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1. 发明申请

US20130005038A1 Method of Separating Cells and Separation Apparatus 有权
标题翻译：分离细胞和分离装置的方法
公开(公告)号：US20130005038A1
公开(公告)日：2013-01-03
申请号：US13583746
申请日：2011-03-09
申请人： Chikashi Nakamura
发明人： Chikashi Nakamura
IPC分类号： C12N5/02 , C12M1/00
CPC分类号： C12M47/04
摘要： A method and apparatus for discriminating and separating only specific cells in cell samples is provided. The cell separation operation includes inserting a needle-shaped body, on which a substance that selectively binds to a marker substance within each target cell has been immobilized, into each of the cell samples on a substrate, thereby causing the marker substance within each target cell in the cell samples to bind to the needle-shaped body through the substance that selectively binds to the marker substance, and then, putting up the needle-shaped body. The binding force between the needle-shaped body and each target cell when the marker substance within each target cell has bound to the needle-shaped body is made greater than an adhesion force of each of the cell samples to the substrate, so that only target cells each containing the marker substance are pulled up and separated from the substrate.
摘要翻译：提供了用于区分和分离细胞样品中特定细胞的方法和装置。细胞分离操作包括将在其上固定有选择性结合每个靶细胞内的标记物质的物质的针状体插入到基底上的每个细胞样品中，从而在每个靶细胞内引起标记物质在细胞样品中通过选择性地结合标记物质的物质结合针状体，然后放置针状体。当每个靶细胞内的标记物质与针状体结合时，针状体与每个靶细胞之间的结合力大于每个细胞样品对基底的粘附力，使得仅靶将每个含有标记物质的细胞从基质中拉起并分离。

2. 发明授权

US06628432B1 Image reader and image reading method 有权
标题翻译：图像读取器和图像读取方法
公开(公告)号：US06628432B1
公开(公告)日：2003-09-30
申请号：US09432424
申请日：1999-11-02
申请人： Toshiaki Oshima , Chikashi Nakamura
发明人： Toshiaki Oshima , Chikashi Nakamura
IPC分类号： H04N104
CPC分类号： H04N1/02855 , H04N1/0288 , H04N1/0467 , H04N1/1017 , H04N1/1043 , H04N1/1048 , H04N1/1052 , H04N1/193
摘要： An image reader is provided with a transparent member which is placed in an optical path from the surface of an original document bed on the side of a carriage to a condensing lens, whereby when the transparent member exists at a predetermined position, the condensing lens can be focused on a translucent original existing at a position above the position of a reflection original. When the transparent member is at a second predetermined position, the condensing lens can be focused on the reflection original. The condensing lens can be focused on more than one position simply by placing the transparent member in the optical path, so that the structure is simple and the manufacturing costs can be reduced.
摘要翻译：图像读取器设置有透明构件，该透明构件被放置在从原稿台的表面在滑架侧面到聚光透镜的光路中，由此当透明构件存在于预定位置时，会聚透镜可聚焦在存在于反射原稿位置上方的半透明原件上。当透明构件处于第二预定位置时，聚焦透镜可以聚焦在反射原稿上。聚光透镜可以简单地通过将透明构件放置在光路中而聚焦在多于一个位置，使得结构简单并且可以降低制造成本。

