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1. 发明授权

US09439997B2 Reinforced absorbable multilayered hemostatis wound dressing 有权
公开(公告)号：US09439997B2
公开(公告)日：2016-09-13
申请号：US11400849
申请日：2006-04-10
申请人： Anne Jessica Gorman , Sanyog Manohar Pendharkar , Guanghui Zhang , Liliana Bar , Israel Nur , Roberto Meidler
发明人： Anne Jessica Gorman , Sanyog Manohar Pendharkar , Guanghui Zhang , Liliana Bar , Israel Nur , Roberto Meidler
IPC分类号： A61L15/00 , A61L15/26 , A61L15/28 , A61L15/32 , A61L15/44 , A61L15/64 , B32B5/02 , B32B5/26 , B32B23/02 , B32B23/10 , B32B27/36
CPC分类号： A61L15/26 , A61F13/00029 , A61L15/28 , A61L15/32 , A61L15/44 , A61L15/64 , A61L2300/418 , A61L2300/608 , A61L2400/04 , B32B5/022 , B32B5/024 , B32B5/026 , B32B5/26 , B32B23/02 , B32B23/10 , B32B27/36 , B32B2250/20 , B32B2262/0276 , B32B2262/04 , B32B2262/06 , B32B2262/062 , B32B2307/726 , B32B2556/00 , Y10T442/2525 , C08L67/04
摘要： The present invention is directed to a reinforced absorbable multilayered hemostatic wound dressing comprising a first absorbable nonwoven fabric, a second absorbable woven or knitted fabric, thrombin and/or fibrinogen.

2. 发明申请

US20140031788A1 RIGID REINFORCING EXOSKELETAL SLEEVE FOR DELIVERY OF FLOWABLE BIOCOMPATIBLE MATERIALS 审中-公开
标题翻译：用于输送可流动的生物成分材料的刚性增强弹性套管
公开(公告)号：US20140031788A1
公开(公告)日：2014-01-30
申请号：US13556790
申请日：2012-07-24
申请人： An-Min Jason Sung , Dennis D. Jamiolkowski , Guanghui Zhang
发明人： An-Min Jason Sung , Dennis D. Jamiolkowski , Guanghui Zhang
IPC分类号： A61M25/02 , A61B17/34
CPC分类号： A61M5/1414 , A61B17/00491 , A61B17/34 , A61B17/3415 , A61B2017/00331 , A61B2017/00469 , A61B2017/3405 , A61B2017/347 , A61M5/1424 , A61M25/02 , A61M2005/1416
摘要： Exoskeletal devices or sleeves that can be used with the delivery tube of an applicator device to help dispense fluids, typically flowable biocompatible materials such as hemostatic agents, adhesives, or sealants, onto specific sites in the human body for a medical reason are disclosed.The exoskeletal devices or sleeves are rigid, pre-shaped, and snappably or slidably affixed to the delivery tube. The exoskeletal devices or sleeves do not come into contact with the flowable biocompatible fluid being dispensed, and they can be placed at any position along the delivery tube to address different application situations. Once the exoskeletal device or sleeve is in place, it can optionally be locked onto the delivery tube to prevent further sliding under stresses when pushed against tissue. Multiple exoskeletal devices or sleeves can also be used to achieve more complicated shapes for hard-to-reach anatomical sites.
摘要翻译：公开了可以与敷贴器装置的输送管一起使用的外骨骼装置或套筒，以帮助将液体（通常是可流动的生物相容性材料，例如止血剂，粘合剂或密封剂）分配到人体的特定部位，用于医学原因。外骨骼装置或套筒是刚性的，预成形的，并且可滑动地或可滑动地固定到输送管。外骨骼装置或套管不会与正在分配的可流动的生物相容性流体接触，并且它们可以放置在沿输送管的任何位置以解决不同的应用情况。一旦外骨骼装置或套筒就位，它可以可选地被锁定在输送管上，以防止在压在组织上时在应力下的进一步滑动。还可以使用多个外骨骼装置或袖子来实现难以到达的解剖部位的更复杂的形状。

