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1. 发明授权

US06588237B2 Knitted fabric 有权
公开(公告)号：US06588237B2
公开(公告)日：2003-07-08
申请号：US10079839
申请日：2002-02-20
申请人： Claire Cole , Michael Starbuck , Phillip Sharrocks , Andrew Ratcliffe
发明人： Claire Cole , Michael Starbuck , Phillip Sharrocks , Andrew Ratcliffe
IPC分类号： D04B716
CPC分类号： A43B23/0255 , D04B1/16 , D10B2403/0114
摘要： A knitted fabric comprising a plurality of knitted stitches which are interconnected to define a plurality of courses and wales, the knitted stitches being formed from a heat fusible yarn, with at least some of said stitches being formed from said heat fusible yarn plated with a ground yarn, the heat fusible yarn being fused together at adjacent points of contact on stitches in order to give the fabric a desired dimensional stability and shape.

2. 发明授权

US09040545B2 Heterocyclyl pyrazolopyrimidine analogues as selective JAK inhibitors 有权
标题翻译：杂环吡唑并嘧啶类似物作为选择性JAK抑制剂
公开(公告)号：US09040545B2
公开(公告)日：2015-05-26
申请号：US13816555
申请日：2011-08-12
申请人： Kathryn Bell , Nelly Piton , Claudio Dagostin , Cyrille Boussard , Andrew Ratcliffe , Nigel Ramsden
发明人： Kathryn Bell , Nelly Piton , Claudio Dagostin , Cyrille Boussard , Andrew Ratcliffe , Nigel Ramsden
IPC分类号： A01N43/90 , A61K31/519 , C07D487/00 , C07D487/04 , C07D519/00 , C07D491/107 , C07D498/08
CPC分类号： C07D487/04 , A61K31/519 , C07D491/107 , C07D498/08 , C07D519/00
摘要： The present invention relates to compounds of formula (I) wherein X1 to X5, Y, Z1 to Z3, and R have the meaning as cited in the description and the claims. Said compounds are useful as JAK inhibitors for the treatment or prophylaxis of immunological, inflammatory, autoimmune, allergic disorders, and immunologically-mediated diseases. The invention also relates to pharmaceutical compositions including said compounds, the preparation of such compounds as well as the use as medicaments.
摘要翻译：本发明涉及其中X1至X5，Y，Z1至Z3和R具有在说明书和权利要求书中引用的含义的式（I）化合物。所述化合物可用作JAK抑制剂，用于治疗或预防免疫学，炎症，自身免疫，过敏性疾病和免疫介导的疾病。本发明还涉及包含所述化合物的药物组合物，这些化合物的制备以及作为药物的用途。

3. 发明申请

US20070156276A1 Process for producing a knitted fabric 失效
标题翻译：针织物的制造方法
公开(公告)号：US20070156276A1
公开(公告)日：2007-07-05
申请号：US10548218
申请日：2004-03-03
申请人： John Smedley , Andrew Ratcliffe
发明人： John Smedley , Andrew Ratcliffe
IPC分类号： G06F19/00
CPC分类号： D04B37/02 , D04B7/26
摘要： A method for creating pattern instructions for an electronic patterning control of a knitting machine to enable the knitting machine to knit fabric having a desired pictorial image as part of the knitted structure, the pictorial image being created by a series of consecutive courses each having knitted stitches formed of a first yarn having a first visual characteristic interspersed with knitted stitches formed of a second yarn having a second visual characteristic, adjacent knitted stitches of the second yarn that are separated by one or more knitted stitches of the first yarn being connected by a float loop spanning said one or more knitted stitches of the first yarn.
摘要翻译：一种用于创建针织机的电子图案化控制的图案指令的方法，以使得针织机能够将具有期望的图形图像的织物编织为针织结构的一部分，该图形由一系列具有编织针迹由具有由具有第二视觉特性的第二纱线形成的针织针迹的第一视觉特征的第一纱线形成，第二纱线的相邻针织线圈由第一纱线的一个或多个针织线分开，该针织线圈由浮子连接循环跨越所述第一纱线的一个或多个针织针迹。

