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1. 发明申请

US20120141529A1 NOROVIRUS AND SAPOVIRUS ANTIGENS 审中-公开
标题翻译： NOROVIRUS和SAPOVIRUS抗原
公开(公告)号：US20120141529A1
公开(公告)日：2012-06-07
申请号：US13355192
申请日：2012-01-20
申请人： Doris Coit , Michael Houghton , Colin McCoin , Angelica Medina-Selby , Michael Vajdy
发明人： Doris Coit , Michael Houghton , Colin McCoin , Angelica Medina-Selby , Michael Vajdy
IPC分类号： A61K39/125 , C12P21/06 , C12N15/63 , C12N1/19 , C12N15/40 , A61P31/14
CPC分类号： C12N9/14 , A61K39/00 , A61K39/12 , A61K2039/5258 , A61K2039/53 , A61K2039/545 , A61K2039/55544 , A61K2039/55555 , C07K14/005 , C07K2319/00 , C07K2319/40 , C12N2770/16022 , C12N2770/16034
摘要： Immunogenic compositions that elicit immune responses against Norovirus and Sapovirus antigens are described. In particular, the invention relates to polynucleotides encoding one or more capsid proteins or other immunogenic viral polypeptides from one or more strains of Norovirus and/or Sapovirus, coexpression of such immunogenic viral polypeptides with adjuvants, and methods of using the polynucleotides in applications including immunization and production of immunogenic viral polypeptides and viral-like particles (VLPs). Methods for producing Norovirus- or Sapovirus-derived multiple epitope fusion antigens or polyproteins and immunogenic compositions comprising one or more immunogenic polypeptides, polynucleotides, VLPs, and/or adjuvants are also described. The immunogenic compositions of the invention may also contain antigens other than Norovirus or Sapovirus antigens, including antigens that can be used in immunization against pathogens that cause diarrheal diseases, such as antigens derived from rotavirus.
摘要翻译：描述了引起针对诺如病毒和曙红病毒抗原的免疫应答的免疫原性组合物。特别地，本发明涉及编码来自一种或多种诺如病毒和/或札幌病毒株的一种或多种衣壳蛋白或其它免疫原性病毒多肽的多核苷酸，这种免疫原性病毒多肽与佐剂的共表达，以及在包括免疫的应用中使用多核苷酸的方法以及产生免疫原性病毒多肽和病毒样颗粒（VLP）。还描述了用于生产包含一种或多种免疫原性多肽，多核苷酸，VLP和/或佐剂的诺如病毒或札幌病毒衍生的多表位融合抗原或多蛋白的免疫原性组合物的方法。本发明的免疫原性组合物还可以含有除诺如病毒或札幌病毒抗原以外的抗原，包括可用于免疫引起腹泻疾病的病原体的抗原，例如来源于轮状病毒的抗原。

2. 发明授权

US08142793B2 Norovirus and Sapovirus antigens 有权
标题翻译：诺如病毒和痘病毒抗原
公开(公告)号：US08142793B2
公开(公告)日：2012-03-27
申请号：US12383425
申请日：2009-03-24
申请人： Doris Coit , Michael Houghton , Colin McCoin , Angelica Medina-Selby , Michael Vajdy
发明人： Doris Coit , Michael Houghton , Colin McCoin , Angelica Medina-Selby , Michael Vajdy
IPC分类号： A01N63/04 , A61K39/38 , A61K39/12 , A61K39/125 , C12P21/04 , C12N5/02 , C12N15/74
CPC分类号： C12N9/14 , A61K39/00 , A61K39/12 , A61K2039/5258 , A61K2039/53 , A61K2039/545 , A61K2039/55544 , A61K2039/55555 , C07K14/005 , C07K2319/00 , C07K2319/40 , C12N2770/16022 , C12N2770/16034
摘要： Immunogenic compositions that elicit immune responses against Norovirus and Sapovirus antigens are described. In particular, the invention relates to polynucleotides encoding one or more capsid proteins or other immunogenic viral polypeptides from one or more strains of Norovirus and/or Sapovirus, coexpression of such immunogenic viral polypeptides with adjuvants, and methods of using the polynucleotides in applications including immunization and production of immunogenic viral polypeptides and viral-like particles (VLPs). Methods for producing Norovirus- or Sapovirus-derived multiple epitope fusion antigens or polyproteins and immunogenic compositions comprising one or more immunogenic polypeptides, polynucleotides, VLPs, and/or adjuvants are also described. The immunogenic compositions of the invention may also contain antigens other than Norovirus or Sapovirus antigens, including antigens that can be used in immunization against pathogens that cause diarrheal diseases, such as antigens derived from rotavirus.
摘要翻译：描述了引起针对诺如病毒和曙红病毒抗原的免疫应答的免疫原性组合物。特别地，本发明涉及编码来自一种或多种诺如病毒和/或札幌病毒株的一种或多种衣壳蛋白或其它免疫原性病毒多肽的多核苷酸，这种免疫原性病毒多肽与佐剂的共表达，以及在包括免疫的应用中使用多核苷酸的方法以及产生免疫原性病毒多肽和病毒样颗粒（VLP）。还描述了用于生产包含一种或多种免疫原性多肽，多核苷酸，VLP和/或佐剂的诺如病毒或札幌病毒衍生的多表位融合抗原或多蛋白的免疫原性组合物的方法。本发明的免疫原性组合物还可以含有除诺如病毒或札幌病毒抗原以外的抗原，包括可用于免疫引起腹泻疾病的病原体的抗原，例如来源于轮状病毒的抗原。