3. 发明授权

US08119160B2 Hemostatic compositions and devices 有权
标题翻译：止血组合物和装置
公开(公告)号：US08119160B2
公开(公告)日：2012-02-21
申请号：US11078049
申请日：2005-03-11
申请人： Dwayne Lee Looney , Guanghui Zhang , Sonia Martins
发明人： Dwayne Lee Looney , Guanghui Zhang , Sonia Martins
IPC分类号： A61K9/16 , B01D39/00 , B01D15/00
CPC分类号： A61L24/104 , A61L24/0036 , A61L24/102
摘要： The present inventions includes a plurality of packed particles that contain interstitial pores, where the interstitial pores have a pore volume and a median pore diameter effective to provide improved absorption of physiological fluids or an aqueous media when placed in contact therewith, compared to a plurality of unpacked particles of the same material, where the particles are made of a biocompatible material and hemostatic agents and have an average diameter suitable for use in providing hemostasis to a site of a body of a mammal requiring hemostasis, hemostatic compositions containing such plurality of packed particles, methods of making such particles and compositions and medical devices suitable for delivering and containing the hemostatic plurality of particles and/or composition to a site of a body.
摘要翻译：本发明包括多个包含间质孔的填充颗粒，其中间隙孔具有孔容积和中值孔径，其有效地提供改善的生理流体吸收或与其接触时的水性介质，与多个相同材料的未包装的颗粒，其中颗粒由生物相容性材料和止血剂制成，并且具有适合用于向要求止血的哺乳动物的身体的部位提供止血的平均直径，含有这种多个包装颗粒的止血组合物制备这种颗粒和组合物的方法以及适于将止血多个颗粒和/或组合物输送并包含在身体部位的医疗装置。

4. 发明授权

US07927626B2 Process of making flowable hemostatic compositions and devices containing such compositions 有权
标题翻译：制备可流动止血组合物和含有这种组合物的装置的方法
公开(公告)号：US07927626B2
公开(公告)日：2011-04-19
申请号：US10896454
申请日：2004-07-21
申请人： Sanyog M. Pendharkar , Anne J. Gorman , Dwayne. Lee Looney , Guanghui Zhang , Ada Rivera
发明人： Sanyog M. Pendharkar , Anne J. Gorman , Dwayne. Lee Looney , Guanghui Zhang , Ada Rivera
IPC分类号： A61K9/14 , C12N9/74 , C12Q1/56 , A01N37/18
CPC分类号： A61K9/0019 , A61K9/10 , A61K9/19 , A61K38/36 , A61K38/363 , A61K38/39 , A61K38/4833 , A61K47/36 , A61K47/42 , A61L24/104 , A61L24/108 , A61L26/0028 , A61L26/0042 , A61L26/0095 , A61L2400/04 , C12N9/6429 , C12Y304/21005
摘要： The present invention is directed to processes of making flowable hemostatic compositions and devices that include the flowable hemostatic composition disposed therein, where a volume of a biocompatible liquid, a volume of a biocompatible gas, and an amount of solid particles of a biocompatible polymer are mixed together to form a substantially homogenous composition including a discontinuous gas phase and the solid particles substantially homogenously dispersed throughout a continuous liquid phase to form a flowable hemostatic composition, and the composition then transferred into a device suitable for applying the flowable hemostatic composition to a site of a body requiring hemostasis under conditions effective to maintain the substantially homogeneous dispersion of the gas phase and the solid particles throughout the liquid phase.
摘要翻译：本发明涉及制备可流动止血组合物和装置的方法，其包括设置在其中的可流动止血组合物，其中生物相容性液体的体积，生物相容性气体的体积和生物相容性聚合物的固体颗粒的量混合一起形成基本上均匀的组合物，其包括不连续气相，并且固体颗粒基本均匀地分散在整个连续液相中以形成可流动的止血组合物，然后将组合物转移到适于将可流动止血组合物施用于在有效维持气相和固体颗粒在整个液相中的基本上均匀分散的条件下需要止血的身体。

5. 发明申请

US20080260810A1 Hemostat 审中-公开
标题翻译：止血剂
公开(公告)号：US20080260810A1
公开(公告)日：2008-10-23
申请号：US11577207
申请日：2005-10-17
申请人： Guanghui Zhang , Sonia Martins , Robin Barone
发明人： Guanghui Zhang , Sonia Martins , Robin Barone
IPC分类号： A61F13/00 , A61L15/38
CPC分类号： A61L15/26 , A61F13/00029 , A61L15/28 , A61L15/32 , A61L15/44 , A61L15/64 , A61L2300/418 , A61L2300/608 , A61L2400/04 , B32B5/022 , B32B5/024 , B32B5/026 , B32B5/26 , B32B23/02 , B32B23/10 , B32B27/36 , B32B2250/20 , B32B2262/0276 , B32B2262/04 , B32B2262/06 , B32B2262/062 , B32B2307/726 , B32B2556/00 , Y10T442/2525 , C08L67/04
摘要： The present invention is directed towards a hemostat comprising an absorbable foam, an absorbable woven or knitted fabric, thrombin and/or fibrinogen.
摘要翻译：本发明涉及包含可吸收泡沫，可吸收织造或针织物，凝血酶和/或纤维蛋白原的止血剂。