4. 发明申请

US20050150258A1 Band with crossover 审中-公开
标题翻译：带交叉带
公开(公告)号：US20050150258A1
公开(公告)日：2005-07-14
申请号：US11072857
申请日：2005-03-04
申请人： John Mitchell , Andrew Ratcliffe
发明人： John Mitchell , Andrew Ratcliffe
IPC分类号： A41C3/00 , A41C3/06 , D04B1/24 , D04B1/00
CPC分类号： A41C3/06 , A41C3/0014 , D04B1/102 , D04B1/243 , D04B1/246 , D10B2403/0332
摘要： A circularly knitted garment having a body portion and a shaped band. The shaped band is defined in the body portion such that a seamless interface is formed between the body portion and the shaped band. The shaped band has at least one crossover portion.
摘要翻译：一种具有主体部分和成形带的圆形针织服装。成形带限定在主体部分中，使得在主体部分和成形带之间形成无缝界面。成形带具有至少一个交叉部分。

5. 发明授权

US09242987B2 Heterocyclyl pyrazolopyrimidine analogues as JAK inhibitors 有权
标题翻译：杂环吡唑并嘧啶类似物作为JAK抑制剂
公开(公告)号：US09242987B2
公开(公告)日：2016-01-26
申请号：US13503083
申请日：2010-10-19
申请人： Nigel Ramsden , Richard John Harrison , Sally Oxenford , Kathryn Bell , Nelly Piton , Claudio Dagostin , Cyrille Broussard , Andrew Ratcliffe
发明人： Nigel Ramsden , Richard John Harrison , Sally Oxenford , Kathryn Bell , Nelly Piton , Claudio Dagostin , Cyrille Broussard , Andrew Ratcliffe
IPC分类号： C07D487/04 , A61K31/519 , A61P29/00 , A61P37/00 , A61P37/08 , A61P41/00 , A61K31/541 , A61K31/5386 , A61K31/5377 , A61K31/496
CPC分类号： C07D487/04
摘要： The invention relates to compounds of formula (I) wherein X1 to X5, Y, Z1 to Z3, and R have the meaning as cited in the description and the claims. Said compounds are useful as JAK inhibitors for the treatment or prophylaxis of immunological, inflammatory, autoimmune, allergic disorders, and immunologically-mediated diseases. The invention also relates to pharmaceutical compositions including said compounds, the preparation of such compounds as well as the use as medicaments.
摘要翻译：本发明涉及式（I）的化合物，其中X 1至X 5，Y，Z 1至Z 3和R具有在说明书和权利要求书中引用的含义。所述化合物可用作JAK抑制剂，用于治疗或预防免疫学，炎症，自身免疫，过敏性疾病和免疫介导的疾病。本发明还涉及包含所述化合物的药物组合物，这些化合物的制备以及作为药物的用途。

6. 发明申请

US20120252779A1 HETEROCYCLYL PYRAZOLOPYRIMIDINE ANALOGUES AS JAK INHIBITORS 有权
标题翻译：作为JAK抑制剂的间苯二酚吡唑啉酮类似物
公开(公告)号：US20120252779A1
公开(公告)日：2012-10-04
申请号：US13503083
申请日：2010-10-19
申请人： Nigel Ramsden , Richard John Harrison , Sally Oxenford , Kathryn Bell , Nelly Piton , Claudio Dagostin , Cyrille Boussard , Andrew Ratcliffe
发明人： Nigel Ramsden , Richard John Harrison , Sally Oxenford , Kathryn Bell , Nelly Piton , Claudio Dagostin , Cyrille Boussard , Andrew Ratcliffe
IPC分类号： A61K31/519 , A61K31/5386 , A61K31/5377 , A61K31/496 , A61P41/00 , C07D487/04 , A61P37/00 , A61P29/00 , A61P37/08 , A61K31/541 , C07D498/08
CPC分类号： C07D487/04
摘要： The invention relates to compounds of formula (I) wherein X1 to X5, Y, Z1 to Z3, and R have the meaning as cited in the description and the claims. Said compounds are useful as JAK inhibitors for the treatment or prophylaxis of immunological, inflammatory, autoimmune, allergic disorders, and immunologically-mediated diseases. The invention also relates to pharmaceutical compositions including said compounds, the preparation of such compounds as well as the use as medicaments.
摘要翻译：本发明涉及式（I）的化合物，其中X 1至X 5，Y，Z 1至Z 3和R具有在说明书和权利要求书中引用的含义。所述化合物可用作JAK抑制剂，用于治疗或预防免疫学，炎症，自身免疫，过敏性疾病和免疫介导的疾病。本发明还涉及包含所述化合物的药物组合物，这些化合物的制备以及作为药物的用途。

