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1. 发明授权

US08889760B2 Photoactivatable crosslinker 有权
标题翻译：可光活化交联剂
公开(公告)号：US08889760B2
公开(公告)日：2014-11-18
申请号：US13074537
申请日：2011-03-29
申请人： Aleksey V. Kurdyumov , Dale G. Swan
发明人： Aleksey V. Kurdyumov , Dale G. Swan
IPC分类号： C07F9/08 , C07F9/12 , C07C49/786 , C07F9/145 , C07F9/40 , A61L17/14 , A61L27/34 , A61L29/08 , A61L31/10 , C07F7/10 , C07F7/18 , C08F2/48
CPC分类号： C09D7/63 , A61L17/145 , A61L27/34 , A61L29/085 , A61L31/10 , A61L2400/18 , A61L2420/02 , C07F7/10 , C07F7/1804 , C07F7/184 , C07F9/06 , C07F9/12 , C07F9/145 , C07F9/4025 , C07F9/4084 , C08F2/48 , C08K5/51 , C08K5/5419 , C08K5/544 , C09D7/1233
摘要： Described herein is a degradable linking agent of formula Photo1-LG-Photo2, wherein Photo1 and Photo2 independently represent at least one photoreactive group and LG represents a linking group comprising one or more silicon atoms or one or more phosphorous atoms. The degradable linking agent includes a covalent linkage between at least one photoreactive group and the linking group, wherein the covalent linkage between at least one photoreactive group and the linking group is interrupted by at least one heteroatom. A method for coating a support surface with the degradable linking agent, coated support surfaces and medical devices are also described.
摘要翻译：本文描述了分子式为Photo1-LG-Photo2的可降解连接剂，其中Photo1和Photo2独立地表示至少一个光反应性基团，LG代表包含一个或多个硅原子或一个或多个磷原子的连接基团。可降解交联剂包括至少一个光反应基团和连接基团之间的共价键，其中至少一个光反应基团和连接基团之间的共价键被至少一个杂原子中断。还描述了用可降解的连接剂，涂覆的支撑表面和医疗装置涂覆支撑表面的方法。

2. 发明授权

US08241655B2 Coatings for medical articles including natural biodegradable polysaccharides 失效
标题翻译：包括天然可生物降解多糖在内的医疗用品涂料
公开(公告)号：US08241655B2
公开(公告)日：2012-08-14
申请号：US11127351
申请日：2005-05-12
申请人： Stephen J. Chudzik , Joseph A. Chinn , Dale G. Swan , Michael J. Burkstrand
发明人： Stephen J. Chudzik , Joseph A. Chinn , Dale G. Swan , Michael J. Burkstrand
IPC分类号： A61K39/395 , A61F2/02
CPC分类号： A61L31/16 , A61F2210/0004 , A61F2310/00389 , A61L27/34 , A61L27/54 , A61L31/10 , A61L2300/232 , A61L2300/252 , A61L2300/258 , A61L2300/406 , A61L2300/416 , A61L2300/418 , A61L2300/622 , C08L5/00
摘要： Biodegradable coatings that include natural biodegradable polysaccharides are described. The coating is formed from a plurality of natural biodegradable polysaccharides having pendent coupling groups.
摘要翻译：描述了包括天然可生物降解多糖的可生物降解涂层。涂层由具有侧联偶合基团的多种天然可生物降解多糖形成。

3. 发明申请

US20120010707A1 METHODS AND REAGENTS FOR PREPARING BIOMOLECULE-CONTAINING COATINGS 审中-公开
标题翻译：制备生物分子涂料的方法和试剂
公开(公告)号：US20120010707A1
公开(公告)日：2012-01-12
申请号：US13242457
申请日：2011-09-23
申请人： Toni M. Heyer , Dale G. Swan , Stephen J. Chudzik , Joseph A. Chinn , Ralph A. Chappa
发明人： Toni M. Heyer , Dale G. Swan , Stephen J. Chudzik , Joseph A. Chinn , Ralph A. Chappa
IPC分类号： A61F2/02 , A61L33/08 , A61L33/10 , A61L33/06
CPC分类号： A61L27/34 , A61L33/0029 , C08L33/06
摘要： Polymeric coatings that include coupled biomolecules are formed on the surface of articles, such as medical devices. A coated layer that includes a synthetic polymer including a reactive group is formed on a surface and then a biomolecule is attached to the reactive group. The synthetic polymer can be an acrylate polymer or an amine-containing polymer having pendent photoreactive groups.
摘要翻译：包括偶联的生物分子的聚合物涂层形成在诸如医疗装置的制品的表面上。在表面上形成包括含有反应性基团的合成聚合物的涂层，然后将生物分子连接到反应性基团上。合成聚合物可以是具有侧基光反应性基团的丙烯酸酯聚合物或含胺聚合物。

