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1. 发明申请

US20200299670A1 POLYMERIC BIOCATALYSTS AND METHODS 审中-公开
公开(公告)号：US20200299670A1
公开(公告)日：2020-09-24
申请号：US16826135
申请日：2020-03-20
申请人： UCHICAGO ARGONNE, LLC , BOARD OF TRUSTEES OF NORTHERN ILLINOIS UNIVERSITY
发明人： Tao Li , Gyorgy Babnigg , Jessica L. Johnson , Erik Sarnello
IPC分类号： C12N11/084 , C12N11/096 , C12N9/42 , C12N9/18
摘要： Biocatalysts disclosed herein can have a core and a shell, with the core including a polymer having a pyridine functional group, and the shell including an enzyme that interacts with the polymer. The biocatalysts disclosed herein can have improved stability, control, and activity as compared to the enzyme in a free, non-interacted state.

2. 发明申请

US20180271098A1 OXADIAZOLE AND PHENOL DERIVATIVES AS ANTIBACTERIAL AND/OR HERBICIDAL AGENTS 审中-公开
公开(公告)号：US20180271098A1
公开(公告)日：2018-09-27
申请号：US15933608
申请日：2018-03-23
申请人： BOARD OF TRUSTEES OF NORTHERN ILLINOIS UNIVERSITY
发明人： Timothy J. Hagen , Michael Thompson , Jeremy R. Troxell , Brian E. Hartnett
IPC分类号： A01N43/82 , C07D413/04 , C07D417/04 , C07D209/12 , A01N43/36
CPC分类号： A01N43/82 , A01N43/36 , C07D209/12 , C07D413/04 , C07D417/04
摘要： Antimicrobial resistance is rising at an alarming rate. The methylerythritol phosphate (MEP) pathway is a metabolic pathway that produces the isoprenoids isopentyl pyrophosphate (IPP) and dimethylallyl pyrophosphate (DMAPP). Notably, the MEP pathway is present in bacteria and not mammals, which made the enzymes of the MEP pathway attractive targets for discovering new anti-infective agents due to reduced chances of off-target interactions leading to side effects. The biophysical properties of 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase (IspD) and 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase (IspE) were determined to aid discovery of novel inhibitors. Thermal shift screening was used as an initial filter to narrow down a library of compounds with thermal shifts greater than 1° C., which could indicate binding to the IspD and IspE enzymes. Follow-up studies were performed using isothermal titration calorimetry and enzymatic inhibition assays. Results from these studies have revealed compounds with high micromolar inhibition of both IspD from Escherichia coli and IspE from Burkholderia thailandensis. The hit compounds are used for future development of more potent IspD and IspE inhibitors.

3. 发明申请

US20180230457A1 LIBRARY-BASED METHODS AND COMPOSITIONS FOR INTRODUCING MOLECULAR SWITCH FUNCTIONALITY INTO PROTEIN AFFINITY REAGENTS 审中-公开
公开(公告)号：US20180230457A1
公开(公告)日：2018-08-16
申请号：US15886271
申请日：2018-02-01
申请人： BOARD OF TRUSTEES OF NORTHERN ILLINOIS UNIVERSITY
发明人： James R. Horn
IPC分类号： C12N15/10 , C07K16/40 , C07K16/44 , G01N33/68
CPC分类号： C12N15/1037 , C07K16/40 , C07K16/44 , C07K2317/14 , C07K2317/22 , C07K2317/569 , C07K2317/90 , C07K2317/92 , C40B30/04 , G01N33/6854
摘要： Methods and compositions are disclosed for introducing molecular switch functionality into a protein affinity reagent to render its binding to a target molecule sensitive to an environmental trigger, such as pH, while maintaining binding affinity to the target molecule. Combinatorial libraries created by the method are also disclosed.

4. 发明申请

US20170355700A1 PYRAZOLOPYRIMIDINE ANTIBACTERIAL AGENTS 审中-公开
公开(公告)号：US20170355700A1
公开(公告)日：2017-12-14
申请号：US15611512
申请日：2017-06-01
申请人： BOARD OF TRUSTEES OF NORTHERN ILLINOIS UNIVERSITY
发明人： Timothy J. Hagen , Joy M. Blain , Gashaw M. Goshu , Brian E. Hartnett
IPC分类号： C07D487/04 , A61K31/519
CPC分类号： C07D487/04 , A61K31/519 , A61K45/06 , Y02A50/411 , A61K2300/00
摘要： Pyrazolopyrimidine compounds for inhibition of isoprenoid biosynthesis have a formula (I) or a pharmaceutically acceptable salt thereof. In formula (I), R1 includes an alkyl group and R2 includes an optionally substituted moiety selected from the group consisting of an optionally substituted benzyl group, an optionally substituted phenethyl group, an optionally substituted ethanol group, an optionally substituted ethyl acetate group, an optionally substituted methyl furan group, an optionally substituted 3-ethyl indole group, and a lower alkyl group. Compositions containing pyrazolopyrimidine compounds and methods for using pyrazolopyrimidine compounds are described.

