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1. 发明授权

US07776310B2 Flexible and/or elastic brachytherapy seed or strand 有权
标题翻译：柔性和/或弹性近距离放射治疗种子或股
公开(公告)号：US07776310B2
公开(公告)日：2010-08-17
申请号：US10665793
申请日：2003-09-19
申请人： Edward J. Kaplan
发明人： Edward J. Kaplan
IPC分类号： A61K51/00 , A61N5/00
CPC分类号： A61L31/16 , A61B5/064 , A61B90/39 , A61B2090/3966 , A61K41/0038 , A61K47/6957 , A61K49/00 , A61K49/0409 , A61K51/1282 , A61L31/02 , A61L31/04 , A61L31/10 , A61L31/146 , A61L31/148 , A61L31/18 , A61L2300/44 , A61L2300/45 , A61N5/1007 , A61N5/1027 , A61N2005/1023 , A61N2005/1024
摘要： A flexible or elastic brachytherapy strand that includes an imaging marker and/or a therapeutic, diagnostic or prophylactic agent such as a drug in a biocompatible carrier that can be delivered to a subject upon implantation into the subject through the bore of a brachytherapy implantation needle has been developed. Strands can be formed as chains or continuous arrays of seeds up to 50 centimeters or more, with or without spacer material, flaccid, rigid, or flexible.
摘要翻译：包括成像标记物和/或治疗性，诊断性或预防性药物的柔性或弹性近距离放射线束，所述治疗剂，诊断或预防剂例如生物相容性载体中的药物，其可以通过近距离放射治疗植入针的孔植入受试者后递送至受试者，已经开发链条可以形成为链条或连续的种子阵列，直到50厘米或更长，具有或不具有间隔物材料，松弛剂，刚性或柔性的。

2. 发明授权

US08470294B2 Flexible and/or elastic brachytherapy seed or strand 有权
标题翻译：柔性和/或弹性近距离放射治疗种子或股
公开(公告)号：US08470294B2
公开(公告)日：2013-06-25
申请号：US12823700
申请日：2010-06-25
申请人： Edward J. Kaplan
发明人： Edward J. Kaplan
IPC分类号： A61K51/00 , A61N5/00
CPC分类号： A61L31/16 , A61B5/064 , A61B90/39 , A61B2090/3966 , A61K41/0038 , A61K47/6957 , A61K49/00 , A61K49/0409 , A61K51/1282 , A61L31/02 , A61L31/04 , A61L31/10 , A61L31/146 , A61L31/148 , A61L31/18 , A61L2300/44 , A61L2300/45 , A61N5/1007 , A61N5/1027 , A61N2005/1023 , A61N2005/1024
摘要： A flexible or elastic brachytherapy strand that includes an imaging marker and/or a therapeutic, diagnostic or prophylactic agent such as a drug in a biocompatible carrier that can be delivered to a subject upon implantation into the subject through the bore of a brachytherapy implantation needle has been developed. Strands can be formed as chains or continuous arrays of seeds up to 50 centimeters or more, with or without spacer material, flaccid, rigid, or flexible.
摘要翻译：包括成像标记物和/或治疗性，诊断性或预防性药物的柔性或弹性近距离放射线束，所述治疗剂，诊断或预防剂例如生物相容性载体中的药物，其可以通过近距离放射治疗植入针的孔植入受试者后递送至受试者，已经开发链条可以形成为链条或连续的种子阵列，直到50厘米或更长，具有或不具有间隔物材料，松弛剂，刚性或柔性的。

