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1. 发明授权

US08506613B2 Miniature method and apparatus for optical stimulation of nerves and other animal tissue 有权
标题翻译：用于光学刺激神经和其他动物组织的微型方法和装置
公开(公告)号：US08506613B2
公开(公告)日：2013-08-13
申请号：US13157217
申请日：2011-06-09
申请人： James S. Webb , Charles I. Miyake , Mark P. Bendett , Charles A. Lemaire
发明人： James S. Webb , Charles I. Miyake , Mark P. Bendett , Charles A. Lemaire
IPC分类号： A61N5/06
CPC分类号： A61N5/0622 , A61N5/0618 , A61N2005/0644 , A61N2005/0651 , A61N2005/0659
摘要： A hand-held self-contained nerve-stimulation device and method using light to provide a source of precise stimulation on one or more nerve fibers. In some embodiments, this simulation is provided through a device and method wherein a laser- or LED-light source is mounted to the handpiece. Light is passed from the light source through optical tip to simulate nerves. In some embodiments, the device is constructed from non-magnetic material such as glass, plastic or ceramics. In some embodiments, the light emanating from the optical tip can be controlled manually or automatically. In some embodiments, the handpiece contains a self-contained power source, such as batteries. In some embodiments, the handpiece is at least in part, activated by remote control in order to prevent moving the handpiece during activation. Some embodiments include a unit operable to sense a response of nerve stimulation and to suppress a laser-ablation surgery operation.
摘要翻译：一种手持式独立神经刺激装置和使用光提供精确刺激来源于一种或多种神经纤维的方法。在一些实施例中，通过装置和方法来提供该模拟，其中将激光或LED光源安装到手持件上。光从光源通过光学尖端传递到模拟神经。在一些实施例中，该装置由诸如玻璃，塑料或陶瓷的非磁性材料构成。在一些实施例中，可以手动或自动地控制从光学尖端发出的光。在一些实施例中，手持件包含诸如电池的独立电源。在一些实施例中，手持件至少部分地通过遥控来激活，以防止在启动期间移动手持件。一些实施例包括可操作以感测神经刺激的反应并抑制激光消融手术操作的单元。

2. 发明申请

US20110238141A1 MINIATURE METHOD AND APPARATUS FOR OPTICAL STIMULATION OF NERVES AND OTHER ANIMAL TISSUE 有权
标题翻译：神经和其他动物组织的光刺激的微型方法和装置
公开(公告)号：US20110238141A1
公开(公告)日：2011-09-29
申请号：US13157217
申请日：2011-06-09
申请人： James S. Webb , Charles I. Miyake , Mark P. Bendett , Charles A. Lemaire
发明人： James S. Webb , Charles I. Miyake , Mark P. Bendett , Charles A. Lemaire
IPC分类号： A61N5/067 , A61N5/06
CPC分类号： A61N5/0622 , A61N5/0618 , A61N2005/0644 , A61N2005/0651 , A61N2005/0659
摘要： A hand-held self-contained nerve-stimulation device and method using light to provide a source of precise stimulation on one or more nerve fibers. In some embodiments, this simulation is provided through a device and method wherein a laser- or LED-light source is mounted to the handpiece. Light is passed from the light source through optical tip to simulate nerves. In some embodiments, the device is constructed from non-magnetic material such as glass, plastic or ceramics. In some embodiments, the light emanating from the optical tip can be controlled manually or automatically. In some embodiments, the handpiece contains a self-contained power source, such as batteries. In some embodiments, the handpiece is at least in part, activated by remote control in order to prevent moving the handpiece during activation. Some embodiments include a unit operable to sense a response of nerve stimulation and to suppress a laser-ablation surgery operation.
摘要翻译：一种手持式独立神经刺激装置和使用光提供精确刺激来源于一种或多种神经纤维的方法。在一些实施例中，通过装置和方法来提供该模拟，其中将激光或LED光源安装到手持件上。光从光源通过光学尖端传递到模拟神经。在一些实施例中，该装置由诸如玻璃，塑料或陶瓷的非磁性材料构成。在一些实施例中，可以手动或自动地控制从光学尖端发出的光。在一些实施例中，手持件包含诸如电池的独立电源。在一些实施例中，手持件至少部分地通过遥控来激活，以防止在启动期间移动手持件。一些实施例包括可操作以感测神经刺激的反应并抑制激光消融手术操作的单元。