4. 发明申请

US20110144373A1 WATER-SOLUBLE DEGRADABLE PHOTO-CROSSLINKER 审中-公开
标题翻译：水溶性可降解照相机
公开(公告)号：US20110144373A1
公开(公告)日：2011-06-16
申请号：US12965020
申请日：2010-12-10
申请人： Dale G. Swan , Emily Rose Rolfes Meyering , Aleksey V. Kurdyumov , Peter H. Duquette , Robert W. Hergenrother , Toni M. Heyer
发明人： Dale G. Swan , Emily Rose Rolfes Meyering , Aleksey V. Kurdyumov , Peter H. Duquette , Robert W. Hergenrother , Toni M. Heyer
IPC分类号： C07C271/58 , C07C309/61 , C07C69/78 , C07C327/48
CPC分类号： G03F7/031 , C07C309/42 , C07C333/08 , C08F2/50 , G03F7/165
摘要： Described herein is a degradable linking agent that includes a core molecule with one or more charged groups; and one or more photoreactive groups covalently attached to the core molecule by one or more degradable linkers.
摘要翻译：本文描述的是可降解的连接剂，其包括具有一个或多个带电基团的核心分子; 和一个或多个可通过一个或多个可降解接头与核心分子共价连接的光反应基团。

5. 发明申请

US20110076337A1 EMULSIONS CONTAINING ARYLBORONIC ACIDS AND MEDICAL ARTICLES MADE THEREFROM 失效
标题翻译：含有ARYLBONONIC酸的乳液及其制品
公开(公告)号：US20110076337A1
公开(公告)日：2011-03-31
申请号：US12894983
申请日：2010-09-30
申请人： Joram Slager , Aleksey V. Kurdyumov , Dale G. Swan
发明人： Joram Slager , Aleksey V. Kurdyumov , Dale G. Swan
IPC分类号： A61K9/107 , A61K47/36
CPC分类号： A61K9/107 , A61K9/0019 , A61K9/0024 , A61K9/113 , A61K9/5036
摘要： The invention provides emulsion compositions that include a hydrophobic compound and an arylboronic acid. An exemplary emulsion comprises a hydrophobic polymer and a halogenated arylboronic acid. Use of an arylboronic acid provides the emulsion with exceptional stability. The stability provides advantages for the formation of articles formed from the emulsion, including microparticles, as well as other implantable or injectable medical articles having polymeric matrices.
摘要翻译：本发明提供了包含疏水化合物和芳基硼酸的乳液组合物。示例性的乳液包含疏水性聚合物和卤代芳基硼酸。使用芳基硼酸提供了非常稳定的乳液。稳定性为形成由乳液形成的制品提供了优点，包括微粒，以及具有聚合物基质的其它可植入或可注射的医疗制品。

6. 发明申请

US20110040057A1 LIGAND-COUPLED INITIATOR POLYMERS AND METHODS OF USE 审中-公开
标题翻译：配体联合发射体聚合物及其使用方法
公开(公告)号：US20110040057A1
公开(公告)日：2011-02-17
申请号：US12911578
申请日：2010-10-25
申请人： Stephen J. Chudzik , Dale G. Swan
发明人： Stephen J. Chudzik , Dale G. Swan
IPC分类号： C08F124/00 , C08F128/02 , C08G18/71
CPC分类号： A61K9/5026 , A61K9/1635 , A61K47/32 , Y10S516/911 , Y10S522/904 , Y10S623/92
摘要： Initiator polymers having an initiator group and a ligand group are provided. The initiator polymers are capable of specifically binding to a receptor on a surface. Using a macromer system, the initiator polymers are useful for the formation of a polymeric matrix on the surface of a material. In particular, initiator polymers are provided that have specificity to pancreatic β cells and can be used to encapsulate cells for transplantation and the treatment of diabetes.
摘要翻译：提供了具有引发剂基团和配体基团的引发剂聚合物。引发剂聚合物能够特异性结合表面上的受体。使用大分子单体体系，引发剂聚合物可用于在材料表面上形成聚合物基质。特别地，提供对胰腺特异性的引发剂聚合物; 细胞，可用于包封细胞进行移植和治疗糖尿病。

