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1. 发明授权

US06584782B2 Method for producing particulate goods 有权
标题翻译：生产颗粒物的方法
公开(公告)号：US06584782B2
公开(公告)日：2003-07-01
申请号：US10182715
申请日：2002-08-08
申请人： Hans Leuenberger , Armin Karl Theodor Prasch , Bernhard Luy
发明人： Hans Leuenberger , Armin Karl Theodor Prasch , Bernhard Luy
IPC分类号： F25D1702
CPC分类号： F26B3/08 , B01J2/16 , F26B5/065
摘要： In the method for producing a particulate material (58) from an at least partially liquid material (35) containing a solvent and/or dispersant, this material (35) is atomized in a process chamber (21) into droplets which are frozen to particles (131) by contact with a freezing fluid. The particles (131) are then dried by freeze-drying in the or in another process chamber (22) having a filter (18) at the top. For the freeze-drying, cooled process gas is passed upward from below through the process chamber (22) and through the filter (18) in such a way that at least a substantial part of the particles (131) rest against the filter (18) at least for a substantial part of the freeze-drying taking place in the process chamber (22). This makes it possible to dry a batch of particles (131) in a short time.
摘要翻译：在从含有溶剂和/或分散剂的至少部分液体材料（35）生产颗粒材料（58）的方法中，将该材料（35）在处理室（21）中雾化成液滴，冷冻至颗粒（131）通过与冷冻液接触。然后通过在顶部具有过滤器（18）的另一处理室（22）中冷冻干燥颗粒（131）。对于冷冻干燥，冷却的工艺气体从下方通过处理室（22）并通过过滤器（18），使得至少大部分颗粒（131）抵靠过滤器（18））至少大部分在处理室（22）中发生的冷冻干燥。这使得可以在短时间内干燥一批颗粒（131）。

2. 发明授权

US4756481A Apparatus for spraying a flowable mass and including an airless spray gun 失效
标题翻译：用于喷射可流动物料并包括无气喷枪的装置
公开(公告)号：US4756481A
公开(公告)日：1988-07-12
申请号：US933976
申请日：1986-11-24
申请人： Hans Leuenberger
发明人： Hans Leuenberger
IPC分类号： B05B9/01 , B05B7/04 , B05B9/08 , B05B9/04
CPC分类号： B05B9/0426 , B05B9/0861
摘要： The mass to be sprayed by the spray gun is stored in an airtight closed storage container. A cushion of pressurized air is generated above the level of the paint mass present in the storage container. This air cushion is fed by means of a manually operated piston pump projecting into the storage container. Accordingly, the mass to be sprayed and fed via the feed line extending to the spray gun is pressurized. Conclusively the feed line can be designed with a longer dimension, the mass to be sprayed can be more viscous and the distance in height between storage container and spray gun can be much larger.
摘要翻译：由喷枪喷洒的质量被储存在密闭的密闭储存容器中。在存储容器中存在的油漆质量的高度上产生加压空气缓冲垫。该气垫通过突出到储存容器中的手动活塞泵进给。因此，通过延伸到喷枪的供给管线被喷射和供给的质量被加压。最后，进料管线可以设计成具有更长的尺寸，待喷涂的质量可以更粘稠，并且储存容器和喷枪之间的高度距离可以大得多。

3. 发明申请

US20050287208A1 Cross-linked powered/microfibrillated cellulose II 审中-公开
标题翻译：交联动力/微纤化纤维素II
公开(公告)号：US20050287208A1
公开(公告)日：2005-12-29
申请号：US11159527
申请日：2005-06-22
申请人： Vijay Kumar , Maria De La Reus Medina , Hans Leuenberger
发明人： Vijay Kumar , Maria De La Reus Medina , Hans Leuenberger
IPC分类号： A61K9/20 , A61K47/38 , C08B5/00 , C08B15/10
CPC分类号： A61K47/38 , A61K9/2054 , C08B15/10
摘要： A new cellulose excipient, UICEL-XL, suitable for use as a binder, filler, and/or disintegrant in the development of solid dosage forms is described. UICEL-XL incorporates a cross-linking agent which provides the excipient with a high degree of crystallinity, high water affinity, and a high specific surface area, thus providing good disintegration properties. UICEL-XL, however, also has the unique distinction of being an effective binder due to its high tensile strength.
摘要翻译：描述了适合用作固体剂型开发中的粘合剂，填料和/或崩解剂的新型纤维素赋形剂UICEL-XL。 UICEL-XL包含交联剂，其赋予赋形剂高结晶度，高亲水性和高比表面积，从而提供良好的崩解性能。然而，由于其高抗拉强度，UICEL-XL也具有作为有效粘合剂的独特区别。

