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1. 发明授权

US08825175B2 Impedance-based stimulation adjustment 有权
标题翻译：基于阻抗的刺激调整
公开(公告)号：US08825175B2
公开(公告)日：2014-09-02
申请号：US13348943
申请日：2012-01-12
申请人： Gary W. King
发明人： Gary W. King
IPC分类号： A61N1/18
CPC分类号： A61N1/36185 , A61N1/08 , A61N1/36521 , A61N1/36535 , G06F19/00
摘要： Techniques for adjusting stimulation are disclosed. A medical device measures an impedance associated with one or more electrodes, e.g., the impedance presented to the medical device by a total electrical circuit that includes the one or more electrodes, the conductors associated with the electrodes, and tissue proximate to the electrodes. The medical device stores at least one patient-specific relationship between impedance and a stimulation parameter, and adjusts the value of the stimulation parameter based on the measured impedance according to the relationship. The medical device may store multiple relationships, and select one the relationships based on, for example, an activity level of the patient, posture of the patient, or a current stimulation program or electrode combination used to deliver stimulation. By adjusting a stimulation parameter, such as amplitude, according to such a relationship, the stimulation intensity as perceived by the patient may be kept substantially constant.
摘要翻译：公开了用于调节刺激的技术。医疗设备测量与一个或多个电极相关联的阻抗，例如通过包括一个或多个电极，与电极相关联的导体和靠近电极的组织的总电路呈现给医疗装置的阻抗。医疗装置存储阻抗和刺激参数之间的至少一个患者特异性关系，并且根据关系根据所测量的阻抗来调整刺激参数的值。医疗设备可以存储多个关系，并且基于例如患者的活动水平，患者的姿势或用于递送刺激的当前刺激程序或电极组合来选择一个关系。通过根据这样的关系调整诸如振幅的刺激参数，可以将患者感觉到的刺激强度保持基本上恒定。

2. 发明授权

US08798759B2 User interface with toolbar for programming electrical stimulation therapy 有权
标题翻译：用户界面，用于编程电刺激治疗工具栏
公开(公告)号：US08798759B2
公开(公告)日：2014-08-05
申请号：US11999722
申请日：2007-12-06
申请人： Steven M. Goetz , Jeffrey T. Keacher , Rajeev Sahasrabudhe , Wende L. Dewing , Jon P. Davis , John Rondoni , Gabriela C. Miyazawa , Gary W. King
发明人： Steven M. Goetz , Jeffrey T. Keacher , Rajeev Sahasrabudhe , Wende L. Dewing , Jon P. Davis , John Rondoni , Gabriela C. Miyazawa , Gary W. King
IPC分类号： A61N1/00
CPC分类号： A61N1/37247 , A61N1/36185
摘要： The disclosure is directed to a user interface with a menu that facilitates stimulation therapy programming. The user interface displays a representation of the electrical leads implanted in the patient and at least one menu with icons that the user can use to adjust the stimulation therapy. The user may drag one or more field shapes from a field shape selection menu onto the desired location relative to the electrical leads. A manipulation tool menu may also allow the user to adjust the field shapes placed on the electrical leads, which represent the stimulation region. The programmer that includes the user interface then generates electrical stimulation parameter values for the stimulator to deliver stimulation according to the field shapes or field shape groups defined/located by the user. The field shapes may represent different types of stimulation representations, such as current density, activation functions, and neuron models.
摘要翻译：本公开针对具有促进刺激治疗编程的菜单的用户界面。用户界面显示植入患者中的电引线的表示以及具有用户可用于调整刺激疗法的图标的至少一个菜单。用户可以将一个或多个场形状从场形选择菜单拖到相对于电引线的期望位置上。操作工具菜单还可以允许用户调整放置在电引线上的场形状，其代表刺激区域。包括用户界面的程序员然后产生刺激器的电刺激参数值，以根据由用户定义/定位的场形状或场形组递送刺激。场形状可以表示不同类型的刺激表示，例如电流密度，激活函数和神经元模型。