3. 发明授权

US06608705B1 Image reading device and focus adjustment method thereof 有权
标题翻译：图像读取装置及其焦点调整方法
公开(公告)号：US06608705B1
公开(公告)日：2003-08-19
申请号：US09331399
申请日：1999-06-21
申请人： Toshiaki Oshima , Chikashi Nakamura
发明人： Toshiaki Oshima , Chikashi Nakamura
IPC分类号： H04N104
CPC分类号： H04N1/00013 , H04N1/00031 , H04N1/00063 , H04N1/00082 , H04N1/02409 , H04N1/03 , H04N1/1013 , H04N1/193
摘要： There are provided an image reading apparatus and a focus adjusting method thereof in which focusing can be accurately conducted by a simple moving mechanism. A condenser lens and line sensor can be moved being integrated with each other. When output values obtained when a document on AF line is read by a line sensor are represented by LS1, LS2, LS3, . . . , and when a broken line graph is considered on which the horizontal axis represents a reading position in the horizontal scanning direction and the vertical axis represents an intensity of an output signal, it is judged that the larger the total distance LM1+LM2+ . . . of the broken lines is, the more accurately the image is in focus. A square root of the sum of the square of a distance between the adjacent reading positions and the square of a difference of intensities of the signals which have been read, is calculated, and it is judged that the larger the sum is, the more accurately the focus is adjusted.
摘要翻译：提供了一种图像读取装置和焦点调节方法，其中可以通过简单的移动机构精确地进行聚焦。可以使聚光透镜和线传感器相互移动。当通过线传感器读取AF线上的文档时获得的输出值由LS1，LS2，LS3表示。。。，并且当考虑横线表示水平扫描方向上的读取位置并且垂直轴表示输出信号的强度的虚线图时，判断总距离LM1 + LM2 +越大。。。的虚线是，图像的焦点越准确。计算相邻读取位置之间的距离的平方和所读取的信号的强度差的平方之和的平方根，并且判断为和越大越准确重点调整。

4. 发明申请

US20110027872A1 CANTILEVER FOR MEASURING INTRA-CELLULAR AND INTER-CELLULAR MICROSPACES 有权
标题翻译：用于测量细胞内和细胞间微细胞的滤波器
公开(公告)号：US20110027872A1
公开(公告)日：2011-02-03
申请号：US12902544
申请日：2010-10-12
申请人： Yukihiro AOKI , Shinichi SHIKATA , Hiroshi UETSUKA , Chikashi NAKAMURA , Nobuo SHIMAMOTO
发明人： Yukihiro AOKI , Shinichi SHIKATA , Hiroshi UETSUKA , Chikashi NAKAMURA , Nobuo SHIMAMOTO
IPC分类号： C12M1/34
CPC分类号： G01Q60/40
摘要： A cantilever for measuring intra-cellular and inter-cellular microspaces of the present invention includes a support portion, a lever portion provided to the support portion so as to protrude therefrom, and a probe portion provided near a free end of the lever portion. The probe portion includes a conductive probe made of a carbon-based material, and an insulating film to coat a periphery of the conductive probe.
摘要翻译：用于测量本发明的细胞内和细胞内的微细胞的悬臂包括支撑部分，设置在支撑部分上以从其突出的杆部分和设置在杆部分的自由端附近的探针部分。探针部分包括由碳基材料制成的导电探针和用于涂覆导电探针周围的绝缘膜。

5. 发明申请

US20100245465A1 LIQUID SUPPLYING APPARATUS AND LIQUID EJECTING APPARATUS 审中-公开
标题翻译：液体供应装置和液体喷射装置
公开(公告)号：US20100245465A1
公开(公告)日：2010-09-30
申请号：US12729508
申请日：2010-03-23
申请人： Chikashi NAKAMURA , Seiya SATO
发明人： Chikashi NAKAMURA , Seiya SATO
IPC分类号： B41J2/165
CPC分类号： B41J2/1652 , B41J2/16526 , B41J2/16532 , B41J2/175 , B41J2/17596
摘要： A liquid ejecting apparatus includes a liquid ejecting head and a cleaning device. The liquid ejecting head has a nozzle formation surface and nozzles formed therethrough. The cleaning device applies a suction force to the inside of the liquid ejecting head through the nozzles to suck the liquid out of the liquid ejecting head for forcible discharging of the liquid. A liquid supplying apparatus includes a liquid supplying passage through which the liquid is supplied from a liquid supplying source at an upstream side, toward the liquid ejecting head at a downstream side. A pump is driven for suction and discharging operations. The pump includes a pump chamber and a displacement member. The displacement member is displaced between two or more positions that include a close position for closing an outlet port through which the liquid flows out of the pump chamber to the downstream side.
摘要翻译：液体喷射装置包括液体喷射头和清洁装置。液体喷射头具有喷嘴形成表面和通过其形成的喷嘴。清洁装置通过喷嘴向液体喷射头的内部施加吸力，以将液体从液体喷射头吸出以强制排出液体。液体供应装置包括液体供应通道，液体从上游侧的液体供给源供给到液体供给通道，在下游侧朝向液体喷射头供给。驱动泵进行抽吸和排放操作。泵包括泵室和排量构件。位移构件在两个或多个位置之间移动，该位置包括用于关闭液体从泵室流出到下游侧的出口的关闭位置。

