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1. 发明申请

US20080267914A1 Chemical Compounds 审中-公开
标题翻译：化学化合物
公开(公告)号：US20080267914A1
公开(公告)日：2008-10-30
申请号：US12089301
申请日：2006-10-09
申请人： Michael Christopher Barnes , Surinder Singh Chana , Helena Dennison , Lyn Jennens , Neil Mathews , Christopher John Pilkington , Keith Charles Spencer , Alexander James Floyd Thomas
发明人： Michael Christopher Barnes , Surinder Singh Chana , Helena Dennison , Lyn Jennens , Neil Mathews , Christopher John Pilkington , Keith Charles Spencer , Alexander James Floyd Thomas
IPC分类号： C07D413/12 , C07D413/14 , A61K31/5377 , A61K31/7056 , A61K38/21 , A61P31/12
CPC分类号： C07D239/94
摘要： Compounds of formula (Ia) are found to be active in inhibiting replication of flaviviridae viruses (Ia), wherein R1 and R2 are the same or different and represent hydrogen, halogen, -L-O—R3, -L-O-L-A or -L-O-L′-A′, wherein each L is the same or different and represents a direct bond or a C1-C4 alkylene group; L′ represents a direct bond or a C2-C4 alkylene group; R3 represents hydrogen, C1-C4 alkyl or C1-C4 haloalkyl; A represents a 5- to 10-membered heterocyclyl group; and A′ represents a C6-C1 aryl group; wherein at least one of R1 and R2 is -L-O—R3, -L-O-L-A or -L-O-L′-A′.
摘要翻译：发现式（Ia）的化合物在抑制黄病毒科病毒（Ia）的复制中是有活性的，其中R 1和R 2相同或不同并且表示氢，卤素，-LOR 3，-LOLA或-LO-L'-A'，其中各L相同或不同，表示直接键或C 1〜 C 4亚烷基; L'表示直接键或C 2 -C 4亚烷基; R 3表示氢，C 1 -C 4烷基或C 1 -C 4烷基或C 1 -C 4 - 卤代烷基; A表示5至10元杂环基; 和A'表示C 6 -C 12芳基; 其中R 1和R 2中的至少一个为-L-O-R 3，-L-O-L-A或-L-O-L-A'。

2. 发明授权

US11927047B1 Doorway transaction barrier 有权
公开(公告)号：US11927047B1
公开(公告)日：2024-03-12
申请号：US17496018
申请日：2021-10-07
申请人： Floyd Thomas
发明人： Floyd Thomas
IPC分类号： E05G7/00 , E05G5/00
CPC分类号： E05G7/008 , E05G5/006 , E05G7/002
摘要： A doorway transaction barrier including a cabin assembly, a chamber assembly and a mounting assembly is disclosed herein. The cabin assembly includes cabin including a front barrier having a front opening. The front barrier further including a two-way microphone to provide communication between a first user and a second user. The chamber assembly including a front wall, a left wall, a right wall and a top wall. The top wall having the cabin assembly mounted thereon. The front wall including a front door to provide access to a front chamber. The top wall including a second door to provide access to the front chamber from an interior side of the cabin. The top wall further including rails receiving a slidable drawer. The front opening providing access to the drawer. The mounting assembly includes a latch to mount the chamber assembly to a frame door.

3. 发明授权

US08008303B2 Biphenyl derivatives and their use in treating hepatitis C 失效
标题翻译：联苯衍生物及其在治疗丙型肝炎中的应用
公开(公告)号：US08008303B2
公开(公告)日：2011-08-30
申请号：US12066983
申请日：2006-09-18
申请人： Christopher James Wheelhouse , Alexander James Floyd Thomas , David John Bushnell , James Lumley , James Iain Salter , Malcolm Clive Carter , Neil Mathews , Christopher John Pilkington , Richard Martyn Angell
发明人： Christopher James Wheelhouse , Alexander James Floyd Thomas , David John Bushnell , James Lumley , James Iain Salter , Malcolm Clive Carter , Neil Mathews , Christopher John Pilkington , Richard Martyn Angell
IPC分类号： C07D295/02 , A61K31/495
CPC分类号： C07D213/75 , C07D205/04 , C07D233/64 , C07D237/28 , C07D279/12 , C07D295/135 , C07D295/26 , C07D307/38 , C07D333/20 , C07D417/12
摘要： Use of a compound which is a biphenyl derivative of formula (I), or a pharmaceutically acceptable salt thereof, for the treatment of Hepatitis C wherein the variables are described herein.
摘要翻译：作为式（I）的联苯衍生物或其药学上可接受的盐的化合物用于治疗丙型肝炎的用途，其中本文描述了变量。

