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1. 发明申请

US20100048690A2 ANTITUMORAL DIHYDROPYRAN-2-ONE COMPOUNDS 有权
标题翻译：抗肿瘤二氢二-2-酮化合物
公开(公告)号：US20100048690A2
公开(公告)日：2010-02-25
申请号：US12304123
申请日：2007-06-15
申请人： Ma Jesus Martin Lopez , Laura Coello Molinero , Jose Fernando Reyes Benitez , Alberto Rodriguez Vicente , Maria Garranzo Garcia-Ibarrola , Carmen Murcia Perez , Andres Francesch Solloso , Francisco Sanchez Sancho , Maria del Carmen Cuevas Marchante , Rogelio Fernandez Rodriguez
发明人： Ma Jesus Martin Lopez , Laura Coello Molinero , Jose Fernando Reyes Benitez , Alberto Rodriguez Vicente , Maria Garranzo Garcia-Ibarrola , Carmen Murcia Perez , Andres Francesch Solloso , Francisco Sanchez Sancho , Maria del Carmen Cuevas Marchante , Rogelio Fernandez Rodriguez
IPC分类号： A61K31/351 , C07D309/30 , C12P17/06 , A61P35/00
CPC分类号： C07D309/32
摘要： Antitumoral compounds obtained from a porifera, of the family Raspailiidae, genus Lithoplocamia, species lithistoides, and derivatives thereof are provided.
摘要翻译：提供了从茯苓，蔷薇科，落叶松属，物种listoistoides及其衍生物获得的抗肿瘤化合物。

2. 发明申请

US20080103320A2 Total Synthesis of Myriaporones 失效
标题翻译：全氟化氢的合成
公开(公告)号：US20080103320A2
公开(公告)日：2008-05-01
申请号：US10523172
申请日：2005-09-01
申请人： Carlos del Pozo Losada , Andres Francesch Solloso , Carmen Cuevas Marchante , Marta Perez Alvarez
发明人： Carlos del Pozo Losada , Andres Francesch Solloso , Carmen Cuevas Marchante , Marta Perez Alvarez
IPC分类号： C07D407/02 , C07D303/34
CPC分类号： C07D407/06 , A61K31/35 , C07D493/08 , Y02P20/55
摘要： Compounds of the general formula (I) or pharmaceutically acceptable salt, derivative, prodrug or stereoisomer thereof are provided: wherein the substituent groups defined by R are each independently selected from the group consisting of H, SiR′3, SOR′, SO2X, C(═O)R′, C(═O)OR′, C(═O)NR′, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, aryl, heteroaryl or aralkyl; the group R′ is selected from substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, aminoalkyl, aryl, aralkyl and heterocyclic groups; and the group R″ is selected from the group consisting of H, OH, OR′, OCOR′, SH, SR′, SOR′, SO2R′, NO2, NH2, NHR′, N(R′)2, NHCOR′, N(COR′)2, NHSO2R′, CN, halogen, C(=O)H, C(=O)R′, CO2H, CO2R′, CH2OR, substituted or unsubstituted alkyl, substituted or unsubstituted haloalkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkylidene, substituted or unsubstituted alkynyl, substituted or unsubstituted aryl, substituted or unsubstituted aralkyl and substituted or unsubstituted heteroaromatic; with the proviso that the compound is not compound 1, 3 or 4 of U.S. Pat. No. 5,514,708. The compounds have antitumour activity. A synthetic route is also provided.

3. 发明申请

US20080269511A2 Total Synthesis of Myriaporones 失效
标题翻译：全氟化氢的合成
公开(公告)号：US20080269511A2
公开(公告)日：2008-10-30
申请号：US10523172
申请日：2005-09-01
申请人： Carlos del Pozo Losada , Andres Francesch Solloso , Carmen Cuevas Marchante , Marta Perez Alvarez
发明人： Carlos del Pozo Losada , Andres Francesch Solloso , Carmen Cuevas Marchante , Marta Perez Alvarez
IPC分类号： C07D407/02 , C07D303/34
CPC分类号： C07D407/06 , A61K31/35 , C07D493/08 , Y02P20/55
摘要： Compounds of the general formula (I) or a pharmaceutically acceptable salt, derivative, prodrug or stereoisomer thereof are provided: wherein the substituent groups defined by R are each independently selected from the group consisting of H, SiR′3, SOR′, SO2X, C(═O)R′, C(═O)OR′, C(═O)NR′, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, aryl, heteroaryl or aralkyl; the group R′ is selected from substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, aminoalkyl, aryl, aralkyl and heterocyclic groups; and the group R″ is selected from the group consisting of H, OH, OR′, OCOR′, SH, SR′, SOR′, SO2R′, NO2, NH2, NHR′, N(R′)2, NHCOR′, N(COR′)2, NHSO2R′, CN, halogen, C(═O)H, C(═O)R′, CO2H, CO2R′, CH2OR, substituted or unsubstituted alkyl, substituted or unsubstituted haloalkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkylidene, substituted or unsubstituted alkynyl, substituted or unsubstituted aryl, substituted or unsubstituted aralkyl and substituted or unsubstituted heteroaromatic; with the proviso that the compound is not compound 1, 3 or 4 of U.S. Pat. No. 5,514,708. The compounds have antitumour activity. A synthetic route is also provided.
摘要翻译：提供了通式（I）化合物或其药学上可接受的盐，衍生物，前药或立体异构体：其中由R定义的取代基各自独立地选自H，SiR'3 （O）OR'，C（ - ）NR'，取代或未取代的烷基，取代或未取代的链烯基，取代或未取代的炔基，芳基，杂芳基或芳烷基; 基团R'选自取代或未取代的烷基，取代或未取代的烯基，取代或未取代的炔基，氨基烷基，芳基，芳烷基和杂环基; 并且基团R“选自H，OH，OR'，OCOR'，SH，SR'，SOR'，SO 2 R'，NO 2， NH 2，NH 2，NH 2，NH 2，NH 2，NH 2，NH 2，NH 3， R 2，R 2，R 2，R 2，R 2，R 2，R 2，R 3，取代或未取代的烷基，取代或未取代的烷基，取代或未取代的亚烷基，取代或未取代的炔基，取代或未取代的芳基，取代或未取代的芳烷基和取代或未取代的芳烷基杂芳族; 条件是该化合物不是美国专利号4,3,3或4的化合物1,3或4。第5,514,708号。该化合物具有抗肿瘤活性。还提供了合成路线。