4. 发明授权

US4926514A Method of and apparatus for removing stains from soiled areas of a plannar textile article 失效
标题翻译：从平纹织物制品的污染区域去除污渍的方法和设备
公开(公告)号：US4926514A
公开(公告)日：1990-05-22
申请号：US299474
申请日：1989-01-18
申请人： Hans Leuenberger
发明人： Hans Leuenberger
IPC分类号： D06B5/08 , D06F43/00
CPC分类号： D06F43/002
摘要： The area which is to be cleaned is intially subjected to a pulsating jet of a liquid which penetrates through the area and which liquid contains a cleaning agent. Thereafter the area is rinsed by a pulsating jet of water which also penetrates through the area. Accordingly, the dirt gets dissolved and a mechanical working of the respective area is achieved simultaneously with a rinsing away of the dirt. Immediately thereafter the now wet area is penetrated by a hot pressurized air jet such to achieve a driving away of the dampness and accordingly a complete drying. If necessary, above sequence is repeated. Due to the speedy drying a forming of rings at the cleaned area is prevented and it is immediately possible to see if a visually complete cleaning has been achieved.
摘要翻译：待清洁的区域直接受到穿透该区域的液体的脉动射流，哪种液体含有清洁剂。此后，该区域通过也穿过该区域的脉动喷射水冲洗。因此，污物变得溶解，并且与污物的漂洗同时实现各个区域的机械加工。此后，现在的湿润区域立即被热的加压空气喷射穿透，从而实现了潮湿的驱逐，并因此完全干燥。如有必要，重复上述顺序。由于快速干燥，防止在清洁区域形成环，并且立即可以看到是否已经实现了目视完整的清洁。

5. 发明授权

US4812407A Membrane, system and process for testing substance diffusion through the membrane and method for making the membrane 失效
标题翻译：通过膜测试物质扩散的膜，系统和方法以及制造膜的方法
公开(公告)号：US4812407A
公开(公告)日：1989-03-14
申请号：US038285
申请日：1987-04-14
申请人： Stephan Buchmann , Hans Leuenberger , Claudia Reinke
发明人： Stephan Buchmann , Hans Leuenberger , Claudia Reinke
IPC分类号： G01N13/00 , C12M1/34 , C12M3/06 , G01N33/15
CPC分类号： C12M25/02 , B01D63/087 , B01D69/10 , B01D71/42
摘要： The system for testing the diffusion behavior of a substance comprises a donor compartment detachably mounted on a holding member of a rotor, rotatably around a vertical axis, said donor compartment being bounded at its bottom by a membrane effective to separate the donor compartment from an acceptor compartment. The membrane comprises a flexible carrier of a bio-compatible, lifeless, light permeable material, on which cells constituting a monocellular layer have been cultivated, for example. By determining the time dependent variation of the quantity of a substance passing through the membrane by diffusion, it is possible to determine the coefficient of diffusion and/or the coefficient of permeability of the membrane and of the cell culture provided thereon. By suitable selection of the cells, conditions may be created that closely resemble those that occur during the absorption of the respective substance through the biophase of a living organism.
摘要翻译：用于测试物质的扩散行为的系统包括可拆卸地安装在转子的保持构件上的供体腔，其围绕垂直轴线可旋转，所述供体室在其底部由有效地将供体隔室与受体分隔开的膜隔间膜包括生物相容性，无生命的透光材料的柔性载体，在其上培养构成单细胞层的细胞。通过通过扩散确定通过膜的物质的量的时间依赖性变化，可以确定膜及其上提供的细胞培养物的扩散系数和/或渗透系数。通过细胞的适当选择，可以产生与通过生物体的生物相吸收相应物质期间发生的条件非常相似的条件。