4. 发明申请

US20080255105A1 Biphenyl Derivatives and Their Use in Treating Hepatitis C 失效
公开(公告)号：US20080255105A1
公开(公告)日：2008-10-16
申请号：US12066983
申请日：2006-09-18
申请人： Christopher James Wheelhouse , Alexander James Floyd Thomas , David John Bushnell , James Lumley , James Iain Salter , Malcolm Clive Carter , Neil Mathews , Christopher John Pilkington , Richard Martyn Angell
发明人： Christopher James Wheelhouse , Alexander James Floyd Thomas , David John Bushnell , James Lumley , James Iain Salter , Malcolm Clive Carter , Neil Mathews , Christopher John Pilkington , Richard Martyn Angell
IPC分类号： A61K31/5375 , C07D265/30 , C07D413/12 , A61K31/541 , A61P31/00 , A61K31/54 , A61K31/5377 , C07D417/12
CPC分类号： C07D213/75 , C07D205/04 , C07D233/64 , C07D237/28 , C07D279/12 , C07D295/135 , C07D295/26 , C07D307/38 , C07D333/20 , C07D417/12
摘要： A compound which is a biphenyl derivative of formula (I), or a pharmaceutically acceptable salt thereof wherein: R1 is a C1-C6 alkyl group or a moiety -A1, -L1-A1, -A1-A1′, -L1-A1-A1′, -A1-L1-A1′, -A1-Y1-A1′, -A1-Het1-A1′, -L1-A1-Y1-A1′, -L1-A1-Het1-A1′, -L1-Het1-A1, -L1-Y1-A1, -L1-Y1-Het1-A1, -L1-Het1-Y1-A1, -L1-Y1-Het1-L1′, -A1-Y1-Het1-A1′, -A1-Het1-Y1-A1′, -A1-Het1-L1-A1′, -A1-L1-Het1-A1′ or -L1-Het1-L1′; -A and B are the same or different and each represent a direct bond or a —CO—NR′—, —NR′—CO—, —NR′—CO2—, —CO—, —NR′—CO—NR″—, —NR′—S(O)2—, —S(O)2—NR′—, —SO2—, —NR′—, —NR′—CO—CO—, —CO—O—, —O—CO—, —(C1-C2 alkylene)-NR′— or —(C1-C2 hydroxyalkylene)-NR′-moiety, wherein R′ and R″ are the same or different and each represent hydrogen or C1-C4 alkyl; —R2 and R3 are the same or different and each represent C1-C4 alkyl, C1-C4 alkoxy, C1-C4 haloalkyl, C1-C4 haloalkoxy or halogen; n and m are the same or different and each represent 0 or 1; R4 is a C1-C6 alkyl group or a moiety -A4, -L4-A4, -A4-A4′, -L4-A4-A4′, -A4-L4-A4′, -A4-Y4-A4′, -A4-Het4-A4′, -L4-A4-Y4-A4′, -L4-A4-Het4-A4′, -L4-Het4-A4, -L4-Y4-A4, -L4-Y4-Het4-A4, -L4-Het4-Y4-A4, -L4-Y4-Het4-L4′, -A4-Y4-Het4-A4′, -A4-Het4-Y4-A4′, -A4-Het4-L4-A4′, -A4-L4-Het4-A4′ or -L4-Het4-L4′, each A1, A4, A1′ and A4′ are the same or different and represent a phenyl, 5- to 10-membered heteroaryl, 5- to 10-membered heterocyclyl or C3-C8 carbocyclyl moiety; each L1 and L4 is the same or different and represents a C1-C4 alkylene or a C1-C4 hydroxyalkylene group; each Y1 and Y4 is the same or different and represents —CO—, —SO— or —S(O)2—; each L1′ and L4′ is the same or different and represents hydrogen or a C1-C4 alkyl group; and each Het1 and Het4 is the same or different and represents —O—, —S— or —NR′—, wherein R′ is hydrogen or a C1-C4 alkyl group, the phenyl, heteroaryl, heterocyclyl and carbocyclyl moieties in R1 and R4 being optionally fused to a phenyl, 5- to 10-membered heteroaryl or 5- to 10-membered heterocyclyl ring; and the phenyl, heteroaryl, heterocyclyl and carbocyclyl moieties in R1 and R4 being unsubstituted or substituted by (a) a single unsubstituted substituent selected from —(C1-C4 alkyl)-X1, —CO2R′, —SO2NR′R″, —S(O)2—R′, —CONR′R″, —NR′—CO—R′″, —NR′—S(O)2—R′″, —CO—NR′—(C1-C4 alkyl)-NR′R″ and —CO—O—(C1-C4 alkyl)-NR′R″ and/or (b) 1, 2 or 3 unsubstituted substituents selected from —(C1-C4 alkyl)-X2, halogen, C1-C4 alkyl, C1-C4 alkoxy, C1-C4 haloalkyl, C1-C4 haloalkoxy, C1-C4 hydroxyalkyl, hydroxy, cyano, nitro and —NR′R″, wherein X1 is —CO2R′, —SO2—R′, —NR′—CO2—R″, —NR′—S(O)2—R′″, —CONR′R″ or —SO2—NR′R″, each X2 is the same or different and is cyano, nitro or —NR′R″, each R′ and R″ is the same or different and represents hydrogen or C1-C4 alkyl and each R′″ is the same or different and represents C1-C4 alkyl.

