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1. 发明申请

US20070048364A1 Free flowing granules containing carbomer 审中-公开
标题翻译：含有卡波姆的自由流动的颗粒
公开(公告)号：US20070048364A1
公开(公告)日：2007-03-01
申请号：US11197102
申请日：2005-08-04
申请人： Yingxu Peng , Yichun Sun , James Johnson , Atul Shukla
发明人： Yingxu Peng , Yichun Sun , James Johnson , Atul Shukla
IPC分类号： A61K9/48 , A61K9/20 , A61K9/14
CPC分类号： A61K9/1694 , A61K9/1617 , A61K9/1635 , A61K9/2013 , A61K9/2027 , A61K9/2077
摘要： Methods for making granules containing a carbomer whereby the carbomer is mixed with a hot-melt binder that does not lower the glass transition temperature of the carbomer more than 20° C., the binder is subjected to a temperature at which the hot-melt binder melts or becomes tacky, thus binding the carbomer to form an agglomerated powder, and permitting granules to form from the agglomerated powder. This subjecting of the binder to the temperature may be after the binder is mixed with the carbomer or the carbomer may be mixed with the binder at a time when the binder is at a temperature at which it will melt or become tacky. The granules may contain a biologically active substance either intragranularly or extragranularly and may be used to make personal care products or pharmaceutical dosage forms, such as controlled release dosage forms which may have bioadhesive properties.
摘要翻译：制造含有卡波姆的颗粒的方法，其中卡波姆与不降低卡波姆的玻璃化转变温度的热熔粘合剂混合超过20℃，将粘合剂经受热熔粘合剂熔融或变粘，因此结合卡波姆以形成附聚粉末，并允许从附聚粉末形成颗粒。粘合剂经受该温度之后可以在粘合剂与卡波姆混合之后，或者当粘合剂处于熔融或变粘的温度时，卡波姆可与粘合剂混合。颗粒可以含有颗粒内或颗粒外的生物活性物质，并且可以用于制备个人护理产品或药物剂型，例如可具有生物粘附性质的控释剂型。

2. 发明申请

US20050266083A1 Vehicles for delivery of biologically active substances 有权
标题翻译：交付生物活性物质的车辆
公开(公告)号：US20050266083A1
公开(公告)日：2005-12-01
申请号：US11194885
申请日：2005-08-01
申请人： Atul Shukla , James Johnson , Yichun Sun , Robert Cooper , Gregg Boring , Dan Scruggs
发明人： Atul Shukla , James Johnson , Yichun Sun , Robert Cooper , Gregg Boring , Dan Scruggs
IPC分类号： A61K9/00 , A61K31/00 , A61K31/65 , A61K47/14 , A61K9/14 , A61K31/19 , A61K31/225
CPC分类号： A61K9/0024 , A61K9/0012 , A61K9/0043 , A61K9/0048 , A61K31/00 , A61K31/65 , A61K47/14
摘要： A formulation containing one or more biologically active substances dissolved, dispersed, emulsified, or suspended within a vehicle of one or more citric acid esters and/or citric acid ethers. Methods for making and using are disclosed, as are kits for administration of the pharmaceutical formulation.
摘要翻译：含有一种或多种在一种或多种柠檬酸酯和/或柠檬酸醚的载体中溶解，分散，乳化或悬浮的生物活性物质的制剂。公开了制备和使用的方法，以及药物制剂的给药试剂盒。

3. 发明申请

US20120107393A1 Pellets for Delivery of Biologically Active Substances 审中-公开
标题翻译：用于递送生物活性物质的颗粒
公开(公告)号：US20120107393A1
公开(公告)日：2012-05-03
申请号：US13279646
申请日：2011-10-24
申请人： Sonia Bedi , Atul Shukla , Krishna Shukla
发明人： Sonia Bedi , Atul Shukla , Krishna Shukla
IPC分类号： A61K9/48 , A61P43/00 , A61K31/635 , A61K9/14 , A61K31/167
CPC分类号： A61K9/4808 , A61K9/1617 , A61K9/1652 , A61K9/2059
摘要： Pellets are made by combining a direct compression binder and a waxy spheronizing agent. The pellets may further contain additional pharmaceutical ingredients and/or a drug. The pellets may be compressed to form tablets or loaded into a capsule shell for oral administration, and the pellets may or may not have an additional coating.
摘要翻译：颗粒通过组合直接压缩粘合剂和蜡状滚圆剂而制成。丸剂可以进一步含有另外的药物成分和/或药物。可以将颗粒压片以形成片剂或装载到用于口服给药的胶囊壳中，并且颗粒可以或可以不具有另外的涂层。

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