3. 发明授权

US08738145B2 Shifting between electrode combinations in electrical stimulation device 有权
公开(公告)号：US08738145B2
公开(公告)日：2014-05-27
申请号：US13251925
申请日：2011-10-03
申请人： Steven M. Goetz , Andrew H. Houchins , Jeffrey T. Keacher , Gary W. King , Kenneth T. Heruth , Roy L. Testerman , Michael T. Lee , Nathan A. Torgerson , Joseph J. Nolan
发明人： Steven M. Goetz , Andrew H. Houchins , Jeffrey T. Keacher , Gary W. King , Kenneth T. Heruth , Roy L. Testerman , Michael T. Lee , Nathan A. Torgerson , Joseph J. Nolan
IPC分类号： A61N1/08 , A61N1/372
CPC分类号： A61N1/37247 , A61N1/36071 , A61N1/36185 , A61N1/37252
摘要： The disclosure is directed to techniques for shifting between two electrode combinations. An amplitude of a first electrode combination is incrementally decreased while an amplitude of a second, or subsequent, electrode combination is concurrently incrementally increased. Alternatively, an amplitude of the first electrode combination is maintained at a target amplitude level while the amplitude of the second electrode combination is incrementally increased. The stimulation pulses of the electrode combinations are delivered to the patient interleaved in time. In this manner, the invention provides for a smooth, gradual shift from a first electrode combination to a second electrode combination, allowing the patient to maintain a continual perception of stimulation. The shifting techniques described herein may be used during programming to shift between different electrode combinations to find an efficacious electrode combination. Additionally, the techniques may be used for shifting between different electrode combinations associated with different stimulation programs or program sets.

4. 发明授权

US08644941B2 Peripheral nerve field stimulation and spinal cord stimulation 有权
标题翻译：外周神经刺激和脊髓刺激
公开(公告)号：US08644941B2
公开(公告)日：2014-02-04
申请号：US11450144
申请日：2006-06-09
申请人： Ethan A. Rooney , Carl D. Wahlstrand , Gary W. King , Thomas E. Cross, Jr. , Jeffrey S. Evanson , Kenneth T. Heruth , Paul W. Wacnik
发明人： Ethan A. Rooney , Carl D. Wahlstrand , Gary W. King , Thomas E. Cross, Jr. , Jeffrey S. Evanson , Kenneth T. Heruth , Paul W. Wacnik
IPC分类号： A61N1/34
CPC分类号： A61N1/36071 , A61N1/0531 , A61N1/0534 , A61N1/0553 , A61N1/0558 , A61N1/36021 , A61N1/37205 , A61N1/37211 , A61N1/375 , A61N1/3756
摘要： Delivery of peripheral nerve field stimulation (PNFS) in combination with one or more other therapies is described. The other therapy delivered in combination with PNFS may be, for example, a different type of neurostimulation, such as spinal cord stimulation (SCS), or a drug. PNFS and the other therapy may be delivered simultaneously, in an alternating fashion, according to a schedule, and/or selectively, e.g., in response to a request received from a patient or clinician. A combination therapy that includes PNFS may be able to more completely address complex or multifocal pain than would be possible through delivery of either PNFS or other therapies alone. Further, the combination of PNFS with one or more other therapies may reduce the likelihood that neural accommodation will impair the perceived effectiveness PNFS or the other therapies.
摘要翻译：描述了外周神经区域刺激（PNFS）与一种或多种其他疗法的结合。与PNFS组合递送的另一疗法可以是例如不同类型的神经刺激，例如脊髓刺激（SCS）或药物。 PNFS和其他治疗可以根据时间表以交替方式同时递送，和/或选择性地，例如响应于从患者或临床医生接收到的请求。包括PNFS的联合治疗可能能够更全面地解决复杂或多焦点疼痛，而不仅仅是通过传送PNFS或其他疗法来实现。此外，PNFS与一种或多种其它疗法的组合可以降低神经调节可能损害所感知的有效性PNFS或其他疗法的可能性。