3. 发明授权

US06832024B2 Method and apparatus for fiber bragg grating production 有权
标题翻译：光纤布拉格光栅生产方法和装置
公开(公告)号：US06832024B2
公开(公告)日：2004-12-14
申请号：US10042943
申请日：2001-11-19
申请人： David C. Gerstenberger , Mark S. Bowers , Dennis D. Lowenthal , Jason N. Farmer , Roy D. Mead , Charles I. Miyake
发明人： David C. Gerstenberger , Mark S. Bowers , Dennis D. Lowenthal , Jason N. Farmer , Roy D. Mead , Charles I. Miyake
IPC分类号： G02B634
CPC分类号： G02B6/02133 , G02B6/02138 , G02F1/353 , G02F1/37 , G02F2001/3507 , G02F2001/354 , G02F2201/16 , H01S3/117 , H01S5/0092 , H01S5/183
摘要： A wide variety of Fiber Bragg writing devices comprising solid state lasers are provided. The solid state lasers emit moderate peak-power output beams which are suitable for efficient production of fiber Bragg gratings without causing embrittlement of the optical waveguide. These solid state lasers generate fourth harmonic output beams with wavelengths of approximately 240 nm, in order to match the primary absorption peak in the ultraviolet range for a typical optical waveguide. Some of these solid state lasers comprise a fequency-doubling crystal and a CLBO crystal used in a non-critically phase-matched orientation as a frequency-quadrupling crystal. In such lasers, both the frequency-doubling crystal and frequency-quadrupling crystal are preferably engineered to minimize or eliminate beam “walkoff.”
摘要翻译：提供了包括固态激光器的各种各样的光纤布拉格写入装置。固态激光器发出中等的峰值功率输出光束，其适合于有效地生产光纤布拉格光栅而不会导致光波导的脆化。这些固态激光器产生具有约240nm波长的第四谐波输出光束，以便匹配典型光波导的紫外范围内的初级吸收峰。这些固体激光器中的一些包括倍频晶体和用于非临界相位匹配取向的CLBO晶体作为频率 - 四重晶体。在这样的激光器中，倍频晶振和四频频率晶体优选地被设计成最小化或消除波束“走走”。

4. 发明授权

US06172997B2 Integrated semiconductor diode laser pumped solid state laser 失效
标题翻译：集成半导体二极管激光泵浦固体激光器
公开(公告)号：US06172997B2
公开(公告)日：2001-01-09
申请号：US09097648
申请日：1998-06-16
申请人： Charles I. Miyake , Leonard P. Pearson , Jeffrey Pierce
发明人： Charles I. Miyake , Leonard P. Pearson , Jeffrey Pierce
IPC分类号： H01S5024
CPC分类号： H01S3/09415 , H01S3/025 , H01S3/0405 , H01S3/042 , H01S3/07 , H01S3/2383
摘要： A method and apparatus for fabricating extremely robust opto-electronic devices on a monolithic support structure is provided. Incorporated into the support structure are registration structures that are used to quickly and accurately align the various components associated with the device, typically eliminating the need for manual component alignment. The registration structures are fabricated using conventional lithographic techniques, offering alignment accuracy of a micrometer or less. Utilizing the registration structures, a gain module is fabricated that is comprised of at least a pump laser, an optical element, and a solid state gain medium. The pump laser is preferably a semiconductor diode laser that pumps the edge of the gain medium, thus eliminating many of the difficulties that arise from end pumping the medium. The optical element, interposed between the pump laser and the gain medium, collimates and/or focuses the emissions from the pump laser onto the laser medium in such a manner as to optimize the efficiency of the module. The gain module may include several pump lasers, thus increasing the achieved output power. The gain module preferably projects through a cutout in a miniature optical bench. The optical bench is comprised of a material with a very low coefficient of thermal expansion, thus providing thermal stability. The surface of the optical bench is metallized, preferably in a pattern of gold pads. Optical components to be attached to the optical bench are metallized as well, thus allowing the components to be soldered into place. The optical bench is used to form various laser systems utilizing the integral gain module.
摘要翻译：提供了一种用于在整体式支撑结构上制造极其鲁棒的光电器件的方法和装置。结合到支撑结构中的是用于快速且准确地对准与装置相关联的各种部件的配准结构，通常消除了对手动部件对准的需要。使用常规光刻技术制造配准结构，提供千分尺或更小的对准精度。利用对准结构，制造增益模块，该增益模块至少包括泵浦激光器，光学元件和固态增益介质。泵浦激光器优选是泵浦增益介质的边缘的半导体二极管激光器，从而消除了端部泵送介质所产生的许多困难。介于泵浦激光器和增益介质之间的光学元件以使得模块的效率最优化的方式将来自泵激光器的发射准直和/或聚焦到激光介质上。增益模块可以包括几个泵浦激光器，从而增加实现的输出功率。增益模块优选通过微型光学平台中的切口突出。光学平台由具有非常低的热膨胀系数的材料组成，从而提供热稳定性。光学平台的表面被金属化，优选地以金焊盘的图案。要连接到光学平台的光学部件也被金属化，从而允许部件被焊接到位。光学台用于形成利用积分增益模块的各种激光系统。

