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1. 发明授权

US07893007B2 Directed evolution of novel binding proteins 失效
标题翻译：新型结合蛋白的定向进化
公开(公告)号：US07893007B2
公开(公告)日：2011-02-22
申请号：US12255793
申请日：2008-10-22
申请人： Robert Charles Ladner , Sonia Kosow Guterman , Bruce Lindsay Roberts , William Markland , Arthur Charles Ley , Rachel Baribault Kent
发明人： Robert Charles Ladner , Sonia Kosow Guterman , Bruce Lindsay Roberts , William Markland , Arthur Charles Ley , Rachel Baribault Kent
IPC分类号： C40B30/04
CPC分类号： C07K14/43504 , A61K38/00 , A61K2800/57 , C07K1/047 , C07K14/00 , C07K14/245 , C07K14/43522 , C07K14/43572 , C07K14/811 , C07K14/8114 , C07K2319/00 , C07K2319/02 , C12N7/00 , C12N15/1037 , C12N2795/14022 , C40B40/02
摘要： In order to obtain a novel binding protein against a chosen target, DNA molecules, each encoding a protein comprising one of a family of similar potential binding domains and a structural signal calling for the display of the protein on the outer surface of a chosen bacterial cell, bacterial spore or phage (genetic package) are introduced into a genetic package. The protein is expressed and the potential binding domain is displayed on the outer surface of the package. The cells or viruses bearing the binding domains which recognize the target molecule are isolated and amplified. The successful binding domains are then characterized. One or more of these successful binding domains is used as a model for the design of a new family of potential binding domains, and the process is repeated until a novel binding domain having a desired affinity for the target molecule is obtained. In one embodiment, the first family of potential binding domains is related to bovine pancreatic trypsin inhibitor, the genetic package is M13 phage, and the protein includes the outer surface transport signal of the M13 gene III protein.
摘要翻译：为了获得针对所选靶标的新型结合蛋白，每个编码包含相似潜在结合结构域的家族之一的蛋白质的DNA分子和要求在选择的细菌细胞的外表面上显示蛋白质的结构信号，细菌孢子或噬菌体（遗传包装）被引入到遗传包装中。蛋白质被表达，并且潜在的结合结构域显示在包装的外表面上。分离和扩增具有识别靶分子的结合域的细胞或病毒。然后表征成功的结合结构域。将这些成功结合结构域中的一个或多个用作设计新的潜在结合结构域家族的模型，并重复该过程，直到获得对靶分子具有所需亲和力的新结合结构域。在一个实施方案中，第一潜在结合域家族与牛胰蛋白酶抑制剂有关，遗传包是M13噬菌体，蛋白质包括M13基因III蛋白的外表面转运信号。

2. 发明申请

US20060218206A1 Method, System, and Program for Merging Log Entries From Multiple Recovery Log Files 审中-公开
标题翻译：从多个恢复日志文件合并日志条目的方法，系统和程序
公开(公告)号：US20060218206A1
公开(公告)日：2006-09-28
申请号：US11423653
申请日：2006-06-12
申请人： Serge Bourbonnais , Elizabeth Hamel , Bruce Lindsay , Chengfei Liu , Jens Stankiewitz , Tuong Truong
发明人： Serge Bourbonnais , Elizabeth Hamel , Bruce Lindsay , Chengfei Liu , Jens Stankiewitz , Tuong Truong
IPC分类号： G06F17/30
CPC分类号： G06F16/2379 , G06F11/1471 , Y10S707/99942 , Y10S707/99953
摘要： A globally unique transaction identifier for each transaction is recorded in log entries pursuant to a two-phase commit protocol, wherein multiple log entries in multiple database recovery logs that correspond to one transaction have a same globally unique transaction identifier. A causally ordered, ascending timestamp value is maintained in the log entries pursuant to the two-phase commit protocol. For each of the multiple database recovery logs, all the log entries related to a single transaction are marked identically with a mark unique to the single transaction in a given one of the database recovery logs. Global changes are identified for the single transaction from the log entries in the multiple database recovery logs based on the marking and the globally unique transaction identifier for each transaction by reading log entries based on the causally ordered, ascending timestamp value.
摘要翻译：每个事务的全局唯一事务标识符根据两阶段提交协议记录在日志条目中，其中对应于一个事务的多个数据库恢复日志中的多个日志条目具有相同的全局唯一事务标识符。根据两阶段提交协议，在日志条目中维护因果秩序的升序时间戳值。对于每个多个数据库恢复日志，与单个事务相关的所有日志条目在给定的一个数据库恢复日志中与单个事务唯一的标记相同地标记。基于标记和每个事务的全局唯一事务标识符，通过基于因果排序的升序时间戳值读取日志条目，从多个数据库恢复日志中的日志条目中识别出单个事务的全局更改。