3. 发明申请

US20110014652A1 Norovirus and sapovirus antigens 有权
标题翻译：诺如病毒和滑鼠病毒抗原
公开(公告)号：US20110014652A1
公开(公告)日：2011-01-20
申请号：US12383419
申请日：2009-03-24
申请人： Doris Coit , Michael Houghton , Colin McCoin , Angelica Medina-Selby , Michael Vajdy
发明人： Doris Coit , Michael Houghton , Colin McCoin , Angelica Medina-Selby , Michael Vajdy
IPC分类号： C12P21/02
CPC分类号： C12N9/14 , A61K39/00 , A61K39/12 , A61K2039/5258 , A61K2039/53 , A61K2039/545 , A61K2039/55544 , A61K2039/55555 , C07K14/005 , C07K2319/00 , C07K2319/40 , C12N2770/16022 , C12N2770/16034
摘要： Immunogenic compositions that elicit immune responses against Norovirus and Sapovirus antigens are described. In particular, the invention relates to polynucleotides encoding one or more capsid proteins or other immunogenic viral polypeptides from one or more strains of Norovirus and/or Sapovirus, coexpression of such immunogenic viral polypeptides with adjuvants, and methods of using the polynucleotides in applications including immunization and production of immunogenic viral polypeptides and viral-like particles (VLPs). Methods for producing Norovirus- or Sapovirus-derived multiple epitope fusion antigens or polyproteins and immunogenic compositions comprising one or more immunogenic polypeptides, polynucleotides, VLPs, and/or adjuvants are also described. The immunogenic compositions of the invention may also contain antigens other than Norovirus or Sapovirus antigens, including antigens that can be used in immunization against pathogens that cause diarrheal diseases, such as antigens derived from rotavirus.
摘要翻译：描述了引起针对诺如病毒和曙红病毒抗原的免疫应答的免疫原性组合物。特别地，本发明涉及编码来自一种或多种诺如病毒和/或札幌病毒株的一种或多种衣壳蛋白或其它免疫原性病毒多肽的多核苷酸，这种免疫原性病毒多肽与佐剂的共表达，以及在包括免疫的应用中使用多核苷酸的方法以及产生免疫原性病毒多肽和病毒样颗粒（VLP）。还描述了用于生产包含一种或多种免疫原性多肽，多核苷酸，VLP和/或佐剂的诺如病毒或札幌病毒衍生的多表位融合抗原或多蛋白的免疫原性组合物的方法。本发明的免疫原性组合物还可以含有除诺如病毒或札幌病毒抗原以外的抗原，包括可用于免疫引起腹泻疾病的病原体的抗原，例如来源于轮状病毒的抗原。

