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1. 发明授权

US06962674B2 Dissolution test apparatus 有权
标题翻译：溶解试验装置
公开(公告)号：US06962674B2
公开(公告)日：2005-11-08
申请号：US09795819
申请日：2001-02-28
申请人： Stephen D. Dean , James E. Swon , C. J. Anthony Fernando , Paul Shoytush
发明人： Stephen D. Dean , James E. Swon , C. J. Anthony Fernando , Paul Shoytush
IPC分类号： G01N13/00 , G01N33/15 , G01N33/48 , B01F7/08 , B01F13/08 , B01F15/00 , G01N33/00
CPC分类号： G01N33/15 , G01N13/00 , G01N2013/006
摘要： A dissolution test apparatus comprises a spindle head assembly interconnected between first and second lateral support members. The lateral support members are translatable along a first axis, and the spindle head assembly is translatable along a second axis, such that the spindle head assembly is movable from a front, operative position at which test procedures are effected, to a rear position at which access to the dissolution test apparatus is enhanced. The spindle head assembly includes a dosage delivery mechanism including an actuatable dosage unit-retaining member. A front portion of the dissolution test apparatus has a tapered width to accommodate a triangular or trapezoidal array of test vessels, resulting in high visibility of the vessels.
摘要翻译：溶解测试装置包括在第一和第二横向支撑构件之间互连的主轴头组件。横向支撑构件可沿着第一轴线平移，并且主轴头组件可沿着第二轴线平移，使得主轴头组件可从执行测试程序的前部操作位置移动到后部位置增加了溶解试验装置的使用。主轴头组件包括剂量递送机构，其包括可致动剂量单位保持构件。溶出测试装置的前部具有锥形宽度以容纳测试容器的三角形或梯形阵列，导致容器的高可见性。

2. 发明授权

US07332128B2 Fiber-optic dissolution systems devices, and methods 失效
标题翻译：光纤溶解系统装置及方法
公开(公告)号：US07332128B2
公开(公告)日：2008-02-19
申请号：US10838907
申请日：2004-05-03
申请人： C. J. Anthony Fernando , James E. Swon , Henry Z. Hofer
发明人： C. J. Anthony Fernando , James E. Swon , Henry Z. Hofer
IPC分类号： G01N21/00
CPC分类号： G01N21/8507 , G01N13/00 , G01N21/253 , G01N33/15 , G01N2013/006 , G01N2021/8521 , G01N2021/8528 , Y10T436/117497 , Y10T436/2575
摘要： A dissolution system provides remote flow cells integrated into a manifold device. The manifold device communicates with liquid input and output lines associated with each flow cell, as well as fiber-optic input and output lines associated with each flow cell. Liquid samples are respectively drawn from dissolution vessels, optically-related measurements are taken, and the samples are thereafter returned their respective vessels. The manifold device can be adapted to receive probe-type instruments that incorporate the fiber-optics, wherein each probe-type instrument is associated with each flow cell. Alternatively, each corresponding pair of fiber-optic input and output lines are disposed in opposing, optically-aligned relation and probe-type instruments are not used. The gap between the ends of the opposing fiber-optic lines provides a light path across the corresponding flow cell. Calibration procedures using blank and/or standard media are performed using the same flow cells, with provisions made for bypassing the vessels in which the samples to be analyzed are held.
摘要翻译：溶解系统提供集成在歧管装置中的远程流动池。歧管装置与与每个流动池相关联的液体输入和输出线路以及与每个流动池相关联的光纤输入和输出线路通信。液体样品分别从溶解容器中抽出，进行光学相关测量，然后将样品返回其各自的容器。歧管装置可以适于接纳包含光纤的探针型仪器，其中每个探针型仪器与每个流动池相关联。或者，每个对应的一对光纤输入和输出线以相对的光学对准关系设置，并且不使用探针型仪器。相对的光纤线路的端部之间的间隙提供穿过相应的流动池的光路。使用空白和/或标准介质的校准程序使用相同的流动池进行，其中为绕过待分析样品的容器进行旁路。