6. 发明授权

US07019191B2 Hemostatic wound dressings and methods of making same 有权
标题翻译：止血伤口敷料及其制作方法
公开(公告)号：US07019191B2
公开(公告)日：2006-03-28
申请号：US10396224
申请日：2003-03-25
申请人： Dwayne Lee Looney , John Crilley , Jian Xin Guo , Guanghui Zhang , Sanyog Manohar Pendharkar
发明人： Dwayne Lee Looney , John Crilley , Jian Xin Guo , Guanghui Zhang , Sanyog Manohar Pendharkar
IPC分类号： A61F13/00
CPC分类号： A61L15/425 , A61L15/28 , A61L2400/04
摘要： The present invention is directed to methods of making wound dressings that include the steps of contacting a fabric substrate having properties effective for use as a hemostat and containing fibers prepared from a biocompatible polymer, with a solution of a water-soluble or water-swellable biocompatible polymer under conditions effective to distribute the polymer solution substantially homogenously on and through the fabric substrate, transferring the fabric substrate to a lyophilization unit under conditions effective to maintain the homogeneous distribution on and throughout the substrate, and lyophilizing the fabric having the polymer solution distributed on and there through.
摘要翻译：本发明涉及制造伤口敷料的方法，其包括以下步骤：使具有有效用作止血剂的性质并且含有由生物相容性聚合物制备的纤维的织物基底与水溶性或水溶胀性生物相容性聚合物在有效地将聚合物溶液基本上均匀地分布在织物基底上并且通过织物基底的条件下，在有效保持基底上和整个基底上的均匀分布的条件下将织物基底转移到冻干单元，并且将具有聚合物溶液分布的织物冻干并通过。

7. 发明授权

US06958223B2 Methods for producing extracellular matrix proteins 失效
标题翻译：生产细胞外基质蛋白的方法
公开(公告)号：US06958223B2
公开(公告)日：2005-10-25
申请号：US10104889
申请日：2002-03-22
申请人： Elliott A. Gruskin , Douglas D. Buechter , Guanghui Zhang , Kevin Connelly
发明人： Elliott A. Gruskin , Douglas D. Buechter , Guanghui Zhang , Kevin Connelly
IPC分类号： C07K14/47 , C07K14/495 , C07K14/51 , C07K14/75 , C07K14/78 , C12N1/21 , C12N15/12 , C12P21/02 , C12P21/00 , C07H21/02
CPC分类号： C07K14/75 , C07K14/4725 , C07K14/495 , C07K14/51 , C07K14/78 , C07K2319/00 , C12P21/02
摘要： Incorporation of certain amino acid analogs into polypeptides produced by cells which do not ordinarily provide polypeptides containing such amino acid analogs is accomplished by subjecting the cells to growth media containing such amino acid analogs. The degree of incorporation can be regulated by adjusting the concentration of amino acid analogs in the media and/or by adjusting osmolality of the media. Such incorporation allows the chemical and physical characteristics of polypeptides to be altered and studied. In addition, nucleic acid and corresponding proteins including a domain from a physiologically active peptide and a domain from an extracellular matrix protein which is capable of providing a self-aggregate are provided. Human extracellular matrix proteins capable of providing a self-aggregate collagen are provided which are produced by prokaryotic cells. Preferred codon usage is employed to produce extracellular matrix proteins in prokaryotics.
摘要翻译：将某些氨基酸类似物掺入由通常不提供含有这种氨基酸类似物的多肽的细胞产生的多肽中，是通过使细胞经受含有这种氨基酸类似物的生长培养基来完成的。可以通过调节培养基中氨基酸类似物的浓度和/或通过调节培养基的重量摩尔渗透压浓度来调节掺入程度。这种结合允许改变和研究多肽的化学和物理特性。此外，提供了核酸和相应的蛋白质，包括来自生理活性肽的结构域和能够提供自聚集体的细胞外基质蛋白的结构域。提供能够提供自身骨胶原蛋白的人细胞外基质蛋白，其由原核细胞产生。使用优选的密码子用于在原核生物中产生细胞外基质蛋白。