3. 发明申请

US20120263643A1 BRACHYTHERAPY SEED 审中-公开
标题翻译： BRACHYTHERAPY种子
公开(公告)号：US20120263643A1
公开(公告)日：2012-10-18
申请号：US13538444
申请日：2012-06-29
申请人： Edward J. Kaplan
发明人： Edward J. Kaplan
IPC分类号： A61K51/00
CPC分类号： A61K9/0024 , A61K9/0002 , A61K41/0038 , A61K47/6957 , A61K49/0409 , A61K51/1282 , A61N5/1027 , A61N2005/1023 , A61N2005/1024 , Y10S977/906
摘要： A radiopaque brachytherapy seed for implantation into a subject includes a biocompatible component, a therapeutically active component including a non-radioactive drug, and a radiopaque marker. The biocompatible component is (a) physically associated with a therapeutically active component and (b) in contact with the radiopaque marker. The brachytherapy seed has a size and shape suitable for passing through the bore of a needle having an interior diameter of less than about 2.7 millimeters (10 gauge).
摘要翻译：用于植入受试者的不透射线近距离放射治疗种子包括生物相容性成分，包括非放射性药物的治疗活性成分和不透射线的标记物。生物相容性成分是（a）与治疗活性成分物理相关，和（b）与不透射线标记物接触。近距离放射治疗种子具有适于穿过内径小于约2.7毫米（10度）的针孔的尺寸和形状。

4. 发明申请

US20100261946A1 FLEXIBLE AND/OR ELASTIC BRACHYTHERAPY SEED OR STRAND 有权
标题翻译：柔性和/或弹性BRACHYTHERAPY种子或条纹
公开(公告)号：US20100261946A1
公开(公告)日：2010-10-14
申请号：US12823700
申请日：2010-06-25
申请人： Edward J. Kaplan
发明人： Edward J. Kaplan
IPC分类号： A61M36/12 , B01F13/00
CPC分类号： A61L31/16 , A61B5/064 , A61B90/39 , A61B2090/3966 , A61K41/0038 , A61K47/6957 , A61K49/00 , A61K49/0409 , A61K51/1282 , A61L31/02 , A61L31/04 , A61L31/10 , A61L31/146 , A61L31/148 , A61L31/18 , A61L2300/44 , A61L2300/45 , A61N5/1007 , A61N5/1027 , A61N2005/1023 , A61N2005/1024
摘要： A flexible or elastic brachytherapy strand that includes an imaging marker and/or a therapeutic, diagnostic or prophylactic agent such as a drug in a biocompatible carrier that can be delivered to a subject upon implantation into the subject through the bore of a brachytherapy implantation needle has been developed. Strands can be formed as chains or continuous arrays of seeds up to 50 centimeters or more, with or without spacer material, flaccid, rigid, or flexible.
摘要翻译：包括成像标记物和/或治疗性，诊断性或预防性药物的柔性或弹性近距离放射线束，所述治疗剂，诊断或预防剂例如生物相容性载体中的药物，其可以通过近距离放射治疗植入针的孔植入受试者后递送至受试者，已经开发链条可以形成为链条或连续的种子阵列，直到50厘米或更长，具有或不具有间隔物材料，松弛剂，刚性或柔性的。

5. 发明授权

US06575890B2 Medical instrument 失效
公开(公告)号：US06575890B2
公开(公告)日：2003-06-10
申请号：US09858658
申请日：2001-05-17
申请人： Edward J. Kaplan , Diego Y. Fontayne , Robert A. Joachim , Steven Bellofatto , Troy H. Phipps , Ernest A. Elgin, III
发明人： Edward J. Kaplan , Diego Y. Fontayne , Robert A. Joachim , Steven Bellofatto , Troy H. Phipps , Ernest A. Elgin, III
IPC分类号： A61M3600
CPC分类号： A61M37/0069 , A61M2005/3289 , A61N5/1007 , A61N5/1027 , A61N2005/1011 , A61N2005/1012
摘要： A medical instrument provides for precise indexing in order to implant seeds into seed implant locations within a patient. The medical instrument is affixed to a targeting fixture, and upon operator actuation of a trigger, is automatically indexed from one seed implant location to a next seed implant location.