3. 发明申请

US20050193024A1 Asynchronous peer-to-peer data replication 失效
标题翻译：异步对等数据复制
公开(公告)号：US20050193024A1
公开(公告)日：2005-09-01
申请号：US10788556
申请日：2004-02-27
申请人： Kevin Beyer , Elizabeth Hamel , Bruce Lindsay , Clarence Pruet
发明人： Kevin Beyer , Elizabeth Hamel , Bruce Lindsay , Clarence Pruet
IPC分类号： G06F7/00 , G06F17/30
CPC分类号： G06F17/30566 , G06F17/30286 , G06F17/30578
摘要： A method and system for providing convergence of data copies in asynchronous data replication in a database system, includes: labeling rows of a plurality of table copies with a monotonic number, a copy identification, and propagation controls; asynchronously capturing at least one labeled change to any row of any of the plurality of table copies from a database recovery log; determining that the captured change is to be communicated to others of the plurality of table copies; communicating the captured change to the others of the plurality of table copies; and applying the communicated change to the others of the plurality of table copies, where the plurality of table copies converge to a same state. In applying the communicated changes, conflicting changes are identified and resolved. In this manner, convergence of data copies in asynchronous data replication is provided, and processing and storage costs are significantly reduced.
摘要翻译：一种用于在数据库系统中异步数据复制中提供数据副本的收敛的方法和系统，包括：用单调数，复制标识和传播控制标记多个表副本的行; 从数据库恢复日志中异步地将至少一个标记的更改捕获到多个表副本中的任一个的任何行的任何行; 确定所捕获的改变将被传送到所述多个表副本中的其他人; 将所捕获的改变传达给所述多个表格副本中的其他更改; 以及将所传送的改变应用于所述多个表副本中的其他表，其中所述多个表副本收敛到相同的状态。在应用传达的更改时，会发现和解决冲突的变化。以这种方式，提供异步数据复制中的数据副本的收敛，并且显着地减少处理和存储成本。

4. 发明授权

US5837500A Directed evolution of novel binding proteins 失效
公开(公告)号：US5837500A
公开(公告)日：1998-11-17
申请号：US415922
申请日：1995-04-03
申请人： Robert Charles Ladner , Sonia Kosow Gutterman , Bruce Lindsay Roberts , William Markland , Arthur Charles Ley , Rachel Baribault Kent
发明人： Robert Charles Ladner , Sonia Kosow Gutterman , Bruce Lindsay Roberts , William Markland , Arthur Charles Ley , Rachel Baribault Kent
IPC分类号： A61K8/64 , A61K38/00 , A61Q11/00 , C07K1/04 , C07K1/107 , C07K14/435 , C07K14/805 , C07K14/81 , C12N1/21 , C12N7/00 , C12N7/01 , C12N15/10 , C40B40/02 , C12N15/62 , C07K19/00
CPC分类号： C40B40/02 , C07K1/047 , C07K1/107 , C07K14/43522 , C07K14/805 , C07K14/8114 , C07K14/8117 , C12N15/1037 , C12N7/00 , A61K38/00 , C12N2795/14111 , C12N2795/14122 , C12N2795/14143
摘要： In order to obtain a novel binding protein against a chosen target, DNA molecules, each encoding a protein comprising one of a family of similar potential binding domains and a structural signal calling for the display of the protein on the outer surface of a chosen bacterial cell, bacterial spore or phage (genetic package) are introduced into a genetic package. The protein is expressed and the potential binding domain is displayed on the outer surface of the package. The cells or viruses bearing the binding domains which recognize the target molecule are isolated and amplified. The successful binding domains are then characterized. One or more of these successful binding domains is used as a model for the design of a new family of potential binding domains, and the process is repeated until a novel binding domain having a desired affinity for the target molecule is obtained. In one embodiment, the first family of potential binding domains is related to bovine pancreatic trypsin inhibitor, the genetic package is M13 phage, and the protein includes the outer surface transport signal of the M13 gene III protein.