5. 外观设计

USD535752S1 Massage roller ball 有权
标题翻译：按摩滚球
公开(公告)号：USD535752S1
公开(公告)日：2007-01-23
申请号：US29215566
申请日：2004-10-21
申请人： Floyd Thomas Smith
设计人： Floyd Thomas Smith

6. 发明授权

US06112625A Extension bar for tool 失效
标题翻译：工具扩展栏
公开(公告)号：US06112625A
公开(公告)日：2000-09-05
申请号：US935237
申请日：1997-09-22
申请人： Floyd Thomas Turtle
发明人： Floyd Thomas Turtle
IPC分类号： B25B23/00 , B25G1/06 , B25B23/16
CPC分类号： B25B23/0071 , B25B23/0021 , B25G1/063 , Y10T403/32918 , Y10T403/32951
摘要： A wrench apparatus includes a wrench head with a swivel adapter, a combination handle and extension bar attachable to the swivel adapter, and a ratchet head. The wrench head includes a tubular member with a longitudinal slot, and an internal C-shaped brace dividing the tubular member into two sockets at opposite ends thereof. One socket includes six sides and five points, and the other socket includes twenty sides and ten points, so that both sockets can securely grip all six sides of a nut or bolt. The points of one socket are offset radially relative to the points of the other socket for providing smaller increments in repositioning freedom. The swivel adapter is pivotally attached between a pair of ears on the wrench head by a removable pin, so that it can be removed and attached between a like pair of ears on the ratchet head. The extension bar includes a female end with a faceted outer surface that prevents it from rolling on a slanted surface, and also enables the extension bar to be gripped and turned by a conventional wrench. In an alternative embodiment, the sockets include fully closed sides, and are divided by an annular brace therebetween.
摘要翻译：扳手装置包括具有旋转适配器的扳手头，可旋转适配器可附接的组合手柄和延伸杆以及棘轮头。扳手头包括具有纵向狭槽的管状构件和内部C形支架，其将管状构件在其相对端分隔成两个插座。一个插座包括六个侧面和五个点，另一个插座包括二十个面和十个点，这样两个插座可以牢固地抓住螺母或螺栓的所有六个侧面。一个插座的点相对于另一插座的点径向偏移，用于在重新定位自由度中提供较小的增量。旋转适配器通过可拆卸的销枢转地安装在扳手头上的一对耳朵之间，使得其可以被移除并附接在棘轮头上的类似的耳朵之间。延伸杆包括具有小平面的外表面的阴端，其防止其在倾斜表面上滚动，并且还使得延伸杆能够被传统的扳手夹紧和转动。在替代实施例中，插座包括完全封闭的侧面，并且由它们之间的环形支架分开。

7. 发明授权

US08739907B2 Vehicle with structural battery pack 失效
标题翻译：带结构电池的车辆
公开(公告)号：US08739907B2
公开(公告)日：2014-06-03
申请号：US13268197
申请日：2011-10-07
申请人： Robert Gordon Storc , James Edward Robertson , Bhavin Narshi Mandalia , Zsolt Almasi , Jean-Yves St. Gelais , Floyd Thomas Elder , Barbara Kardasz
发明人： Robert Gordon Storc , James Edward Robertson , Bhavin Narshi Mandalia , Zsolt Almasi , Jean-Yves St. Gelais , Grzegorz Kardasz , Floyd Thomas Elder
IPC分类号： B60R16/04
CPC分类号： B62D21/00 , B60K1/04 , B60K2001/0438 , B60L11/1877 , B62D25/2009 , Y02T10/7005 , Y02T10/705
摘要： In an aspect, the invention is directed to a vehicle chassis for a vehicle that is at least partly driven by an electric motor, wherein the vehicle chassis incorporates a battery pack that acts as a structural member of the chassis.
摘要翻译：一方面，本发明涉及至少部分地由电动机驱动的用于车辆的车辆底盘，其中车辆底盘包括用作底盘的结构构件的电池组。

