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1. 发明申请

US20120234699A1 BIOSENSOR AND METHOD FOR DETERMINING AN ANALYTE CONCENTRATION 有权
标题翻译：生物传感器和确定分析仪浓度的方法
公开(公告)号：US20120234699A1
公开(公告)日：2012-09-20
申请号：US13301105
申请日：2011-11-21
申请人： Chien-Chong Hong , Meng-Hua Chung , Chih-Chung Lin
发明人： Chien-Chong Hong , Meng-Hua Chung , Chih-Chung Lin
IPC分类号： G01N27/327 , G01N33/50
CPC分类号： G01N27/227 , G01N33/5438 , G01N2600/00
摘要： A method of determining an analyte concentration employs a biosensor that includes a molecularly imprinted polymer film formed on a metal layer. The biosensor is connected to a charge/discharge circuit and charged and discharged during exposure to a solution containing an analyte. Voltage values during discharge are measured, and a characteristic parameter of the voltage values, which is associated with a concentration of the analyte detected by the biosensor, is determined. An unknown concentration of the analyte is determined by comparing the characteristic parameter to reference data representing a relation between known concentration of the analyte and the characteristic parameter of the biosensor. A biosensor, such as an anesthetic biosensor, is also disclosed.
摘要翻译：确定分析物浓度的方法采用包括在金属层上形成的分子印迹聚合物膜的生物传感器。生物传感器连接到充电/放电电路，并在暴露于含有分析物的溶液时进行充放电。测量放电期间的电压值，并且确定与由生物传感器检测到的分析物的浓度相关联的电压值的特征参数。通过将特征参数与表示分析物的已知浓度与生物传感器的特征参数之间的关系的参考数据进行比较来确定分析物的未知浓度。还公开了生物传感器，例如麻醉生物传感器。

2. 发明申请

US20110247707A1 MICROFLUIDIC CHIP DEVICE AND METHOD OF MAKING THE SAME 审中-公开
标题翻译：微流芯片装置及其制造方法
公开(公告)号：US20110247707A1
公开(公告)日：2011-10-13
申请号：US12871089
申请日：2010-08-30
申请人： Chien-Chong Hong , Jui-Chun Chen
发明人： Chien-Chong Hong , Jui-Chun Chen
IPC分类号： F15B13/00 , B32B38/00 , B32B37/02
CPC分类号： F04B43/043 , F04B19/006 , F05C2225/00 , Y02P20/582 , Y10T137/8376 , Y10T156/10
摘要： A microfluidic chip device includes a substrate layer and a microfluidic layer. The substrate layer is made from a shape memory polymer, and includes a transformative portion that can change in volume when changing in shape between a memory shape and a temporary shape. The microfluidic layer is laminated with the substrate layer and has a microchannel that is in fluid communication with the transformative portion. The transformative portion produces a fluid driving pressure within the microchannel when changing between the memory shape and the temporary shape. A method of making the microfluidic chip device is also disclosed.
摘要翻译：微流体芯片器件包括衬底层和微流体层。衬底层由形状记忆聚合物制成，并且包括当存储器形状和临时形状之间形状变化时体积变化的变形部分。微流体层与基底层层叠，并具有与变形部分流体连通的微通道。当在存储器形状和临时形状之间变化时，变换部分在微通道内产生流体驱动压力。还公开了制造微流体芯片器件的方法。

3. 发明申请

US20110193262A1 Method for forming a microstructure on a polymeric substrate 审中-公开
标题翻译：在聚合物基材上形成微结构的方法
公开(公告)号：US20110193262A1
公开(公告)日：2011-08-11
申请号：US12924945
申请日：2010-10-07
申请人： Chien-Chong Hong , Pin Huang , Jiann Shieh
发明人： Chien-Chong Hong , Pin Huang , Jiann Shieh
IPC分类号： B29C59/02
CPC分类号： B29C59/022 , B29C2059/023
摘要： A method for forming a microstructure on a polymeric substrate includes: providing a master mold formed with a micro-feature thereon, the micro-feature having a base portion and a plurality of protrusion portions protruding from the base portion, each of the protrusion portions having a tapered anisotropic shape, including a free end distal from the base portion, and being spaced apart from an adjacent one of the protrusion portions, a distance between the free ends of two adjacent ones of the protrusion portions being not greater than 40 nm; and impressing the free end of each of the protrusion portions of the micro-feature into the polymeric substrate at an elevated temperature T1, the polymeric substrate having a pyrolysis temperature Tp greater than the elevated temperature T1.
摘要翻译：在聚合物基材上形成微观结构的方法包括：提供形成有微结构的母模，所述微型部件具有基部和从所述基部突出的多个突起部，每个所述突出部分具有锥形各向异性形状，包括远离基部的自由端，并且与相邻的突出部分间隔开，两个相邻的突出部分的自由端之间的距离不大于40nm; 并且在升高的温度T1下将微特征的每个突出部分的自由端压印到聚合物基底中，聚合物基底的热解温度Tp高于升高的温度T1。

