for the somatostatin receptor subtypes SSTR1 and/or SSTR4 and can be used for the treatment or diagnosis of diseases or conditions wherein an interaction with SSTR1 and/or SSTR4 is indicated to be useful.
摘要翻译：本发明涉及式（I）的（杂）芳基磺酰氨基基肽模拟物，其中R1，R2，R3，A，B，D，Q，k和n如所公开的定义，或其药学上可接受的盐或酯。式（I）化合物对生长抑素受体亚型SSTR1和/或SSTR4具有高亲和力和选择性，并且可用于治疗或诊断与SSTR1和/或SSTR4的相互作用被认为有用的疾病或病症。

6. 发明申请

US20070052949A1 Refractometer 有权
$Refractometer$
标题翻译：折射仪
公开(公告)号：US20070052949A1
公开(公告)日：2007-03-08
申请号：US11501827
申请日：2006-08-10
申请人： Harri Salo
发明人： Harri Salo
IPC分类号： G01N21/41
CPC分类号： G01N21/41
摘要： A refractometer is disclosed having a light source and an optical window to be positioned in a process liquid. A beam of rays is directed from the light source to an interface (RP) between the process liquid and the optical window and leading back part of the beam of rays refracted from the interface to the inside of the optical window. An image formed in the above manner is observed. The beam of rays from the light source is directed to the interface (RP) between the process liquid and the optical window from the side of the process liquid and in the direction of the interface.
摘要翻译：公开了一种折射计，其具有将光源和光学窗口定位在处理液体中。光束从光源被引导到处理液体和光学窗口之间的界面（RP），并且从光学窗口内部的界面折射出的光束的前后部分。观察以上述方式形成的图像。来自光源的射线束从处理液体的侧面和界面的方向被引导到处理液体和光学窗口之间的界面（RP）。

7. 发明授权

US06760098B2 Refractometer 有权
$Refractometer$
标题翻译：折射仪
公开(公告)号：US06760098B2
公开(公告)日：2004-07-06
申请号：US09918528
申请日：2001-08-01
申请人： Harri Salo
发明人： Harri Salo
IPC分类号： G01N2141
CPC分类号： G01N21/431 , G01N2021/434
摘要： The invention relates to a refractometer comprising an optical module (4) arranged floatingly inside a housing structure, which module comprises an optical window (2) to be positioned in a process fluid (3), and means for forming an illuminating beam and for directing it into the process fluid (3) through the optical window (2) and for directing back the part of the illuminating beam that is reflected from the process fluid, and further, means for watching the image formed in said manner. The optical module (4) is arranged to be supported against the housing structure by means of sealing (5) arranged between the optical window (2) and the housing structure. In order to provide a device suitable for difficult conditions, the housing structure part (6) in contact with the process fluid (3) against which the optical window (2) is arranged to be supported via sealing (5) is formed of a material that is chemically durable, mechanically rigid and durable and has good thermal conductivity.
摘要翻译：本发明涉及一种折射仪，其包括浮动地设置在壳体结构内的光学模块（4），该模块包括位于过程流体（3）中的光学窗口（2），以及用于形成照明光束并用于引导通过光学窗口（2）进入过程流体（3）并且用于引导从过程流体反射的照明光束的部分，并且还用于观察以所述方式形成的图像的装置。光学模块（4）被布置成通过布置在光学窗（2）和壳体结构之间的密封（5）支撑住壳体结构。为了提供适合于困难条件的装置，与光学窗口（2）布置成通过密封（5）支撑的处理流体（3）接触的壳体结构部分（6）由材料形成化学耐久，机械刚性和耐用，并具有良好的导热性。

8. 发明授权

US6067151A Refractometer 有权
$Refractometer$
标题翻译：折射仪
公开(公告)号：US6067151A
公开(公告)日：2000-05-23
申请号：US206371
申请日：1998-12-07
申请人： Harri Salo
发明人： Harri Salo
IPC分类号： G01N21/43 , G01N21/41
CPC分类号： G01N21/4133
摘要： A refractometer, comprising a light source arranged in a frame structure, an optical window to be positioned in a process solution, means for directing a beam of rays from the light source to an interface between the optical window and the process solution, part of the beam of rays being absorbed partly into the solution and part of it being reflected back from the solution entirely and creating an image, in which the location of a borderline between a light area and a dark area depends on the refractive index of the process solution, and an image detector, by means of which the image created in said manner is observed. To eliminate changing angles of the optical window, the light source, the optical window, the means for directing the beam of rays and the image detector are arranged in a rigid analyser module, which is positioned floatingly inside the frame structure to support on a substantially inelastic sealing arranged between the frame structure and the optical window by pressing the analyser module by spring means against the sealing.
摘要翻译：一种折射计，包括以框架结构布置的光源，待定位在处理溶液中的光学窗口，用于将来自光源的光束引导到光学窗口和处理溶液之间的界面的装置，光束被部分地吸收到溶液中，并且其一部分被完全从溶液反射回来并产生一个图像，其中光区域和暗区域之间的边界位置取决于处理溶液的折射率，以及图像检测器，通过该图像检测器观察以所述方式创建的图像。为了消除光学窗口的变化的角度，光源，光学窗口，用于引导光束的装置和图像检测器被布置在刚性分析器模块中，该分析器模块浮动地位于框架结构内部，以基本上支撑通过用分析器模块通过按压分析器模块抵抗密封而布置在框架结构和光学窗口之间的非弹性密封。