8. 发明申请

US20100278835A1 NOVEL COMPOUNDS 660 审中-公开
标题翻译：新型化合物660
公开(公告)号：US20100278835A1
公开(公告)日：2010-11-04
申请号：US12720094
申请日：2010-03-09
申请人： Helen Blade , Heather Marie Jackson , Gary Peter Tomkinson , Elisa Ann Carron , James Andrew Lumley , Christopher John Pilkington , Alexander James Floyd Thomas , Justin Warne
发明人： Helen Blade , Heather Marie Jackson , Gary Peter Tomkinson , Elisa Ann Carron , James Andrew Lumley , Christopher John Pilkington , Alexander James Floyd Thomas , Justin Warne
IPC分类号： A61K31/519 , C07D403/06 , A61K31/517 , C07D471/04 , A61P31/14 , A61P11/00 , A61K39/42
CPC分类号： C07D403/06 , C07D471/04
摘要： The invention provides compounds of formula (I) wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11 and R12 are as defined in the specification, and optical isomers, racemates and tautomers thereof, and pharmaceutically acceptable salts thereof; together with processes for their preparation, pharmaceutical compositions containing them and their use in therapy. The compounds are useful in the treatment of respiratory syncytial virus (RSV).
摘要翻译：本发明提供式（I）化合物，其中R 1，R 2，R 3，R 4，R 5，R 6，R 7，R 8，R 9，R 10，R 11和R 12如本说明书中所定义，及其旋光异构体，外消旋体和互变异构体，其药学上可接受的盐; 以及其制备方法，含有它们的药物组合物及其在治疗中的用途。该化合物可用于治疗呼吸道合胞病毒（RSV）。

9. 发明申请

US20100158863A1 TRIAZOLOANILINOPYRIMIDINE DERIVATIVES FOR USE AS ANTIVIRAL AGENTS 审中-公开
标题翻译：用作抗病毒剂的三唑烷基吡啶衍生物
公开(公告)号：US20100158863A1
公开(公告)日：2010-06-24
申请号：US12160506
申请日：2007-01-11
申请人： Neil Mathews , Alexander James Floyd Thomas , Keith Charles Spencer , Nathalie Tiberghien , Christopher John Pilkington , Lyn Jennens , Surinder Chana , Ian John Fraser
发明人： Neil Mathews , Alexander James Floyd Thomas , Keith Charles Spencer , Nathalie Tiberghien , Christopher John Pilkington , Lyn Jennens , Surinder Chana , Ian John Fraser
IPC分类号： A61K31/517 , C07D403/12 , C07D413/14 , A61K31/5377 , A61P31/14 , A61K38/21 , A61K31/7056
CPC分类号： C07D403/12 , C07D401/14 , C07D403/14 , C07D405/14 , C07D409/14
摘要： A quinazoline derivative of formula (I), or a pharmaceutically acceptable salt thereof: formula (I) for use in treatment of prevention of a flaviviridae infection.
摘要翻译：式（I）的喹唑啉衍生物或其药学上可接受的盐：用于治疗预防黄病毒科感染的式（I）。

10. 发明授权

US07244237B2 Heated massage ball 有权
标题翻译：加热按摩球
公开(公告)号：US07244237B2
公开(公告)日：2007-07-17
申请号：US10975782
申请日：2004-10-28
申请人： Floyd Thomas Smith
发明人： Floyd Thomas Smith
IPC分类号： A61H1/00
CPC分类号： A61H15/02 , A61H2015/0064 , A61H2201/0207 , A61H2201/0228 , A61H2201/0242 , A61H2201/0257 , A61H2201/0292
摘要： A heated massage ball apparatus has a ball that may be heated retained within a grip that allows for the ball to rotate freely therewithin. The ball may be heated, for example, in a microwave oven, and may be substantially hollow and filled with a liquid that retains heat. The grip is pliable enough to allow the forced insertion or ejection of the ball past its widest circumference. An opening in the bottom of the base may facilitate the removal of the ball from the base, whereby the user inserts a finger therein to force the ball out of the grip. A heating base can accept the grip and ball and provide heat to the ball, such as a heated conductor that extends through the bottom opening in the grip and heats the ball by direct contact and thermal conduction. An electrical circuit may be included that provides on/off and temperature controls, a heating element, a temperature-sensing means, a thermostat, and a display for indicating a target and current ball temperatures.
摘要翻译：加热的按摩球装置具有保持在能够使球自由旋转的把手内的加热球。球可以例如在微波炉中加热，并且可以基本上是中空的并且填充有保持热量的液体。抓地力足够柔软以允许球强制插入或弹出超过其最宽的圆周。基部底部的开口可以有助于从基座移除球，由此使用者将手指插入其中以迫使球离开手柄。加热基座可以接受把手和球并且向球提供热量，例如延伸穿过手柄中的底部开口的加热导体，并通过直接接触和热传导来加热球。可以包括提供开/关和温度控制的电路，加热元件，温度感测装置，恒温器和用于指示目标和当前球温度的显示器。

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