4. 发明授权

US07871625B2 HCV multiple epitope fusion antigens with modified proteolytic cleavage sites and uses thereof 有权
标题翻译：具有修饰的蛋白水解切割位点的HCV多表位融合抗原及其用途
公开(公告)号：US07871625B2
公开(公告)日：2011-01-18
申请号：US11661577
申请日：2005-08-26
申请人： David Chien , Doris Coit , Carlos George-Nascimento , Sansan Lin , Angelica Medina-Selby , Laura Tandeske
发明人： David Chien , Doris Coit , Carlos George-Nascimento , Sansan Lin , Angelica Medina-Selby , Laura Tandeske
IPC分类号： A61K39/00 , C12N15/00
CPC分类号： C07K14/005 , A61K39/00 , C12N2770/24222 , G01N33/5767 , G01N2469/20
摘要： Modified HCV multiple epitope fusion antigens (MEFAs) are described. The proteins include modified sequences such that proteolytic cleavage of the MEFAs by HCV NS3 protease is inhibited. HCV immunoassays including the modified MEFAs are also described.
摘要翻译：描述了修饰的HCV多表位融合抗原（MEFA）。蛋白质包括修饰的序列，使得HCV NS3蛋白酶对MEFAs的蛋白水解切割被抑制。还描述了包括修饰的MEFAs的HCV免疫测定。

5. 发明申请

US20100291129A1 Norovirus and sapovirus antigens 有权
标题翻译：诺如病毒和滑鼠病毒抗原
公开(公告)号：US20100291129A1
公开(公告)日：2010-11-18
申请号：US12383420
申请日：2009-03-24
申请人： Doris Coit , Michael Houghton , Colin McCoin , Angelica Medina-Selby , Michael Vajdy
发明人： Doris Coit , Michael Houghton , Colin McCoin , Angelica Medina-Selby , Michael Vajdy
IPC分类号： A61K39/125 , A61K39/295 , A61P31/14 , A61P31/00 , A61K39/12
CPC分类号： C12N9/14 , A61K39/00 , A61K39/12 , A61K2039/5258 , A61K2039/53 , A61K2039/545 , A61K2039/55544 , A61K2039/55555 , C07K14/005 , C07K2319/00 , C07K2319/40 , C12N2770/16022 , C12N2770/16034
摘要： Immunogenic compositions that elicit immune responses against Norovirus and Sapovirus antigens are described. In particular, the invention relates to polynucleotides encoding one or more capsid proteins or other immunogenic viral polypeptides from one or more strains of Norovirus and/or Sapovirus, coexpression of such immunogenic viral polypeptides with adjuvants, and methods of using the polynucleotides in applications including immunization and production of immunogenic viral polypeptides and viral-like particles (VLPs). Methods for producing Norovirus- or Sapovirus-derived multiple epitope fusion antigens or polyproteins and immunogenic compositions comprising one or more immunogenic polypeptides, polynucleotides, VLPs, and/or adjuvants are also described. The immunogenic compositions of the invention may also contain antigens other than Norovirus or Sapovirus antigens, including antigens that can be used in immunization against pathogens that cause diarrheal diseases, such as antigens derived from rotavirus.
摘要翻译：描述了引起针对诺如病毒和曙红病毒抗原的免疫应答的免疫原性组合物。特别地，本发明涉及编码来自一种或多种诺如病毒和/或札幌病毒株的一种或多种衣壳蛋白或其它免疫原性病毒多肽的多核苷酸，这种免疫原性病毒多肽与佐剂的共表达，以及在包括免疫的应用中使用多核苷酸的方法以及产生免疫原性病毒多肽和病毒样颗粒（VLP）。还描述了用于生产包含一种或多种免疫原性多肽，多核苷酸，VLP和/或佐剂的诺如病毒或札幌病毒衍生的多表位融合抗原或多蛋白的免疫原性组合物的方法。本发明的免疫原性组合物还可以含有除诺如病毒或札幌病毒抗原以外的抗原，包括可用于免疫引起腹泻疾病的病原体的抗原，例如来源于轮状病毒的抗原。