5. 发明授权

US09309232B2 Synthesis of novel inhibitors of isoprenoid biosynthesis 有权
标题翻译：新型类异戊二烯生物合成抑制剂的合成
公开(公告)号：US09309232B2
公开(公告)日：2016-04-12
申请号：US14390548
申请日：2013-04-23
申请人： BOARD OF TRUSTEES OF NORTHERN ILLINOIS UNIVERSITY , EMERALD BIOSTRUCTURES, INC.
发明人： Timothy J. Hagen , Zheng Zhang , Zachary Lazowski , Michael Clare , Darren W. Begley
IPC分类号： A61K31/506 , C07D405/12 , C07D403/12 , C07F9/6571 , C07D239/47 , C07D417/12 , A61K45/06 , A61K31/4164 , C07D233/64 , C07D401/12 , C07D403/06 , C07D405/06 , A61K31/4174 , C07D413/12
CPC分类号： C07D233/64 , A61K31/4164 , A61K31/4174 , A61K31/4178 , A61K31/506 , A61K45/06 , C07D239/47 , C07D401/12 , C07D403/06 , C07D403/12 , C07D405/06 , C07D405/12 , C07D413/12 , C07D417/12 , C07F9/657136 , Y02A50/411 , A61K2300/00
摘要： Antibacterial IspF inhibitor compounds and compositions are described. Methods include administering described compounds and compositions to treat bacterial or parasitic infections and to inhibit or parasite or bacterial growth.
摘要翻译：描述了抗菌IspF抑制剂化合物和组合物。方法包括施用所述化合物和组合物以治疗细菌或寄生虫感染并抑制或寄生或细菌生长。

6. 发明申请

US20160033659A1 HIGH PERFORMANCE COMPUTING FOR THREE DIMENSIONAL PROTON COMPUTED TOMOGRAPHY 审中-公开
标题翻译：用于三维计算机图像的高性能计算
公开(公告)号：US20160033659A1
公开(公告)日：2016-02-04
申请号：US14811046
申请日：2015-07-28
申请人： BOARD OF TRUSTEES OF NORTHERN ILLINOIS UNIVERSITY , FERMI RESEARCH ALLIANCE, LLC
发明人： George Coutrakon , Paul Rubinov , Vishnu Zutshi , Alexandre S. Dychkant , Bela Erdelyi , Victor Rykalin , Sergey Uzunyan , Greg Selberg , John Rauch , Peter Wilson
IPC分类号： G01T1/24 , G01T1/161
CPC分类号： G01T1/248 , G01T1/201 , G01T1/2985
摘要： A high performance computer system for three dimensional proton computed tomography and method of imaging an object are disclosed. The system includes a proton computed tomography (pCT) detector assembly with an arrangement of fibers attached to silicon photo multipliers (SiPMs). An electronic circuit amplifies and digitizes signals received from the SiPMs and communicates the digitized data over a network for image reconstruction.
摘要翻译：公开了用于三维质子计算机断层摄影的高性能计算机系统和对象成像方法。该系统包括质子计算机断层摄影（pCT）检测器组件，其具有连接到硅光电倍增器（SiPM）的光纤布置。电子电路放大并数字化从SiPM接收的信号，并通过网络传送数字化数据进行图像重构。

7. 发明授权

US09140810B2 High performance computing for three dimensional proton computed tomography (HPC-pCT) 有权
标题翻译：三维质子计算机断层扫描（HPC-pCT）的高性能计算
公开(公告)号：US09140810B2
公开(公告)日：2015-09-22
申请号：US14319684
申请日：2014-06-30
申请人： BOARD OF TRUSTEES OF NORTHERN ILLINOIS UNIVERSITY , FERMI RESEARCH ALLIANCE, LLC , UNIVERSITY OF WOLLONGONG
发明人： Nicholas Karonis , George Coutrakon , Kirk Duffin , Bela Erdelyi , Kevin Naglich , Scott Penfold , Paul Rubinov , Victor Rykalin , Vishnu Zutshi
IPC分类号： G01N23/04 , G01T1/29 , G01T1/20
CPC分类号： G01T1/29 , G01T1/201
摘要： A proton computed tomography (pCT) detector system, including two tracking detectors in sequence on a first side of an object to be imaged, two tracking detectors in sequence on an opposite side of the object to be imaged, a calorimeter, and a computer cluster, wherein the tracking detectors include plastic scintillation fibers. All fibers in the detector system are read out by Silicon Photomultipliers (SiPM). A method of imaging an object by emitting protons from a source through two tracking detectors, through and around the object, and through two opposite tracking detectors, detecting energy of the protons with a calorimeter, and imaging the object.
摘要翻译：一种质子计算机断层摄影（pCT）检测器系统，包括在待成像对象的第一侧上的两个跟踪检测器，依次在待成像对象的另一侧上的两个跟踪检测器，量热计和计算机集群其中跟踪检测器包括塑料闪烁纤维。检测器系统中的所有光纤由硅光电倍增管（SiPM）读出。一种通过从源通过两个跟踪检测器，物体周围和周围的物质以及通过两个相对的跟踪检测器发射质子来成像物体的方法，用量热计检测质子的能量，并对物体进行成像。