7. 发明授权

US07272462B2 Process for producing a knitted fabric 失效
公开(公告)号：US07272462B2
公开(公告)日：2007-09-18
申请号：US10548218
申请日：2004-03-03
申请人： John Smedley , Andrew Ratcliffe
发明人： John Smedley , Andrew Ratcliffe
IPC分类号： G06F19/00
CPC分类号： D04B37/02 , D04B7/26
摘要： A method for creating pattern instructions for an electronic patterning control of a knitting machine to enable the knitting machine to knit fabric having a desired pictorial image as part of the knitted structure, the pictorial image being created by a series of consecutive courses each having knitted stitches formed of a first yarn having a first visual characteristic interspersed with knitted stitches formed of a second yarn having a second visual characteristic, adjacent knitted stitches of the second yarn that are separated by one or more knitted stitches of the first yarn being connected by a float loop spanning said one or more knitted stitches of the first yarn.

8. 发明申请

US20050009831A1 Chemical compounds 失效
公开(公告)号：US20050009831A1
公开(公告)日：2005-01-13
申请号：US10803566
申请日：2004-03-18
申请人： Andrew Ratcliffe , Roger Aitchison Walsh , Tahir Majid , Sukanthini Thurairatnam , Shelley Amendola , David Aldous , John Souness , Conception Nemecek , Sylvie Wentzler , Corinne Venot
发明人： Andrew Ratcliffe , Roger Aitchison Walsh , Tahir Majid , Sukanthini Thurairatnam , Shelley Amendola , David Aldous , John Souness , Conception Nemecek , Sylvie Wentzler , Corinne Venot
IPC分类号： A61K31/495 , A61K31/498 , A61K31/4985 , A61K31/5377 , A61K31/551 , A61K45/00 , A61P35/00 , A61P43/00 , C07D487/04
CPC分类号： A61K31/495 , C07D487/04 , Y02A50/411
摘要： The present invention concerns compounds of general formula (I): in which: R1 represents hydrogen, R4, —C(═Y)—NHR4, —SO2NHR4, —C(=Z1)—R4, —SO2—R4 or —C(=Z1)—OR4; R2 represents hydrogen, cyano, halogen or —C≡C—R5; R3 represents hydrogen, acyl, alkoxycarbonyl, alkyl, aroyl, aryl, aryloxycarbonyl, carboxy, cycloalkenyl, cycloalkyl, heteroaroyl, heteroaryl, heterocycloalkyl or —C(═O)—NY1Y2; R4 represents optionally substituted alkyl, cycloalkyl, cycloalkenyl, heterocycloalkyl, aryl or heteroaryl R5 represents hydrogen or alkyl; R6 represents alkyl, acyl, alkoxycarbonyl, alkylsulfonyl, aryl, arylsulfonyl, aroyl, cycloalkyl, cycloalkenyl, heteroaryl, heteroarylsulfonyl, heteroaroyl and heterocycloalkyl; R7 represents optionally substituted alkyl, cycloalkyl or cycloalkylalkyl, R8 represents hydrogen, alkyl, alkenyl, aryl, arylalkyl, heteroaryl or heteroarylalkyl; R9 represents alkyl, aryl, arylalkyl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroarylalkyl, heterocycloalkyl or heterocycloalkylalkyl; R10 represents hydrogen or lower alkyl; R11 represents alkyl, aryl, arylalkyl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroarylalkyl, heterocycloalkyl or heterocycloalkylalkyl; or alkyl optionally substituted by —NY1Y2; R12 represents aryl or heteroaryl; or alkyl, cycloalkyl, cycloalkylalkyl, heterocycloalkyl or heterocycloalkylalkyl each optionally substituted Y represents O, S or NCN; Y1 and Y2 (Y3 and Y4) are independently in particular hydrogen, alkyl, aryl, cycloalkyl, cycloalkenyl, heteroaryl or heterocycloalkyl; or the group —NY1Y2 may form 5-7 membered ring or the group —NY3Y4 (—NY5Y6) may form a cyclic amine; Z (Z1) represents O or S; Z2 represents O or S(O)p; n is zero or an integer 1 or 2; m is 1 or 2; p is 1 or 2; and their corresponding N-oxides, their prodrugs; their pharmaceutically acceptable salts and solvates (e.g. hydrates), also together with one or more pharmaceutically acceptable carriers or excipients, such novel indolizines derivatives with inhibitory effects towards kinase proteins and especially for use for preventing or treating diseases that may be modulated by the inhibition of such kinase proteins and particularly solid tumours.