4. 发明申请

US20090186938A1 ANTITUMORAL DIHYDROPYRAN-2-ONE COMPOUNDS 有权
标题翻译：抗肿瘤二氢二-2-酮化合物
公开(公告)号：US20090186938A1
公开(公告)日：2009-07-23
申请号：US12304123
申请日：2007-06-15
申请人： Ma Jesus Martin Lopez , Laura Coello Molinero , Jose Fernando Reyes Benitez , Alberto Rodriguez Vicente , Maria Garranzo Garcia-Ibarrola , Carmen Murcia Perez , Andres Francesch Solloso , Francisco Sanchez Sancho , Maria del Carmen Cuevas Marchante , Rogelio Fernandez Rodriguez
发明人： Ma Jesus Martin Lopez , Laura Coello Molinero , Jose Fernando Reyes Benitez , Alberto Rodriguez Vicente , Maria Garranzo Garcia-Ibarrola , Carmen Murcia Perez , Andres Francesch Solloso , Francisco Sanchez Sancho , Maria del Carmen Cuevas Marchante , Rogelio Fernandez Rodriguez
IPC分类号： A61K31/351 , C07D309/30 , C12P17/06 , A61P35/00
CPC分类号： C07D309/32
摘要： Antitumoral compounds obtained from a porifera, of the family Raspailiidae, genus Lithoplocamia, species lithistoides, and derivatives thereof are provided.
摘要翻译：提供了从茯苓，蔷薇科，落叶松属，物种listoistoides及其衍生物获得的抗肿瘤化合物。

5. 发明申请

US20090030068A1 Antitumour Compounds 审中-公开
标题翻译：抗肿瘤药物
公开(公告)号：US20090030068A1
公开(公告)日：2009-01-29
申请号：US12097212
申请日：2006-12-14
申请人： Ma Jesus Martin Lopez , Jose Fernando Reyes Benitez , Rogelio Fernandez Rodriguez , Andres Francesch Solloso , Maria del Carmen Cuevas Marchante , Laura Coello Molinero
发明人： Ma Jesus Martin Lopez , Jose Fernando Reyes Benitez , Rogelio Fernandez Rodriguez , Andres Francesch Solloso , Maria del Carmen Cuevas Marchante , Laura Coello Molinero
IPC分类号： A61K31/335 , C07D323/00 , A61P35/00
CPC分类号： C07D493/18
摘要： The invention relates to novel antitumor compounds of general formula as well as their corresponding pharmaceutically acceptable salts, derivatives, prodrugs and stereoisomers. These compounds can be obtained by isolating a sponge from family Theonellidae, genus Theonella and species swinhoei, and forming derivatives from the isolated compounds. These compounds have cytotoxic activity and can be used for the treatment of the cancer.
摘要翻译：本发明涉及通式的新型抗肿瘤化合物及其相应的药学上可接受的盐，衍生物，前药和立体异构体。这些化合物可以通过从Theonellidae，Theonella属和swinhoei种分离海绵，并从分离的化合物形成衍生物获得。这些化合物具有细胞毒性活性，可用于治疗癌症。

6. 发明申请

US20090124647A1 Indole Derivatives as Antitumoral Compounds 审中-公开
标题翻译：吲哚衍生物作为抗肿瘤化合物
公开(公告)号：US20090124647A1
公开(公告)日：2009-05-14
申请号：US12093563
申请日：2006-11-13
申请人： Jose Fernando Reyes Benitez , Andres Francesch Solloso , Carmen Cuevas Marchante , Marta Altuna Urquijo , Daniel Pla Queral , Mercedes Alvarez Domingo , Fernando Albericio Palomera
发明人： Jose Fernando Reyes Benitez , Andres Francesch Solloso , Carmen Cuevas Marchante , Marta Altuna Urquijo , Daniel Pla Queral , Mercedes Alvarez Domingo , Fernando Albericio Palomera
IPC分类号： A61K31/506 , C07D403/04
CPC分类号： C07D403/04
摘要： Antitumoural compounds of general formula (I); wherein Ar is an heterocyclic group of formula (a) and R1, R2, R3, R4, R5, R6, R7, n and the dotted line take permitted meanings can be obtained from a tunicate of the family Polyclinidae, genus Aplidium, species cyaneum, and the invention further provides derivatives thereof.
摘要翻译：通式（I）的抗肿瘤化合物; 其中Ar是式（a）的杂环基，R 1，R 2，R 3，R 4，R 5，R 6，R 7，n和虚线取允许的含义可以从id科，亚科，本发明还提供其衍生物。

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