5. 发明授权

US08630715B2 Rule-based stimulation program search 有权
标题翻译：基于规则的刺激程序搜索
公开(公告)号：US08630715B2
公开(公告)日：2014-01-14
申请号：US13330016
申请日：2011-12-19
申请人： Steven M. Goetz , Donald R. Johnson , Andrew H. Houchins , Jeffrey T. Keacher , Theodore J. Stone , Kenneth T. Heruth , Gary W. King , Roy L. Testerman
发明人： Steven M. Goetz , Donald R. Johnson , Andrew H. Houchins , Jeffrey T. Keacher , Theodore J. Stone , Kenneth T. Heruth , Gary W. King , Roy L. Testerman
IPC分类号： A61N1/372
CPC分类号： A61N1/37264 , A61N1/36071 , A61N1/36132 , A61N1/36185 , A61N1/37247 , G06F19/00 , G16H40/63 , G16H50/20
摘要： Techniques that involve application of one or more rules to a “parent” program to generate a plurality of different “child” programs are described. Each of the rules may define a respective electrode configuration modification, and each child program may be a variation of the parent based on a modification of the electrode configuration of the parent according to one of the rules. The systems or devices may generate further generations of child programs from a previous generation child program using the same one or more rules. The child programs may be provided to a user, so that the user may test the efficacy of the new programs, assisting the user in identifying desirable programs. The child programs may be relatively minor variations of the parent program, and the user may “fine tune” a generally desirable parent program by testing the child programs.
摘要翻译：描述涉及将一个或多个规则应用于“父”程序以生成多个不同的“子”程序的技术。每个规则可以限定相应的电极配置修改，并且每个子程序可以是基于根据规则之一的父母的电极配置的修改的父母的变体。系统或设备可以使用相同的一个或多个规则从上一代子程序生成更多代的子程序。子程序可以被提供给用户，使得用户可以测试新程序的功效，帮助用户识别期望的程序。子程序可能是父程序的相对小的变化，并且用户可以通过测试子程序来“微调”通常期望的父程序。

6. 发明申请

US20120040548A1 CONNECTOR FOR IMPLANTABLE MEDICAL LEAD 有权
标题翻译：可植入医疗用连接器
公开(公告)号：US20120040548A1
公开(公告)日：2012-02-16
申请号：US13262998
申请日：2010-04-09
申请人： Gary W. King
发明人： Gary W. King
IPC分类号： H01R4/28 , H01R13/62
CPC分类号： A61N1/3752 , H01R13/6275 , H01R24/58 , H01R2107/00 , H01R2201/12
摘要： A connector (500) for operably coupling a medical lead to an implantable medical device includes first and second pivotably coupled elongate members (510, 520). Each of the first and second elongate members has (i) a proximal end portion (512, 522), and (ii) a distal end portion (514, 524) for engaging the lead. The lead has a proximal end portion having a shoulder. The first and second elongate members are pivotably coupled such that the distal end portions of the first and second elongate members are moveable to allow insertion of the lead proximally past the distal end portions of the elongate members and to allow the distal end portions to engage the lead distal the shoulder.
摘要翻译：用于将医用引线可操作地连接到可植入医疗装置的连接器（500）包括第一和第二可枢转耦合的细长构件（510,520）。第一和第二细长构件中的每一个具有（i）近端部分（512,522）和（ii）用于接合引线的远端部分（514,524）。引线具有具有肩部的近端部分。第一和第二细长构件可枢转地联接，使得第一和第二细长构件的远端部分可移动以允许引线向近侧插入穿过细长构件的远端部分并且允许远端部分接合引导远离肩膀。