7. 发明申请

US20110009292A1 ATTACHMENT OF MOLECULES TO SURFACES 有权
标题翻译：分子对表面的附着
公开(公告)号：US20110009292A1
公开(公告)日：2011-01-13
申请号：US12878236
申请日：2010-09-09
申请人： Ronald F. Ofstead , Melvin J. Swanson , Dale G. Swan
发明人： Ronald F. Ofstead , Melvin J. Swanson , Dale G. Swan
IPC分类号： C40B40/04 , C08F222/40
CPC分类号： C07H21/00 , B01J2219/00387 , B01J2219/00608 , B01J2219/00612 , B01J2219/00626 , B01J2219/00637 , B01J2219/00659 , B01J2219/00722 , C08F8/00 , C08F2800/10 , C08F2800/20 , C40B40/06 , C40B60/14 , G01N33/54353 , Y10T428/31855 , C08F220/54 , C08F220/56
摘要： The present invention relates to methods, reagents, and substrates that can be used for, for example, immobilizing biomolecules, such as nucleic acids and proteins. In an embodiment, the present invention relates to surfaces coated with a polymer according to the present invention. In an embodiment, the present invention relates to methods for thermochemically and/or photochemically attaching molecules to a surface at a high density.
摘要翻译：本发明涉及可用于例如固定生物分子例如核酸和蛋白质的方法，试剂和底物。在一个实施方案中，本发明涉及涂覆有根据本发明的聚合物的表面。在一个实施方案中，本发明涉及以高密度将分子热化学和/或光化学连接到表面上的方法。

8. 发明授权

US07348055B2 Reagent and method for providing coatings on surfaces 有权
标题翻译：用于在表面上提供涂层的试剂和方法
公开(公告)号：US07348055B2
公开(公告)日：2008-03-25
申请号：US10028518
申请日：2001-12-21
申请人： Ralph A. Chappa , Sean M. Stucke , Richard A. Amos , Terrence P. Everson , Stephen J. Chudzik , Dale G. Swan , Peter H. Duquette
发明人： Ralph A. Chappa , Sean M. Stucke , Richard A. Amos , Terrence P. Everson , Stephen J. Chudzik , Dale G. Swan , Peter H. Duquette
IPC分类号： B32B27/00
CPC分类号： B82Y30/00 , A61L27/34 , C09D4/00 , Y10S522/904 , Y10T428/249991 , Y10T428/249992 , C08F220/56 , C08F220/54
摘要： A grafting reagent and related method of using the reagent to form a polymeric layer on a support surface, and particularly a porous support surface, in a manner that provides and/or preserves desired properties (such as porosity) of the surface. The reagent and method can be used to provide a thin, conformable, uniform, uncrosslinked coating having desired properties onto the surface of a preformed, and particularly a porous, polymeric substrate. The method includes the steps of a) providing a porous support surface, b) providing a nonpolymeric grafting reagent comprising a photoinitator group, c) providing one or more polymerizable monomers adapted to be contacted with the surface, in the presence of the grafting reagent, and to be polymerized upon activation of the photoinitiator; and d) applying the grafting reagent and monomer(s) to the surface in a manner, and under conditions, suitable to coat the surface with the grafting reagent and to cause the polymerization of monomers to the surface upon activation of the grafting reagent.
摘要翻译：以提供和/或保留表面的所需性质（例如孔隙率）的方式使用试剂在支撑表面上，特别是多孔载体表面上形成聚合物层的接枝试剂和相关方法。试剂和方法可用于提供具有所需性质的薄的，一致的，均匀的未交联的涂层，其具有预先形成的，特别是多孔的聚合物基材的表面。该方法包括以下步骤：a）提供多孔载体表面，b）提供包含光引发剂基团的非聚合物接枝剂，c）在接枝剂存在下，提供适于与表面接触的一种或多种可聚合单体，并在激活光引发剂时聚合; 和d）以接枝试剂的方式和条件下将接枝试剂和单体施用于表面，并且在接枝试剂活化时使单体聚合成表面。

