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1. 发明申请

US20100179446A1 DEVICE AND PROCEDURE FOR VISUAL THREE-DIMENSIONAL PRESENTATION OF ECG DATA 审中-公开
标题翻译：心电数据视觉三维显示的设备和程序
公开(公告)号：US20100179446A1
公开(公告)日：2010-07-15
申请号：US12726168
申请日：2010-03-17
申请人： Bosko Bojovic , Ljupco Hadzievski , Petar Belicev
发明人： Bosko Bojovic , Ljupco Hadzievski , Petar Belicev
IPC分类号： A61B5/0402
CPC分类号： A61B5/04011 , A61B5/044 , G16H15/00
摘要： The analysis of ECG (electrocardiogram) data by exploiting computerized three-dimensional spatial presentation of the measured data using the vector concept. A three-dimensional presentation of the human heart may be correlated with waveforms specific for standard ECG or derived ECG signals based on the dipole approximation of the heart electrical activity. The three-dimensional heart model may be rotated, and the ECG signals are interactively linked to the model. Cardiac ischemia (inadequate blood supply) is detected by calculating an ECG ST-segment vector magnitude or an ST-T spatial angle change of a heart vector from the heart model and comparing these to respective predetermined ischemia criteria, using actual or virtual ECG lead sites.
摘要翻译：通过使用矢量概念利用计算机化的三维空间呈现测量数据对ECG（心电图）数据进行分析。基于心脏电活动的偶极近似，人心脏的三维呈现可以与针对标准ECG或导出的ECG信号的波形相关。可以旋转三维心脏模型，并且将ECG信号交互地链接到模型。通过计算来自心脏模型的心脏矢量的ECG ST段矢量大小或ST-T空间角度变化来检测心脏缺血（供血不足），并使用实际或虚拟ECG导联位点将其与相应的预定缺血标准进行比较。

2. 发明申请

US20160296132A1 MOBILE THREE-LEAD CARDIAC MONITORING DEVICE AND METHOD FOR AUTOMATED DIAGNOSTICS 审中-公开
标题翻译：移动三引线监护装置及自动诊断方法
公开(公告)号：US20160296132A1
公开(公告)日：2016-10-13
申请号：US15096159
申请日：2016-04-11
申请人： Bosko BOJOVIC , Ljupco HADZIEVSKI , Vladan VUKCEVIC , Uros MITROVIC , Marjan MILETIC
发明人： Bosko BOJOVIC , Ljupco HADZIEVSKI , Vladan VUKCEVIC , Uros MITROVIC , Marjan MILETIC
IPC分类号： A61B5/04 , A61B5/00 , A61B5/0404
CPC分类号： A61B5/0404 , A61B5/0006 , A61B5/04011 , A61B5/04012 , A61B5/04085 , A61B5/046 , A61B5/6823 , A61B5/6825 , A61B5/684 , A61B5/6898 , A61B5/747 , A61B2560/0468 , A61B2562/0209 , G06F19/00 , G06F19/3418 , G16H40/63 , G16H40/67 , G16H50/20
摘要： Methods and apparatuses, including devices and systems, for remote and detection and/or diagnosis of acute myocardial infarction (AMI). In particular, described herein are handheld devices having an electrode configuration capable of recording three orthogonal ECG lead signals in an orientation-specific manner, and transmitting these signals to a processor. The processor may be remote or local, and it may automatically or semi-automatically detect AMI, atrial fibrillation or other heart disorders based on the analyses of the deviation of the recorded 3 cardiac signals with respect to previously stored baseline recordings.
摘要翻译：用于远程和检测和/或诊断急性心肌梗死（AMI）的方法和装置，包括装置和系统。特别地，这里描述的是具有能够以取向特定方式记录三个正交ECG导联信号并且将这些信号传输到处理器的电极配置的手持式设备。处理器可以是远程的或局部的，并且可以基于对记录的3个心脏信号相对于先前存储的基线记录的偏差的分析来自动或半自动地检测AMI，心房颤动或其他心脏病。

