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1. 发明申请

US20120128743A1 POLYMER PARTICLES 审中-公开
标题翻译：聚合物颗粒
公开(公告)号：US20120128743A1
公开(公告)日：2012-05-24
申请号：US13202880
申请日：2010-02-24
申请人： Brian Stanley Hawkett , Thi Thuy Binh Pham , Christopher Henry Such
发明人： Brian Stanley Hawkett , Thi Thuy Binh Pham , Christopher Henry Such
IPC分类号： A61K8/02 , C08L33/12 , C09D133/12 , C09D125/06 , C09J133/12 , C08L33/02 , C08L33/26 , A61K9/14 , C08L25/06 , C09J125/06 , B82B3/00 , B82Y30/00
CPC分类号： C08F2/20 , C08F2/38 , C08F285/00 , C08F287/00 , C08F293/005 , C08F2438/03 , C08L2666/02 , C09D151/003 , C09J151/003 , C08F212/08 , C08F220/14 , C08F212/36
摘要： The present invention relates to a method of forming polymer on the surface of polymer particles, the method comprising: (i) providing a dispersion comprising a continuous aqueous phase, a dispersed organic phase comprising one or more ethylenically unsaturated monomers, and a RAFT agent as a stabiliser for said organic phase; (ii) polymerising the one or more ethylenically unsaturated monomers under the control of the RAFT agent to form an aqueous dispersion of seed polymer particles; (iii) crosslinking the seed polymer particles; (iv) swelling the crosslinked seed particles with one or more ethylenically unsaturated monomers to form an aqueous dispersion of monomer swollen crosslinked seed polymer particles; (v) increasing the temperature of the monomer swollen crosslinked seed polymer particles to expel at least some of the monomer therein onto the surface of the particles; and polymerising at least the expelled monomer to form polymer on the surface of the particles.
摘要翻译：本发明涉及在聚合物颗粒表面上形成聚合物的方法，该方法包括：（i）提供包含连续水相的分散体，包含一种或多种烯属不饱和单体的分散的有机相和RAFT试剂，所述有机相的稳定剂; （ii）在RAFT试剂的控制下聚合一种或多种烯键式不饱和单体以形成种子聚合物颗粒的水分散体; （iii）使种子聚合物颗粒交联; （iv）用一种或多种烯属不饱和单体使交联的种子颗粒膨胀以形成单体溶胀的交联种子聚合物颗粒的水分散体; （v）增加单体溶胀的交联种子聚合物颗粒的温度以将其中的至少一些单体排出到颗粒的表面上; 并至少聚合排出的单体以在颗粒的表面上形成聚合物。

2. 发明申请

US20110196088A1 POLYMER PRODUCT AND INTERFACIAL POLYMERISATION PROCESS USING RAFT AGENT 有权
标题翻译：聚合物产品和使用RAFT代理的界面聚合方法
公开(公告)号：US20110196088A1
公开(公告)日：2011-08-11
申请号：US13090920
申请日：2011-04-20
申请人： Brian Stanley HAWKETT , Christopher Henry Such , Duc Ngoc Nguyen
发明人： Brian Stanley HAWKETT , Christopher Henry Such , Duc Ngoc Nguyen
IPC分类号： C09D153/00 , C09D133/12 , C09D133/02
CPC分类号： C08F2/38 , B82Y30/00 , C01P2004/64 , C08F220/06 , C08F220/14 , C08F220/18 , C08F230/08 , C08F2438/03 , C09B67/0008 , C09C1/24 , C09C1/3676 , C09C3/10 , Y10T428/2998
摘要： The invention provides a method of polymerising monomer to form polymer at the surface of solid particulate material, said method comprising: providing a dispersion of said solid particulate material in a continuous hydrophilic liquid phase, said dispersion comprising a hydrophilic RAFT agent as a stabiliser for said solid particulate material, and said continuous hydrophilic liquid phase comprising one or more ethylenically unsaturated monomers; and polymerising said one or more ethylenically unsaturated monomers under the control of said hydrophilic RAFT agent to thereby form polymer at the surface of said solid particulate material.
摘要翻译：本发明提供了一种在固体颗粒材料的表面聚合单体以形成聚合物的方法，所述方法包括：提供所述固体颗粒材料在连续亲水性液相中的分散体，所述分散体包含亲水性RAFT试剂作为所述固体颗粒材料和所述连续亲水性液相包含一种或多种烯属不饱和单体; 并在所述亲水性RAFT试剂的控制下使所述一种或多种烯属不饱和单体聚合，从而在所述固体颗粒材料的表面形成聚合物。

