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1. 发明授权

US09044523B2 Reduction of contaminants in blood and blood products using photosensitizers and peak wavelengths of light 有权
标题翻译：使用光敏剂和光的峰值波长减少血液和血液制品中的污染物
公开(公告)号：US09044523B2
公开(公告)日：2015-06-02
申请号：US11840759
申请日：2007-08-17
申请人： Dennis J. Hlavinka , Raymond P. Goodrich , Heather Reddy
发明人： Dennis J. Hlavinka , Raymond P. Goodrich , Heather Reddy
IPC分类号： A01N1/02 , A61L2/24 , A61K41/00 , A61L2/00 , A61L2/08 , A61L2/10 , C07F11/00 , C07F13/00 , C07F15/02 , C07F17/00
CPC分类号： A61L2/24 , A61K41/0019 , A61L2/0011 , A61L2/0088 , A61L2/08 , A61L2/10 , C07F11/005 , C07F13/005 , C07F15/02 , C07F17/00
摘要： Methods and apparatuses are provided for reduction of pathogens in fluids containing blood products. Preferred methods include the steps of adding an effective, non-toxic amount of a photosensitizer such as riboflavin to the blood product and exposing the fluid to light having a peak wavelength.
摘要翻译：提供了用于减少含有血液制品的流体中的病原体的方法和装置。优选的方法包括将有效的无毒量的光敏剂如核黄素添加到血液制品中并将流体暴露于具有峰值波长的光的步骤。

2. 发明申请

US20110220290A1 Heat Weld Tubing Connectors 审中-公开
标题翻译：热焊管连接器
公开(公告)号：US20110220290A1
公开(公告)日：2011-09-15
申请号：US13114170
申请日：2011-05-24
申请人： Dennis J. Hlavinka , Keith Manica , Frank Corbin, III , Terrence M. Cussen
发明人： Dennis J. Hlavinka , Keith Manica , Frank Corbin, III , Terrence M. Cussen
IPC分类号： B29C65/02
CPC分类号： F16L47/02 , A61M39/143 , A61M39/146 , A61M39/18 , B29C65/2046 , B29C65/2076 , B29C66/0042 , B29C66/00441 , B29C66/1122 , B29C66/1142 , B29C66/5221 , B29C66/71 , B29C66/712 , B29C66/73116 , B29C66/73921 , B29C66/80 , B29C66/8122 , B29C66/81821 , B29C66/8432 , B29C66/857 , B29K2021/003 , B29K2023/00 , B29K2027/06 , B29K2101/12 , B29K2827/18 , B29C65/00 , B29K2909/02 , B29K2867/00 , B29K2905/02 , B29K2905/10
摘要： The present invention provides thermoplastic tubes, thermoplastic melting plates, thermoplastic tube connecting apparatus, and methods for using the same.
摘要翻译：本发明提供热塑性管，热塑性熔融板，热塑性管连接装置及其使用方法。

3. 发明申请

US20100282980A1 Stable Calibration Means for Apparatus for Photo Reduction of Contaminants in Blood 审中-公开
标题翻译：用于血液中污染物减少照片的装置的稳定校正装置
公开(公告)号：US20100282980A1
公开(公告)日：2010-11-11
申请号：US12760627
申请日：2010-04-15
申请人： Abraham BELKIND , Daniel Thomas MCGINNIS , Dennis J. HLAVINKA , Terrence M. CUSSEN
发明人： Abraham BELKIND , Daniel Thomas MCGINNIS , Dennis J. HLAVINKA , Terrence M. CUSSEN
IPC分类号： A61L2/08 , H01L31/0232 , G02B5/10 , C23C16/513
CPC分类号： G01J1/429 , A61K41/0019 , A61L2/0047 , A61L2/0052 , A61L2202/14 , A61L2202/22 , G01J1/04 , G01J2001/0481 , G01N21/4785 , G02B5/0808
摘要： An apparatus for irradiating blood or blood products, preferably with ultra violet or visible light, to reduce contaminants in the blood or blood products. A removable radiometer having light integrating chambers detects the light intensity, allowing the radiation characteristics of the apparatus to be calibrated. The light chambers have an aluminum reflecting surface prepared by machining, grit blasting, polishing and plasma treatment including plasma cleaning and oxidation.
摘要翻译：用于照射血液或血液制品的装置，优选用紫外或可见光照射，以减少血液或血液制品中的污染物。具有光积分室的可移动辐射计检测光强度，允许校准装置的辐射特性。光室具有通过机械加工，喷砂，抛光和等离子体处理（包括等离子体清洁和氧化）制备的铝反射表面。