3. 发明申请

US20110184300A1 ATRIAL FIBRILLATION DETECTION BASED ON ABSENCE OF CONSISTENT P-LOOPS IN AVERAGED VECTORCARDIOGRAM 审中-公开
标题翻译：基于平均VECTORCARDIOGRAM中一致P-LOOPS的不足的ATRIAL FIBRILLATION检测
公开(公告)号：US20110184300A1
公开(公告)日：2011-07-28
申请号：US12694236
申请日：2010-01-26
申请人： Alexei Shvilkin , Bosko Bojovic , Ljupco Hadzievski , Dorin Panescu
发明人： Alexei Shvilkin , Bosko Bojovic , Ljupco Hadzievski , Dorin Panescu
IPC分类号： A61B5/046
CPC分类号： A61B5/046 , A61B5/04011
摘要： A method for determining the presence of atrial fibrillation includes obtaining data from at least three orthogonal leads indicative of electrical activity of a heart over multiple heart beats, averaging the data to obtain an average heart beat, generating, from the averaged data, an average heart beat vectorcardiogram (VCG) that is a function of voltage level, comparing, over a segment of the average heart beat, the average heart beat VCG with a threshold value, and indicating whether the average heart beat VCG exceeds or does not exceed the threshold value.
摘要翻译：用于确定房颤的存在的方法包括从至少三个正交引线获得数据，所述正交引线指示心脏在多个心跳上的电活动，平均数据以获得平均心跳，从平均数据生成平均心脏拍摄作为电压电平的函数的矢量心电图（VCG），将平均心跳的片段，具有阈值的平均心跳VCG进行比较，并且指示平均心跳VCG是否超过或不超过阈值。

4. 发明授权

US08209002B2 Method and apparatus for quantitative assessment of cardiac electrical events 有权
公开(公告)号：US08209002B2
公开(公告)日：2012-06-26
申请号：US12184068
申请日：2008-07-31
申请人： Branislav Vajdic , Alexander D. Lunginovic , Ljupco Hadzievski , Bosko Bojovic
发明人： Branislav Vajdic , Alexander D. Lunginovic , Ljupco Hadzievski , Bosko Bojovic
IPC分类号： A61B5/04
CPC分类号： A61B5/04011 , A61B5/0452
摘要： Method and apparatus for computer enabled analysis of ECG (electro cardiographic) data by exploiting computerized three-dimensional spatial presentation of the measured data using vectors. A three-dimensional presentation of the human heart may be correlated with waveforms specific for standard ECG or derived ECG signals based on the dipole approximation of the heart electrical activity. Additional tools for analyzing ECG data are also provided which may be used to determine the time of cardiac electrical events, to select specific beats for automated cardiac interval determination, and to flag ECGs that have been evaluated by automated means but may benefit by human reading.

5. 发明申请

US20110112413A1 METHOD FOR AUTOMATED EKG ANALYSIS 审中-公开
标题翻译：自动EKG分析方法
公开(公告)号：US20110112413A1
公开(公告)日：2011-05-12
申请号：US12614352
申请日：2009-11-06
申请人： Dorin Panescu , Bosko Bojovic , Ljupco Hadzievski , Uros Mitrovic , Ihor Gussak
发明人： Dorin Panescu , Bosko Bojovic , Ljupco Hadzievski , Uros Mitrovic , Ihor Gussak
IPC分类号： A61B5/02
CPC分类号： A61B5/04011 , G06T11/206
摘要： Systems and methods for analyzing electronic cardiac signals for use in clinical diagnostics are described. System and method embodiments are configured to assist in the analysis of details of EKG signals and vector cardiograms to determine how patients should be categorized into specific cardiac risk categories, such as an acute coronary syndrome category. System configurations may comprise memory devices, computing systems, and EKG data sources positioned at various local or remote positions, and connected via various data connectivity modalities. Various parameters may be utilized to assist in the drawing of one or more conclusions regarding the cardiac condition of a patient.
摘要翻译：描述用于分析用于临床诊断的电子心脏信号的系统和方法。系统和方法实施例被配置为协助分析EKG信号和载体心电图的细节，以确定如何将患者分类为特定的心脏危险类别，例如急性冠状动脉综合征类别。系统配置可以包括位于各种本地或远程位置的存储设备，计算系统和EKG数据源，并经由各种数据连接方式连接。可以使用各种参数来帮助绘制关于患者的心脏状况的一个或多个结论。