3. 发明申请

US20090258979A1 POLYMER PRODUCT AND INTERFACIAL POLYMERISATION PROCESS USING RAFT AGENT 有权
标题翻译：聚合物产品和使用RAFT代理的界面聚合方法
公开(公告)号：US20090258979A1
公开(公告)日：2009-10-15
申请号：US12295994
申请日：2007-04-03
申请人： Brian Stanley Hawkett , Christopher Henry Such , Duc Ngoc Nguyen
发明人： Brian Stanley Hawkett , Christopher Henry Such , Duc Ngoc Nguyen
IPC分类号： C08K5/3417 , C08L33/14
CPC分类号： C08F2/38 , B82Y30/00 , C01P2004/64 , C08F220/06 , C08F220/14 , C08F220/18 , C08F230/08 , C08F2438/03 , C09B67/0008 , C09C1/24 , C09C1/3676 , C09C3/10 , Y10T428/2998
摘要： The invention provides a method of polymerising monomer to form polymer at the surface of solid particulate material, said method comprising: providing a dispersion of said solid particulate material in a continuous hydrophilic liquid phase, said dispersion comprising a hydrophilic RAFT agent as a stabiliser for said solid particulate material, and said continuous hydrophilic liquid phase comprising one or more ethylenically unsaturated monomers; and polymerising said one or more ethylenically unsaturated monomers under the control of said hydrophilic RAFT agent to thereby form polymer at the surface of said solid particulate material.
摘要翻译：本发明提供了一种在固体颗粒材料的表面聚合单体以形成聚合物的方法，所述方法包括：提供所述固体颗粒材料在连续亲水性液相中的分散体，所述分散体包含亲水性RAFT试剂作为所述固体颗粒材料和所述连续亲水性液相包含一种或多种烯属不饱和单体; 并在所述亲水性RAFT试剂的控制下使所述一种或多种烯属不饱和单体聚合，从而在所述固体颗粒材料的表面形成聚合物。

4. 发明授权

US08765183B2 Polymer microgel beads 失效
标题翻译：聚合物微凝胶珠
公开(公告)号：US08765183B2
公开(公告)日：2014-07-01
申请号：US12993047
申请日：2009-05-15
申请人： Brian Stanley Hawkett , Nirmesh Jain
发明人： Brian Stanley Hawkett , Nirmesh Jain
IPC分类号： A61K9/14
CPC分类号： A61K9/0009 , A61K9/0019 , A61K9/1611 , A61K9/1635 , A61K41/0052 , A61K51/1213 , C08F2/32 , C08F2/38 , C08F2/44 , C08F4/00 , C08F220/56 , C08K2201/01
摘要： The present invention relates to polymer microgel beads having a polymeric matrix with nanomagnetic particles dispersed substantially uniformly therethrough, wherein a steric stabiliser is associated with the particles, the steric stabiliser being a polymeric material that (i) does not form part of the polymeric matrix of the beads, and (ii) comprises a steric stabilising polymeric segment and an anchoring polymeric segment, wherein the steric stabilising polymeric segment is different from the anchoring polymeric segment, and wherein the anchoring polymeric segment has an affinity toward the surface of the nanomagnetic particles and secures the stabiliser to the particles.
摘要翻译：本发明涉及具有基本均匀地分散有纳米磁性颗粒的聚合物基质的聚合物微凝胶珠粒，其中空间稳定剂与颗粒缔合，空间稳定剂是聚合物材料，（i）不形成聚合物基质的一部分所述珠粒和（ii）包含空间稳定聚合物链段和锚定聚合物链段，其中所述空间稳定聚合物链段不同于所述锚定聚合物链段，并且其中所述锚定聚合物链段对所述纳米磁性颗粒的表面具有亲和性，将稳定剂固定在颗粒上。

