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1. 发明授权

US07091375B2 Method for the production of 2=-keto-l-gulonic acid C4C10 alkyl esters 失效
标题翻译：制备2 =酮-1-古洛糖酸C 4 C 10烷基酯的方法
公开(公告)号：US07091375B2
公开(公告)日：2006-08-15
申请号：US10534334
申请日：2003-11-07
申请人： Thomas Domschke , Martin Merger , Georg Grossmann , Tillmann Faust
发明人： Thomas Domschke , Martin Merger , Georg Grossmann , Tillmann Faust
IPC分类号： C07D305/12
CPC分类号： C07H7/027 , Y02P20/127
摘要： The invention relates to a method for producing 2-keto-L-gulonic acid-C4–C10 alkyl ester by esterifying 2-keto-L-gulonic acid (KGS) with an unsaturated, branched or unbranched C4–C10 alcohol. The inventive method is characterized by the fact that an aqueous KGS solution is reacted with a C4–C10 alcohol up to an esterification degree of 20 to 70 percent in a pre-esterification process carried out under acidic catalysis conditions; and the obtained product is dehydrogenated with an unsaturated, branched or unbranched C4–C10 alcohol in a continuous rectification device, whereby the esterification reaction continues, n-butanol preferably being used as the alkyl alcohol. In a preferred embodiment, the aqueous KGS solution is concentrated up to or beyond the limit of solubility prior to the esterification process, preferably by catalyzing a homogeneous or heterogeneous catalyst, especially sulfonic acid, at temperatures of 50 to 120° C. In another embodiment, the produced KGS ester is reacted in one or several additional steps so as to obtain L-ascorbic acid.
摘要翻译：本发明涉及通过酯化2-酮-L-古洛糖酸（KGS）制备2-酮-L-古洛糖酸-C 4 -C 10烷基酯的方法）与不饱和，支链或非支链C 4 -C 10醇。本发明的方法的特征在于，将KGS水溶液与C 4 -C 10 - 醇反应，直到酯化程度为20至70％在酸性催化条件下进行酯化过程; 并将得到的产物用连续精馏装置中的不饱和支链或非支链C 4 -C 10醇脱氢，由此继续进行酯化反应，正丁醇优选为用作烷基醇。在优选的实施方案中，在酯化过程之前，优选通过在50至120℃的温度下催化均相或多相催化剂，特别是磺酸，将KGS水溶液浓缩至或超过溶解度的极限。在另一个实施方案中，所制备的KGS酯在一个或几个附加步骤中反应，以获得L-抗坏血酸。

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