6. 发明申请

US20110105928A1 ECG Reconstruction For Atrial Activity Monitoring And Detection 审中-公开
标题翻译：心房重建心房活动监测和检测
公开(公告)号：US20110105928A1
公开(公告)日：2011-05-05
申请号：US12613488
申请日：2009-11-05
申请人： Bosko Bojovic , Ljupco Hadzievski , Dorin Panescu
发明人： Bosko Bojovic , Ljupco Hadzievski , Dorin Panescu
IPC分类号： A61B5/0402
CPC分类号： A61B5/0006 , A61B5/046
摘要： A system includes a mobile unit having a plurality of electrodes, numbering less than ten, that are configured to contact a patient to obtain electrical signals therefrom, and a diagnostic center disposed remotely from the mobile unit. The mobile unit and/or the diagnostic center are configured to construct a first portion of an ECG (electrocardiogram) corresponding to a first portion of a cardiac cycle of the patient by processing information based on received electrical signals using a first set of transformation parameters corresponding to the first portion of the cardiac cycle. The first portion may correspond to atrial or ventricular activity.
摘要翻译：系统包括具有多个数量小于十的电极的移动单元，其被配置为接触患者以从其获得电信号，以及远离移动单元设置的诊断中心。移动单元和/或诊断中心被配置为通过使用对应于第一组变换参数的接收的电信号处理信息来构造对应于患者心脏周期的第一部分的ECG（心电图）的第一部分到心脏周期的第一部分。第一部分可以对应于心房或心室活动。

7. 发明申请

US20060217620A1 Apparatus and method for cordless recording and telecommunication transmission of three special ecg leads and their processing 失效
标题翻译：三种专用导航线的无绳录音和电信传输的设备及方法及其处理
公开(公告)号：US20060217620A1
公开(公告)日：2006-09-28
申请号：US10568868
申请日：2004-08-19
申请人： Bosko Bojovic , Ljupco Hadzievski , Petar Belicev
发明人： Bosko Bojovic , Ljupco Hadzievski , Petar Belicev
IPC分类号： A61B5/0402
CPC分类号： A61B5/0006 , A61B5/0404 , A61B5/0428 , A61B2560/0468
摘要： The invention is related to a device and method for cordless recording, telecommunication transmission, and processing of three special ECG leads by the means of the mobile device (1) and diagnostic-calibration center (2) where the reconstruction of standard ECG leads is performed. Reconstruction parameters are determined previously by calibration for each patient. In urgent situation, a patient (3) performs recording of three special ECG leads with the mobile device (1), and sends the memorized data to the diagnostic-calibration device (2) via a cellular telephone (4). The patient can trace the process of recording and sending the data with the help of sound and light indicators. Diagnostic-calibration center (2) is equipped with a PC computer (6) connected to a receiving cellular telephone (7) and calibration ECG device (8) with 14 electrodes. Ten electrodes are grouped into a standard 12-channel ECG cable, while the remaining four are used for recording of three special ECG leads and are grouped into a separate box (9) with integrated electrodes arranged identically as the integrated electrodes on the mobile device (1).
摘要翻译：本发明涉及一种用于通过移动设备（1）和诊断校准中心（2）的三个专用ECG引线的无绳记录，电信传输和处理的装置和方法，其中执行标准ECG引导的重建。先前通过每个患者的校准来确定重建参数。在紧急情况下，患者（3）通过移动设备（1）执行三个特殊ECG导联的记录，并通过蜂窝电话（4）将存储的数据发送到诊断校准设备（2）。患者可以通过声光指示器跟踪记录和发送数据的过程。诊断校准中心（2）配备有连接到接收蜂窝电话（7）的PC计算机（6）和具有14个电极的校准ECG装置（8）。十个电极被分组成标准的12通道ECG电缆，而其余四个电极用于记录三个特殊的ECG导联，并且分组成具有集成电极的单独的盒子（9），其中集成电极作为集成电极排列在移动装置上 1）