4. 发明授权

US08734890B2 Method for forming a molecularly imprinted polymer biosensor 有权
标题翻译：形成分子印迹聚合物生物传感器的方法
公开(公告)号：US08734890B2
公开(公告)日：2014-05-27
申请号：US12889494
申请日：2010-09-24
申请人： Chien-Chong Hong , Po-Hsiang Chang , Chih-Chung Lin
发明人： Chien-Chong Hong , Po-Hsiang Chang , Chih-Chung Lin
IPC分类号： A61L33/00
CPC分类号： G03F7/0002 , B82Y10/00 , B82Y40/00 , G01N33/54373 , G01N2600/00 , G03F7/027
摘要： A method for forming a molecularly imprinted polymer biosensor includes: (a) preparing a reaction solution including an imprinting molecule, a functional monomer, an initiator, and a crosslinking agent; (b) disposing the reaction solution in a space between upper and lower substrates each of which is made of a light-transmissible material; (c) disposing on the upper substrate a photomask having a patterned hole; (d) irradiating the reaction solution through the patterned hole of the photomask and the upper substrate so that the reaction solution undergoes polymerization to form a polymer between the upper and lower substrates; (e) removing the upper substrate after the polymer is formed on the lower substrate; and (f) extracting the imprinting molecule from the polymer so that a patterned molecularly imprinted polymer film is formed on the lower substrate.
摘要翻译：形成分子印迹聚合物生物传感器的方法包括：（a）制备包括印迹分子，官能单体，引发剂和交联剂的反应溶液; （b）将反应溶液设置在上下基板之间的空间中，每个基板由透光材料制成; （c）在上基板上设置具有图案化孔的光掩模; （d）通过光掩模和上基板的图案化孔照射反应溶液，使得反应溶液进行聚合以在上基板和下基板之间形成聚合物; （e）在下基板上形成聚合物之后去除上基板; 和（f）从聚合物中提取压印分子，使得在下基板上形成图案化的分子印迹聚合物膜。

5. 发明申请

US20110241260A1 METHOD FOR FORMING A MOLECULARLY IMPRINTED POLYMER BIOSENSOR 有权
标题翻译：形成分子量聚合物生物传感器的方法
公开(公告)号：US20110241260A1
公开(公告)日：2011-10-06
申请号：US12889494
申请日：2010-09-24
申请人： Chien-Chong HONG , Po-Hsiang CHANG , Chih-Chung LIN
发明人： Chien-Chong HONG , Po-Hsiang CHANG , Chih-Chung LIN
IPC分类号： B29C35/08
CPC分类号： G03F7/0002 , B82Y10/00 , B82Y40/00 , G01N33/54373 , G01N2600/00 , G03F7/027
摘要： A method for forming a molecularly imprinted polymer biosensor includes: (a) preparing a reaction solution including an imprinting molecule, a functional monomer, an initiator, and a crosslinking agent; (b) disposing the reaction solution in a space between upper and lower substrates each of which is made of a light-transmissible material; (c) disposing on the upper substrate a photomask having a patterned hole; (d) irradiating the reaction solution through the patterned hole of the photomask and the upper substrate so that the reaction solution undergoes polymerization to form a polymer between the upper and lower substrates; (e) removing the upper substrate after the polymer is formed on the lower substrate; and (f) extracting the imprinting molecule from the polymer so that a patterned molecularly imprinted polymer film is formed on the lower substrate.
摘要翻译：形成分子印迹聚合物生物传感器的方法包括：（a）制备包括印迹分子，官能单体，引发剂和交联剂的反应溶液; （b）将反应溶液设置在上下基板之间的空间中，每个基板由透光材料制成; （c）在上基板上设置具有图案化孔的光掩模; （d）通过光掩模和上基板的图案化孔照射反应溶液，使得反应溶液进行聚合以在上基板和下基板之间形成聚合物; （e）在下基板上形成聚合物之后去除上基板; 和（f）从聚合物中提取压印分子，使得在下基板上形成图案化的分子印迹聚合物膜。

