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    • 6. 发明授权
    • Calcium phosphopeptide complexes
    • 钙磷酸肽复合物
    • US06780844B1
    • 2004-08-24
    • US09380738
    • 1999-12-06
    • Eric C. Reynolds
    • Eric C. Reynolds
    • A61K3803
    • C07K14/4732A61K8/64A61K33/42A61K38/00A61K2800/58A61Q11/00
    • Phosphopeptides containing the Ser(P) cluster sequence motif Ser(P)-Ser(P)-Ser(P)-Glu-Glu- can stabilize their own weight in amorphous calcium phosphate (ACP) and amorphous calcium fluoride phosphate (ACFP). The amorphous phases stabilized by the phosphopeptides are an excellent delivery vehicle to co-localise calcium, fluoride, and phosphate ions at the tooth surface in a slow-release amorphous form producing superior anticaries efficacy. These amorphous phases stabilized by the phosphopeptides also have utility as dietary supplements to increase calcium bioavailability and to help prevent diseases associated with calcium deficiencies.
    • 含有Ser(P)簇序列基序Ser(P)-Ser(P)-Ser(P)-Glu-Glu-的磷酸化肽可以稳定其在无定形磷酸钙(ACP)和无定形磷酸氟化钙(ACFP)中的自身重量。 通过磷酸肽稳定的无定形相是在牙齿表面以缓释非晶形式共同定位钙,氟化物和磷酸根离子的优异递送载体,产生优异的抗aries效。 由磷酸肽稳定的这些非晶相也可用作膳食补充剂以增加钙的生物利用度并帮助预防与钙缺乏相关的疾病。