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    • 1. 发明授权
    • Method for evaluation of erythema utilizing skin reflectance measurements
    • 使用皮肤反射测量评估红斑的方法
    • US4423736A
    • 1984-01-03
    • US310474
    • 1981-10-13
    • David P. DeWittRobert E. HannemannBarrett F. RobinsonEdward J. Hanley
    • David P. DeWittRobert E. HannemannBarrett F. RobinsonEdward J. Hanley
    • A61B5/103G01N21/55A61B6/00
    • A61B5/445A61B5/0059A61B5/411A61B5/443G01N21/55
    • A method is disclosed for evaluating erythema utilizing skin reflection measurements. By collecting and analyzing data representative of both normal and erythematous skin utilizing reflectance spectra within a range of 400 to 700 nm, distinctive spectral features of erythema have been identified. A relationship representing a function of normal and erythematous skin reflectance at three specific wavelengths (500 nm, 550 nm, and 595 nm) was developed to provide an absolute measure of the vascular response of the skin, which measure is independent of pigmentation characteristics of the skin and takes into consideration normal fluctuations in skin color. By varying the exposure of the skin to radiation from a predetermined source and then measuring the reflectance of the skin at particular time periods and at a plurality (preferably three) of different wavelengths, the relative changes in superficial blood volume due to erythema are isolated. The method is thus useful for monitoring dosage dependence and time response of erythema, and is particularly well suited, for example, for determining sensitivity of skin to ultraviolet radiation, evaluation of sun screening agents and/or screening of individuals for susceptibility to irritation and/or irritants.
    • 公开了一种利用皮肤反射测量来评估红斑的方法。 通过利用400至700nm范围内的反射光谱收集和分析代表正常和红斑皮肤的数据,已经鉴定了红斑的特征性光谱特征。 开发了表示在三个特定波长(500nm,550nm和595nm)处的正常和红斑皮肤反射率的函数的关系,以提供对皮肤的血管反应的绝对测量,该测量与皮肤的色素沉着特性无关 皮肤并考虑皮肤颜色的正常波动。 通过改变皮肤暴露于来自预定源的辐射,然后在特定时间段和多个(优选三个)不同波长下测量皮肤的反射率,分离由于红斑引起的浅表血容量的相对变化。 因此,该方法可用于监测红斑的剂量依赖性和时间反应,并且特别适用于例如确定皮肤对紫外线辐射的敏感性,阳光筛选剂的评估和/或个体对刺激易感性的筛选和/ 或刺激物。