7. 发明申请

US20110230940A1 SHIFTING BETWEEN ELECTRODE COMBINATIONS IN ELECTRICAL STIMULATION DEVICE 审中-公开
标题翻译：电刺激装置中电极组合之间的移位
公开(公告)号：US20110230940A1
公开(公告)日：2011-09-22
申请号：US13152870
申请日：2011-06-03
申请人： Steven M. Goetz , Andrew H. Houchins , Jeffrey T. Keacher , Gary W. King , Kenneth T. Heruth , Roy L. Testerman , Michael T. Lee , Nathan A. Torgerson , Joseph J. Nolan
发明人： Steven M. Goetz , Andrew H. Houchins , Jeffrey T. Keacher , Gary W. King , Kenneth T. Heruth , Roy L. Testerman , Michael T. Lee , Nathan A. Torgerson , Joseph J. Nolan
IPC分类号： A61N1/36
CPC分类号： A61N1/37247 , A61N1/36071 , A61N1/36185 , A61N1/37252
摘要： The disclosure is directed to techniques for shifting between two electrode combinations. An amplitude of a first electrode combination is incrementally decreased while an amplitude of a second, or subsequent, electrode combination is concurrently incrementally increased. Alternatively, an amplitude of the first electrode combination is maintained at a target amplitude level while the amplitude of the second electrode combination is incrementally increased. The stimulation pulses of the electrode combinations are delivered to the patient interleaved in time. In this manner, the invention provides for a smooth, gradual shift from a first electrode combination to a second electrode combination, allowing the patient to maintain a continual perception of stimulation. The shifting techniques described herein may be used during programming to shift between different electrode combinations to find an efficacious electrode combination. Additionally, the techniques may be used for shifting between different electrode combinations associated with different stimulation programs or program sets.
摘要翻译：本公开涉及用于在两个电极组合之间移位的技术。第一电极组合的振幅逐渐减小，而第二或随后的电极组合的振幅同时递增地增加。或者，第一电极组合的振幅保持在目标振幅水平，而第二电极组合的振幅逐渐增加。电极组合的刺激脉冲在时间上交付给患者。以这种方式，本发明提供从第一电极组合到第二电极组合的平滑，逐渐的移动，允许患者保持连续的刺激感知。本文描述的移位技术可以在编程期间用于在不同电极组合之间移动以找到有效的电极组合。另外，这些技术可用于在与不同刺激程序或程序集相关联的不同电极组合之间进行移位。

8. 发明授权

US07957814B2 Shifting between electrode combinations in electrical stimulation device 有权
标题翻译：在电刺激装置中的电极组合之间移动
公开(公告)号：US07957814B2
公开(公告)日：2011-06-07
申请号：US12392876
申请日：2009-02-25
申请人： Steven M. Goetz , Andrew H. Houchins , Jeffrey T. Keacher , Gary W. King , Kenneth T. Heruth , Roy L. Testerman , Michael T. Lee , Nathan A. Torgerson , Joseph J. Nolan
发明人： Steven M. Goetz , Andrew H. Houchins , Jeffrey T. Keacher , Gary W. King , Kenneth T. Heruth , Roy L. Testerman , Michael T. Lee , Nathan A. Torgerson , Joseph J. Nolan
IPC分类号： A61N1/18
CPC分类号： A61N1/37247 , A61N1/36071 , A61N1/36185 , A61N1/37252
摘要： The disclosure is directed to techniques for shifting between two electrode combinations. An amplitude of a first electrode combination is incrementally decreased while an amplitude of a second, or subsequent, electrode combination is concurrently incrementally increased. Alternatively, an amplitude of the first electrode combination is maintained at a target amplitude level while the amplitude of the second electrode combination is incrementally increased. The stimulation pulses of the electrode combinations are delivered to the patient interleaved in time. In this manner, the invention provides for a smooth, gradual shift from a first electrode combination to a second electrode combination, allowing the patient to maintain a continual perception of stimulation. The shifting techniques described herein may be used during programming to shift between different electrode combinations to find an efficacious electrode combination. Additionally, the techniques may be used for shifting between different electrode combinations associated with different stimulation programs or program sets.
摘要翻译：本公开涉及用于在两个电极组合之间移位的技术。第一电极组合的振幅逐渐减小，而第二或随后的电极组合的振幅同时递增地增加。或者，第一电极组合的振幅保持在目标振幅水平，而第二电极组合的振幅逐渐增加。电极组合的刺激脉冲在时间上交付给患者。以这种方式，本发明提供从第一电极组合到第二电极组合的平滑，逐渐的移动，允许患者保持连续的刺激感知。本文描述的移位技术可以在编程期间用于在不同电极组合之间移动以找到有效的电极组合。另外，这些技术可用于在与不同刺激程序或程序集相关联的不同电极组合之间进行移位。