9. 发明授权

US07631569B2 Arrangement for moving measuring head of measuring device into and out of process space 有权
标题翻译：将测量装置测量头移入和移出工艺空间的布置
公开(公告)号：US07631569B2
公开(公告)日：2009-12-15
申请号：US11450386
申请日：2006-06-12
申请人： Harri Salo
发明人： Harri Salo
IPC分类号： G01D11/00
CPC分类号： G01B5/0004 , G01N2001/2057
摘要： An arrangement for moving a measuring head of a measuring device into and out of a process space. The arrangement includes a valve member that is attached to a wall of the process space. A measuring device is attached to the valve member and includes a body part provided with an elongated portion which in turn has a measuring head at one end. The measurement device also includes a placement device arranged to seize the measuring device and to move it through the valve member into a first position in which the measuring head extends into the process space and, correspondingly, into a second position in which the measuring head is not in contact with the process space. The placement device includes a stop element configured to seize the measuring device and to form a sealed casing around the body part of the measuring device, and a housing part arranged to attach to the valve member and to form a sealed casing around the stop element. The placement device is equipped with features that move the stop element seizing the body part of the measuring device inside the housing part so that the measuring device moves between the first position and the second position.
摘要翻译：一种用于将测量装置的测量头移入和移出工艺空间的装置。该装置包括附接到处理空间的壁的阀构件。测量装置附接到阀构件并且包括设置有细长部分的主体部分，细长部分在一端具有测量头。测量装置还包括布置成将测量装置抓住并将其移动通过阀构件的放置装置到第一位置，在第一位置，测量头延伸到处理空间中，并且相应地进入第二位置，其中测量头不与过程空间接触。放置装置包括：止动元件，其构造成抓住测量装置并且围绕测量装置的主体部分形成密封壳体;以及壳体部分，其布置成附接到阀构件并且围绕止动元件形成密封壳体。所述放置装置配备有使所述止动元件将所述测量装置的主体部分卡在所述壳体部内部的特征，使得所述测量装置在所述第一位置与所述第二位置之间移动。

10. 发明申请

US20070051194A1 Arrangement for moving measuring head of measuring device into and out of process space 有权
标题翻译：将测量装置测量头移入和移出工艺空间的布置
公开(公告)号：US20070051194A1
公开(公告)日：2007-03-08
申请号：US11450386
申请日：2006-06-12
申请人： Harri Salo
发明人： Harri Salo
IPC分类号： G01D21/00
CPC分类号： G01B5/0004 , G01N2001/2057
摘要： An arrangement for moving a measuring head of a measuring device into and out of a process space. The arrangement comprises: a valve member to be attached to a wall of the process space; a measuring device to be attached to the valve member, the measuring device comprising a body part provided with an elongated portion which in turn has a measuring head at one end thereof; and a placement device arranged to seize the measuring device and to move it through the valve member into a first position in which the measuring head extends into the process space and, correspondingly, into a second position in which the measuring head is not in contact with the process space. The placement device comprises a stop element configured to seize the measuring device and to form a sealed casing around the body part of the measuring device, and a housing part arranged to attach to the valve member and to form a sealed casing around the stop element. The placement device is equipped with means for moving the stop element seizing the body part of the measuring device inside the housing part in such a manner that the measuring device moves between the first position and the second position.
摘要翻译：一种用于将测量装置的测量头移入和移出工艺空间的装置。该装置包括：阀构件，其附接到处理空间的壁; 测量装置，其附接到所述阀构件，所述测量装置包括主体部分，所述主体部分设置有细长部分，所述细长部分在其一端依次具有测量头; 以及放置装置，布置成抓住测量装置并将其移动通过阀构件进入第一位置，在第一位置，测量头延伸到处理空间中，并且相应地进入到测量头不与其接触的第二位置过程空间。所述放置装置包括：止动元件，其构造成抓住所述测量装置并且围绕所述测量装置的主体部分形成密封壳体;以及壳体部件，其布置成附接到所述阀构件并且围绕所述止动元件形成密封壳体。该放置装置具有用于使止动元件以使得测量装置在第一位置和第二位置之间移动的方式将止动元件移动到使壳体部分内部的测量装置的主体部分移动的装置。

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