6. 发明授权

US07527801B2 Norovirus and Sapovirus antigens 有权
标题翻译：诺如病毒和痘病毒抗原
公开(公告)号：US07527801B2
公开(公告)日：2009-05-05
申请号：US11603913
申请日：2006-11-22
申请人： Doris Coit , Michael Houghton , Colin McCoin , Angelica Medina-Selby , Michael Vajdy
发明人： Doris Coit , Michael Houghton , Colin McCoin , Angelica Medina-Selby , Michael Vajdy
IPC分类号： A01N63/04 , A61K39/38 , A61K39/12 , A61K39/125 , C12P21/04 , C12N5/02 , C12N15/74 , A61K39/187
CPC分类号： C12N9/14 , A61K39/00 , A61K39/12 , A61K2039/5258 , A61K2039/53 , A61K2039/545 , A61K2039/55544 , A61K2039/55555 , C07K14/005 , C07K2319/00 , C07K2319/40 , C12N2770/16022 , C12N2770/16034
摘要： Immunogenic compositions that elicit immune responses against Norovirus and Sapovirus antigens are described. In particular, the invention relates to polynucleotides encoding one or more capsid proteins or other immunogenic viral polypeptides from one or more strains of Norovirus and/or Sapovirus, coexpression of such immunogenic viral polypeptides with adjuvants, and methods of using the polynucleotides in applications including immunization and production of immunogenic viral polypeptides and viral-like particles (VLPs). Methods for producing Norovirus- or Sapovirus-derived multiple epitope fusion antigens or polyproteins and immunogenic compositions comprising one or more immunogenic polypeptides, polynucleotides, VLPs, and/or adjuvants are also described. The immunogenic compositions of the invention may also contain antigens other than Norovirus or Sapovirus antigens, including antigens that can be used in immunization against pathogens that cause diarrheal diseases, such as antigens derived from rotavirus.
摘要翻译：描述了引起针对诺如病毒和曙红病毒抗原的免疫应答的免疫原性组合物。特别地，本发明涉及编码来自一种或多种诺如病毒和/或札幌病毒株的一种或多种衣壳蛋白或其它免疫原性病毒多肽的多核苷酸，这种免疫原性病毒多肽与佐剂的共表达，以及在包括免疫的应用中使用多核苷酸的方法以及产生免疫原性病毒多肽和病毒样颗粒（VLP）。还描述了用于生产包含一种或多种免疫原性多肽，多核苷酸，VLP和/或佐剂的诺如病毒或札幌病毒衍生的多表位融合抗原或多蛋白的免疫原性组合物的方法。本发明的免疫原性组合物还可以含有除诺如病毒或札幌病毒抗原以外的抗原，包括可用于免疫引起腹泻疾病的病原体的抗原，例如来源于轮状病毒的抗原。

7. 发明授权

US06630298B2 HCV antigen/antibody combination assay 有权
公开(公告)号：US06630298B2
公开(公告)日：2003-10-07
申请号：US09881239
申请日：2001-06-14
申请人： David Y. Chien , Phillip Arcangel , Laura Tandeske , Carlos George-Nascimento , Doris Coit , Angelica Medina-Selby
发明人： David Y. Chien , Phillip Arcangel , Laura Tandeske , Carlos George-Nascimento , Doris Coit , Angelica Medina-Selby
IPC分类号： C12Q170
CPC分类号： C07K14/005 , C07K2319/00 , C12N2770/24222 , G01N33/5767 , G01N2333/18 , G01N2469/10 , G01N2469/20
摘要： An HCV core antigen and NS3/4a antibody combination assay that can detect both HCV antigens and antibodies present in a sample using a single solid matrix, is provided, as well as immunoassay solid supports for use in the assay.

8. 发明申请

US20130273109A1 METHOD FOR GENERATING A PARVOVIRUS B19 VIRUS-LIKE PARTICLE 有权
标题翻译：用于产生PARVVVUSUS B19病毒样颗粒的方法
公开(公告)号：US20130273109A1
公开(公告)日：2013-10-17
申请号：US13639820
申请日：2011-04-07
申请人： Ethan Settembre , Angelica Medina-Selby , Doris Coit , Philip R. Dormitzer
发明人： Ethan Settembre , Angelica Medina-Selby , Doris Coit , Philip R. Dormitzer
IPC分类号： A61K39/23
CPC分类号： A61K39/23 , A61K2039/5258 , A61K2039/53 , C07K14/005 , C12N7/00 , C12N2750/14222 , C12N2750/14223 , C12N2750/14243 , C12N2830/20 , C12N2830/34 , Y02A50/412
摘要： The invention provides a process for generating parvovirus VP1/VP2 virus like particles (VLPs). The invention further provides methods for purification of the parvovirus VLPs and immunogenic compositions that contain the VLPs. The invention also includes recombinant nucleic acid molecules that encode parvovirus VP1 and VP2, and host cells that contain the recombinant nucleic acids.
摘要翻译：本发明提供了产生细小病毒VP1 / VP2病毒样颗粒（VLP）的方法。本发明还提供了用于纯化包含VLP的细小病毒VLP和免疫原性组合物的方法。本发明还包括编码细小病毒VP1和VP2的重组核酸分子以及含有重组核酸的宿主细胞。