9. 发明授权

US07720548B2 Impedance-based stimulation adjustment 有权
标题翻译：基于阻抗的刺激调整
公开(公告)号：US07720548B2
公开(公告)日：2010-05-18
申请号：US11414530
申请日：2006-04-28
申请人： Gary W. King
发明人： Gary W. King
IPC分类号： A61N1/18
CPC分类号： A61N1/36185 , A61N1/08 , A61N1/36521 , A61N1/36535 , G06F19/00
摘要： Techniques for adjusting stimulation are disclosed. A medical device measures an impedance associated with one or more electrodes, e.g., the impedance presented to the medical device by a total electrical circuit that includes the one or more electrodes, the conductors associated with the electrodes, and tissue proximate to the electrodes. The medical device stores at least one patient-specific relationship between impedance and a stimulation parameter, and adjusts the value of the stimulation parameter based on the measured impedance according to the relationship. The medical device may store multiple relationships, and select one the relationships based on, for example, an activity level of the patient, posture of the patient, or a current stimulation program or electrode combination used to deliver stimulation. By adjusting a stimulation parameter, such as amplitude, according to such a relationship, the stimulation intensity as perceived by the patient may be kept substantially constant.
摘要翻译：公开了用于调节刺激的技术。医疗设备测量与一个或多个电极相关联的阻抗，例如通过包括一个或多个电极，与电极相关联的导体和靠近电极的组织的总电路呈现给医疗装置的阻抗。医疗装置存储阻抗和刺激参数之间的至少一个患者特异性关系，并且根据关系根据所测量的阻抗来调整刺激参数的值。医疗设备可以存储多个关系，并且基于例如患者的活动水平，患者的姿势或用于递送刺激的当前刺激程序或电极组合来选择一个关系。通过根据这样的关系调整诸如振幅的刺激参数，可以将患者感觉到的刺激强度保持基本上恒定。

10. 发明授权

US07657318B2 Technique for adjusting the locus of excitation of electrically excitable tissue 失效
标题翻译：调整电可激发组织激发轨迹的技术
公开(公告)号：US07657318B2
公开(公告)日：2010-02-02
申请号：US11273310
申请日：2005-11-14
申请人： Gary W. King , Robert Leinders , Greg Hrdlicka , Michael D. Baudino
发明人： Gary W. King , Robert Leinders , Greg Hrdlicka , Michael D. Baudino
IPC分类号： A61N1/36
CPC分类号： A61N1/36164 , A61N1/0531 , A61N1/0534 , A61N1/0551 , A61N1/36017 , A61N1/36071 , A61N1/36167
摘要： The locus of electrically excitable tissue where action potentials are induced can be controlled using the physiological principle of electrotonus. In one embodiment, first and second pulses are applied to first and second electrodes, respectively, to generate first and second subthreshold potential areas, respectively, within the tissue. The locus within the tissue where action potentials are induced is determined by a superposition of the first and second subthreshold areas according to the physiological principle of electrotonus. In another embodiment, a two-dimensional array of electrodes are formed. The cathode may be positioned near the center of the two-dimensional array or may be left out. The first and second subthreshold areas may thereby be steered. An array of anodal rings may be used to contain the field of excitation.
摘要翻译：诱导动作电位的电可激发组织的位置可以使用电渗的生理原理进行控制。在一个实施例中，分别将第一和第二脉冲施加到第一和第二电极，以在组织内分别产生第一和第二亚阈值电位区域。通过根据电生理原理的第一和第二亚阈值区域的叠加来确定在组织内产生动作电位的位点。在另一个实施例中，形成二维电极阵列。阴极可以位于二维阵列的中心附近，或者可以被排除。从而可以控制第一和第二亚阈值区域。阳极环阵列可用于包含激发场。

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