会员体验
专利管家(专利管理)
工作空间(专利管理)
风险监控(情报监控)
数据分析(专利分析)
侵权分析(诉讼无效)
联系我们
交流群
官方交流:
QQ群: 891211   
微信请扫码    >>>
现在联系顾问~
热词
    • 3. 发明申请
    • Norovirus and sapovirus antigens
    • 诺如病毒和滑鼠病毒抗原
    • US20110014652A1
    • 2011-01-20
    • US12383419
    • 2009-03-24
    • Doris CoitMichael HoughtonColin McCoinAngelica Medina-SelbyMichael Vajdy
    • Doris CoitMichael HoughtonColin McCoinAngelica Medina-SelbyMichael Vajdy
    • C12P21/02
    • C12N9/14A61K39/00A61K39/12A61K2039/5258A61K2039/53A61K2039/545A61K2039/55544A61K2039/55555C07K14/005C07K2319/00C07K2319/40C12N2770/16022C12N2770/16034
    • Immunogenic compositions that elicit immune responses against Norovirus and Sapovirus antigens are described. In particular, the invention relates to polynucleotides encoding one or more capsid proteins or other immunogenic viral polypeptides from one or more strains of Norovirus and/or Sapovirus, coexpression of such immunogenic viral polypeptides with adjuvants, and methods of using the polynucleotides in applications including immunization and production of immunogenic viral polypeptides and viral-like particles (VLPs). Methods for producing Norovirus- or Sapovirus-derived multiple epitope fusion antigens or polyproteins and immunogenic compositions comprising one or more immunogenic polypeptides, polynucleotides, VLPs, and/or adjuvants are also described. The immunogenic compositions of the invention may also contain antigens other than Norovirus or Sapovirus antigens, including antigens that can be used in immunization against pathogens that cause diarrheal diseases, such as antigens derived from rotavirus.
    • 描述了引起针对诺如病毒和曙红病毒抗原的免疫应答的免疫原性组合物。 特别地,本发明涉及编码来自一种或多种诺如病毒和/或札幌病毒株的一种或多种衣壳蛋白或其它免疫原性病毒多肽的多核苷酸,这种免疫原性病毒多肽与佐剂的共表达,以及在包括免疫的应用中使用多核苷酸的方法 以及产生免疫原性病毒多肽和病毒样颗粒(VLP)。 还描述了用于生产包含一种或多种免疫原性多肽,多核苷酸,VLP和/或佐剂的诺如病毒或札幌病毒衍生的多表位融合抗原或多蛋白的免疫原性组合物的方法。 本发明的免疫原性组合物还可以含有除诺如病毒或札幌病毒抗原以外的抗原,包括可用于免疫引起腹泻疾病的病原体的抗原,例如来源于轮状病毒的抗原。