5. 发明授权

US4114930A Swaged tube coupling 失效
标题翻译：开管耦合
公开(公告)号：US4114930A
公开(公告)日：1978-09-19
申请号：US700677
申请日：1976-06-28
申请人： Donald Leroy Perkins , Bruce Lindsay Streckenbach
发明人： Donald Leroy Perkins , Bruce Lindsay Streckenbach
IPC分类号： B21D39/04 , F16L13/14
CPC分类号： F16L13/146 , B21D39/04 , Y10T29/49833 , Y10T29/49934 , Y10T29/49945
摘要： A coupling to support tubing both inside and outside. The end of the tubing is swaged by a press-fit sleeve onto a tubular insert having exterior serrations and the tubing becomes permanently held between the insert and the sleeve. In a variation a ring encircles the end of the tubing. This ring and the tubing are swaged together to become fastened between the insert and the sleeve.
摘要翻译：连接到内部和外部支撑管道。管道的端部通过压配合套筒模压到具有外部锯齿的管状插入件上，并且管道永久地保持在插入件和套筒之间。在一个变体中，环环绕管道的端部。该环和管子一起锻压以固定在插入件和套筒之间。

6. 发明申请

US20120254321A1 PROVIDING ADDITIONAL EMAIL CONTENT IN AN EMAIL CLIENT 有权
标题翻译：在电子邮件客户端提供额外的电子邮件内容
公开(公告)号：US20120254321A1
公开(公告)日：2012-10-04
申请号：US13079123
申请日：2011-04-04
申请人： David Bruce Lindsay , Baskaran Dharmarajan , Geoffrey M. Clark
发明人： David Bruce Lindsay , Baskaran Dharmarajan , Geoffrey M. Clark
IPC分类号： G06F15/16
CPC分类号： G06Q10/107
摘要： One or more techniques and/or systems are disclosed for providing additional content in an email. An email service can receive the email at an email server. Prior to the email being sent to an email client, metadata for a parameter used to retrieve the additional content is identified and collected. The collected metadata is sent to the email client used by the intended recipient of the email (e.g., on a smart phone). When the user attempts to access the email, the email server can respond by sending script code to the email client, which, in combination with locally stored metadata retrieved from the email, provides the additional content in the email. In this manner, an email regarding a package, for example, can include not only a tracking number but also a status of the delivery of the package, where the status may be different/updated each time the email is accessed.
摘要翻译：公开了用于在电子邮件中提供附加内容的一个或多个技术和/或系统。电子邮件服务可以在电子邮件服务器上接收电子邮件。在将电子邮件发送到电子邮件客户端之前，识别并收集用于检索附加内容的参数的元数据。收集的元数据被发送到电子邮件的预期收件人使用的电子邮件客户端（例如，在智能电话上）。当用户尝试访问电子邮件时，电子邮件服务器可以通过向电子邮件客户端发送脚本代码来进行响应，电子邮件客户端与本地存储的从电子邮件检索的元数据结合在电子邮件中提供附加内容。以这种方式，例如，关于包裹的电子邮件不仅可以包括跟踪号码，而且还可以包括每次接入电子邮件时状态可能不同/更新的包裹的传送状态。

7. 发明申请

US20120110499A1 VIRTUALIZED LAYOUTS 审中-公开
公开(公告)号：US20120110499A1
公开(公告)日：2012-05-03
申请号：US12915702
申请日：2010-10-29
申请人： Jeremy Eric Hance , David Bruce Lindsay , Jacob Edward Savin
发明人： Jeremy Eric Hance , David Bruce Lindsay , Jacob Edward Savin
IPC分类号： G06F3/048
CPC分类号： G06F3/0482 , G06F9/452
摘要： One or more techniques and/or systems are disclosed for virtualizing data in a user interface (UI). A virtual layout viewport is identified which comprises an area that may be viewed in a UI, where at least some data from one or more tuples of data is to be realized in the viewable area of the UI. Data that is to be realized in the viewport is identified from the one or more tuples of data, and the identified data is realized in the viewport, such as by creating a representation of the data for display in the UI. The realized data can be virtualized by removing the representation when the virtual layout viewport is modified in relation to a display of tuple data (e.g., an item is scrolled out of view).
摘要翻译：公开了用于在用户界面（UI）中虚拟化数据的一个或多个技术和/或系统。识别虚拟布局视口，其包括可以在UI中观看的区域，其中来自一个或多个数据元组的至少一些数据将在UI的可见区域中实现。要在视口中实现的数据是从一个或多个数据元组中识别的，并且识别的数据在视口中实现，例如通过创建用于在UI中显示的数据的表示。当虚拟布局视口相对于元组数据的显示被修改（例如，一个项目被滚出视图）时，通过去除表示来实现所实现的数据。