3. 发明授权

US06727480B2 Waterless vessel heating system and method 有权
标题翻译：无水容器加热系统及方法
公开(公告)号：US06727480B2
公开(公告)日：2004-04-27
申请号：US09911103
申请日：2001-07-23
申请人： C. J. Anthony Fernando , James E. Swon , Michael F. Haw
发明人： C. J. Anthony Fernando , James E. Swon , Michael F. Haw
IPC分类号： H05B336
CPC分类号： H05B1/025 , B01F1/00 , B01F1/0011 , B01F2215/0037 , B01J19/0013 , B01J2219/00011 , B01J2219/00038 , B01J2219/00063 , B01J2219/00135 , B01J2219/002 , B01J2219/00213 , B01J2219/00238 , B01L7/00 , B01L2300/1805 , G01N13/00 , G01N33/15 , G01N2013/006 , H05B3/00 , H05B3/34 , H05B3/54 , H05B2203/005 , H05B2203/014 , H05B2203/017 , H05B2203/037
摘要： A dissolution testing system comprises a vessel plate on which a plurality of vessels are mounted. Each vessel includes a lateral wall having an outer surface around which a plurality of flexible heater elements are attached. Each heater element includes a transparent surface area, a heat conductive element extending along the transparent surface area, a temperature sensing element extending along the transparent surface area, and an electrical contact element connected to the heat conductive element and the temperature sensing element. The heater element can have more than one heating zone, with at least one of the heating zones being selectively energizable. The transparent heater element allows unobstructed view into the interior of its vessel, and reduces the time required to achieve a stabilized set point temperature in the vessel. A heater control system communicates with each heat conductive element and each temperature sensing element through a corresponding one of the electrical contact elements. The heater control system permits each vessel to be controlled independently of the other vessels.
摘要翻译：溶解测试系统包括其上安装有多个容器的容器板。每个容器包括具有外表面的侧壁，多个柔性加热器元件围绕该外表面附接。每个加热器元件包括透明表面区域，沿着透明表面区域延伸的导热元件，沿着透明表面区域延伸的温度感测元件以及连接到导热元件和温度检测元件的电接触元件。加热器元件可以具有多于一个加热区，其中至少一个加热区可选择性地通电。透明加热器元件允许在其容器的内部看不到障碍物，并且减少在容器中达到稳定的设定点温度所需的时间。加热器控制系统通过相应的一个电接触元件与每个导热元件和每个温度感测元件连通。加热器控制系统允许每个容器独立于其他容器进行控制。

4. 发明授权

US06661512B2 Sample analysis system with fiber optics and related method 失效
公开(公告)号：US06661512B2
公开(公告)日：2003-12-09
申请号：US10076316
申请日：2002-02-13
申请人： C. J. Anthony Fernando , James E. Swon
发明人： C. J. Anthony Fernando , James E. Swon
IPC分类号： G01J342
CPC分类号： G01N21/253
摘要： A sample measurement and analysis system comprises a fiber-optic channel selecting apparatus, a plurality of optical source lines, a plurality of optical return lines, a plurality of sample test sites, and an optical receiving device. The selecting apparatus comprises an optical input selection device, an optical output selection device, and a controller element. The optical input selection device defines a first optical path running between a first input end and a first output end. The first output end is rotatable to a plurality of first index positions defined along a first circular path. The optical output selection device defines a second optical path running between a second input end and a second output end. The second input end is rotatable to a plurality of second index positions defined along a second circular path. The controller element communicates with the optical input selection device and the optical output selection device for selectively aligning the first optical path with the first index positions and the second optical path with the second index positions.