8. 发明申请

US20050209525A1 Device and procedure for visual three-dimensional presentation of ECG data 有权
标题翻译： ECG数据视觉三维显示的设备和程序
公开(公告)号：US20050209525A1
公开(公告)日：2005-09-22
申请号：US11036930
申请日：2005-01-14
申请人： Bosko Bojovic , Ljupco Hadzievski , Petar Belicev
发明人： Bosko Bojovic , Ljupco Hadzievski , Petar Belicev
IPC分类号： A61B5/04 , A61B5/044 , G06F17/00 , A61B5/0402
CPC分类号： A61B5/04011 , A61B5/044 , G06F19/00 , G16H15/00
摘要： The invention relates to the analysis of ECG data by exploiting computerized three-dimensional spatial presentation of the measured data using the vector concept. A three-dimensional presentation of the human heart may be correlated with waveforms specific for standard ECG or derived ECG signals based on the dipole approximation of the heart electrical activity. The three-dimensional heart model may be rotated, and the ECG signals are interactively linked to the model. In the visualization process, different types of signal presentation may be used, including graphical presentation of the heart vector hodograph, graphical presentation of the signal waveform in an arbitrary chosen point on the heart, and graphical presentation of the map of equipotential lines on the heart in a chosen moment. Additional tools for analyzing ECG data are also provided which may be interactively used with the display tools.
摘要翻译：本发明涉及通过使用矢量概念利用计算机化的三维空间呈现测量数据来分析ECG数据。基于心脏电活动的偶极近似，人心脏的三维呈现可以与针对标准ECG或导出的ECG信号的波形相关。可以旋转三维心脏模型，并且将ECG信号交互地链接到模型。在可视化过程中，可以使用不同类型的信号呈现，包括心脏矢量图的图形呈现，心脏上任意选择点的信号波形的图形呈现，以及心脏上等位线的图形的图示在选择的时刻。还提供了用于分析ECG数据的附加工具，其可以与显示工具交互地使用。

9. 发明申请

US20170290522A1 MOBILE THREE-LEAD CARDIAC MONITORING DEVICE AND METHOD FOR AUTOMATED DIAGNOSTICS 审中-公开
公开(公告)号：US20170290522A1
公开(公告)日：2017-10-12
申请号：US15632155
申请日：2017-06-23
申请人： Bosko BOJOVIC , Ljupco HADZIEVSKI , Vladan VUKCEVIC , Uros MITROVIC , Marjan MILETIC
发明人： Bosko BOJOVIC , Ljupco HADZIEVSKI , Vladan VUKCEVIC , Uros MITROVIC , Marjan MILETIC
IPC分类号： A61B5/0404 , A61B5/046 , A61B5/04 , A61B5/0408 , A61B5/00
CPC分类号： A61B5/0404 , A61B5/0006 , A61B5/04011 , A61B5/04012 , A61B5/04085 , A61B5/046 , A61B5/6823 , A61B5/6825 , A61B5/684 , A61B5/6898 , A61B5/747 , A61B2560/0468 , A61B2562/0209 , G06F19/00 , G06F19/3418 , G16H40/63 , G16H50/20
摘要： Methods and apparatuses, including devices and systems, for remote and detection and/or diagnosis of acute myocardial infarction (AMI). In particular, described herein are handheld devices having an electrode configuration capable of recording three orthogonal ECG lead signals in an orientation-specific manner, and transmitting these signals to a processor. The processor may be remote or local, and it may automatically or semi-automatically detect AMI, atrial fibrillation or other heart disorders based on the analyses of the deviation of the recorded 3 cardiac signals with respect to previously stored baseline recordings.

10. 发明申请

US20130096447A1 System and methods for serial analysis of electrocardiograms 审中-公开
标题翻译：心电图串联分析系统及方法
公开(公告)号：US20130096447A1
公开(公告)日：2013-04-18
申请号：US13573593
申请日：2012-09-27
申请人： Akshay Dhawan , Brian Wenzel , Samuel George , Bosko Bojovic , Ihor Gussak , Dorin Panescu
发明人： Akshay Dhawan , Brian Wenzel , Samuel George , Bosko Bojovic , Ihor Gussak , Dorin Panescu
IPC分类号： A61B5/04
CPC分类号： A61B5/04017 , A61B5/04011 , A61B5/743
摘要： Systems and methods for serial analysis of electrocardiograms are presented, wherein serial electrocardiographic (ECG) assessment is incorporated with three-dimensional vectorial analysis of the cardiac electrical signal, using changes in novel 3D-based vectorial markers over time to improve diagnostic sensitivity for acute coronary syndromes (ACS), and improve differentiation of ACS from the broad range of heart diseases that resemble ACS on ECG.
摘要翻译：提出了心电图串联分析的系统和方法，其中串联心电图（ECG）评估结合心电信号的三维矢量分析，使用新颖的基于3D的矢量标记随时间的变化，以提高急性冠脉综合征的诊断敏感性综合征（ACS），并改善ACS与心电图类似于ACS的广泛心脏病的分化。

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