6. 发明申请

US20110066386A1 ANESTHETIC SENSING OPTICAL MICROFLUIDIC CHIP SYSTEM 审中-公开
标题翻译： ANTICHETIC SENSING OPTICAL MICROFLUIDIC芯片系统
公开(公告)号：US20110066386A1
公开(公告)日：2011-03-17
申请号：US12560836
申请日：2009-09-16
申请人： Chien-Chong Hong , Po-Hsiang Chang , Chih-Chung Lin
发明人： Chien-Chong Hong , Po-Hsiang Chang , Chih-Chung Lin
IPC分类号： G06F19/00 , H01L31/12
CPC分类号： G01N21/05 , G01N21/253 , G01N21/77 , G01N2021/0346 , G01N2021/058
摘要： The invention discloses an anesthetic sensing optical microfluidic chip system. The anesthetic sensing optical microfluidic chip system includes a biochip, a light source, and a detector. The biochip includes a substrate, a micro-channel, and a molecularly imprinted biosensor. The micro-channel is bonded beyond the substrate. The molecularly imprinted biosensor is disposed in the micro-channel, and a surface of the molecularly imprinted biosensor has a plurality of imprinted sites. When a sample including a plurality of anesthetic molecules is injected into the micro-channel and flowing through the surface of the molecularly imprinted biosensor, some of the anesthetic molecules are captured by the imprinted sites. The light source emits a sensing light to the plastic biochip, and the detector receives the sensing light passing through the imprinted sites on the surface of the molecularly imprinted biosensor and generates a detecting result based on the received sensing light.
摘要翻译：本发明公开了一种麻醉感应光学微流体芯片系统。麻醉感测光学微流体芯片系统包括生物芯片，光源和检测器。生物芯片包括底物，微通道和分子印迹生物传感器。微通道粘合在基底之外。分子印迹生物传感器设置在微通道中，分子印迹生物传感器的表面具有多个印迹位点。当将包含多个麻醉分子的样品注入微通道并流过分子印迹生物传感器的表面时，一些麻醉分子被印迹位点捕获。光源向塑料生物芯片发射感测光，并且检测器接收通过分子印迹生物传感器表面上的印记位点的感测光，并基于接收到的感测光产生检测结果。

7. 发明授权

US08651451B2 Microfluidic device with fluid driving capability 有权
标题翻译：具有流体驱动能力的微流体装置
公开(公告)号：US08651451B2
公开(公告)日：2014-02-18
申请号：US13198743
申请日：2011-08-05
申请人： Chien-Chong Hong , Cheng-Han Tsai
发明人： Chien-Chong Hong , Cheng-Han Tsai
IPC分类号： F16K31/02
CPC分类号： F16K99/0028 , F16K99/0046 , F16K99/0049
摘要： A microfluidic device includes: a shape memory substrate having a shape memory polymer matrix and a plurality of particles embedded in the shape memory polymer matrix, the shape memory polymer matrix being thermally transformable from a temporary shape to an original shape, the particles being made from a magnetically coercive material; and a microfluidic chip attached sealingly to the shape memory substrate and defining a microfluidic channel. The shape memory polymer matrix is indented inwardly to form an indented space in fluid communication with the microfluidic channel when the shape memory polymer matrix is heated to transform from the temporary shape to the original shape.
摘要翻译：微流体装置包括：具有形状记忆聚合物基体和嵌入在形状记忆聚合物基质中的多个颗粒的形状记忆基质，所述形状记忆聚合物基质可从临时形状热转变成原始形状，所述颗粒由磁力矫顽材料; 以及密封地连接到形状记忆基底并限定微流体通道的微流体芯片。当形状记忆聚合物基质被加热以从临时形状转变为原始形状时，形状记忆聚合物基体向内凹入以形成与微流体通道流体连通的凹陷空间。