5. 发明授权

US06562301B1 Vessel centering system and method 有权
标题翻译：船舶定心系统及方法
公开(公告)号：US06562301B1
公开(公告)日：2003-05-13
申请号：US09697963
申请日：2000-10-27
申请人： Stephen D. Dean , C. J. Anthony Fernando , James E. Swon
发明人： Stephen D. Dean , C. J. Anthony Fernando , James E. Swon
IPC分类号： B01L302
CPC分类号： B01L3/5082 , B01F7/1605 , B01L9/06 , G01N13/00 , G01N33/15 , G01N2013/006
摘要： A vessel centering system comprises a vessel, an annular, spacer member, a fastening element, and an elastometric component. The vessel includes an outer surface and a vessel groove formed on a circumference of the vessel outer surface. The spacer member is fitted in the vessel groove and extends outwardly with respect to the vessel. The first and second lateral end surfaces define a spacing therebetween. The spacer member includes a tangential bore and an annular groove. The tangential bore extends along a line generally tangential to a curvature of the spacer member. The fastening element, which could be a screw, is disposed in the tangential bore in engagement with the ring member and extends across the ring spacing. The elastometric component, which could be a gasket or O-ring, is disposed in the annular groove. A plurality of biased bearings can be provided instead of the elastometric component. When the vessel is installed in the aperture of a vessel plate, concentricity between the inner surfaces of the vessel and a shaft extending into the vessel is easily obtained.
摘要翻译：容器对中系统包括容器，环形隔离构件，紧固元件和弹性组件。容器包括形成在容器外表面的圆周上的外表面和容器凹槽。间隔件装配在容器槽中并相对于容器向外延伸。第一和第二侧端表面之间限定了间隔。间隔件包括切向孔和环形槽。切向孔沿着与间隔件的曲率大致相切的线延伸。可以是螺钉的紧固元件设置在与环构件接合的切向孔中，并且跨越环间隔延伸。可以是垫圈或O形环的弹性组件设置在环形槽中。可以提供多个偏置的轴承来代替弹性组件。当容器安装在容器板的孔中时，容器的内表面和延伸到容器中的轴之间的同心度容易获得。

6. 发明授权

US06303909B1 Waterless vessel heating system and method 有权
标题翻译：无水容器加热系统及方法
公开(公告)号：US06303909B1
公开(公告)日：2001-10-16
申请号：US09603305
申请日：2000-06-23
申请人： C. J. Anthony Fernando , James E. Swon , Michael F. Haw
发明人： C. J. Anthony Fernando , James E. Swon , Michael F. Haw
IPC分类号： H05B336
CPC分类号： G01N13/00 , B01F1/00 , B01F1/0011 , B01F2215/0037 , B01J19/0013 , B01J2219/00011 , B01J2219/00038 , B01J2219/00063 , B01J2219/00135 , B01J2219/002 , B01J2219/00213 , B01J2219/00238 , B01L7/00 , B01L2300/1805 , G01N33/15 , G01N2013/006 , H05B3/00 , H05B3/34 , H05B3/54 , H05B2203/005 , H05B2203/014 , H05B2203/017 , H05B2203/037
摘要： A dissolution testing system comprises a vessel plate on which a plurality of vessels are mounted. Each vessel includes a lateral wall having an outer surface around which a plurality of flexible heater elements are attached. Each heater element includes a transparent surface area, a heat conductive element extending along the transparent surface area, a temperature sensing element extending along the transparent surface area, and an electrical contact element connected to the heat conductive element and the temperature sensing element. The transparent heater element allows unobstructed view into the interior of its vessel, and reduces the time required to achieve a stabilized set point temperature in the vessel. A heater control system communicates with each heat conductive element and each temperature sensing element through a corresponding one of the electrical contact elements. The heater control system permits each vessel to be controlled independently of the other vessels.
摘要翻译：溶解测试系统包括其上安装有多个容器的容器板。每个容器包括具有外表面的侧壁，多个柔性加热器元件围绕该外表面附接。每个加热器元件包括透明表面区域，沿着透明表面区域延伸的导热元件，沿着透明表面区域延伸的温度感测元件以及连接到导热元件和温度检测元件的电接触元件。透明加热器元件允许在其容器的内部看不到障碍物，并且减少在容器中达到稳定的设定点温度所需的时间。加热器控制系统通过相应的一个电接触元件与每个导热元件和每个温度感测元件连通。加热器控制系统允许每个容器独立于其他容器进行控制。