5. 发明申请

US20080077198A1 MINIATURE APPARATUS AND METHOD FOR OPTICAL STIMULATION OF NERVES AND OTHER ANIMAL TISSUE 有权
标题翻译：神经和其他动物组织的光学刺激的微型装置和方法
公开(公告)号：US20080077198A1
公开(公告)日：2008-03-27
申请号：US11536639
申请日：2006-09-28
申请人： James S. Webb , Charles I. Miyake , Mark P. Bendett , Charles A. Lemaire
发明人： James S. Webb , Charles I. Miyake , Mark P. Bendett , Charles A. Lemaire
IPC分类号： A61N5/06
CPC分类号： A61N5/0622 , A61N5/0618 , A61N2005/0644 , A61N2005/0651 , A61N2005/0659
摘要： A hand-held self-contained nerve-stimulation device and method using light to provide a source of precise stimulation on one or more nerve fibers. In some embodiments, this simulation is provided through a device and method wherein a laser- or LED-light source is mounted to the handpiece. Light is passed from the light source through optical tip to simulate nerves. In some embodiments, the device is constructed from non-magnetic material such as glass, plastic or ceramics. In some embodiments, the light emanating from the optical tip can be controlled manually or automatically. In some embodiments, the handpiece contains a self-contained power source, such as batteries. In some embodiments, the handpiece is at least in part, activated by remote control in order to prevent moving the handpiece during activation. Some embodiments include a unit operable to sense a response of nerve stimulation and to suppress a laser-ablation surgery operation.
摘要翻译：一种手持式独立神经刺激装置和使用光提供精确刺激来源于一种或多种神经纤维的方法。在一些实施例中，通过装置和方法来提供该模拟，其中将激光或LED光源安装到手持件上。光从光源通过光学尖端传递到模拟神经。在一些实施例中，该装置由诸如玻璃，塑料或陶瓷的非磁性材料构成。在一些实施例中，可以手动或自动地控制从光学尖端发出的光。在一些实施例中，手持件包含诸如电池的独立电源。在一些实施例中，手持件至少部分地通过遥控来激活，以防止在启动期间移动手持件。一些实施例包括可操作以感测神经刺激的反应并抑制激光消融手术操作的单元。

6. 发明授权

US07184616B2 Method and apparatus for fiber Bragg grating production 有权
标题翻译：光纤布拉格光栅生产方法和装置
公开(公告)号：US07184616B2
公开(公告)日：2007-02-27
申请号：US10040286
申请日：2001-10-29
申请人： Roy M. Mead , Charles I. Miyake
发明人： Roy M. Mead , Charles I. Miyake
IPC分类号： G02F1/295
CPC分类号： G02F1/353 , G02B6/02133 , G02B6/02138 , G02B6/124 , G02B2006/12107 , G02F1/37 , G02F2001/3507 , G02F2001/354 , G02F2201/16 , H01S3/0675 , H01S3/117 , H01S5/146
摘要： Fiber Bragg writing devices comprising solid state lasers are provided. The solid state lasers comprise optical parametric oscillators and emit moderate peak-power output beams at wavelengths which are suitable for efficient production of fiber Bragg gratings without causing embrittlement of the optical waveguide. These solid state lasers generate output beams with wavelengths of approximately 240 nm, in order to match the primary absorption peak in the ultraviolet range for a typical optical waveguide. Some of these solid state lasers generate tunable wavelength beams using an optical parametric oscillator (“OPO”), then generate harmonics of these tunable beams. Other lasers mix the tunable beam with fixed wavelengths derived from the pump laser to reach the desired output wavelength.
摘要翻译：提供了包括固态激光器的光纤布拉格写入装置。固态激光器包括光参量振荡器，并且发射适合于有效地生产光纤布拉格光栅而不引起光波导脆化的波长的适度的峰值功率输出光束。这些固态激光器产生波长为约240nm的输出光束，以便匹配典型光波导的紫外范围内的初级吸收峰。这些固态激光器中的一些使用光学参量振荡器（“OPO”）产生可调波长光束，然后产生这些可调波束的谐波。其他激光器将可调波束与来自泵浦激光器的固定波长混合以达到所需的输出波长。