6. 发明授权

US07282020B2 Deflectable implantation device and method of use 有权
标题翻译：可偏转植入装置及其使用方法
公开(公告)号：US07282020B2
公开(公告)日：2007-10-16
申请号：US10127107
申请日：2002-04-22
申请人： Edward J. Kaplan
发明人： Edward J. Kaplan
IPC分类号： A61M36/00 , A61N5/00
CPC分类号： A61M37/0069 , A61B17/3468 , A61B2017/00867 , A61M25/0662 , A61M2205/0266 , A61N5/1007 , A61N2005/1011
摘要： Systems, apparatus, components and methods are disclosed that allow the clinician to circumvent the pubic arch in instances where it interferes with insertion of instrumentation into the prostate or periprostatic tissue. The systems, apparatus and components disclosed herein employ structures, such as needles and trocars, of shape memory alloys, such as nickel-titanium (Ni—Ti) for the purpose of avoiding the pubic arch when accessing the prostate from the perineum.
摘要翻译：公开了允许临床医生在妨碍仪器插入前列腺或静脉周围组织的情况下绕过耻骨弓的系统，装置，部件和方法。本文公开的系统，装置和组件采用诸如镍 - 钛（Ni-Ti）的形状记忆合金的结构，例如针和套管针，用于在从会阴访问前列腺时避免耻骨弓。

7. 发明授权

US06746661B2 Brachytherapy seed 有权
标题翻译：近距离放射治疗种子
公开(公告)号：US06746661B2
公开(公告)日：2004-06-08
申请号：US09861326
申请日：2001-05-18
申请人： Edward J. Kaplan
发明人： Edward J. Kaplan
IPC分类号： A61K5100
CPC分类号： A61K9/0024 , A61K9/0002 , A61K41/0038 , A61K47/6957 , A61K49/0409 , A61K51/1282 , A61N5/1027 , A61N2005/1023 , A61N2005/1024 , Y10S977/906
摘要： A radiopaque brachytherapy seed for implantation into a subject includes a biocompatible component, a therapeutically active component including a non-radioactive drug, and a radiopaque marker. The biocompatible component is (a) physically associated with a therapeutically active component and (b) in contact with the radiopaque marker. The brachytherapy seed has a size and shape suitable for passing through the bore of a needle having an interior diameter of less than about 2.7 millimeters (10 gauge).
摘要翻译：用于植入受试者的不透射线近距离放射治疗种子包括生物相容性成分，包括非放射性药物的治疗活性成分和不透射线的标记物。生物相容性成分是（a）与治疗活性成分物理相关，和（b）与不透射线标记物接触。近距离放射治疗种子具有适于穿过内径小于约2.7毫米（10度）的针孔的尺寸和形状。

8. 发明授权

US06514193B2 Method of administering a therapeutically active substance 有权
标题翻译：施用治疗活性物质的方法
公开(公告)号：US06514193B2
公开(公告)日：2003-02-04
申请号：US09861196
申请日：2001-05-18
申请人： Edward J. Kaplan
发明人： Edward J. Kaplan
IPC分类号： A61M3100
CPC分类号： A61K9/0024 , A61K9/0002 , A61K41/0038 , A61K47/6957 , A61K49/0409 , A61K51/1282 , A61N5/1027 , A61N2005/1023 , A61N2005/1024 , Y10S977/906
摘要： A method for administering a therapeutically active component including a non-radioactive drug to a target tissue in a subject includes the steps of: (a) providing a brachytherapy seed having a size and shape suitable for passing through the bore of a needle having an interior diameter of less than about 2.7 millimeters (10 gauge); (b) providing a brachytherapy implantation instrument comprising at least one brachytherapy implantation needle having a bore having an interior diameter of less than about 2.7 millimeters (10 gauge), and being adapted to accept the brachytherapy seed into the bore of the at least one brachytherapy implantation needle and deliver the accepted implantation device into a target tissue; (c) introducing the brachytherapy seed into the bore of the at least one implantation needle of the brachytherapy implantation instrument; (d) introducing at least a portion of the at least one brachytherapy implantation needle into a target tissue in the subject; and (e) actuating the brachytherapy implantation instrument such that the brachytherapy seed is delivered through the bore of the brachytherapy implantation needle into the target tissue.
摘要翻译：向受试者的靶组织施用包含非放射性药物的治疗活性成分的方法包括以下步骤：（a）提供近距离放射治疗种子，其具有适于通过具有内部的针的孔的尺寸和形状直径小于约2.7毫米（10规）; （b）提供近距离放射治疗植入器械，其包括至少一个近距离放射治疗植入针，其具有内径小于约2.7毫米（10规格）的孔，并适于将近距离放射疗法种子接纳到所述至少一个近距离放射治疗植入针并将接受的植入装置递送到靶组织中; （c）将近距离放射治疗种子引入近距离放射治疗植入器械的至少一个植入针的孔中; （d）将所述至少一个近距离放射治疗植入针的至少一部分引入所述受试者的靶组织中; 和（e）致动近距离放射治疗植入器械，使得近距离放射治疗种子通过近距离放射治疗植入针的孔输送到靶组织中。