7. 发明授权

US07151869B2 Fiber-optic channel selecting apparatus 失效
公开(公告)号：US07151869B2
公开(公告)日：2006-12-19
申请号：US11157254
申请日：2005-06-21
申请人： C. J. Anthony Fernando , James E. Swon
发明人： C. J. Anthony Fernando , James E. Swon
IPC分类号： G02B6/26 , G01N1/10 , G02B6/00
CPC分类号： G02B6/3504 , G01N21/255 , G01N21/31 , G02B6/3548 , G02B6/3558 , G02B6/3574 , G02B6/3582
摘要： An apparatus for selectively coupling fiber optic lines comprises an optical input selection device, an optical output selection device, and a rotatable coupling mechanism interconnecting the optical input selection device and the optical output selection device. The optical input selection device is rotatable about a first central axis, and comprises a first input end and a first output end. The first input end is disposed collinearly with the first central axis, and the first output end is disposed at a radially offset distance from the first central axis. The optical output selection device is rotatable about a second central axis, and comprises a second input end and a second output end. The second input end is disposed at a radially offset distance from the second central axis, and the second output end is disposed collinearly with the second central axis. Rotation of the coupling mechanism causes rotation of the first output end and the second input end.

8. 发明授权

US06950568B2 Fiber-optic channel selecting apparatus 失效
标题翻译：光纤通道选择装置
公开(公告)号：US06950568B2
公开(公告)日：2005-09-27
申请号：US10077723
申请日：2002-02-14
申请人： C. J. Anthony Fernando , James E. Swon
发明人： C. J. Anthony Fernando , James E. Swon
IPC分类号： G01N21/25 , G01N21/31 , G02B6/35 , G02B6/26
CPC分类号： G02B6/3504 , G01N21/255 , G01N21/31 , G02B6/3548 , G02B6/3558 , G02B6/3574 , G02B6/3582
摘要： An apparatus for selectively coupling fiber optic lines comprises an optical input selection device, an optical output selection device, and a rotatable coupling mechanism interconnecting the optical input selection device and the optical output selection device. The optical input selection device is rotatable about a first central axis, and comprises a first input end and a first output end. The first input end is disposed collinearly with the first central axis, and the first output end is disposed at a radially offset distance from the first central axis. The optical output selection device is rotatable about a second central axis, and comprises a second input end and a second output end. The second input end is disposed at a radially offset distance from the second central axis, and the second output end is disposed collinearly with the second central axis. Rotation of the coupling mechanism causes rotation of the first output end and the second input end.
摘要翻译：用于选择性地耦合光纤线路的装置包括光输入选择装置，光输出选择装置和互连光输入选择装置和光输出选择装置的可旋转耦合机构。光学输入选择装置可围绕第一中心轴线旋转，并且包括第一输入端和第一输出端。第一输入端与第一中心轴线共线设置，第一输出端设置在与第一中心轴线径向偏移的距离处。光输出选择装置可围绕第二中心轴线旋转，并且包括第二输入端和第二输出端。第二输入端设置在距离第二中心轴线的径向偏移距离处，第二输出端与第二中心轴线共线设置。联接机构的旋转引起第一输出端和第二输入端的旋转。