9. 发明授权

US06603040B1 Surface coating agents 有权
标题翻译：表面涂层剂
公开(公告)号：US06603040B1
公开(公告)日：2003-08-05
申请号：US09888709
申请日：2001-06-25
申请人： Dale G. Swan
发明人： Dale G. Swan
IPC分类号： C07C30928
CPC分类号： A61L27/28 , A61L27/34 , A61L29/08 , A61L29/085 , A61L33/0088 , A61L33/04 , C07C309/42 , Y10T428/31504
摘要： Compounds useful as surface coating agents, including compounds of the formula: wherein X1 comprises a first photoreactive species; X2 comprises a second photoreactive species; Y comprises a nonpolymeric core molecule comprising an aromatic group; and Z comprises at least one charged group. The Y core can include an aromatic group such as a benzene radical, the charged groups Z can be independently selected from the organic acids that include sulfonic acid, carboxylic acid, and phosphoric acid, and the photoreactive species of X1 and X2 can independently be aryl ketones, such as those selected from the group acetophenone, benzophenone, anthraquinone, anthrone, and anthrone-like heterocycles, and their substituted derivatives. Examples of such coating agents include 4,5-bis(4-benzoylphenylmethyleneoxy) benzene-1,3-disulfonic acid di(potassium and/or sodium) salt, 2,5-bis(4-benzoylphenylmethyleneoxy) benzene-1,4-disulfonic acid di(potassium and/or sodium) salt (Compound II), and 2,5-bis(4-benzoylphenylmethyleneoxy) benzene-1-sulfonic acid monopotassium and/or monosodium salt.
摘要翻译：可用作表面包衣剂的化合物，包括下式的化合物：其中X1包含第一光反应性物质; X2包含第二光反应性物质; Y包含含有芳基的非聚合核心分子; Z包含至少一个带电基团。 Y芯可以包括苯基等芳基，带电基团Z可以独立地选自包括磺酸，羧酸和磷酸的有机酸，并且X1和X2的光反应性物质可以独立地为芳基酮，例如选自苯乙酮，二苯甲酮，蒽醌，蒽酮和蒽酮类杂环的那些，及其取代的衍生物。这种包衣剂的实例包括4,5-双（4-苯甲酰基苯基亚甲基氧基）苯-1,3-二磺酸二（钾和/或钠）盐，2,5-双（4-苯甲酰基苯基亚甲基氧基）苯-1,4- 盐（二盐酸盐）（化合物II）和2,5-双（4-苯甲酰基苯基亚甲基氧基）苯-1-磺酸单钾盐和/或单钠盐。

10. 发明授权

US06278018B1 Surface coating agents 有权
标题翻译：表面涂层剂
公开(公告)号：US06278018B1
公开(公告)日：2001-08-21
申请号：US09460551
申请日：1999-12-14
申请人： Dale G. Swan
发明人： Dale G. Swan
IPC分类号： C07C30928
CPC分类号： A61L27/28 , A61L27/34 , A61L29/08 , A61L29/085 , A61L33/0088 , A61L33/04 , C07C309/42 , Y10T428/31504
摘要： Compounds useful as surface coating agents, including compounds of the formula: wherein X1 comprises a first photoreactive species; X2 comprises a second photoreactive species; Y comprises a nonpolymeric core molecule comprising an aromatic group; and Z comprises at least one charged group. The Y core can include an aromatic group such as a benzene radical, the charged groups Z can be independently selected from the organic acids that include sulfonic acid, carboxylic acid, and phosphoric acid, and the photoreactive species of X1 and X2 can independently be aryl ketones, such as those selected from the group acetophenone, benzophenonie, anthraquinone, anthrone, and anthrone-like heterocycles, and their substituted derivatives. Examples of such coating agents include 4,5-bis(4-benzoylphenylmethyleneoxy) benzene-1,3-disulfonic acid di(potassium and/or sodium) salt, 2,5-bis(4-benzoylphenylmethyleneoxy)benzene-1,4-disulfonic acid di(potassium and/or sodium) salt (Compound II), and 2,5-bis(4-benzoylphenylmethyleneoxy)benzene-1-sulfonic acid monopotassium and/or monosodium salt.
摘要翻译：可用作表面包衣剂的化合物，包括下式的化合物：其中X1包含第一光反应性物质; X2包含第二光反应性物质; Y包含含有芳基的非聚合核心分子; Z包含至少一个带电基团。 Y芯可以包括苯基等芳基，带电基团Z可以独立地选自包括磺酸，羧酸和磷酸的有机酸，并且X1和X2的光反应性物质可以独立地为芳基酮，例如选自苯乙酮，二苯甲酮，蒽醌，蒽酮和蒽酮类杂环的那些，及其取代的衍生物。这种包衣剂的实例包括4,5-双（4-苯甲酰基苯基亚甲基氧基）苯-1,3-二磺酸二（钾和/或钠）盐，2,5-双（4-苯甲酰基苯基亚甲基氧基）苯-1,4- 盐（二盐酸盐）（化合物II）和2,5-双（4-苯甲酰基苯基亚甲基氧基）苯-1-磺酸单钾盐和/或单钠盐。

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