5. 发明申请

US20110129417A1 ADMINISTRABLE COMPOSITIONS 有权
标题翻译：行政组成
公开(公告)号：US20110129417A1
公开(公告)日：2011-06-02
申请号：US12993056
申请日：2009-05-15
申请人： Brian Stanley Hawkett , Nirmesh Jain , Thi Thuy Pham , Yanjun Wang , Gregory Goodman Warr
发明人： Brian Stanley Hawkett , Nirmesh Jain , Thi Thuy Pham , Yanjun Wang , Gregory Goodman Warr
IPC分类号： A61K51/06 , A61K9/14 , A61K49/12 , A61K33/26 , A61K33/04 , A61P35/00 , A61M37/00
CPC分类号： A61K9/0009 , A61K9/0019 , A61K9/1611 , A61K9/1635 , A61K41/0052 , A61K49/0404 , A61K49/0419 , A61K51/1244
摘要： The present invention relates to a composition suitable for administration to a subject, the composition comprising pharmacologically acceptable particulate material dispersed throughout a pharmacologically acceptable liquid carrier, the particulate material being maintained in the dispersed state by a steric stabiliser, wherein the steric stabiliser is a polymeric material comprising a steric stabilising polymeric segment and an anchoring polymeric segment, one or both of which are derived from one or more ethylenically unsaturated monomers that have been polymerised by a living polymerisation technique, wherein the steric stabilising polymeric segment is different from the anchoring polymeric segment, and wherein the anchoring polymeric segment has an affinity toward the surface of the particulate material and secures the stabiliser to the particulate material.
摘要翻译：本发明涉及适用于给予受试者的组合物，所述组合物包含分散在药理学上可接受的液体载体中的药理学上可接受的颗粒材料，所述颗粒材料通过空间稳定剂维持在分散状态，其中所述空间稳定剂是聚合物包含空间稳定聚合物链段和锚定聚合物链段的材料，其一种或两者衍生自已经通过活性聚合技术聚合的一种或多种烯属不饱和单体，其中所述空间稳定聚合物链段不同于所述锚定聚合物链段，并且其中所述锚定聚合物链段对所述颗粒材料的表面具有亲和性，并将所述稳定剂固定在所述颗粒材料上。

6. 发明授权

US08709486B2 Administrable compositions 有权
标题翻译：可管理组合
公开(公告)号：US08709486B2
公开(公告)日：2014-04-29
申请号：US12993056
申请日：2009-05-15
申请人： Brian Stanley Hawkett , Nirmesh Jain , Thi Thuy Binh Pham , Yanjun Wang , Gregory Goodman Warr
发明人： Brian Stanley Hawkett , Nirmesh Jain , Thi Thuy Binh Pham , Yanjun Wang , Gregory Goodman Warr
IPC分类号： A61K9/14
CPC分类号： A61K9/0009 , A61K9/0019 , A61K9/1611 , A61K9/1635 , A61K41/0052 , A61K49/0404 , A61K49/0419 , A61K51/1244
摘要： The present invention relates to a composition suitable for administration to a subject, the composition comprising pharmacologically acceptable particulate material dispersed throughout a pharmacologically acceptable liquid carrier, the particulate material being maintained in the dispersed state by a steric stabilizer, wherein the steric stabilizer is a polymeric material comprising a steric stabilizing polymeric segment and an anchoring polymeric segment, one or both of which are derived from one or more ethylenically unsaturated monomers that have been polymerized by a living polymerization technique, wherein the steric stabilizing polymeric segment is different from the anchoring polymeric segment, and wherein the anchoring polymeric segment has an affinity toward the surface of the particulate material and secures the stabilizer to the particulate material.
摘要翻译：本发明涉及适用于给予受试者的组合物，所述组合物包含分散在药理学上可接受的液体载体中的药理学上可接受的颗粒材料，所述颗粒材料通过空间稳定剂保持在分散状态，其中所述空间稳定剂是聚合物包含空间稳定聚合物链段和锚定聚合物链段的材料，其中一个或两个衍生自已经通过活性聚合技术聚合的一种或多种烯属不饱和单体，其中所述空间稳定聚合物链段不同于所述锚定聚合物链段，并且其中所述锚定聚合物链段对所述颗粒材料的表面具有亲和性，并将所述稳定剂固定在所述颗粒材料上。