4. 发明授权

US07582049B2 Fluid separation devices, systems and/or methods using a centrifuge and roller pump 失效
标题翻译：流体分离装置，使用离心机和滚子泵的系统和/或方法
公开(公告)号：US07582049B2
公开(公告)日：2009-09-01
申请号：US11307451
申请日：2006-02-08
申请人： Dennis J. Hlavinka , William G Palsulich , Thomas J. Felt , Frank Corbin, III
发明人： Dennis J. Hlavinka , William G Palsulich , Thomas J. Felt , Frank Corbin, III
IPC分类号： B04B5/02
CPC分类号： A61M1/0209 , A61M1/3693 , B04B5/0428
摘要： A centrifugal fluid separation system is disclosed for centrifugally separating a composite fluid into components thereof. This centrifugal separation system includes at least a centrifugal rotor which has a composite fluid containment area, a fluid flow channel/tubing and at least one separated component collection area defined therein. A composite fluid to be separated is delivered to the fluid containment area where under centrifugal forces the composite fluid is separated into components and then from which a component travels through an outlet channel to a respective separated component fluids flowing therethrough. A centrally disposed pump is also provided to move the separated component(s) to the collection area(s). Optical sensing of the interface of the separated fluid components may be used with a clamp to stop flow. A disposable bag and tubing system is also disclosed for use with reusable rotor devices.
摘要翻译：公开了用于将复合流体离心分离成其组分的离心流体分离系统。该离心分离系统至少包括离心转子，其具有复合流体容纳区域，流体流动通道/管道和限定在其中的至少一个分离的部件收集区域。要分离的复合流体被输送到流体容纳区域，在离心力作用下，复合流体被分离成组分，然后组分通过出口通道行进到流过其中的各自分离的组分流体。还提供了一个集中设置的泵以将分离的部件移动到收集区域。分离的流体组分的界面的光学感测可以与夹具一起使用以阻止流动。还公开了一次性袋和管道系统，用于可重复使用的转子装置。

5. 发明申请

US20080096750A1 Methods for Washing a Red Blood Cell Component and for Removing Prions Therefrom 有权
标题翻译：洗涤红细胞成分和去除朊病毒的方法
公开(公告)号：US20080096750A1
公开(公告)日：2008-04-24
申请号：US11875334
申请日：2007-10-19
申请人： Dennis J. HLAVINKA , Raymond P. GOODRICH , Eric T. HANSEN
发明人： Dennis J. HLAVINKA , Raymond P. GOODRICH , Eric T. HANSEN
IPC分类号： B01D43/00 , B04B5/02
CPC分类号： A61M1/3693 , A61M1/0209 , A61M1/0218 , A61M1/3692 , A61M1/3696 , A61M1/3698 , B04B5/0428 , B04B9/14 , B04B2009/143
摘要： A method for washing multiple units of blood product including providing a centrifuge having a wash cell for each unit of blood product, balancing the centrifuge to accommodate for differences in the wash cells, and transferring supernatant including any wash solution from each unit of blood product on the centrifuge.
摘要翻译：一种用于洗涤多个血液制品单元的方法，包括提供具有用于每个血液制品单位的洗涤池的离心机，平衡离心机以适应洗涤细胞的差异，以及将来自每一单位血液制品的任何洗涤溶液的上清液离心机