9. 发明授权

US07888004B2 HCV non-structural polypeptide 有权
标题翻译： HCV非结构多肽
公开(公告)号：US07888004B2
公开(公告)日：2011-02-15
申请号：US12287006
申请日：2008-10-03
申请人： Doris Coit , Angelica Medina-Selby , Mark Selby , Michael Houghton
发明人： Doris Coit , Angelica Medina-Selby , Mark Selby , Michael Houghton
IPC分类号： A61K39/29 , A61K39/12
CPC分类号： C07K14/005 , A61K39/00 , A61K47/593 , A61K47/62 , A61K2039/53 , A61K2039/57 , C12N2770/24222
摘要： Polypeptides comprising a mutant non-structural Hepatitis C virus useful in diagnostic and/or immunogenic compositions are disclosed, in which the mutant is an N-terminal mutation that functionally disrupts the catalytic domain of NS3. Polynucleotides encoding these polypeptides, host cells transformed with polynucleotides and methods of using the polypeptides and polynucleotides are also disclosed.
摘要翻译：公开了包含可用于诊断和/或免疫原性组合物的突变非结构性丙型肝炎病毒的多肽，其中所述突变体是功能性破坏NS3的催化结构域的N-末端突变。还公开了编码这些多肽的多核苷酸，用多核苷酸转化的宿主细胞和使用多肽和多核苷酸的方法。

10. 发明申请

US20110014219A1 Norovirus and Sapovirus antigens 有权
标题翻译：诺如病毒和痘病毒抗原
公开(公告)号：US20110014219A1
公开(公告)日：2011-01-20
申请号：US12383425
申请日：2009-03-24
申请人： Doris Coit , Michael Houghton , Colin McCoin , Angelica Medina-Selby , Michael Vajdy
发明人： Doris Coit , Michael Houghton , Colin McCoin , Angelica Medina-Selby , Michael Vajdy
IPC分类号： A61K39/12 , C07H21/04 , A61K39/295 , A61P31/14 , C12N1/19 , C12N5/10 , A61K31/7088
CPC分类号： C12N9/14 , A61K39/00 , A61K39/12 , A61K2039/5258 , A61K2039/53 , A61K2039/545 , A61K2039/55544 , A61K2039/55555 , C07K14/005 , C07K2319/00 , C07K2319/40 , C12N2770/16022 , C12N2770/16034
摘要： Immunogenic compositions that elicit immune responses against Norovirus and Sapovirus antigens are described. In particular, the invention relates to polynucleotides encoding one or more capsid proteins or other immunogenic viral polypeptides from one or more strains of Norovirus and/or Sapovirus, coexpression of such immunogenic viral polypeptides with adjuvants, and methods of using the polynucleotides in applications including immunization and production of immunogenic viral polypeptides and viral-like particles (VLPs). Methods for producing Norovirus- or Sapovirus-derived multiple epitope fusion antigens or polyproteins and immunogenic compositions comprising one or more immunogenic polypeptides, polynucleotides, VLPs, and/or adjuvants are also described. The immunogenic compositions of the invention may also contain antigens other than Norovirus or Sapovirus antigens, including antigens that can be used in immunization against pathogens that cause diarrheal diseases, such as antigens derived from rotavirus.
摘要翻译：描述了引起针对诺如病毒和曙红病毒抗原的免疫应答的免疫原性组合物。特别地，本发明涉及编码来自一种或多种诺如病毒和/或札幌病毒株的一种或多种衣壳蛋白或其它免疫原性病毒多肽的多核苷酸，这种免疫原性病毒多肽与佐剂的共表达，以及在包括免疫的应用中使用多核苷酸的方法以及产生免疫原性病毒多肽和病毒样颗粒（VLP）。还描述了用于生产包含一种或多种免疫原性多肽，多核苷酸，VLP和/或佐剂的诺如病毒或札幌病毒衍生的多表位融合抗原或多蛋白的免疫原性组合物的方法。本发明的免疫原性组合物还可以含有除诺如病毒或札幌病毒抗原以外的抗原，包括可用于免疫引起腹泻疾病的病原体的抗原，例如来源于轮状病毒的抗原。

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