7. 发明申请

US20110118533A1 POLYMER MICROGEL BEADS AND PREPARATIVE METHOD THEREOF 有权
标题翻译：聚合物微孔珠及其制备方法
公开(公告)号：US20110118533A1
公开(公告)日：2011-05-19
申请号：US12993040
申请日：2009-05-15
申请人： Brian Stanley Hawkett , Nirmesh Jain
发明人： Brian Stanley Hawkett , Nirmesh Jain
IPC分类号： A61K9/14 , A01N25/08 , A61N2/00
CPC分类号： A61K9/0009 , A61K9/0019 , A61K9/1611 , A61K9/1635 , A61K41/0052 , C08F2/32 , C08F2/38 , C08F2/44 , C08F4/00 , C08F220/56 , C08F293/005 , C08F2438/03 , C08K3/08 , C08K3/22 , C08K9/08
摘要： The present invention relates to polymer microgel beads having a polymeric matrix with nanomagnetic particles dispersed substantially uniformly therethrough, wherein a steric stabiliser is associated with the particles, the steric stabiliser being a polymeric material that (i) forms at least part of the polymeric matrix of the beads, and (ii) comprises a steric stabilising polymeric segment and an anchoring polymeric segment, wherein the steric stabilising polymeric segment is different from the anchoring polymeric segment, and wherein the anchoring polymeric segment has an affinity toward the surface of the nanomagnetic particles and secures the stabiliser to the particles.
摘要翻译：本发明涉及聚合物微粒凝胶珠，其具有基本均匀地分散有纳米磁性颗粒的聚合物基质，其中空间稳定剂与颗粒缔合，空间稳定剂是聚合物材料，（i）形成聚合物基质的至少一部分所述珠粒和（ii）包含空间稳定聚合物链段和锚定聚合物链段，其中所述空间稳定聚合物链段不同于所述锚定聚合物链段，并且其中所述锚定聚合物链段对所述纳米磁性颗粒的表面具有亲和性，将稳定剂固定在颗粒上。

8. 发明申请

US20080268250A1 Polymerisation Process and Polymer Product 有权
标题翻译：聚合工艺和聚合物产品
公开(公告)号：US20080268250A1
公开(公告)日：2008-10-30
申请号：US11664592
申请日：2005-10-04
申请人： Brian Stanley Hawkett , Christopher Henry Such , Duc Ngoc Nguyen , Jason Michael Farrugia , Olga Maree Mackinnon
发明人： Brian Stanley Hawkett , Christopher Henry Such , Duc Ngoc Nguyen , Jason Michael Farrugia , Olga Maree Mackinnon
IPC分类号： B32B15/02 , B05D5/00 , C08K7/00
CPC分类号： B05D7/00 , C08F2/18 , C08F2/44 , C08F212/08 , C08F292/00 , C08F293/005 , C08F2438/03 , C08L2666/02 , C09D5/028 , C09D5/03 , C09D153/00 , C09J153/00 , Y10T428/2998
摘要： A method of polymerising monomer to form polymer at the surface of particulate material, said method comprising: providing a dispersion of said particulate material in a continuous liquid phase, said dispersion comprising a RAFT agent as a stabiliser for said particulate material, and said continuous liquid phase comprising one or more ethylenically unsaturated monomers; and polymerising said one or more ethylenically unsaturated monomers under the control of said RAFT agent to thereby form polymer at the surface of said particulate material.
摘要翻译：一种在颗粒材料的表面聚合单体以形成聚合物的方法，所述方法包括：提供所述颗粒材料在连续液相中的分散体，所述分散体包含RAFT剂作为所述颗粒材料的稳定剂，所述连续液体包含一种或多种烯属不饱和单体; 并在所述RAFT试剂的控制下使所述一种或多种烯属不饱和单体聚合，从而在所述颗粒材料的表面形成聚合物。