8. 发明申请

US20150224122A1 THERAPEUTIC USES OF GLUTATHIONE MIMICS 有权
公开(公告)号：US20150224122A1
公开(公告)日：2015-08-13
申请号：US14694699
申请日：2015-04-23
申请人： BOARD OF TRUSTEES OF NORTHERN ILLINOIS UNIVERSITY
发明人： Elizabeth R. Gaillard , James P. Dillon
IPC分类号： A61K31/661
CPC分类号： A61K31/661
摘要： A prodrug having antioxidant activity, including a phosphorylated compound having a thiol group. A method of treating oxidative stress by administering a prodrug of a phosphorylated compound including a thiol group, removing a phosphate group of the prodrug, and treating oxidative stress. A method of increasing bioavailability of a thiol compound by creating a prodrug by phosphorylating a thiol compound, administering the prodrug, preventing first pass metabolism of the prodrug, removing a phosphate group from the prodrug, and providing active drug to a site in need of therapy from oxidative stress. A method of preventing radiation damage to healthy tissue by administering a prodrug comprising a phosphorylated compound including a thiol group, removing a phosphate group of the prodrug to provide active drug, and preventing radiation damage to healthy tissue.

9. 发明申请

US20150201309A1 SYSTEM AND METHOD FOR WIRELESS POSITIONING AND LOCATION DETERMINATION 审中-公开
标题翻译：用于无线定位和位置确定的系统和方法
公开(公告)号：US20150201309A1
公开(公告)日：2015-07-16
申请号：US14668620
申请日：2015-03-25
申请人： Board of Trustees of Northern Illinois University
发明人： Lichuan Liu
IPC分类号： H04W4/02
CPC分类号： H04W4/025 , G01S5/0289 , G01S5/10
摘要： A system and method for wireless sensor networks (WSN) positioning that is cost-effective, scalable, can be easily implemented, and provides improved performance and accuracy. A plurality of reference nodes with known locations transmit linear frequency modulation continuous waves (FMCW), while sensor nodes receive these waves and calculate the range difference among them based on the time frequency difference arrival (TFDA). The location information of the sensor nodes is obtained through the solving of a set of hyperbolic equations. Multidimensional scaling may be used or hybrid optimizing algorithm (HOA) processing to combine steepest-descent processing with Taylor series expansion to increase accuracy.
摘要翻译：可以容易地实现具有成本效益，可扩展性的无线传感器网络（WSN）定位的系统和方法，并提供改进的性能和准确性。具有已知位置的多个参考节点发射线性频率调制连续波（FMCW），而传感器节点接收这些波，并且基于时间差异到达（TFDA）计算它们之间的距离差。传感器节点的位置信息通过求解一组双曲线方程得到。可以使用多维缩放或混合优化算法（HOA）处理来将最大下降处理与泰勒级数展开相结合以增加精度。

10. 发明申请

US20140263355A1 WEB INSULATION SYSTEM, VALVE FOR A WEB INSULATION SYSTEM, AND A STORAGE CONTAINER USING THE WEB INSULATION SYSTEM 有权
标题翻译：网络绝缘系统，网络绝缘系统的阀门和使用网络绝缘系统的存储容器
公开(公告)号：US20140263355A1
公开(公告)日：2014-09-18
申请号：US13837369
申请日：2013-03-15
申请人： Board of Trustees of Northern Illinois University
发明人： Michael Wallace VERHULST , Joseph D. NIX , Christopher W. SMITH
IPC分类号： F17C13/00
CPC分类号： F17C3/08 , F17C3/02 , F17C13/001 , F17C13/08 , F17C2201/01 , F17C2201/0109 , F17C2201/0119 , F17C2201/0128 , F17C2201/0138 , F17C2201/032 , F17C2201/056 , F17C2203/016 , F17C2203/0366 , F17C2203/0391 , F17C2203/0602 , F17C2203/0629 , F17C2203/0631 , F17C2205/0149 , F17C2205/0196 , F17C2205/0323 , F17C2205/0394 , F17C2221/014 , F17C2221/017 , F17C2223/0161 , F17C2223/033 , F17C2260/033 , F17C2270/01
摘要： A storage system, including an outer casing having an evacuated inner volume; a vessel for storage located within the outer casing and having a plurality of protrusions distributed on an outer surface thereof; and a plurality of filamentary strands spanning the inner volume, wherein at least some of the plurality of protrusions are essentially tangentially contacted by a plurality of the filamentary strands to secure the vessel in six degrees of freedom relative to the outer casing.
摘要翻译：一种存储系统，包括具有抽真空内容积的外壳; 用于储存的容器，其位于外壳内并且具有分布在其外表面上的多个突起; 以及跨越所述内部体积的多个丝状细丝，其中所述多个突起中的至少一些基本上由多个所述丝状丝切向接触，以将所述容器相对于所述外部壳体固定在六个自由度。

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