9. 发明申请

US20110118532A1 Brachytherapy seed 审中-公开
标题翻译：近距离放射治疗种子
公开(公告)号：US20110118532A1
公开(公告)日：2011-05-19
申请号：US10852407
申请日：2004-05-24
申请人： Edward J. Kaplan
发明人： Edward J. Kaplan
IPC分类号： A61M36/12
CPC分类号： A61K9/0024 , A61K9/0002 , A61K41/0038 , A61K47/6957 , A61K49/0409 , A61K51/1282 , A61N5/1027 , A61N2005/1023 , A61N2005/1024 , Y10S977/906
摘要： A radiopaque brachytherapy seed for implantation into a subject includes a biocompatible component, a therapeutically active component including a non-radioactive drug, and a radiopaque marker. The biocompatible component is (a) physically associated with a therapeutically active component and (b) in contact with the radiopaque marker. The brachytherapy seed has a size and shape suitable for passing through the bore of a needle having an interior diameter of less than about 2.7 millimeters (10 gauge).
摘要翻译：用于植入受试者的不透射线近距离放射治疗种子包括生物相容性成分，包括非放射性药物的治疗活性成分和不透射线的标记物。生物相容性成分是（a）与治疗活性成分物理相关，和（b）与不透射线标记物接触。近距离放射治疗种子具有适于穿过内径小于约2.7毫米（10度）的针孔的尺寸和形状。

10. 发明授权

US07922645B2 Deflectable implantation device and method for use 有权
标题翻译：可偏转植入装置及其使用方法
公开(公告)号：US07922645B2
公开(公告)日：2011-04-12
申请号：US11873295
申请日：2007-10-16
申请人： Edward J. Kaplan
发明人： Edward J. Kaplan
IPC分类号： A61N5/00
CPC分类号： A61M37/0069 , A61B17/3468 , A61B2017/00867 , A61M25/0662 , A61M2205/0266 , A61N5/1007 , A61N2005/1011
摘要： Systems, apparatus, components and methods are disclosed that allow the clinician to circumvent the pubic arch in instances where it interferes with insertion of instrumentation into the prostate or periprostatic tissue. The systems, apparatus and components disclosed herein employ structures, such as needles and trocars, of shape memory alloys, such as nickel-titanium (Ni—Ti) for the purpose of avoiding the pubic arch when accessing the prostate from the perineum.
摘要翻译：公开了允许临床医生在妨碍仪器插入前列腺或静脉周围组织的情况下绕过耻骨弓的系统，装置，部件和方法。本文公开的系统，装置和组件采用诸如镍 - 钛（Ni-Ti）的形状记忆合金的结构，例如针和套管针，用于在从会阴访问前列腺时避免耻骨弓。

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