9. 发明授权

US09339781B2 Polymer particles 有权
标题翻译：聚合物颗粒
公开(公告)号：US09339781B2
公开(公告)日：2016-05-17
申请号：US14122700
申请日：2012-05-31
申请人： Matthew Paul Baker , Timothy Warren Davey , Brian Stanley Hawkett , Duc Ngoc Nguyen , Christopher Henry Such
发明人： Matthew Paul Baker , Timothy Warren Davey , Brian Stanley Hawkett , Duc Ngoc Nguyen , Christopher Henry Such
IPC分类号： B01J13/18 , B01J13/22
CPC分类号： B01J13/18 , B01J13/22 , C01P2002/88 , C01P2004/04 , C08F2/18 , C08F2/44 , C09B67/0013 , C09C1/3676 , Y10T428/2989
摘要： The present invention relates to a method of preparing an aqueous dispersion of polymer encapsulated particulate material, the method comprising: providing a dispersion of the particulate material in a continuous aqueous phase, the dispersion comprising ethylenically unsaturated monomer and a stabilizer for the particulate material; and polymerizing the ethylenically unsaturated monomer by non-living free radical polymerization to form polymer that encapsulates the particulate material, thereby providing the aqueous dispersion of polymer encapsulated particulate material; wherein polymerization of the ethylenically unsaturated monomer comprises: (a) polymerizing a monomer composition that includes ionizable ethylenically unsaturated monomer so as to form a base responsive water swellable non-living polymer layer that encapsulates the particulate material; and (b) polymerizing a monomer composition that includes non-ionizable ethylenically unsaturated monomer so as to form an extensible, water and base permeable non-living polymer layer that encapsulates the base responsive water swellable polymer layer.
摘要翻译：本发明涉及一种制备聚合物包封的颗粒材料的水分散体的方法，所述方法包括：提供颗粒材料在连续水相中的分散体，所述分散体包含烯键式不饱和单体和用于颗粒材料的稳定剂; 并通过非活性自由基聚合使烯属不饱和单体聚合形成包封颗粒材料的聚合物，从而提供聚合物包封的颗粒材料的水性分散体; 其中所述烯键式不饱和单体的聚合包括：（a）聚合包含可离子化的烯属不饱和单体的单体组合物，以便形成包封所述颗粒材料的碱性响应性水溶胀性非活性聚合物层; 和（b）使包含不可离子化的烯属不饱和单体的单体组合物聚合，以便形成包封碱性响应性水溶胀性聚合物层的可延伸的水和基底可渗透的非活性聚合物层。

10. 发明申请

US20150037252A1 Method for the Treatment of a Solid Tumour 审中-公开
标题翻译：固体肿瘤治疗方法
公开(公告)号：US20150037252A1
公开(公告)日：2015-02-05
申请号：US14112673
申请日：2012-04-20
申请人： Brian Stanley Hawkett , Trevor William Hambley , Nicole Sarah Bryce , Thi Thuy Binh Pham , Nirmesh Jain
发明人： Brian Stanley Hawkett , Trevor William Hambley , Nicole Sarah Bryce , Thi Thuy Binh Pham , Nirmesh Jain
IPC分类号： A61K47/34 , A61K51/12 , A61K31/136 , A61K47/02 , A61K31/704
CPC分类号： A61K47/34 , A61K9/0019 , A61K31/136 , A61K31/337 , A61K31/513 , A61K31/704 , A61K33/00 , A61K33/24 , A61K45/06 , A61K47/02 , A61K51/1244 , B82Y5/00 , A61K2300/00
摘要： The present invention relates generally to a method of treating a neoplastic condition and to agents useful for same. More particularly, the present invention is directed to a method of facilitating the treatment of a solid tumor in a localised manner via the co-administration of particulate material and a cellular toxin. The method of the present invention is useful in a range of therapeutic treatments including the treatment of primary and metastatic tumors.
摘要翻译：本发明一般涉及治疗肿瘤病症的方法和可用于其的药剂。更具体地，本发明涉及通过共同给予颗粒物质和细胞毒素以局部方式促进固体肿瘤的治疗的方法。本发明的方法可用于一系列治疗性治疗，包括治疗原发性和转移性肿瘤。

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