6. 发明授权

US09175255B2 Method of separating cells and separation apparatus 有权
标题翻译：分离细胞和分离装置的方法
公开(公告)号：US09175255B2
公开(公告)日：2015-11-03
申请号：US13583746
申请日：2011-03-09
申请人： Chikashi Nakamura
发明人： Chikashi Nakamura
IPC分类号： C12M1/00 , C12M3/00
CPC分类号： C12M47/04
摘要： A method and apparatus for discriminating and separating only specific cells in cell samples is provided. The cell separation operation includes inserting a needle-shaped body, on which a substance that selectively binds to a marker substance within each target cell has been immobilized, into each of the cell samples on a substrate, thereby causing the marker substance within each target cell in the cell samples to bind to the needle-shaped body through the substance that selectively binds to the marker substance, and then, pulling up the needle-shaped body. The binding force between the needle-shaped body and each target cell when the marker substance within each target cell has bound to the needle-shaped body is made greater than an adhesion force of each of the cell samples to the substrate, so that only target cells each containing the marker substance are pulled up and separated from the substrate.
摘要翻译：提供了用于区分和分离细胞样品中特定细胞的方法和装置。细胞分离操作包括将在其上固定有选择性结合每个靶细胞内的标记物质的物质的针状体插入到基底上的每个细胞样品中，从而在每个靶细胞内引起标记物质在细胞样品中通过选择性结合标记物质的物质结合针状体，然后拉起针状体。当每个靶细胞内的标记物质与针状体结合时，针状体与每个靶细胞之间的结合力大于每个细胞样品对基底的粘附力，使得仅靶将每个含有标记物质的细胞从基质中拉起并分离。

7. 发明授权

US08349603B2 Cantilever for measuring intra-cellular and inter-cellular microspaces 有权
标题翻译：悬臂用于测量细胞内和细胞间的间隙
公开(公告)号：US08349603B2
公开(公告)日：2013-01-08
申请号：US12902544
申请日：2010-10-12
申请人： Yukihiro Aoki , Shinichi Shikata , Hiroshi Uetsuka , Chikashi Nakamura , Nobuo Shimamoto
发明人： Yukihiro Aoki , Shinichi Shikata , Hiroshi Uetsuka , Chikashi Nakamura , Nobuo Shimamoto
IPC分类号： C12M1/34
CPC分类号： G01Q60/40
摘要： A cantilever for measuring intra-cellular and inter-cellular microspaces of the present invention includes a support portion, a lever portion provided to the support portion so as to protrude therefrom, and a probe portion provided near a free end of the lever portion. The probe portion includes a conductive probe made of a carbon-based material, and an insulating film to coat a periphery of the conductive probe.
摘要翻译：用于测量本发明的细胞内和细胞内的微细胞的悬臂包括支撑部分，设置在支撑部分上以从其突出的杆部分和设置在杆部分的自由端附近的探针部分。探针部分包括由碳基材料制成的导电探针和用于涂覆导电探针周围的绝缘膜。

