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1. 发明授权

US07381451B1 Strain engineering—HDP thin film with tensile stress for FEOL and other applications 有权
标题翻译：应变工程 - 具有拉伸应力的HDP薄膜，用于FEOL等应用
公开(公告)号：US07381451B1
公开(公告)日：2008-06-03
申请号：US10991890
申请日：2004-11-17
申请人： Chi-i Lang , Ratsamee Limdulpaiboon , Cayetano Gonzalez
发明人： Chi-i Lang , Ratsamee Limdulpaiboon , Cayetano Gonzalez
IPC分类号： H05H1/24 , B05D3/02 , H05H1/02
CPC分类号： C23C16/402 , C23C16/56 , H01J37/3244 , H01L21/84 , H01L27/1203 , H01L29/7846
摘要： High density plasma (HDP) techniques form high tensile stress silicon oxide films. The HDP techniques use low enough temperatures to deposit high tensile stress silicon oxide films in transistor architectures and fabrication processes effective for generating channel strain without adversely impacting transistor integrity. Methods involve a two phase process: a HDP deposition phase, wherein silanol groups are formed in the silicon oxide film, and a bond reconstruction phase, wherein water is removed and tensile stress is induced in the silicon oxide film. Transistor strain can be generated in NMOS or PMOS devices using strategic placement of the high tensile stress silicon oxide. Example applications include high tensile stress silicon oxides for use in shallow trench isolation structures, pre-metal dielectric layer and silicon on insulator substrates.
摘要翻译：高密度等离子体（HDP）技术形成高拉伸应力氧化硅膜。 HDP技术使用足够低的温度在晶体管架构和制造工艺中沉积高拉伸应力氧化硅膜，这有效地用于产生通道应变而不会不利地影响晶体管的完整性。方法涉及两相工艺：HDP沉积相，其中在氧化硅膜中形成硅烷醇基团，以及键合重构阶段，其中除去水并在氧化硅膜中引发拉伸应力。晶体管应变可以在NMOS或PMOS器件中使用高拉伸应力氧化硅的策略放置来产生。示例性应用包括用于浅沟槽隔离结构，预金属介电层和绝缘体上硅衬底的高拉伸应力氧化硅。

2. 发明授权

US06335157B1 Method based on localization of Hsp90 to the centrosome 失效
标题翻译：基于Hsp90定位于中心体的方法
公开(公告)号：US06335157B1
公开(公告)日：2002-01-01
申请号：US09307143
申请日：1999-05-07
申请人： Cayetano Gonzalez , Bodo Lange
发明人： Cayetano Gonzalez , Bodo Lange
IPC分类号： C12Q100
CPC分类号： G01N33/5091 , G01N33/5008 , G01N33/5035 , G01N33/6875
摘要： The present invention is directed to methods for screening for fragments, derivatives and analogs of Hsp90 that are altered in their subcellular localization, and thus, altered in their activity as compared to wild type Hsp90. The present invention is also directed to screening for modulators of Hsp90 activity as determined by assaying for altered subcellular localization of Hsp90. The present invention is further directed to diagnostic, prognostic and screening uses of Hsp90/centrosome co-purification.
摘要翻译：本发明涉及用于筛选Hsp90的片段，衍生物和类似物的方法，所述片段，衍生物和类似物在其亚细胞定位中被改变，因此与野生型Hsp90相比其活性发生改变。本发明还涉及通过测定Hsp90的改变的亚细胞定位来测定Hsp90活性的调节剂。本发明进一步涉及Hsp90 /中心体共同纯化的诊断，预后和筛选用途。

3. 发明授权

US07848888B2 Method for identification of biologically active agents 有权
标题翻译：生物活性剂鉴定方法
公开(公告)号：US07848888B2
公开(公告)日：2010-12-07
申请号：US10618913
申请日：2003-07-14
申请人： Edward Faeldt , Luis Serrano , Cayetano Gonzalez , Christian Boulin , Christopher J. Cummings , Juan Botas , Huda Zoghbi
发明人： Edward Faeldt , Luis Serrano , Cayetano Gonzalez , Christian Boulin , Christopher J. Cummings , Juan Botas , Huda Zoghbi
IPC分类号： C12Q1/68 , G01N33/48
CPC分类号： G06T7/20 , G06T7/0012 , G06T2207/30004
摘要： The present invention provides a method for screening for the effect of a test agent on a population of biological specimens, preferably insects, comprising the steps of providing a population of specimens, administering at least one test agent to the population, creating a digitized movie showing the movements of members of the population, measuring at least one trait of members of the population, and correlating the traits of the population with the effect of the test agent. The invention also provides a method for preparing a medicament useful for the treatment of a mammalian disease.
摘要翻译：本发明提供了一种用于筛选测试试剂对生物标本群体（优选昆虫）的影响的方法，其包括以下步骤：提供一组标本，向群体施用至少一种测试试剂，产生数字化电影，其显示人口的流动，衡量人口的至少一个特征，并将人口的特征与检验人员的影响相关联。本发明还提供了制备用于治疗哺乳动物疾病的药物的方法。

4. 发明申请

US20090202108A1 ASSAYING AND IMAGING SYSTEM IDENTIFYING TRAITS OF BIOLOGICAL SPECIMENS 审中-公开
标题翻译：生物样本的检测和成像系统鉴定
公开(公告)号：US20090202108A1
公开(公告)日：2009-08-13
申请号：US12210685
申请日：2008-09-15
申请人： Edward Faeldt , Luis Serrano , Cayetano Gonzalez , Christian Boulin , Christopher J. Cummings , Juan Botas , Huda Zoghbi
发明人： Edward Faeldt , Luis Serrano , Cayetano Gonzalez , Christian Boulin , Christopher J. Cummings , Juan Botas , Huda Zoghbi
IPC分类号： G06K9/00
CPC分类号： G06T7/20 , G06T7/0012 , Y02A90/24 , Y02A90/26
摘要： A method of system is provided for assaying specimens. In connection with such system or method, plural multi-pixel target images of a field of view are obtained at different corresponding points in time over a given sample period. A background image is obtained using a plural set of the plural target images. For a range of points in time, the background image is removed from the target images to produce corresponding background-removed target images. Analysis is performed using at least a portion of the corresponding background-removed target images to identify visible features of the specimens. A holding structure is provided to hold a set of discrete specimen containers. A positioning mechanism is provided to position a plural subset of the containers to place the moving specimens within the plural subset of the containers within a field of view of the camera.
摘要翻译：提供了一种用于测定样品的系统方法。关于这种系统或方法，在给定的采样周期的不同对应的时间点获得视场的多个多像素目标图像。使用多组多个目标图像获得背景图像。对于时间点的范围，从目标图像中去除背景图像，以产生相应的背景去除的目标图像。使用至少一部分相应的背景去除的目标图像进行分析以识别样本的可见特征。提供保持结构以保持一组离散的标本容器。提供了定位机构来定位容器的多个子集，以将移动的样本放置在相机的视野内的容器的多个子集内。

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