6. 发明授权

US06736768B2 Fluid separation devices, systems and/or methods using a fluid pressure driven and/or balanced approach 有权
标题翻译：使用流体压力驱动和/或平衡方法的流体分离装置，系统和/或方法
公开(公告)号：US06736768B2
公开(公告)日：2004-05-18
申请号：US10008989
申请日：2001-11-02
申请人： Thomas J. Felt , Dennis J. Hlavinka
发明人： Thomas J. Felt , Dennis J. Hlavinka
IPC分类号： B04B100
CPC分类号： B04B5/0442 , A61M1/0231 , A61M1/3693 , A61M1/3696 , A61M1/38 , B04B5/0428 , B04B7/08 , B04B9/08 , B04B2005/045 , B04B2005/0464 , B04B2009/143
摘要： A centrifugal separation device separates a composite fluid, such as blood, into the components thereof. The fluid is delivered to a fluid receiving area in a rotor from which area the fluid travels through a radial inlet channel having an inlet channel height to a proximal end of a circumferential fluid separation channel. Near a distal end of the separation channel, fluid components travel into distinct first and second outlet channels. The height of the first channel is greater than the height of the more distal second channel. The inlet channel height is greater than the height of the first channel. The rotor may be balanced by axially symmetrical sets of inlet channels, separation channels and outlet channels or by a balance channel connected to the separation channel but displaced from the outlet channels.
摘要翻译：离心分离装置将诸如血液的复合流体分离成其组分。流体被输送到转子中的流体接收区域，流体从该区域流过具有到周向流体分离通道的近端的入口通道高度的径向入口通道。在分离通道的远端附近，流体组分行进到不同的第一和第二出口通道。第一通道的高度大于较远端第二通道的高度。入口通道高度大于第一通道的高度。转子可以通过轴向对称的入口通道，分离通道和出口通道组合或通过连接到分离通道但从出口通道移位的平衡通道来平衡。

7. 发明授权

US5345070A Radio frequency tubing sealer 失效
标题翻译：射频管封口机
公开(公告)号：US5345070A
公开(公告)日：1994-09-06
申请号：US21507
申请日：1993-02-23
申请人： Dennis J. Hlavinka , Frank Corbin, III , Robert L. White
发明人： Dennis J. Hlavinka , Frank Corbin, III , Robert L. White
IPC分类号： A61M5/14 , B29C57/10 , B29C65/00 , B29C65/04 , B29C65/74 , B29L23/00 , B65B51/10 , H05B6/62
CPC分类号： B29C65/04 , B29C65/743 , B29C66/1122 , B29C66/4312 , B29C66/73921 , B29C66/8122 , B29C66/81263 , B29C66/81422 , B29C66/8187 , B29C66/8322 , B29C66/857 , B29C66/8614 , B29C57/10 , B29C66/71 , B29C66/81871 , B29L2023/007 , B29L2031/753 , Y10S128/24 , Y10S604/905
摘要： An insulating sleeve retains heat in the plastic of a flexible plastic medical tube when the plastic of the medical tube is dielectrically heated by a radio frequency tubing sealer. The heat retained by the insulating sleeve permits additional melting of the plastic of the medical tube after a seal has been formed. The additional melting results in forming an easily tearable web between the segments of the medical tube in the same operation as the sealing operation. The medical tube is selectively sealed without forming the easily tearable web by using the radio frequency tubing sealer without the insulating sleeve.
摘要翻译：当医疗管的塑料被射频管密封器介电加热时，绝缘套管在柔性塑料医疗管的塑料中保持热量。在形成密封件之后，由绝缘套管保留的热量允许医用管的塑料的额外熔化。在与密封操作相同的操作中，额外的熔化导致在医疗管的段之间形成容易撕裂的网。通过使用没有绝缘套筒的射频管封口机，医疗管被选择性地密封，而不形成易撕层。

8. 发明授权

US08048055B2 Clamp assembly for displacing fluid from portions of fluid containers 有权
标题翻译：用于从流体容器的部分排出流体的夹紧组件
公开(公告)号：US08048055B2
公开(公告)日：2011-11-01
申请号：US12548656
申请日：2009-08-27
申请人： Dennis J. Hlavinka , Terrence M. Cussen
发明人： Dennis J. Hlavinka , Terrence M. Cussen
IPC分类号： A61M19/00 , A61M37/00 , B65D33/00
CPC分类号： A61L2/0011 , A61M1/0277 , A61M1/3683
摘要： Clamps and methods are disclosed for clamping portions of fluid containers and displacing fluid from portions of fluid containers. In one embodiment, a clamp has a first jaw having a photopermeable main body portion and a second jaw. The first and second jaws are operatively associated so that at least one jaw, or both jaws, may be moved between clamped and released positions. The clamp is sized to receive a portion of a fluid container and displace fluid in the fluid container from a clamped region of the fluid container when the first and/or second jaw(s) are in the clamped position. The photopermeable main body portion(s) of the first and/or second jaw(s) allow some light to reach the clamped region of the fluid container during photoradiation to inactivate pathogens in the fluid. Various clamp embodiments and assemblies having lock members and interlocks are also disclosed herein.
摘要翻译：公开了用于夹紧流体容器的部分并且从流体容器的部分移出流体的夹具和方法。在一个实施例中，夹具具有具有光透过主体部分和第二钳口的第一钳口。第一和第二钳口可操作地相关联，使得至少一个钳口或两个钳口可在夹紧位置和释放位置之间移动。当第一和/或第二钳口处于夹紧位置时，夹具的尺寸设定成接收流体容器的一部分并且从流体容器的夹紧区域移动流体容器中的流体。第一和/或第二钳口的光透过主体部分允许一些光在光辐射期间到达流体容器的夹紧区域以灭活流体中的病原体。本文还公开了具有锁定构件和互锁的各种夹具实施例和组件。