8. 发明授权

US08632717B2 Method of nanoimprinting a piezoelectric polymeric material for forming high aspect ratio nanopillars 有权
标题翻译：用于形成高纵横比的纳米柱的压电聚合材料的纳米压印方法
公开(公告)号：US08632717B2
公开(公告)日：2014-01-21
申请号：US13204168
申请日：2011-08-05
申请人： Chien-Chong Hong , Sheng-Yuan Huang
发明人： Chien-Chong Hong , Sheng-Yuan Huang
IPC分类号： B29C67/24 , B28B11/08 , B32B27/32
CPC分类号： B29C59/022 , B29C35/02 , B29C2059/023 , B82Y30/00 , B82Y40/00
摘要： A method of nanoimprinting a piezoelectric polymeric material includes: heating a surface of the piezoelectric polymeric material to an imprinting temperature greater than (Tc−25)° C. and less than Tc, in which Tc is the Curie temperature of the piezoelectric polymeric material; and pressing the heated surface of the piezoelectric polymeric material using a nanoimprinting template having a nanopillar structure so as to form the piezoelectric polymeric material with high aspect ratio nanopillars.
摘要翻译：纳米压印压电聚合物材料的方法包括：将压电聚合物材料的表面加热至高于（Tc-25）℃且小于Tc的压印温度，其中Tc是压电聚合物材料的居里温度; 并使用具有纳米柱结构的纳米压印模板压制压电聚合材料的加热表面，以形成具有高纵横比的纳米柱的压电聚合材料。

9. 发明申请

US20130180852A1 ELECTRODE, SENSOR CHIP USING THE SAME AND METHOD OF MAKING THE SAME 审中-公开
标题翻译：电极，传感器芯片及其制造方法
公开(公告)号：US20130180852A1
公开(公告)日：2013-07-18
申请号：US13618200
申请日：2012-09-14
申请人： Chien-Chong Hong , Hong-Ren Jian , Kuo-Ti Peng , I-Ming Chu
发明人： Chien-Chong Hong , Hong-Ren Jian , Kuo-Ti Peng , I-Ming Chu
IPC分类号： C23F17/00 , C23C14/34 , G01N27/30 , C25B11/04 , C25D13/12 , B05D1/00 , B82Y99/00 , B82Y30/00
CPC分类号： G01N27/308 , B82Y30/00 , C23C14/024 , C23C14/18 , C23C14/34 , C25D13/02
摘要： A working electrode includes a conducting layer, a carbon nanotube layer electrophoretically deposited on the conducting layer; and a gold nanoparticle layer sputter-deposited on the carbon nanotube layer. A sensor chip having the working electrode and a method of fabricating the working electrode are also disclosed.
摘要翻译：工作电极包括导电层，电导沉积在导电层上的碳纳米管层; 以及溅射沉积在碳纳米管层上的金纳米颗粒层。还公开了具有工作电极的传感器芯片和制造工作电极的方法。

10. 发明授权

US08858780B2 Biosensor and method for determining an analyte concentration 有权
标题翻译：用于确定分析物浓度的生物传感器和方法
公开(公告)号：US08858780B2
公开(公告)日：2014-10-14
申请号：US13301105
申请日：2011-11-21
申请人： Chien-Chong Hong , Meng-Hua Chung , Chih-Chung Lin
发明人： Chien-Chong Hong , Meng-Hua Chung , Chih-Chung Lin
IPC分类号： G01N27/327 , G01N33/543
CPC分类号： G01N27/227 , G01N33/5438 , G01N2600/00
摘要： A method of determining an analyte concentration employs a biosensor that includes a molecularly imprinted polymer film formed on a metal layer. The biosensor is connected to a charge/discharge circuit and charged and discharged during exposure to a solution containing an analyte. Voltage values during discharge are measured, and a characteristic parameter of the voltage values, which is associated with a concentration of the analyte detected by the biosensor, is determined. An unknown concentration of the analyte is determined by comparing the characteristic parameter to reference data representing a relation between known concentration of the analyte and the characteristic parameter of the biosensor. A biosensor, such as an anesthetic biosensor, is also disclosed.
摘要翻译：确定分析物浓度的方法采用包括在金属层上形成的分子印迹聚合物膜的生物传感器。生物传感器连接到充电/放电电路，并在暴露于含有分析物的溶液时进行充放电。测量放电期间的电压值，并且确定与由生物传感器检测到的分析物的浓度相关联的电压值的特征参数。通过将特征参数与表示分析物的已知浓度与生物传感器的特征参数之间的关系的参考数据进行比较来确定分析物的未知浓度。还公开了生物传感器，例如麻醉生物传感器。

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