6. 发明授权

US4656056A Process of treating a particulate material and apparatus for implementing the process 失效
标题翻译：处理颗粒物质的方法和实施该方法的装置
公开(公告)号：US4656056A
公开(公告)日：1987-04-07
申请号：US735265
申请日：1985-05-17
申请人： Hans Leuenberger
发明人： Hans Leuenberger
IPC分类号： B01J2/00 , B01J2/12 , B01J2/16 , B05D1/00
CPC分类号： B01J2/003 , B01J2/00 , B01J2/12 , B01J2/16
摘要： A particulate material containing particles to be agglomerated and/or provided with a coating is introduced in batches into a space bounded by a container, in which a gas, in particular air, is passed through the particles. The particles are set in motion, for instance by the gas, such as in whirling motion, to form a whirling, layer. The particles are wetted by means of a mixture consisting of a gas and the vapor of a wetting agent. This mixture is introduced into the space containing the particles, and cold gas and a mixture of warm gas and wetting agent are supplied for example, alternately. In this manner, the particles may be wetted uniformly and relatively fast, and held at a relatively low temperature. This is of considerable advantage when processing thermolabile materials.
摘要翻译：含有要团聚和/或提供涂层的颗粒的颗粒材料分批地被引入由容器中限定的空间中，其中气体，特别是空气通过该颗粒。颗粒被运动，例如通过气体，例如旋转运动，以形成旋转层。颗粒通过由气体和润湿剂的蒸气组成的混合物润湿。将该混合物引入到含有颗粒的空间中，并且例如交替地提供冷气体和暖气和润湿剂的混合物。以这种方式，可以使颗粒均匀且相对较快地润湿并保持在较低的温度。这在处理不耐热材料时具有相当大的优势。

7. 发明授权

US4608764A Process of drying a particulate material and apparatus for implementing the process 失效
标题翻译：干燥颗粒材料的过程和用于实施该方法的设备
公开(公告)号：US4608764A
公开(公告)日：1986-09-02
申请号：US735264
申请日：1985-05-17
申请人： Hans Leuenberger
发明人： Hans Leuenberger
IPC分类号： F26B3/06 , F26B3/08 , F26B5/06 , F26B11/14 , F26B11/18 , F26B17/10 , F26B13/30
CPC分类号： F26B11/181 , F26B11/14 , F26B3/08 , F26B5/06
摘要： The particles of the particulate material to be dried are cooled before the drying operation proper, or in the initial phase thereof, to a temperature low enough to make the liquid to be extracted solidify. At least the drying operation proper is carried out in a space bounded by a container, in which a gas, more particularly air, is passed through the particles. While in said space, the particles are subjected to motion, for example, they are whirled by the gas to form a whirling layer. The temperature of the gas is adjusted to have at least a considerable part of the drying operation take place by sublimation, the heat energy required for the sublimiation being supplied to the particles at least in part by the gas passed through them. In this way, the particulate material may be dried with care and nevertheless in relatively large batches, and with limited time expenditure.
摘要翻译：要干燥的颗粒材料的颗粒在干燥操作适当之前或其初始阶段被冷却到足够低的温度以使待提取的液体固化。至少干燥操作适用于由容器限定的空间中，其中气体，更特别是空气通过该颗粒。在所述空间中，颗粒受到运动，例如，它们被气体旋转以形成旋转层。气体的温度被调节为至少相当大一部分通过升华进行干燥操作，升华所需的热能至少部分地由通过它们的气体提供给颗粒。以这种方式，颗粒材料可以小心地干燥，然而以相对较大的批次和有限的时间花费来干燥。

8. 发明申请

US20110014024A1 METHOD AND DEVICE FOR CONTINUOUSLY JOINING AT LEAST TWO IMBRICATED FLOWS OF FLAT PRINTED PRODUCTS 审中-公开
标题翻译：用于连续地连接平面印刷产品的至少两个不平衡流的方法和装置
公开(公告)号：US20110014024A1
公开(公告)日：2011-01-20
申请号：US12838219
申请日：2010-07-16
申请人： Hans Leuenberger , Iwan Iseli
发明人： Hans Leuenberger , Iwan Iseli
IPC分类号： B65H29/66
CPC分类号： B65H29/6681 , B65H2404/2613
摘要： A method for continuously joining at least two imbricated flows of flat printed products which are conveyed at equal speeds and spaced from one another, the method includes initially offsetting a first imbricated flow of flat printed products relative to a second imbricated flow of flat printed products so as to form a first lateral overlapping area of both imbricated flows, continuously lifting the printed products of both imbricated flows in the first lateral overlapping area until the lateral overlapping is eliminated, and lowering or dropping the printed products of both imbricated flows in the raised lateral overlapping area, so that partially a printed product of the first imbricated or the second imbricated flow comes to rest above the first or second imbricated flows above a printed product of the respectively other imbricated flow, whereby a single imbricated flow with a second overlapping area of the printed products is formed.
摘要翻译：一种用于连续地连接至少两个以相等的速度和相互间隔地输送的扁平印刷产品的流动的方法，所述方法包括首先相对于第二平坦印刷产品的流动首先偏移平面印刷产品的第一渗透流，因此为了形成两个流动的第一横向重叠区域，连续提升第一横向重叠区域中的两个渗透流的印刷产品，直到消除横向重叠，并且将两个渗透流的印刷产品降低或降低使得部分地第一渗透流体或第二渗透流体的印刷产品停留在位于相应的其它渗透流体的印刷产品上方的第一或第二渗透流体上方，由此单个填充流体具有第二重叠区域形成印刷品。