9. 发明申请

US20090317296A1 Clamp Assembly for Displacing Fluid from Portions of Fluid Containers 有权
标题翻译：用于从流体容器的部分排出流体的夹紧组件
公开(公告)号：US20090317296A1
公开(公告)日：2009-12-24
申请号：US12548656
申请日：2009-08-27
申请人： Dennis J. HLAVINKA , Terrence M. CUSSEN
发明人： Dennis J. HLAVINKA , Terrence M. CUSSEN
IPC分类号： A61M1/02 , B01L11/00
CPC分类号： A61L2/0011 , A61M1/0277 , A61M1/3683
摘要： Clamps and methods are disclosed for clamping portions of fluid containers and displacing fluid from portions of fluid containers. In one embodiment, a clamp has a first jaw having a photopermeable main body portion and a second jaw. The first and second jaws are operatively associated so that at least one jaw, or both jaws, may be moved between clamped and released positions. The clamp is sized to receive a portion of a fluid container and displace fluid in the fluid container from a clamped region of the fluid container when the first and/or second jaw(s) are in the clamped position. The photopermeable main body portion(s) of the first and/or second jaw(s) allow some light to reach the clamped region of the fluid container during photoradiation to inactivate pathogens in the fluid. Various clamp embodiments and assemblies having lock members and interlocks are also disclosed herein.
摘要翻译：公开了用于夹紧流体容器的部分并且从流体容器的部分移出流体的夹具和方法。在一个实施例中，夹具具有具有光透过主体部分和第二钳口的第一钳口。第一和第二钳口可操作地相关联，使得至少一个钳口或两个钳口可在夹紧位置和释放位置之间移动。当第一和/或第二钳口处于夹紧位置时，夹具的尺寸设定成接收流体容器的一部分并且从流体容器的夹紧区域移动流体容器中的流体。第一和/或第二钳口的光透过主体部分允许一些光在光辐射期间到达流体容器的夹紧区域以灭活流体中的病原体。本文还公开了具有锁定构件和互锁的各种夹具实施例和组件。

10. 发明授权

US07033512B2 Fluid separation devices, systems and/or methods using a centrifuge and roller pump 失效
公开(公告)号：US07033512B2
公开(公告)日：2006-04-25
申请号：US10413890
申请日：2003-04-14
申请人： Dennis J. Hlavinka , William G. Palsulich , Thomas J. Felt , Frank Corbin, III
发明人： Dennis J. Hlavinka , William G. Palsulich , Thomas J. Felt , Frank Corbin, III
IPC分类号： C02F1/38
CPC分类号： A61M1/0209 , A61M1/3693 , B04B5/0428
摘要： A centrifugal fluid separation system is disclosed for centrifugally separating a composite fluid into components thereof. This centrifugal separation system includes at least a centrifugal rotor which has a composite fluid containment area, a fluid flow channel/tubing and at least one separated component collection area defined therein. A composite fluid to be separated is delivered to the fluid containment area where under centrifugal forces the composite fluid is separated into components and then from which a component travels through an outlet channel to a respective separated component fluids flowing therethrough. A centrally disposed pump is also provided to move the separated component(s) to the collection area(s). Optical sensing of the interface of the separated fluid components may be used with a clamp to stop flow. A disposable bag and tubing system is also disclosed for use with reusable rotor devices.

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