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    • 4. 发明授权
    • Blood coagulation analyzer
    • 凝血分析仪
    • US06524861B1
    • 2003-02-25
    • US09235530
    • 1999-01-22
    • Eric S. Anderson
    • Eric S. Anderson
    • G01N3386
    • G01N33/86Y10T436/11Y10T436/113332Y10T436/114165Y10T436/115831Y10T436/12
    • One method and apparatus for analyzing clotting characteristics of a blood sample includes the use of a non-linear equation having coefficients capable of being related to the underlying clotting processes. The non-linear equation is curve fit to a waveform of a clotting sample to provide values for the coefficients of the non-linear function. Once the coefficients are obtained, an inference engine may be used to evaluate the non-linear relationship between the coefficients and factor concentrations within the blood sample. Advantageously, the waveform of the actual sample may be detrended to extract a residual oscillatory component to aid in the determination of initial coefficients for simplifying the curve fit operation. The non-linear equation may additionally be used for providing simulated clotting waveforms for testing clot analysis instruments. A residual oscillatory component may advantageously be extracted from the clotting signal. The oscillatory components may be used to provide a high quality clot time indicator for the sample. In addition, the oscillatory component may be used to correct for clot anomalies by correlating the frequency of the oscillatory to various physical characteristics of the blood clot. The oscillatory component may be used to provide initial estimates for values of the coefficients of the logistic. The logistic, because it represents knowledge as to the underlying chemistry of the clotting process, may also be used to provide initial estimates for coefficients of the logistic, and may also be used to enhance the accuracy of existing polynomial template clot analysis techniques. The logistic model may also be used to verify the operation of clot analysis tools.
    • 用于分析血液样本的凝血特征的一种方法和装置包括使用具有能够与潜在凝血过程相关的系数的非线性方程式。 非线性方程曲线拟合到凝血样本的波形,以提供非线性函数系数的值。 一旦获得了系数,就可以使用推理机来评估血样中系数和因子浓度之间的非线性关系。 有利地,可以将实际样品的波形去除以提取残余振荡分量,以帮助确定初始系数以简化曲线拟合操作。 非线性方程可另外用于提供用于测试凝块分析仪器的模拟凝血波形。 可以有利地从凝血信号中提取残留振荡成分。 振荡组分可用于为样品提供高质量的凝血时间指示剂。 此外,通过将振荡频率与血块的各种物理特征相关联,振荡组件可用于校正血块异常。 振荡分量可用于为物流系数的值提供初始估计。 因为它代表关于凝血过程的基础化学的知识的逻辑,也可以用于提供逻辑系数的初始估计,并且还可以用于增强现有多项式模板凝块分析技术的准确性。 物流模型也可用于验证凝块分析工具的操作。