9. 发明授权

US5370635A Device for delivering a medicament 失效
标题翻译：用于递送药物的装置
公开(公告)号：US5370635A
公开(公告)日：1994-12-06
申请号：US122492
申请日：1993-09-30
申请人： Sabina Strausak , Hans Leuenberger
发明人： Sabina Strausak , Hans Leuenberger
IPC分类号： A61M37/00 , A61K9/70 , A61M5/00 , A61K9/22
CPC分类号： A61K9/7023
摘要： A device for delivering a medicament has a membrane (7) with at least one permeable area (7b) permeable to the medicament and a reservoir space (25) which contains a solvent and the medicament at least partially dissolved therein, An adjustable and/or deformable control element (7) is disposed on the side of the membrane (7) facing the reservoir space (25) with which the access of the medicament from the reservoir space (25) to at least one permeable area (7b) of the membrane (7) can be changed. In addition an electronic device (37) is provided with which the control element (17) can be automatically controlled via a motor (37). The device permits the periodic alteration of the delivery rate of the medicament which is advantageous in many cases.
摘要翻译：用于递送药物的装置具有膜（7），其具有可渗透药物的至少一个可渗透区域（7b）和容纳溶剂的储存空间（25），并且药物至少部分地溶解在其中。可调整和/或可变形控制元件（7）设置在面向储存空间（25）的膜（7）侧面上，药物从储存空间（25）进入至膜的至少一个可渗透区域（7b）（7）可以改变。此外，设置有电子装置（37），控制元件（17）可以经由马达（37）自动控制。该装置允许定期改变药物的输送速率，这在许多情况下是有利的。

10. 发明授权

US4895733A Method and system for agglomerating particles and/or for coating particles 失效
标题翻译：聚集颗粒和/或涂覆颗粒的方法和系统
公开(公告)号：US4895733A
公开(公告)日：1990-01-23
申请号：US194988
申请日：1988-05-05
申请人： Georgios Imanidis , Hans Leuenberger , Reinhard Nowak , Jurg M. Studer , Stefan Winzap
发明人： Georgios Imanidis , Hans Leuenberger , Reinhard Nowak , Jurg M. Studer , Stefan Winzap
IPC分类号： B01J2/14 , A23P1/02 , B01J2/00 , B01J2/16 , B01J8/00
CPC分类号： B01J2/16 , B01J2/14 , Y10S118/05
摘要： A vessel (1) contains a rotor disc (23) mounted for rotation around a vertical axis (17) and arranged to bound a processing space (31) disposed above it. The agglomeration and/or the coating of particles are accomplished by moving the particles by the rotation of the rotor disc (23) and by means of a gas, in particular air, passed upwardly through the processing space (31) and by spraying them with a liquid. The torque required for the rotation of the rotor disc (23) is continuously measured by means of a torque measuring member (75) disposed between the rotor disc (23) and the drive device (77) arranged to drive the same. The agglomeration and/or the coating operation is controlled on the basis of the time-dependent variation of the torque and/or of the first derivative of the same, and/or of a variable having relation to the torque and/or its derivative. In this way, agglomerated particles and/or particles provided with a coat may be produced, the particles possessing relatively accurately prescribed properties, such as for example particle sizes lying within a prescribed range.
摘要翻译： PCT No.PCT / CH87 / 00114 Sec。 371日期：1988年5月5日 102（e）日期1988年5月5日PCT提交1987年9月8日PCT公布。出版物WO88 / 01904 日期为1988年3月24日。容器（1）包含转子盘（23），转子盘（23）安装成围绕垂直轴线（17）旋转并且布置成结合设置在其上方的处理空间（31）。颗粒的聚集和/或涂层是通过转子盘（23）的旋转和通过气体（特别是空气）向上通过处理空间（31）并通过将它们喷洒在液体。通过设置在转子盘（23）和驱动装置（77）之间的扭矩测量构件（75）连续地测量转子盘（23）旋转所需的扭矩。基于扭矩和/或其一阶导数和/或与扭矩和/或其衍生物有关的变量的时间依赖性变化来控制凝聚和/或涂覆操作。以这种方式，可以产生具有涂层的附聚颗粒和/或颗粒，所述颗粒具有相对准确的规定性质，例如粒径在规定范围内。

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