9. 发明授权

US06764651B2 Fiber-optic dissolution systems, devices, and methods 失效
标题翻译：光纤溶解系统，装置和方法
公开(公告)号：US06764651B2
公开(公告)日：2004-07-20
申请号：US10014270
申请日：2001-11-07
申请人： C. J. Anthony Fernando , James E. Swon , Henry Z. Hofer
发明人： C. J. Anthony Fernando , James E. Swon , Henry Z. Hofer
IPC分类号： G01N2101
CPC分类号： G01N21/8507 , G01N13/00 , G01N21/253 , G01N33/15 , G01N2013/006 , G01N2021/8521 , G01N2021/8528 , Y10T436/117497 , Y10T436/2575
摘要： A dissolution system provides remote flow cells integrated into a manifold device. The manifold device communicates with liquid input and output lines associated with each flow cell, as well as fiber-optic input and output lines associated with each flow cell. Liquid samples are respectively drawn from dissolution vessels, optically-related measurements are taken, and the samples are thereafter returned their respective vessels. The manifold device can be adapted to receive probe-type instruments that incorporate the fiber-optics, wherein each probe-type instrument is associated with each flow cell. Alternatively, each corresponding pair of fiber-optic input and output lines are disposed in opposing, optically-aligned relation and probe-type instruments are not used. The gap between the ends of the opposing fiber-optic lines provides a light path across the corresponding flow cell. Calibration procedures using blank and/or standard media are performed using the same flow cells, with provisions made for bypassing the vessels in which the samples to be analyzed are held.
摘要翻译：溶解系统提供集成在歧管装置中的远程流动池。歧管装置与与每个流动池相关联的液体输入和输出线路以及与每个流动池相关联的光纤输入和输出线路通信。液体样品分别从溶解容器中抽出，进行光学相关测量，然后将样品返回其各自的容器。歧管装置可以适于接纳包含光纤的探针型仪器，其中每个探针型仪器与每个流动池相关联。或者，每个对应的一对光纤输入和输出线以相对的光学对准关系设置，并且不使用探针型仪器。相对的光纤线路的端部之间的间隙提供穿过相应的流动池的光路。使用空白和/或标准介质的校准程序使用相同的流动池进行，其中为绕过待分析样品的容器进行旁路。

10. 发明授权

US06673319B2 Vessel centering system and method 有权
标题翻译：船舶定心系统及方法
公开(公告)号：US06673319B2
公开(公告)日：2004-01-06
申请号：US09798142
申请日：2001-03-02
申请人： Stephen D. Dean , James E. Swon , C. J. Anthony Fernando
发明人： Stephen D. Dean , James E. Swon , C. J. Anthony Fernando
IPC分类号： B01L302
CPC分类号： B01L3/5082 , B01F7/1605 , B01L9/06 , G01N13/00 , G01N33/15 , G01N2013/006
摘要： A vessel centering system comprises a vessel, an annular spacer member, a fastening element, and a first magnetic element. The vessel includes an outer surface and a vessel groove formed on a circumference of the vessel outer surface. The spacer member is fitted in the vessel groove and extends outwardly with respect to the vessel. The first and second lateral end surfaces define a spacing therebetween. The spacer member includes a tangential bore extending along a line generally tangential to a curvature of the spacer member. The fastening element, which could be a screw, is disposed in the tangential bore in engagement with the ring member and extends across the ring spacing. The first magnetic element is supported by or enclosed within the spacer member. A vessel plate with a vessel mounting aperture is structured to accommodate the mounting or installation of the vessel. A second magnetic element is supported by the vessel plate. When the vessel is inserted in the aperture of a vessel plate, magnetic attraction causes the first and second magnetic elements to become aligned with each other, and concentricity between the inner surfaces of the vessel and a shaft extending into the vessel is thereby established.
摘要翻译：容器对中系统包括容器，环形间隔件，紧固元件和第一磁性元件。容器包括形成在容器外表面的圆周上的外表面和容器凹槽。间隔件装配在容器槽中并相对于容器向外延伸。第一和第二侧端表面之间限定了间隔。间隔构件包括沿着大体上与间隔构件的曲率相切的线延伸的切向孔。可以是螺钉的紧固元件设置在与环构件接合的切向孔中，并且跨越环间隔延伸。第一磁性元件由间隔件支撑或封闭在间隔件内。具有容器安装孔的容器板被构造成适应容器的安装或安装。第二磁性元件由容器板支撑。当容器插入容器板的孔中时，磁吸引力使第一和第二磁性元件彼此对准，从而建立了容器的内表面和延伸到容器中的轴之间的同心度。

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