7. 发明授权

US06836592B2 Method and apparatus for fiber Bragg grating production 失效
标题翻译：光纤布拉格光栅生产方法和装置
公开(公告)号：US06836592B2
公开(公告)日：2004-12-28
申请号：US10038099
申请日：2001-10-29
申请人： Roy M. Mead , Charles I. Miyake
发明人： Roy M. Mead , Charles I. Miyake
IPC分类号： G02B634
CPC分类号： G02B6/02138 , G02B6/02133 , G02F1/353 , G02F1/37 , G02F2001/3507 , G02F2001/354 , G02F2201/16
摘要： A wide variety of Fiber Bragg writing devices comprising solid state lasers are provided. The solid state lasers emit moderate peak-power output beams which are suitable for efficient production of fiber Bragg gratings without causing embrittlement of the optical waveguide. These solid state lasers generate output beams with wavelengths of approximately 240 nm, in order to match the primary absorption peak in the ultraviolet range for a typical optical waveguide. In some embodiments, the solid state lasers comprise Ti:sapphire lasers which are tuned to produce fundamental wavelengths which are frequency-multiplied. In other embodiments, the output beam of a Ti:sapphire laser is mixed with a harmonic beam from a pump laser. Some embodiments output the third harmonic of a fundamental beam.
摘要翻译：提供了包括固态激光器的各种各样的光纤布拉格写入装置。固态激光器发出中等的峰值功率输出光束，其适合于有效地生产光纤布拉格光栅而不会导致光波导的脆化。这些固态激光器产生波长为约240nm的输出光束，以便匹配典型光波导的紫外范围内的初级吸收峰。在一些实施例中，固态激光器包括被调谐以产生倍频的基本波长的Ti：蓝宝石激光器。在其他实施例中，Ti：蓝宝石激光器的输出光束与来自泵浦激光器的谐波束混合。一些实施例输出基波束的三次谐波。

8. 发明授权

US4791634A Capillary heat pipe cooled diode pumped slab laser 失效
标题翻译：毛细管热管冷却二极管泵浦板激光器
公开(公告)号：US4791634A
公开(公告)日：1988-12-13
申请号：US102394
申请日：1987-09-29
申请人： Charles I. Miyake
发明人： Charles I. Miyake
IPC分类号： F28D15/02 , H01S3/0941 , H01S5/024 , H01S5/40 , H01S3/04
CPC分类号： H01S5/02469 , F28D15/0266 , H01S3/0941 , H01S3/042 , H01S3/0606 , H01S5/4025
摘要： A diode pumped slab laser (DPSL) that is cooled by a capillary heat pipe cooling apparatus. The DPSL contains a diode array that is cooled by one or more capillary evaporators that are adjacent to the diode array of the DPSL or contained within a thermally conductive substrate surrounding the diode array of the DPSL. The capillary evaporators convert the liquid phase of a working fluid to a vapor phase which is circulated to a condenser. The condenser causes the phase of the working fluid to change to a liquid phase which is then drawn back to the capillary evaporators by the evaporation of the working fluid within the capillary evaporator. In one embodiment, the diode array is interleaved with heat sink strips that conduct the heat away from the diode array strips and toward a closely spaced capillary evaporator wick facing the diode array. The vapor is carried away from the diode array in the channels formed between consecutive heat sink strips.
摘要翻译：由毛细管热管冷却装置冷却的二极管泵浦平板激光器（DPSL）。 DPSL包含二极管阵列，其被一个或多个毛细管蒸发器冷却，其与DPSL的二极管阵列相邻或包含在围绕DPSL的二极管阵列的导热基底内。毛细管蒸发器将工作流体的液相转化为循环到冷凝器的气相。冷凝器使工作流体的相变为液相，然后液相通过毛细管蒸发器内的工作流体的蒸发而被吸回毛细管蒸发器。在一个实施例中，二极管阵列与散热片交错，该散热片将热量从二极管阵列带导向远离面对二极管阵列的紧密间隔的毛细管式蒸发器芯。在连续的散热片条之间形成的通道中，蒸气被从二极管阵列移走。