8. 发明申请

US20080199945A1 CANTILEVER FOR MEASURING INTRA-CELLULAR AND INTER-CELLULAR MICROSPACES 审中-公开
标题翻译：用于测量细胞内和细胞间微细胞的滤波器
公开(公告)号：US20080199945A1
公开(公告)日：2008-08-21
申请号：US11943089
申请日：2007-11-20
申请人： Yukihiro AOKI , Shinichi SHIKATA , Hiroshi UETSUKA , Chikashi NAKAMURA , Nobuo SHIMAMOTO
发明人： Yukihiro AOKI , Shinichi SHIKATA , Hiroshi UETSUKA , Chikashi NAKAMURA , Nobuo SHIMAMOTO
IPC分类号： C12M1/00
CPC分类号： G01Q60/40
摘要： A cantilever for measuring intra-cellular and inter-cellular microspaces of the present invention includes a support portion, a lever portion provided to the support portion so as to protrude therefrom, and a probe portion provided near a free end of the lever portion. The probe portion includes a conductive probe made of a carbon-based material, and an insulating film to coat a periphery of the conductive probe.
摘要翻译：用于测量本发明的细胞内和细胞内的微细胞的悬臂包括支撑部分，设置在支撑部分上以从其突出的杆部分和设置在杆部分的自由端附近的探针部分。探针部分包括由碳基材料制成的导电探针和用于涂覆导电探针周围的绝缘膜。

9. 发明申请

US20080038838A1 Dioxin-Binding Material and Method of Detecting or Quantifying Dioxin 审中-公开
标题翻译：二恶英结合材料和二恶英的检测或定量方法
公开(公告)号：US20080038838A1
公开(公告)日：2008-02-14
申请号：US10574910
申请日：2004-10-01
申请人： Chikashi Nakamura , Jun Miyake , Ikuo Obataya , Noriyuki Nakamura , Katsuhisa Shirai , Yasuhiro Inuyama
发明人： Chikashi Nakamura , Jun Miyake , Ikuo Obataya , Noriyuki Nakamura , Katsuhisa Shirai , Yasuhiro Inuyama
IPC分类号： C07K7/06 , C07D319/00 , G01N33/543 , G01N33/566 , C07K7/00
CPC分类号： G01N33/5308 , B01J20/22 , C07K7/06 , G01N2430/40
摘要： A principal object of the present invention is to provide low-cost techniques for readily detecting or quantifying dioxins using substances which are inexpensive and can be easily produced, and extracting dioxins using such substances. Dioxin binding peptides of the present invention are highly selective to dioxins, and are therefore capable of detecting or quantifying dioxins in test samples containing impurities. Dioxin binding peptides of the present invention are also capable of selectively extracting dioxins from impurity-containing test samples, and are therefore useful in simple pretreatment for quantifying and analyzing dioxins.
摘要翻译：本发明的主要目的是提供一种便宜地检测或定量二恶英的低成本技术，其使用便宜且易于制备的物质，并且使用这些物质提取二恶英。本发明的二恶英结合肽对二恶英具有高选择性，因此能够检测或定量含有杂质的测试样品中的二恶英。本发明的二恶英结合肽也能够从含杂质的测试样品中选择性地提取二恶英，因此可用于量化和分析二恶英的简单预处理。

10. 发明授权

US06513361B2 Method for detecting low molecular weight compound in solution 失效
公开(公告)号：US06513361B2
公开(公告)日：2003-02-04
申请号：US09749979
申请日：2000-12-27
申请人： Jun Miyake , Chikashi Nakamura , Seong-Hun Song , Sang-Mok Chang , Takaaki Arai
发明人： Jun Miyake , Chikashi Nakamura , Seong-Hun Song , Sang-Mok Chang , Takaaki Arai
IPC分类号： G01N2902
CPC分类号： G01N29/32 , B82Y30/00 , G01G3/13 , G01N29/036 , G01N29/348 , G01N2291/0222 , G01N2291/0251 , G01N2291/0255
摘要： The invention relates to a method for detecting a low molecular weight compound in a solution which utilizes a quartz resonator and which comprises capturing a low molecular weight compound between an adsorptive film (A) for a low molecular weight compound provided on the surface of a quartz resonator and an adsorptive film (A) for a low molecular weight compound provided on the surface of a signal enhancing material and comprises detecting the shift in frequency of the quartz resonator before and after the capture.

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