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1. 发明授权

US3586973A Standard field strength meter 失效
标题翻译：标准场强计
公开(公告)号：US3586973A
公开(公告)日：1971-06-22
申请号：US3586973D
申请日：1969-12-15
申请人： ROBERT A LAWTON , CHARLES MCKAY ALLRED
发明人： LAWTON ROBERT A , ALLRED CHARLES MCKAY
IPC分类号： G01R29/08 , G01R31/02
CPC分类号： G01R29/0871
摘要： A hollow conductive sphere having a narrow insulated gap along an equator is suspended in a radio frequency electromagnetic field with the plane of the gap perpendicular to the electric field vector. The sphere halves are electrically connected together by a series resonant LC circuit disposed in the sphere. The resonant circuit is tuned to the frequency of the field. The field impinging on the sphere causes a current to flow across the equator of the sphere, via the resonant circuit. The field strength can accurately be related to the resonant current by an analysis of the scattering of the field by the sphere. To measure the current, the sphere contains a circuit for detecting the voltage developed across the inductance of the LC circuit and for energizing a miniature incandescent lamp when the detected voltage exceeds a threshold value. The light from the lamp is visible through a small diameter tube disposed through the sphere wall (the tube is a waveguide below cutoff for the impinging field). The sphere thus provides an optical indication when the field exceeds a threshold or standard field value. The sphere is calibrated by adjusting the threshold circuit to cause the lamp to light when the appropriate radio frequency current is passed through the resonant circuit. The calibration current is applied to the sphere by means of two hollow conductors of the same diameter as the sphere which are connected to the two sphere halves near the equator containing the insulated gap. The two hollow conductors form the inner conductor of a coaxial line. The calibration current applied to the coaxial line thus flows across the gap just as the induced current does when the sphere is in the field being tested.

2. 发明授权

US5851782A Inhibitors of ceramidase 失效
标题翻译：神经酰胺酶抑制剂
公开(公告)号：US5851782A
公开(公告)日：1998-12-22
申请号：US745128
申请日：1996-11-08
申请人： Yusuf A. Hannun , Alicja Bielawska , Charles McKay
发明人： Yusuf A. Hannun , Alicja Bielawska , Charles McKay
IPC分类号： A61K31/00 , A61K31/165 , C12Q1/34 , A61K31/70
CPC分类号： C12Q1/34 , A61K31/00 , A61K31/165 , G01N2333/98 , G01N2405/08
摘要： The present invention relates, in general, to the bioeffector molecule ceramide and, in particular, to methods of effecting intracellular accumulation of ceramide. The invention further relates to methods of selecting compounds that inhibit alkaline ceramidase and that can be used to treat diseases/disorders associated with cell hyperplasia or dedifferentiation.
摘要翻译：本发明一般涉及生物分解剂分子神经酰胺，特别是涉及神经酰胺的细胞内积累的方法。本发明还涉及选择抑制碱性神经酰胺酶并可用于治疗与细胞增生或去分化相关的疾病/病症的化合物的方法。

3. 发明授权

US5830916A Inhibitor of ceramidase 失效
标题翻译：神经酰胺酶抑制剂
公开(公告)号：US5830916A
公开(公告)日：1998-11-03
申请号：US652238
申请日：1996-05-23
申请人： Yusuf A. Hannun , Alicja Bielawska , Charles McKay
发明人： Yusuf A. Hannun , Alicja Bielawska , Charles McKay
IPC分类号： A61K31/00 , A61K31/165 , C12Q1/34 , A61K31/16
CPC分类号： C12Q1/34 , A61K31/00 , A61K31/165 , G01N2333/98 , G01N2405/08
摘要： The present invention relates, in general, to the bioeffector molecule ceramide and, in particular, to methods of effecting intracellular accumulation of ceramide. The invention further relates to methods of selecting compounds that inhibit alkaline ceramidase and that can be used to treat diseases/disorders associated with cell hyperplasia or dedifferentiation.
摘要翻译：本发明一般涉及生物分解剂分子神经酰胺，特别是涉及神经酰胺的细胞内积累的方法。本发明还涉及选择抑制碱性神经酰胺酶并可用于治疗与细胞增生或去分化相关的疾病/病症的化合物的方法。

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