9. 发明授权

US06538817B1 Method and apparatus for optical coherence tomography with a multispectral laser source 失效
标题翻译：用于光谱相干断层扫描与多光谱激光源的方法和装置
公开(公告)号：US06538817B1
公开(公告)日：2003-03-25
申请号：US09690562
申请日：2000-10-17
申请人： Jason N. Farmer , Charles I. Miyake
发明人： Jason N. Farmer , Charles I. Miyake
IPC分类号： G02B2710
CPC分类号： G01N21/4795 , H01S5/005 , H01S5/4031
摘要： A method and apparatus for performing optical coherence tomography using a wavelength multiplexed source is provided. The single output beam of the source is of a large bandwidth, thus providing a high resolution tomography system. In order to achieve high contrast as well, the wavelength multiplexed source has minimal wavelength separation between spectrally adjacent lasers and has an output beam with an approximately Gaussian spectral shape. The source is preferably comprised of one or more multi-gain element arrays multiplexed together within a single external resonator cavity. Interposed between the array and the resonator cavity output coupler are a collimating element and a diffraction grating. The collimating element can be a refractive optic, a reflective optic, or, for some applications, a ¼ pitch GRIN lens. The diffraction grating can either be transmissive or reflective. The combination of the diffraction grating and the collimating element forces each emitter within the array to lase at a distinct wavelength. In order to achieve an overall bandwidth greater than the gain bandwidth of a single emitter array, either multiple arrays of differing center wavelength are packaged together or a large array is used with a laterally varying quantum well thickness or epitaxy. An intracavity spatial filter can be used to improve the beam quality and reduce cross-talk. An optical coherence tomography imaging system is coupled to the resonator cavity.
摘要翻译：提供一种使用波长多路复用源执行光学相干断层摄影的方法和装置。源的单个输出光束具有大的带宽，从而提供高分辨率层析成像系统。为了实现高对比度，波长复用源在频谱相邻的激光器之间具有最小的波长间隔，并且具有近似高斯光谱形状的输出光束。源极优选地由在单个外部谐振器腔内复用在一起的一个或多个多增益元件阵列组成。阵列与谐振腔输出耦合器之间是一个准直元件和衍射光栅。准直元件可以是折射光学元件，反射光学元件，或者对于一些应用，可以使用1/4的GRIN透镜。衍射光栅可以是透射的或反射的。衍射光栅和准直元件的组合迫使阵列内的每个发射器以不同的波长发光。为了实现大于单个发射器阵列的增益带宽的总带宽，将不同中心波长的多个阵列封装在一起，或者使用具有横向变化的量子阱厚度或外延的大阵列。可以使用腔内空间滤波器来提高光束质量并减少串扰。光学相干断层成像系统耦合到谐振腔。

10. 发明授权

US06208673B1 Multifunction solid state laser system 有权
标题翻译：多功能固态激光系统
公开(公告)号：US06208673B1
公开(公告)日：2001-03-27
申请号：US09316513
申请日：1999-05-21
申请人： Charles I. Miyake
发明人： Charles I. Miyake
IPC分类号： H01S310
CPC分类号： G02F1/39 , G02F2001/3548
摘要： A method and apparatus for obtaining multiple wavelengths of varying temporal format from a single solid state laser are provided. Accordingly, the output from the solid state laser can either be sent through a series of non-linear crystals to obtain UV radiation or through an OPO cavity to obtain IR radiation. In order to provide the different wavelengths in the temporal formats commonly used for various medical procedures, the laser source may be operated in two different modes. When the laser system produces UV radiation a pulse of short duration is desired and the laser source is operated in the standard Q-switched mode or is mode locked. Conversely, when the laser system produces IR radiation, a pulse of long duration is desired and the laser source is operated in the free running mode. The outputs from the UV and IR portions of the system can either be directed to the object to be treated through a common beam delivery system or through separate beam delivery systems, for example utilizing optical fibers or waveguides.
摘要翻译：提供了一种用于从单个固态激光器获得变化的时间格式的多个波长的方法和装置。因此，来自固体激光器的输出可以通过一系列非线性晶体发送以获得UV辐射或通过OPO腔以获得IR辐射。为了提供通常用于各种医疗程序的时间格式的不同波长，激光源可以以两种不同的模式操作。当激光系统产生紫外辐射时，需要持续时间较短的脉冲，激光源以标准Q开关模式运行或被锁定。相反，当激光系统产生IR辐射时，需要长时间的脉冲，激光源以自由运行模式运行。来自系统的UV和IR部分的输出可以通过公共光束传送系统或通过单独的光束传送系统（例如利用光纤或波导）被引导到待处理的对象。

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