9. 发明授权

US06886367B2 Circular knitted garments having seamless shaped bands 有权
标题翻译：圆形针织服装具有无缝形状的乐队
公开(公告)号：US06886367B2
公开(公告)日：2005-05-03
申请号：US10404918
申请日：2003-04-01
申请人： John C. Mitchell , Andrew Ratcliffe , Chris Williamson
发明人： John C. Mitchell , Andrew Ratcliffe , Chris Williamson
IPC分类号： A41C3/00 , A41C3/06 , D04B1/24 , A41B9/00
CPC分类号： A41C3/06 , A41C3/0014 , D04B1/102 , D04B1/246 , D10B2403/0332
摘要： A circularly knitted garment having a body portion and a shaped band is provided. The body portion has a first area defined therein. The shaped band is also defined in the body portion such that a seamless interface is formed between the body portion and the shaped band.
摘要翻译：提供具有主体部分和成形带的圆形针织服装。主体部分具有限定在其中的第一区域。成形带也被限定在主体部分中，使得在主体部分和成形带之间形成无缝界面。

10. 发明申请

US20130190292A1 HETEROCYCLYL PYRAZOLOPYRIMIDINE ANALOGUES AS SELECTIVE JAK INHIBITORS 有权
标题翻译：作为选择性JAK抑制剂的杂环基亚氨基嘧啶类似物
公开(公告)号：US20130190292A1
公开(公告)日：2013-07-25
申请号：US13816555
申请日：2011-08-12
申请人： Kathryn Bell , Nelly Piton , Claudio Dagostin , Cyrille Boussard , Andrew Ratcliffe , Nigel Ramsden
发明人： Kathryn Bell , Nelly Piton , Claudio Dagostin , Cyrille Boussard , Andrew Ratcliffe , Nigel Ramsden
IPC分类号： C07D487/04 , C07D491/107 , C07D498/08
CPC分类号： C07D487/04 , A61K31/519 , C07D491/107 , C07D498/08 , C07D519/00
摘要： The present invention relates to compounds of formula (I) wherein X1 to X5, Y, Z1 to Z3, and R have the meaning as cited in the description and the claims. Said compounds are useful as JAK inhibitors for the treatment or prophylaxis of immunological, inflammatory, autoimmune, allergic disorders, and immunologically-mediated diseases. The invention also relates to pharmaceutical compositions including said compounds, the preparation of such compounds as well as the use as medicaments.
摘要翻译：本发明涉及其中X1至X5，Y，Z1至Z3和R具有在说明书和权利要求书中引用的含义的式（I）化合物。所述化合物可用作JAK抑制剂，用于治疗或预防免疫学，炎症，自身免疫，过敏性疾病和免疫介导的疾病。本发明还涉及包含所述化合物的药物组合物，这些化合物的制备以及作为药物的用途。

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