8. 发明申请

US20070288537A1 METHOD AND APPARATUS FOR REPLICATING DATA ACROSS MULTIPLE COPIES OF A TABLE IN A DATABASE SYSTEM 有权
标题翻译：用于在数据库系统中复制表的多个复制数据的方法和装置
公开(公告)号：US20070288537A1
公开(公告)日：2007-12-13
申请号：US11771801
申请日：2007-06-29
申请人： Serge BOURBONNAIS , Elizabeth Hamel , Bruce Lindsay , Stephen Todd
发明人： Serge BOURBONNAIS , Elizabeth Hamel , Bruce Lindsay , Stephen Todd
IPC分类号： G06F12/00
CPC分类号： G06F17/30578 , G06F17/30345 , Y10S707/99938
摘要： A method for handling transaction messages in asynchronous data replication in a database system, in which the database system includes a source node and a target node, and each transaction message has information concerning a row change to a table copy at the source node. The method includes determining whether a first transaction message has a dependency on a preceding non-completed transaction message. Responsive to the first transaction message having a dependency on the preceding non-completed transaction, the method further includes holding the first transaction message, completing the preceding non-completed transaction message including applying the row change associated with the preceding non-completed transaction message to the table copy at the target node, and responsive to completing the preceding non-completed transaction message, releasing the first transaction message and applying the row change associated with the first transaction message to the table copy at the target node.
摘要翻译：一种用于在数据库系统中处理异步数据复制中的事务消息的方法，其中数据库系统包括源节点和目标节点，并且每个事务消息具有关于在源节点处的表副本的行更改的信息。该方法包括确定第一交易消息是否具有对先前未完成的交易消息的依赖性。响应于对先前未完成的交易具有依赖性的第一交易消息，该方法还包括保存第一交易消息，完成前述未完成交易消息，包括将与先前未完成的交易消息相关联的行变更应用于在目标节点处的表副本，并且响应于完成上述未完成的交易消息，释放第一交易消息并将与第一交易消息相关联的行变更应用于目标节点处的表副本。

9. 发明申请

US20070233439A1 METHOD AND APPARATUS FOR SIMULATING OPERATION IN A DATA PROCESSING SYSTEM 有权
标题翻译：用于模拟数据处理系统中的操作的方法和装置
公开(公告)号：US20070233439A1
公开(公告)日：2007-10-04
申请号：US11278124
申请日：2006-03-30
申请人： MATTHEW CARROLL , Christian Garcia-Arellano , Sam Lightstone , Bruce Lindsay , Adam Storm , Daniele Zilio , Adriana Zubiri
发明人： MATTHEW CARROLL , Christian Garcia-Arellano , Sam Lightstone , Bruce Lindsay , Adam Storm , Daniele Zilio , Adriana Zubiri
IPC分类号： G06G7/48
CPC分类号： G06F17/5022
摘要： Methods and systems are provided for executing a simulation of an operation in a data processing system. In one implementation, the method includes executing an operation under a first set of conditions, determining a characteristic associated with the execution of the operation under the first set of conditions, and executing a simulation of the operation under a second set of conditions different from the first set of conditions. The simulation of the operation is constrained by the determined characteristic. The method can further include determining a cost/benefit of executing the operation under a set of conditions different from the first set of conditions based at least in part on the simulation.
摘要翻译：提供了用于执行数据处理系统中的操作的模拟的方法和系统。在一个实现中，该方法包括在第一组条件下执行操作，确定与第一组条件下的操作的执行相关联的特性，以及在与第二组条件不同的第二组条件下执行操作的模拟第一套条件。操作的模拟受到确定的特性的约束。该方法还可以包括至少部分地基于模拟来确定在与第一组条件不同的一组条件下执行操作的成本/益处。

10. 发明申请

US20070085285A1 Cart with precision steering for transporting materials 审中-公开
标题翻译：带精密转向的车载运输材料
公开(公告)号：US20070085285A1
公开(公告)日：2007-04-19
申请号：US11253512
申请日：2005-10-19
申请人： Bruce Lindsay
发明人： Bruce Lindsay
IPC分类号： B62B3/00
CPC分类号： B62B3/001 , B62B5/065
摘要： A cart with a manually operated steering mechanism comprising a base coupled to a frame and a cart body with a steering column and steering mechanism. The base further comprises several mechanical steering linkages including a steering push rod, push rod slat, and tie rod; a rack and gear assembly where the gear is coupled to the steering column and the rack is coupled to the steering push rod; and a rack and pinion assembly where the rack is coupled to the tie rod and the pinion is coupled to a pinion shaft whereby a first end engages the rack and a second end is coupled to the steering column through a miter gear assembly. The mechanical linkages are supported by and coupled to the base by support braces and the steering column also capable of being telescopically adjustable.
摘要翻译：具有手动操作的转向机构的推车包括联接到框架的底座和具有转向柱和转向机构的推车主体。基座还包括几个机械转向连杆，包括转向推杆，推杆板条和拉杆; 齿轮和齿轮组件，其中齿轮联接到转向柱并且齿条联接到转向推杆; 以及齿条和小齿轮组件，其中齿条联接到拉杆并且小齿轮联接到小齿轮轴，由此第一端接合齿条，并且第二端通过斜切齿轮组件联接到转向柱。机械连杆由支撑支架支撑并连接到底座，转向柱还能够可伸缩地调节。

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