8. 发明授权

US06927287B1 Nucleic acid encoding extracellular matrix protein or fragment thereof 失效
标题翻译：核酸编码细胞外基质蛋白或其片段
公开(公告)号：US06927287B1
公开(公告)日：2005-08-09
申请号：US10153469
申请日：2002-05-22
申请人： Elliott A. Gruskin , Douglas D. Buechter , Guanghui Zhang , Kevin Connelly
发明人： Elliott A. Gruskin , Douglas D. Buechter , Guanghui Zhang , Kevin Connelly
IPC分类号： C07K14/51 , C07K14/78 , C12N1/21 , C12P21/02 , C07H21/02 , C07K14/435 , C12Q21/04
CPC分类号： C12P21/02 , C07K14/51 , C07K14/78 , C07K2319/00
摘要： Incorporation of certain amino acid analogs into polypeptides produced by cells which do not ordinarily provide polypeptides containing such amino acid analogs is accomplished by subjecting the cells to growth media containing such amino acid analogs. The degree of incorporation can be regulated by adjusting the concentration of amino acid analogs in the media and/or by adjusting osmolality of the media. Such incorporation allows the chemical and physical characteristics of polypeptides to be altered and studied. In addition, nucleic acid and corresponding proteins including a domain from a physiologically active peptide and a domain from an extracellular matrix protein which is capable of providing a self-aggregate are provided. Human extracellular matrix proteins capable of providing a self-aggregate collagen are provided which are produced by prokaryotic cells. Preferred codon usage is employed to produce extracellular matrix proteins in prokaryotics.
摘要翻译：将某些氨基酸类似物掺入由通常不提供含有这种氨基酸类似物的多肽的细胞产生的多肽中，是通过使细胞经受含有这种氨基酸类似物的生长培养基来完成的。可以通过调节培养基中氨基酸类似物的浓度和/或通过调节培养基的重量摩尔渗透压浓度来调节掺入程度。这种结合允许改变和研究多肽的化学和物理特性。此外，提供了核酸和相应的蛋白质，包括来自生理活性肽的结构域和能够提供自聚集体的细胞外基质蛋白的结构域。提供能够提供自身骨胶原蛋白的人细胞外基质蛋白，其由原核细胞产生。使用优选的密码子用于在原核生物中产生细胞外基质蛋白。

9. 发明授权

US06630167B2 Hyaluronic acid anti-adhesion barrier 有权
公开(公告)号：US06630167B2
公开(公告)日：2003-10-07
申请号：US10036239
申请日：2001-12-28
申请人： Guanghui Zhang
发明人： Guanghui Zhang
IPC分类号： A61K914
CPC分类号： C08B37/0072 , A61F2013/00217 , A61L31/042 , A61L31/146 , A61L31/16 , C08L5/08
摘要： Methods of forming crosslinked hyaluronic acid anti-adhesion barriers, crosslinked hyaluronic acid anti-adhesions barriers, methods for preventing or inhibiting adhesions, and methods of promoting healing of a wound are provided. The method of forming the crosslinked hyaluronic acid anti-adhesion barrier includes freeze-drying a solution including hyaluronic acid to form a hyaluronic acid foam, which is then reacted with a crosslinking agent to form a crosslinked hyaluronic acid foam. The crosslinked hyaluronic acid foam is mixed with a solution containing hyaluronic acid to form an anti-adhesion barrier.

10. 发明授权

US09149511B2 Procoagulant peptides and their derivatives and uses therefor 有权
标题翻译：促凝肽及其衍生物及其用途
公开(公告)号：US09149511B2
公开(公告)日：2015-10-06
申请号：US13173013
申请日：2011-06-30
申请人： Yi-Lan Wang , Guanghui Zhang
发明人： Yi-Lan Wang , Guanghui Zhang
IPC分类号： A61K38/08 , A61K38/17 , A61K38/38 , A61P17/02 , A61K38/39 , A61L24/00 , A61L24/10
CPC分类号： A61L26/0052 , A61K38/39 , A61L24/0015 , A61L24/108 , A61L26/009 , A61L2300/25 , A61L2300/252 , A61L2300/418 , A61L2400/04
摘要： The present invention is directed to a hemostatic or tissue sealing material having (a) a peptide having a sequence SEQ ID NO: 1 or an amino acid analog sequence thereof, and (b) a scaffold for said peptide or amino acid analog sequence. The scaffold is preferably hemostatic, such as a natural or genetically engineered absorbable polymer, a synthetic absorbable polymer, or combinations thereof. The natural or genetically engineered absorbable polymers can be selected from the group consisting of a protein, a polysaccharide, or combinations thereof.
摘要翻译：本发明涉及一种止血或组织密封材料，其具有（a）具有序列SEQ ID NO：1或其氨基酸类似物序列的肽，和（b）所述肽或氨基酸类似物序列的支架。支架优选为止血剂，例如天然或遗传工程可吸收聚合物，合成可吸收聚合物或其组合。天然或遗传工程可吸收聚合物可以选自蛋白质，多糖或其组合。

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